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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (unaudited) - USD ($) $ in Millions | 9 Months Ended
--- | ---
Sep. 30, 2025 | Sep. 30, 2024
Operating Activities: |  |
Net income (loss): | $ 6,327 | $ (1,303)
Adjustments to reconcile Net income (loss) to Net cash provided by operating activities: |  |
Depreciation expense | 280 | 286
Amortization expense | 1,793 | 1,788
Stock-based compensation expense | 664 | 613
Deferred income taxes | 282 | (1,465)
Net (gain) loss from equity securities | (198) | 148
Acquired in-process research and development expenses | 485 | 4,674
In-process research and development impairments | 190 | 4,180
Other, net | 213 | 294
Changes in operating assets and liabilities: |  |
Accounts receivable, net | (546) | 67
Inventories | (913) | (200)
Prepaid expenses and other | (275) | (113)
Accounts payable | (37) | 348
Income tax assets and liabilities, net | (1,974) | (1,268)
Accrued and other liabilities | 401 | (197)
Net cash provided by operating activities | 6,692 | 7,853
Investing Activities: |  |
Purchases of marketable debt securities | (2,557) | (244)
Proceeds from sales of marketable debt securities | 514 | 2,265
Proceeds from maturities of marketable debt securities | 32 | 327
Acquisitions, including in-process research and development, net of cash acquired | (461) | (4,765)
Purchases of equity securities | (119) | (453)
Purchases of property, plant and equipment | (358) | (376)
Other investing activities, net | (9) | 23
Net cash used in investing activities | (2,958) | (3,224)
Financing Activities: |  |
Proceeds from issuances of common stock | 376 | 249
Repurchases of common stock under repurchase programs | (1,692) | (800)
Repayments of debt and other obligations | (1,780) | (1,963)
Payments of dividends | (3,009) | (2,945)
Other financing activities, net | (377) | (234)
Net cash used in financing activities | (6,482) | (5,693)
Effect of exchange rate changes on cash and cash equivalents | 87 | 15
Net change in cash and cash equivalents | (2,661) | (1,049)
Cash and cash equivalents at beginning of period | 9,991 | 6,085
Cash and cash equivalents at end of period | $ 7,330 | $ 5,037

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