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Derivative Financial Instruments - Summary of Effect of Foreign Currency Exchange Contracts (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Derivative Instruments and Hedging Activities Disclosure [Abstract]
Gain (loss) recognized in AOCI	$ 147	$ (118)	$ 76
Gain (loss) reclassified from AOCI into Product sales	(67)	47	127
Gain (loss) recognized in Other income (expense), net	$ 21	$ (51)	$ 22

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Amount of realized and unrealized gain (loss) of derivative instruments not designated or qualifying as hedging instruments.

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Amount, before tax and reclassification, of gain (loss) from derivative instrument designated and qualifying cash flow hedge included in assessment of hedge effectiveness.

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Amount, before tax, of reclassification of gain (loss) from accumulated other comprehensive income (AOCI) for derivative instrument designated and qualifying as cash flow hedge included in assessment of hedge effectiveness.

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