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Employee Benefits - Narrative (Details) - USD ($)
$ / shares in Units, shares in Millions, $ in Millions
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Oct. 23, 2020
Apr. 07, 2020
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Stock-based compensation expense $ 1,076 $ 636 $ 845    
Value of stock issued 100 90 91    
Matching contribution expense $ 144 110 91    
2004 Plan | Common Stock           
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Common stock authorized (in shares) 309        
Shares available for future grant (in shares) 96        
2018 Plan | Common Stock           
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Common stock authorized (in shares)         12
Immunomedics Plan | Common Stock           
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Common stock authorized (in shares)       26  
Stock option          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Expiration period 10 years        
Intrinsic value of options exercised $ 179 $ 209 $ 412    
Weighted average grant date fair value $ 11.69 $ 12.15 $ 17.03    
Unrecognized compensation cost $ 55        
Period for recognition 2 years 3 months 18 days        
Stock option | Minimum          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Stock options vesting period 3 years        
Stock option | Maximum          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Stock options vesting period 4 years        
RSUs          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Granted $ 70.94 64.31 77.98    
RSUs | Minimum          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Stock options vesting period 3 years        
RSUs | Maximum          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Stock options vesting period 4 years        
PSUs          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Granted $ 83.64 $ 68.30 $ 88.76    
PSUs | Minimum          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Stock options vesting period 1 year        
Payout percentage 0.00%        
PSUs | Maximum          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Stock options vesting period 2 years        
Payout percentage 200.00%        
Restricted stock and performance share awards          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Unrecognized compensation cost $ 860        
Period for recognition 2 years 2 months 12 days        
Employee stock purchase plan          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Shares available for future grant (in shares) 7        
Purchase price of common stock (percent) 85.00%        
Issuances under employee stock purchase plan (in shares) 2        
Value of stock issued $ 100        
Capital shares reserved for future issuance 79        
Deferred compensation plan | Level 1 | Fair value, recurring          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Marketable equity securities $ 218 $ 171      
Fair value at grant date | Restricted stock and performance share awards          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Total fair value of vested stock awards as of vesting date 479 450 $ 481    
Fair value at vesting date | Restricted stock and performance share awards          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Total fair value of vested stock awards as of vesting date $ 459 $ 372 $ 446