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Income Taxes - Schedule of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Millions | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
--- | --- | --- | ---
Deferred tax assets: |  |  |
Net operating loss carryforwards | $ 413 | $ 587 |
Stock-based compensation | 117 | 113 |
Reserves and accruals not currently deductible | 700 | 444 |
Excess of tax basis over book basis of intangible assets | 1,157 | 1,177 |
Upfront and milestone payments | 1,310 | 1,144 |
Research and other credit carryforwards | 249 | 219 |
Equity investments | 117 | 116 |
Liability related to future royalties | 274 | 247 |
Other, net | 292 | 311 |
Total deferred tax assets before valuation allowance | 4,629 | 4,358 |
Valuation allowance | (520) | (398) | $ (217)
Total deferred tax assets | 4,109 | 3,960 |
Deferred tax liabilities: |  |  |
Property, plant and equipment | (227) | (202) |
Excess of book basis over tax basis of intangible assets | (6,719) | (6,168) |
Other | (180) | (202) |
Total deferred tax liabilities | (7,126) | (6,572) |
Net deferred tax assets (liabilities) | $ (3,017) | $ (2,612) |

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