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Property, Plant and Equipment - Schedule of property, plant and equipment (Details) - USD ($)
$ in Millions
Dec. 31, 2020
Dec. 31, 2019
Property, Plant and Equipment [Abstract]    
Land and land improvements $ 404 $ 404
Buildings and improvements (including leasehold improvements) 3,678 3,358
Laboratory and manufacturing equipment 904 805
Office, computer equipment and other 793 634
Construction in progress 856 723
Property, plant and equipment, gross 6,635 5,924
Less: accumulated depreciation and amortization 1,668 1,422
Property, plant and equipment, net $ 4,967 $ 4,502