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Commitments and Contingencies - Additional Information (Details) - USD ($) $ in Millions | 1 Months Ended | 3 Months Ended |  |
--- | --- | --- | --- | ---
Dec. 31, 2016 | Mar. 31, 2016 | Mar. 31, 2018 | Sep. 30, 2016 | Mar. 31, 2019 | Dec. 31, 2018
Loss Contingencies [Line Items] |  |  |  |  |  |
Litigation accrual |  |  |  |  | $ 0 | $ 0
Indenix [Member] |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |
Damages awarded | $ 2,540 |  |  |  |  |
Motion invalidated past damages, amount |  |  | $ 2,540 |  |  |
Merck '499 and '712 patents |  |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |  |
Damages awarded |  | $ 200 |  |  |  |
Damages awarded but dismissed, amount |  |  |  | $ 200 |  |

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