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INCOME TAXES | 3 Months Ended
--- | ---
Mar. 31, 2025
Income Tax Disclosure [Abstract] |
INCOME TAXES | INCOME TAXES The following table summarizes our Income tax expense (benefit):
|  | Three Months Ended |  |
|  | March 31, |  |
(in millions, except percentages) |  | 2025 |  | 2024 |  |  |  |
Income (loss) before income taxes |  | $ | 1,649 |  |  | $ | (4,486) |  |  |  |  |
Income tax expense (benefit) |  | $ | 334 |  |  | $ | (315) |  |  |  |  |
Effective tax rate |  | 20.2 | % |  | 7.0 | % |  |  |  |
Our effective income tax rate of 20.2% for the three months ended March 31, 2025 differed from the U.S. federal statutory rate of 21% primarily due to tax benefits from stock-based compensation and provision to return adjustments, partially offset by fair value losses on our equity investments that are non-deductible for income tax purposes. Our effective income tax rate of 7.0% for the three months ended March 31, 2024 differed from the U.S. federal statutory rate of 21% primarily due to $3.9 billion of non-deductible acquired IPR&D expense recorded in connection with our acquisition of CymaBay, partially offset by a decrease in state deferred tax liabilities associated with the $2.4 billion NSCLC IPR&D intangible asset impairment charge and settlements with tax authorities. Our income tax returns are subject to audit by federal, state and foreign tax authorities. We are currently under examination by the Internal Revenue Service for our 2019 to 2021 tax years. There are differing interpretations of tax laws and regulations, and as a result, significant disputes may arise with these tax authorities involving issues on the timing and amount of deductions and allocations of income among various tax jurisdictions. We periodically evaluate our exposures associated with our tax filing positions.

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