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PROPERTY, PLANT AND EQUIPMENT | 12 Months Ended
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Dec. 31, 2024
Property, Plant and Equipment [Abstract] |
PROPERTY, PLANT AND EQUIPMENT | PROPERTY, PLANT AND EQUIPMENT The following table summarizes our Property, plant and equipment, net by asset type:
|  | December 31,
(in millions) |  | 2024 |  | 2023
Land and land improvements |  | $ | 561 |  |  | $ | 561 |
Buildings and improvements (including leasehold improvements) |  | 4,539 |  |  | 4,328 |
Laboratory and manufacturing equipment |  | 1,192 |  |  | 1,147 |
Office, computer equipment and other |  | 1,090 |  |  | 1,069 |
Construction in progress |  | 501 |  |  | 661 |
Subtotal |  | 7,884 |  |  | 7,766 |
Less: accumulated depreciation |  | 2,470 |  |  | 2,449 |
Total |  | $ | 5,414 |  |  | $ | 5,317 |
The following table summarizes our Property, plant and equipment, net by geography:
|  | December 31,
(in millions) |  | 2024 |  | 2023
U.S. |  | $ | 4,787 |  |  | 4,691 |
International(1) |  | 627 |  |  | 626 |
Total |  | $ | 5,414 |  |  | $ | 5,317 |
_______________________________ (1) All individual international locations accounted for less than 10% of the total balances.

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- Definition The entire disclosure for long-lived, physical asset used in normal conduct of business and not intended for resale. Includes, but is not limited to, work of art, historical treasure, and similar asset classified as collections. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 360 -Name Accounting Standards Codification -Publisher FASB -URI https://asc.fasb.org/360/tableOfContent Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Name Accounting Standards Codification -Section 50 -Paragraph 6 -SubTopic 360 -Topic 958 -Publisher FASB -URI https://asc.fasb.org/1943274/2147477798/958-360-50-6 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Name Accounting Standards Codification -Section 50 -Paragraph 1 -Subparagraph (d) -SubTopic 360 -Topic 958 -Publisher FASB -URI https://asc.fasb.org/1943274/2147477798/958-360-50-1 Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Name Accounting Standards Codification -Section 50 -Paragraph 7 -SubTopic 360 -Topic 958 -Publisher FASB -URI https://asc.fasb.org/1943274/2147477798/958-360-50-7 + Details
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