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Property, Plant and Equipment
12 Months Ended
Dec. 31, 2020
Property, Plant and Equipment [Abstract]  
Property, plant and equipment PROPERTY, PLANT AND EQUIPMENT
The following table summarizes our Property, plant and equipment, net:
December 31,
(in millions)20202019
Land and land improvements$404 $404 
Buildings and improvements (including leasehold improvements)3,678 3,358 
Laboratory and manufacturing equipment904 805 
Office, computer equipment and other793 634 
Construction in progress856 723 
Subtotal6,635 5,924 
Less: accumulated depreciation and amortization1,668 1,422 
Total$4,967 $4,502 
We had unamortized capitalized software costs, included in Office, computer equipment and other, of $124 million and $108 million as of December 31, 2020 and 2019, respectively. Capitalized interest on construction in-progress is included in Property, plant and equipment. Interest capitalized in 2020, 2019 and 2018 was not material.
Long-Lived Assets
The net book value of our property, plant and equipment (less office, computer equipment and other) in the United States was $3.8 billion as of December 31, 2020, $3.5 billion as of December 31, 2019 and $3.2 billion as of December 31, 2018. The corresponding amount in international locations was $897 million as of December 31, 2020, $791 million as of December 31, 2019 and $620 million as of December 31, 2018. All individual international locations accounted for less than 10% of the total balances.