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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Millions
 3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Operating Activities:    
Net income $ 12 $ 1,722
Adjustments to reconcile net income to net cash provided by operating activities:    
Depreciation expense 80 78
Amortization expense 445 395
Stock-based compensation expense 130 139
Acquired in-process research and development expenses 0 62
In-process research and development impairment 2,700 0
Deferred income taxes (651) 71
Net loss from equity securities 96 351
Other 190 201
Changes in operating assets and liabilities:    
Accounts receivable, net 699 975
Inventories 53 (69)
Prepaid expenses and other (20) (8)
Accounts payable (91) (253)
Income taxes payable (146) (316)
Accrued and other liabilities (1,657) (738)
Net cash provided by operating activities 1,840 2,610
Investing Activities:    
Purchases of marketable debt securities (613) (931)
Proceeds from sales of marketable debt securities 119 60
Proceeds from maturities of marketable debt securities 506 619
Acquisitions, including in-process research and development, net of cash acquired (30) (1,255)
Purchases of equity securities (28) (279)
Capital expenditures (247) (165)
Other (777) (91)
Net cash used in investing activities (1,070) (2,042)
Financing Activities:    
Proceeds from issuances of common stock 94 88
Repurchases of common stock (352) (309)
Repayments of debt and other obligations (500) (1,250)
Payments of dividends (945) (917)
Other (91) (89)
Net cash used in financing activities (1,794) (2,477)
Effect of exchange rate changes on cash and cash equivalents (18) (23)
Net change in cash and cash equivalents (1,042) (1,932)
Cash and cash equivalents at beginning of period 5,338 5,997
Cash and cash equivalents at end of period $ 4,296 $ 4,065