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Employee Benefits - Summary of Stock-Based Compensation (Details) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock-based compensation expense included in total costs and expenses $ 645 $ 635 $ 1,076
Income tax effect (91) (100) (222)
Stock-based compensation expense, net of tax 553 535 854
RSUs      
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock-based compensation expense included in total costs and expenses 557 558 546
PSUs      
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock-based compensation expense included in total costs and expenses 25 17 25
Stock options      
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock-based compensation expense included in total costs and expenses 28 29 44
ESPP      
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock-based compensation expense included in total costs and expenses 26 31 28
Acquisition-related expense      
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock-based compensation expense included in total costs and expenses 8 0 433
Acquisition-related expense | MiroBio Ltd.      
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock-based compensation expense included in total costs and expenses 8    
Acquisition-related expense | Immunomedics, Inc.      
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock-based compensation expense included in total costs and expenses     289
Acquisition-related expense | Forty Seven, Inc.      
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock-based compensation expense included in total costs and expenses     144
Cost of goods sold      
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock-based compensation expense included in total costs and expenses 46 40 109
Research and development expenses      
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock-based compensation expense included in total costs and expenses 285 287 462
Selling, general and administrative expenses      
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]      
Stock-based compensation expense included in total costs and expenses $ 313 $ 308 $ 505