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Property, Plant and Equipment
 12 Months Ended
Dec. 31, 2022
Property, Plant and Equipment [Abstract]  
Property, Plant and Equipment PROPERTY, PLANT AND EQUIPMENT
The following table summarizes our Property, plant and equipment, net:
December 31,
(in millions)20222021
Land and land improvements$562 $404 
Buildings and improvements (including leasehold improvements)4,390 3,794 
Laboratory and manufacturing equipment1,110 952 
Office, computer equipment and other(1)
880 807 
Construction in progress719 1,057 
Subtotal7,661 7,014 
Less: accumulated depreciation and amortization2,186 1,893 
Total$5,475 $5,121 
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(1)     Includes $104 million and $131 million of unamortized capitalized software costs as of December 31, 2022 and 2021, respectively.
The net book value of our property, plant and equipment in the U.S. was $4.5 billion and $4.1 billion as of December 31, 2022 and 2021, respectively. The corresponding amount in international locations was $973 million and $963 million as of December 31, 2022 and 2021, respectively. All individual international locations accounted for less than 10% of the total balances.