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Property, Plant and Equipment - Schedule of Property, Plant and Equipment (Details) - USD ($) $ in Millions	Dec. 31, 2021	Dec. 31, 2020
Property, Plant and Equipment [Abstract]
Land and land improvements	$ 404	$ 404
Buildings and improvements (including leasehold improvements)	3,794	3,678
Laboratory and manufacturing equipment	952	904
Office, computer equipment and other	807	793
Construction in progress	1,057	856
Subtotal	7,014	6,635
Less: accumulated depreciation and amortization	1,893	1,668
Total	$ 5,121	$ 4,967

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Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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Amount before accumulated depreciation of building structures held for productive use including addition, improvement, or renovation to the structure, including, but not limited to, interior masonry, interior flooring, electrical, and plumbing.

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Amount of structure or a modification to a structure under construction. Includes recently completed structures or modifications to structures that have not been placed into service.

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Amount before accumulated depreciation of tangible personal property used to produce goods and services, including, but is not limited to, tools, dies and molds, computer and office equipment.

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