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Property, Plant and Equipment (Tables)
12 Months Ended
Dec. 31, 2021
Property, Plant and Equipment [Abstract]  
Property, Plant and Equipment
The following table summarizes our Property, plant and equipment, net:
December 31,
(in millions)20212020
Land and land improvements$404 $404 
Buildings and improvements (including leasehold improvements)3,794 3,678 
Laboratory and manufacturing equipment952 904 
Office, computer equipment and other807 793 
Construction in progress1,057 856 
Subtotal7,014 6,635 
Less: accumulated depreciation and amortization1,893 1,668 
Total$5,121 $4,967