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Property, plant and equipment (Tables) | 12 Months Ended
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Dec. 31, 2019
Property, Plant and Equipment Disclosure [Abstract] |
Property, Plant and Equipment | Property, plant and equipment (in millions):
|  | December 31,
|  | 2019 |  | 2018
Land and land improvements |  | $ | 404 |  |  | $ | 404 |
Buildings and improvements (including leasehold improvements) |  | 3,358 |  |  | 2,344 |
Laboratory and manufacturing equipment |  | 805 |  |  | 697 |
Office and computer equipment |  | 634 |  |  | 558 |
Construction in progress |  | 723 |  |  | 1,194 |
Subtotal |  | 5,924 |  |  | 5,197 |
Less accumulated depreciation and amortization |  | (1,422 | ) |  | (1,191 | )
Total |  | $ | 4,502 |  |  | $ | 4,006 |

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- Definition Tabular disclosure of physical assets used in the normal conduct of business and not intended for resale. Includes, but is not limited to, balances by class of assets, depreciation and depletion expense and method used, including composite depreciation, and accumulated deprecation. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(13)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6391035&loc=d3e2868-110229 + Details
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