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Property, Plant and Equipment
12 Months Ended
Dec. 31, 2021
Property, Plant and Equipment [Abstract]  
Property, Plant and Equipment PROPERTY, PLANT AND EQUIPMENT
The following table summarizes our Property, plant and equipment, net:
December 31,
(in millions)20212020
Land and land improvements$404 $404 
Buildings and improvements (including leasehold improvements)3,794 3,678 
Laboratory and manufacturing equipment952 904 
Office, computer equipment and other807 793 
Construction in progress1,057 856 
Subtotal7,014 6,635 
Less: accumulated depreciation and amortization1,893 1,668 
Total$5,121 $4,967 
We had unamortized capitalized software costs, included in Office, computer equipment and other, of $131 million and $124 million as of December 31, 2021 and 2020, respectively. Capitalized interest on construction in progress is included in Property, plant and equipment, net on our Consolidated Balance Sheets. Interest capitalized in 2021 and 2020 was not material.
The net book value of our property, plant and equipment in the United States was $4.1 billion and $4.0 billion as of December 31, 2021 and 2020, respectively. The corresponding amount in international locations was $963 million and $940 million as of December 31, 2021 and 2020, respectively. All individual international locations accounted for less than 10% of the total balances.