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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Millions
 9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Operating Activities:    
Net income $ 2,933 $ 5,825
Adjustments to reconcile net income to net cash provided by operating activities:    
Depreciation expense 240 239
Amortization expense 1,335 1,276
Stock-based compensation expense 463 476
Acquired in-process research and development expenses 786 270
In-process research and development impairment 2,700 0
Deferred income taxes (1,214) 243
Net loss from equity securities 596 667
Other 546 508
Changes in operating assets and liabilities:    
Accounts receivable, net (125) 272
Inventories (34) (24)
Prepaid expenses and other 12 (17)
Accounts payable (38) (242)
Income taxes payable (564) (463)
Accrued and other liabilities (1,131) (851)
Net cash provided by operating activities 6,505 8,179
Investing Activities:    
Purchases of marketable debt securities (1,398) (2,891)
Proceeds from sales of marketable debt securities 370 506
Proceeds from maturities of marketable debt securities 1,232 1,808
Acquisitions, including in-process research and development, net of cash acquired (1,579) (1,540)
Purchases of equity securities (166) (332)
Capital expenditures (547) (423)
Other (3) 19
Net cash used in investing activities (2,091) (2,853)
Financing Activities:    
Proceeds from issuances of common stock 133 157
Repurchases of common stock (604) (497)
Repayments of debt and other obligations (1,500) (3,750)
Payments of dividends (2,794) (2,711)
Other (150) (134)
Net cash used in financing activities (4,915) (6,935)
Effect of exchange rate changes on cash and cash equivalents (138) (26)
Net change in cash and cash equivalents (639) (1,635)
Cash and cash equivalents at beginning of period 5,338 5,997
Cash and cash equivalents at end of period $ 4,699 $ 4,362