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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (unaudited) - USD ($)
shares in Millions, $ in Millions
 3 Months Ended 6 Months Ended
Jun. 30, 2026
Jun. 30, 2025
Jun. 30, 2026
Jun. 30, 2025
Revenues:        
Total revenues $ 7,803 $ 7,082 $ 14,763 $ 13,749
Costs and expenses:        
Cost of goods sold 1,579 1,501 3,023 3,041
Research and development expenses 1,764 1,491 3,136 2,870
Acquired in-process research and development expenses 11,183 61 11,290 315
In-process research and development impairments 1,750 190 1,750 190
Selling, general and administrative expenses 1,921 1,365 3,372 2,623
Total costs and expenses 18,197 4,608 22,571 9,038
Operating (loss) income (10,394) 2,474 (7,808) 4,711
Interest expense 247 254 487 513
Other (income) expense, net (387) (208) (621) 120
(Loss) income before income taxes (10,254) 2,429 (7,674) 4,077
Income tax expense 242 468 801 802
Net (loss) income $ (10,496) $ 1,960 $ (8,475) $ 3,275
Basic (loss) earnings per share (in dollars per share) $ (8.45) $ 1.57 $ (6.82) $ 2.63
Diluted (loss) earnings per share (in dollars per share) $ (8.45) $ 1.56 $ (6.82) $ 2.61
Shares used in basic (loss) earnings per share calculation (in shares) 1,243 1,245 1,243 1,246
Shares used in diluted (loss) earnings per share calculation (in shares) 1,243 1,255 1,243 1,257
Product sales        
Revenues:        
Total revenues $ 7,627 $ 7,054 $ 14,574 $ 13,668
Royalty, contract and other revenues        
Revenues:        
Total revenues $ 176 $ 27 $ 189 $ 81