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Acquisition, Divestitures, Licensing Arrangements, Collaborative Arrangements and Privately Held Investment - Collaboration Arrangement (Details) - USD ($) $ in Millions |  | 3 Months Ended | 9 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | ---
Jan. 01, 2018 | Apr. 01, 2018 | Apr. 02, 2017 | Sep. 30, 2018 | Dec. 31, 2013 | Dec. 31, 2017
Merck [Member] | Collaborative Arrangement [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Collaborator's revenue and expense ownership percentage |  |  |  | 60.00% |  |
Company's revenue and expense ownership percentage |  |  |  | 40.00% |  |
Upfront payments received |  |  |  | $ 40 |  |
Eli Lilly & Company [Member] | Collaborative Arrangement [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Deferred milestone revenue recognized |  |  |  | 33 |  |
Other (Income)/Deductions, Net [Member] | Merck [Member] | Collaborative Arrangement [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Upfront payments received |  |  | $ 90 |  |  |
Milestone payment receivable |  | $ 40 |  |  |  | $ 60
Deferred milestone revenue recognized |  | 90 |  |  |  |
Other Noncurrent Liabilities [Member] | Merck [Member] | Collaborative Arrangement [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Deferred milestone payment |  |  |  |  |  | $ 60
Other Noncurrent Liabilities [Member] | Eli Lilly & Company [Member] | Collaborative Arrangement [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Deferred milestone revenue recognized |  |  |  | 9 |  |
Deferred Revenue [Member] | Eli Lilly & Company [Member] | Collaborative Arrangement [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Upfront payments received |  |  |  |  | $ 200 |
Other Current Liabilities [Member] | Eli Lilly & Company [Member] | Collaborative Arrangement [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Deferred milestone revenue recognized |  |  |  | $ 24 |  |
Revenues [Member] | Difference between Revenue Guidance in Effect before and after Topic 606 [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Cumulative effect adjustment to retained earnings, pre-tax | $ 584 | 584 |  |  |  |
Revenues [Member] | Difference between Revenue Guidance in Effect before and after Topic 606 [Member] | Other (Income)/Deductions, Net [Member] | Merck [Member] | Collaborative Arrangement [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Deferred milestone revenue recognized |  | 85 |  |  |  |
Revenues [Member] | Difference between Revenue Guidance in Effect before and after Topic 606 [Member] | Other Noncurrent Liabilities [Member] | Merck [Member] | Collaborative Arrangement [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Deferred milestone payment |  | 60 |  |  |  |
Revenues [Member] | Difference between Revenue Guidance in Effect before and after Topic 606 [Member] | Deferred Revenue [Member] | Eli Lilly & Company [Member] | Collaborative Arrangement [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Deferred milestone revenue recognized |  | $ 107 |  |  |  |

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