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Employee Benefits - Narrative (Details) - USD ($)
$ / shares in Units, shares in Millions, $ in Millions
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Value of stock issued $ 111 $ 100 $ 90
Matching contribution expense $ 166 144 110
2004 Plan | Common Stock       
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Common stock authorized (in shares) 309    
Shares available for future grant (in shares) 82    
2018 Plan | Common Stock       
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Common stock authorized (in shares) 12    
Immunomedics Plan | Common Stock       
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Common stock authorized (in shares) 26    
Stock option      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Expiration period 10 years    
Intrinsic value of options exercised $ 48 $ 179 $ 209
Weighted average grant date fair value (in dollars per share) $ 10.05 $ 11.69 $ 12.15
Unrecognized compensation cost $ 47    
Period for recognition 2 years 3 months 18 days    
Stock option | Minimum      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Stock options vesting period 3 years    
Stock option | Maximum      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Stock options vesting period 4 years    
RSUs      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Granted (in dollars per share) $ 65.42 70.94 64.31
RSUs | Minimum      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Stock options vesting period 3 years    
RSUs | Maximum      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Stock options vesting period 4 years    
PSUs      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Granted (in dollars per share) $ 71.31 $ 83.64 $ 68.30
PSUs | Minimum      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Stock options vesting period 1 year    
Payout percentage 0.00%    
PSUs | Maximum      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Stock options vesting period 2 years    
Payout percentage 200.00%    
Restricted stock and performance share awards      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Unrecognized compensation cost $ 917    
Period for recognition 2 years 2 months 12 days    
ESPP      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Shares available for future grant (in shares) 5    
Purchase price of common stock (percent) 85.00%    
Issuances under employee stock purchase plan (in shares) 2    
Value of stock issued $ 111    
Capital shares reserved for future issuance (in shares) 79    
Deferred compensation plan | Fair value, recurring | Fair value      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Marketable equity securities $ 261 $ 218  
Fair value at grant date | Restricted stock and performance share awards      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Total fair value of vested stock awards as of vesting date 503 479 $ 450
Fair value at vesting date | Restricted stock and performance share awards      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Total fair value of vested stock awards as of vesting date $ 471 $ 459 $ 372