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Acquisition, Divestitures, Licensing Arrangements, Collaborative Arrangements and Privately Held Investment - AstraZeneca (Details) - USD ($) |  | 3 Months Ended | 12 Months Ended |
--- | --- | --- | --- | ---
Dec. 22, 2016 | Apr. 01, 2018 | Dec. 31, 2017 | Sep. 30, 2018
Business Acquisition [Line Items] |  |  |  |  |
Goodwill | [1] |  |  | $ 55,952,000,000 | $ 55,614,000,000
AstraZeneca [Member] |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |
Payments for acquisitions, cash portion |  |  |  | $ 605,000,000 |
Milestone payment |  |  | $ 125,000,000 |  |
Deferred payment |  | $ 175,000,000 |  |  |
Maximum amount of potential milestone payments |  | 75,000,000 |  |  |
Maximum amount of potential sales-related payments |  | $ 600,000,000 |  |  |
Term of royalty payments |  | 10 years |  |  |
Consideration transferred in business acquisition |  | $ 1,040,000,000 |  |  |
Identifiable intangible assets |  | 894,000,000 |  |  |
Other current assets |  | 92,000,000 |  |  |
Goodwill |  | 73,000,000 |  |  |
Deferred tax liabilities |  | 19,000,000 |  |  |
In Process Research and Development [Member] | AstraZeneca [Member] |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |
Identifiable intangible assets |  | 166,000,000 |  |  |
Developed Technology Rights [Member] | AstraZeneca [Member] |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |
Identifiable intangible assets |  | 728,000,000 |  |  |
Minimum [Member] | AstraZeneca [Member] |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |
Undiscounted royalty payments |  | 292,000,000 |  |  |
Maximum [Member] | AstraZeneca [Member] |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |
Undiscounted royalty payments |  | $ 512,000,000 |  |  |
[1] | Amounts may not add due to rounding.

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