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Income Taxes - Schedule of Deferred Tax Assets and Liabilities (Details) - USD ($)
$ in Millions
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Deferred tax assets:      
Net operating loss carryforwards $ 430 $ 413  
Stock-based compensation 95 117  
Reserves and accruals not currently deductible 645 700  
Excess of tax basis over book basis of intangible assets 1,067 1,157  
Upfront and milestone payments 1,298 1,310  
Research and other credit carryforwards 233 249  
Equity investments 196 129  
Liability related to sale of future royalties 278 274  
Capitalized R&D expenditures 784 0  
Other, net 263 292  
Total deferred tax assets before valuation allowance 5,289 4,641  
Valuation allowance (599) (520) $ (398)
Total deferred tax assets 4,690 4,121  
Deferred tax liabilities:      
Property, plant and equipment (234) (227)  
Excess of book basis over tax basis of intangible assets (5,728) (6,719)  
Other (160) (192)  
Total deferred tax liabilities (6,122) (7,138)  
Net deferred tax assets (liabilities) $ (1,432) $ (3,017)