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AVAILABLE-FOR-SALE DEBT SECURITIES AND EQUITY SECURITIES (Tables)
6 Months Ended
Jun. 30, 2022
Debt Securities, Available-for-Sale [Abstract]  
Reconciliation of Available-for-Sale Debt Securities from Cost Basis to Fair Value
The following table summarizes our available-for-sale debt securities:
June 30, 2022December 31, 2021
(in millions)Amortized CostGross Unrealized GainsGross Unrealized LossesEstimated Fair Value Amortized CostGross Unrealized GainsGross Unrealized LossesEstimated Fair Value 
U.S. treasury securities$433 $— $(7)$427 $408 $— $(1)$407 
U.S. government agencies securities— — — — — — 
Non-U.S. government securities32 — — 31 50 — — 50 
Certificates of deposit88 — — 88 249 — — 249 
Corporate debt securities1,410 — (23)1,386 1,365 — (2)1,363 
Residential mortgage and asset-backed securities361 — (3)358 425 — (1)424 
Total$2,324 $— $(34)$2,290 $2,501 $— $(4)$2,497 
Summary of Classification of Available-for-Sale Debt Securities
The following table summarizes the classification of our available-for-sale debt securities in our Condensed Consolidated Balance Sheets:
(in millions)June 30, 2022December 31, 2021
Cash and cash equivalents$29 $
Short-term marketable debt securities924 1,182 
Long-term marketable debt securities1,337 1,309 
Total$2,290 $2,497 
Summary of Available-for-Sale Debt Securities by Contractual Maturity
The following table summarizes our available-for-sale debt securities by contractual maturity:
June 30, 2022
(in millions)Amortized CostFair Value
Within one year$962 $953 
After one year through five years1,338 1,313 
After five years through ten years15 15 
After ten years
Total$2,324 $2,290 
Summary of Equity Securities
The following table summarizes the classification of our equity securities measured at fair value on a recurring basis, including our equity method investments in Galapagos and Arcus for which we elected and applied the fair value option as we believe it best reflects the underlying economics of these investments, on our Condensed Consolidated Balance Sheets:
(in millions)June 30, 2022December 31, 2021
Cash and cash equivalents$3,094 $3,661 
Prepaid and other current assets477 885 
Other long-term assets1,140 1,197 
Total$4,711 $5,743