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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (unaudited) - USD ($) $ in Millions | 3 Months Ended
--- | ---
Mar. 31, 2025 | Mar. 31, 2024
Operating Activities: |  |
Net income (loss) | $ 1,315 | $ (4,170)
Adjustments to reconcile Net income (loss) to net cash provided by operating activities: |  |
Depreciation expense | 97 | 94
Amortization expense | 599 | 596
Stock-based compensation expense | 209 | 187
Deferred income taxes | (199) | (723)
Net loss from equity securities | 426 | 14
Acquired in-process research and development expenses | 253 | 4,131
In-process research and development impairments | 0 | 2,430
Other, net | 91 | 119
Changes in operating assets and liabilities: |  |
Accounts receivable, net | 79 | (66)
Inventories | (223) | (45)
Prepaid expenses and other | 12 | (37)
Accounts payable | (105) | 72
Income tax assets and liabilities, net | (552) | (208)
Accrued and other liabilities | (244) | (175)
Net cash provided by operating activities | 1,757 | 2,219
Investing Activities: |  |
Purchases of marketable debt securities | 0 | (244)
Proceeds from sales of marketable debt securities | 0 | 2,265
Proceeds from maturities of marketable debt securities | 0 | 327
Acquisitions, including in-process research and development, net of cash acquired | (273) | (4,043)
Purchases of equity securities | (16) | (410)
Purchases of property, plant and equipment | (104) | (105)
Other investing activities, net | (23) | 5
Net cash used in investing activities | (415) | (2,207)
Financing Activities: |  |
Proceeds from issuances of common stock | 252 | 146
Repurchases of common stock under repurchase programs | (730) | (400)
Repayments of debt and other obligations | (1,762) | 0
Payments of dividends | (1,010) | (990)
Other financing activities, net | (176) | (116)
Net cash used in financing activities | (3,426) | (1,361)
Effect of exchange rate changes on cash and cash equivalents | 19 | (18)
Net change in cash and cash equivalents | (2,065) | (1,367)
Cash and cash equivalents at beginning of period | 9,991 | 6,085
Cash and cash equivalents at end of period | $ 7,926 | $ 4,718

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- Definition Amount of cash and cash equivalents, and cash and cash equivalents restricted to withdrawal or usage. Excludes amount for disposal group and discontinued operations. Cash includes, but is not limited to, currency on hand, demand deposits with banks or financial institutions, and other accounts with general characteristics of demand deposits. Cash equivalents include, but are not limited to, short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 230 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 8 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482913/230-10-50-8 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 230 -SubTopic 10 -Name Accounting Standards Codification -Section 45 -Paragraph 24 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482740/230-10-45-24 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 4 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482740/230-10-45-4 + Details
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