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Employee Benefits - Summary of Stock-Based Compensation (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock-based compensation expense included in total costs and expenses $ 635 $ 1,076 $ 636
Income tax effect (100) (222) 2
Stock-based compensation expense, net of tax 535 854 638
Stock-based compensation expense 635 643 636
Income tax expense following U.S. Court of Appeals decision     114
Forty Seven, Inc.      
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Accelerated stock-based expense   144  
Immunomedics, Inc.      
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Accelerated stock-based expense   289  
Cost of goods sold      
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock-based compensation expense included in total costs and expenses 40 109 48
Research and development expenses      
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock-based compensation expense included in total costs and expenses 287 462 289
Selling, general and administrative expenses      
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock-based compensation expense included in total costs and expenses $ 308 $ 505 $ 299