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Segment, Geographic and Other Revenue Information (Tables) | 12 Months Ended
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Dec. 31, 2018
Segment Reporting [Abstract] |
Reconciliation of Revenue from Segments to Consolidated |
The following table provides selected income statement information by reportable segment:
|  | Revenues |  | Earnings(a) |  | Depreciation and Amortization(b)
|  | Year Ended December 31, |  | Year Ended December 31, |  | Year Ended December 31,
(MILLIONS OF DOLLARS) |  | 2018 |  |  | 2017 |  |  | 2016 |  |  | 2018 |  |  | 2017 |  |  | 2016 |  |  | 2018 |  |  | 2017 |  |  | 2016 |
Reportable Segments: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
IH(c) |  | $ | 33,426 |  |  | $ | 31,422 |  |  | $ | 29,197 |  |  | $ | 20,258 |  |  | $ | 18,809 |  |  | $ | 16,166 |  |  | $ | 629 |  |  | $ | 534 |  |  | $ | 583 |
EH(c) |  | 20,221 |  |  | 21,124 |  |  | 23,627 |  |  | 10,712 |  |  | 11,460 |  |  | 13,065 |  |  | 547 |  |  | 579 |  |  | 600 |
Total reportable segments |  | 53,647 |  |  | 52,546 |  |  | 52,824 |  |  | 30,970 |  |  | 30,269 |  |  | 29,231 |  |  | 1,175 |  |  | 1,113 |  |  | 1,183 |
Other business activities(d), (e) |  | — |  |  | — |  |  | — |  |  | (2,977 | ) |  | (3,137 | ) |  | (3,020 | ) |  | 93 |  |  | 90 |  |  | 85 |
Reconciling Items: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Corporate(c), (e) |  | — |  |  | — |  |  | — |  |  | (5,096 | ) |  | (5,452 | ) |  | (5,448 | ) |  | 363 |  |  | 337 |  |  | 356 |
Purchase accounting adjustments(e) |  | — |  |  | — |  |  | — |  |  | (4,786 | ) |  | (4,758 | ) |  | (4,185 | ) |  | 4,620 |  |  | 4,565 |  |  | 3,890 |
Acquisition-related costs(e) |  | — |  |  | — |  |  | — |  |  | (318 | ) |  | (456 | ) |  | (785 | ) |  | 12 |  |  | 39 |  |  | 7 |
Certain significant items(f) |  | — |  |  | — |  |  | — |  |  | (4,305 | ) |  | (2,647 | ) |  | (5,888 | ) |  | 38 |  |  | 52 |  |  | 200 |
Other unallocated(c), (e) |  | — |  |  | — |  |  | — |  |  | (1,603 | ) |  | (1,514 | ) |  | (1,554 | ) |  | 82 |  |  | 72 |  |  | 35 |
|  | $ | 53,647 |  |  | $ | 52,546 |  |  | $ | 52,824 |  |  | $ | 11,885 |  |  | $ | 12,305 |  |  | $ | 8,351 |  |  | $ | 6,384 |  |  | $ | 6,269 |  |  | $ | 5,757 |
(a) | Income from continuing operations before provision/(benefit) for taxes on income. IH’s earnings include d ividend income from our investment in ViiV of $253 million in 2018 and $266 million in 2017. For additional information, see Note 4.
(b) | Certain production facilities are shared. Depreciation is allocated based on estimates of physical production. Amounts here relate solely to the depreciation and amortization associated with continuing operations.
(c) | In connection with the StratCO reporting change, in 2017, we reclassified approximately $468 million of costs from IH, approximately $176 million of costs from EH and approximately $70 million of costs from Corporate to Other unallocated costs, and in 2016, we reclassified approximately $312 million of costs from IH, approximately $167 million of costs from EH and approximately $43 million of costs from Corporate to Other unallocated costs to conform to the current period presentation.
(d) | Other business activities includes the costs managed by our WRD and GPD organizations.
(e) | For a description, see the “Other Costs and Business Activities” section above.
(f) | Certain significant items are substantive and/or unusual, and in some cases recurring, items (such as restructuring or legal charges) that, either as a result of their nature or size, would not be expected to occur as part of our normal business on a regular basis.
For Earnings in 2018, certain significant items includes: (i) restructuring charges and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $977 million, (ii) net charges for certain legal matters of $157 million, (iii) income of $1 million, representing an adjustment to amounts previously recorded to write down the HIS net assets to fair value less costs to sell, (iv) certain asset impairment charges of $3.1 billion, (v) charges for business and legal entity alignment of $4 million, (vi) net losses on early retirement of debt of $3 million and (vii) other charges of $65 million, which includes, among other things, a non-cash $343 million pre-tax gain in Other (income)/deductions––net associated with our transaction with Bain Capital to create a new biopharmaceutical company, Cerevel, to continue development of a portfolio of clinical and preclinical stage neuroscience assets primarily targeting disorders of the central nervous system, a $119 million charge, in the aggregate, in Selling, informational and administrative expenses, for a special one-time bonus paid to virtually all Pfizer colleagues, excluding executives, which was one of several actions taken by us after evaluating the expected positive net impact of the December 2017 enactment of the legislation commonly referred to as the TCJA, $59 million of incremental costs associated with the design, planning and implementation of the new organizational structure, effective in the beginning of 2019, and primarily including consulting, legal, tax, and advisory services and a non-cash $50 million pre-tax gain in Other (income)/deductions––net as a result of the contribution of our allogeneic CAR T cell therapy development program assets in connection with our contribution agreement entered into with Allogene. For additional information, see Note 2B, Note 3 and Note 4. For Earnings in 2017, certain significant items includes: (i) restructuring charges and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $204 million, (ii) charges for certain legal matters of $237 million, (iii) charges of $55 million, representing adjustments to amounts previously recorded to write-down the HIS net assets to fair value less costs to sell, (iv) certain asset impairment charges of $379 million, (v) charges for business and legal entity alignment of $71 million, (vi) net losses on early retirement of debt of $999 million and (vii) other charges of $700 million. For additional information, see Note 2B, Note 3 and Note 4. For Earnings in 2016, certain significant items includes: (i) restructuring charges and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $1.4 billion, (ii) charges for certain legal matters of $494 million, (iii) an impairment charge related to the write-down of the HIS net assets to fair value less estimated costs to sell of $1.7 billion, (iv) certain asset impairment charges of $1.4 billion, (v) charges for business and legal entity alignment of $261 million, (vi) net losses on early retirement of debt of $312 million and (vii) other charges of $294 million. For additional information, see Note 3 and Note 4.
Reconciliation of Operating Profit (Loss) from Segments to Consolidated |
The following table provides selected income statement information by reportable segment:
|  | Revenues |  | Earnings(a) |  | Depreciation and Amortization(b)
|  | Year Ended December 31, |  | Year Ended December 31, |  | Year Ended December 31,
(MILLIONS OF DOLLARS) |  | 2018 |  |  | 2017 |  |  | 2016 |  |  | 2018 |  |  | 2017 |  |  | 2016 |  |  | 2018 |  |  | 2017 |  |  | 2016 |
Reportable Segments: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
IH(c) |  | $ | 33,426 |  |  | $ | 31,422 |  |  | $ | 29,197 |  |  | $ | 20,258 |  |  | $ | 18,809 |  |  | $ | 16,166 |  |  | $ | 629 |  |  | $ | 534 |  |  | $ | 583 |
EH(c) |  | 20,221 |  |  | 21,124 |  |  | 23,627 |  |  | 10,712 |  |  | 11,460 |  |  | 13,065 |  |  | 547 |  |  | 579 |  |  | 600 |
Total reportable segments |  | 53,647 |  |  | 52,546 |  |  | 52,824 |  |  | 30,970 |  |  | 30,269 |  |  | 29,231 |  |  | 1,175 |  |  | 1,113 |  |  | 1,183 |
Other business activities(d), (e) |  | — |  |  | — |  |  | — |  |  | (2,977 | ) |  | (3,137 | ) |  | (3,020 | ) |  | 93 |  |  | 90 |  |  | 85 |
Reconciling Items: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Corporate(c), (e) |  | — |  |  | — |  |  | — |  |  | (5,096 | ) |  | (5,452 | ) |  | (5,448 | ) |  | 363 |  |  | 337 |  |  | 356 |
Purchase accounting adjustments(e) |  | — |  |  | — |  |  | — |  |  | (4,786 | ) |  | (4,758 | ) |  | (4,185 | ) |  | 4,620 |  |  | 4,565 |  |  | 3,890 |
Acquisition-related costs(e) |  | — |  |  | — |  |  | — |  |  | (318 | ) |  | (456 | ) |  | (785 | ) |  | 12 |  |  | 39 |  |  | 7 |
Certain significant items(f) |  | — |  |  | — |  |  | — |  |  | (4,305 | ) |  | (2,647 | ) |  | (5,888 | ) |  | 38 |  |  | 52 |  |  | 200 |
Other unallocated(c), (e) |  | — |  |  | — |  |  | — |  |  | (1,603 | ) |  | (1,514 | ) |  | (1,554 | ) |  | 82 |  |  | 72 |  |  | 35 |
|  | $ | 53,647 |  |  | $ | 52,546 |  |  | $ | 52,824 |  |  | $ | 11,885 |  |  | $ | 12,305 |  |  | $ | 8,351 |  |  | $ | 6,384 |  |  | $ | 6,269 |  |  | $ | 5,757 |
(a) | Income from continuing operations before provision/(benefit) for taxes on income. IH’s earnings include d ividend income from our investment in ViiV of $253 million in 2018 and $266 million in 2017. For additional information, see Note 4.
(b) | Certain production facilities are shared. Depreciation is allocated based on estimates of physical production. Amounts here relate solely to the depreciation and amortization associated with continuing operations.
(c) | In connection with the StratCO reporting change, in 2017, we reclassified approximately $468 million of costs from IH, approximately $176 million of costs from EH and approximately $70 million of costs from Corporate to Other unallocated costs, and in 2016, we reclassified approximately $312 million of costs from IH, approximately $167 million of costs from EH and approximately $43 million of costs from Corporate to Other unallocated costs to conform to the current period presentation.
(d) | Other business activities includes the costs managed by our WRD and GPD organizations.
(e) | For a description, see the “Other Costs and Business Activities” section above.
(f) | Certain significant items are substantive and/or unusual, and in some cases recurring, items (such as restructuring or legal charges) that, either as a result of their nature or size, would not be expected to occur as part of our normal business on a regular basis.
For Earnings in 2018, certain significant items includes: (i) restructuring charges and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $977 million, (ii) net charges for certain legal matters of $157 million, (iii) income of $1 million, representing an adjustment to amounts previously recorded to write down the HIS net assets to fair value less costs to sell, (iv) certain asset impairment charges of $3.1 billion, (v) charges for business and legal entity alignment of $4 million, (vi) net losses on early retirement of debt of $3 million and (vii) other charges of $65 million, which includes, among other things, a non-cash $343 million pre-tax gain in Other (income)/deductions––net associated with our transaction with Bain Capital to create a new biopharmaceutical company, Cerevel, to continue development of a portfolio of clinical and preclinical stage neuroscience assets primarily targeting disorders of the central nervous system, a $119 million charge, in the aggregate, in Selling, informational and administrative expenses, for a special one-time bonus paid to virtually all Pfizer colleagues, excluding executives, which was one of several actions taken by us after evaluating the expected positive net impact of the December 2017 enactment of the legislation commonly referred to as the TCJA, $59 million of incremental costs associated with the design, planning and implementation of the new organizational structure, effective in the beginning of 2019, and primarily including consulting, legal, tax, and advisory services and a non-cash $50 million pre-tax gain in Other (income)/deductions––net as a result of the contribution of our allogeneic CAR T cell therapy development program assets in connection with our contribution agreement entered into with Allogene. For additional information, see Note 2B, Note 3 and Note 4. For Earnings in 2017, certain significant items includes: (i) restructuring charges and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $204 million, (ii) charges for certain legal matters of $237 million, (iii) charges of $55 million, representing adjustments to amounts previously recorded to write-down the HIS net assets to fair value less costs to sell, (iv) certain asset impairment charges of $379 million, (v) charges for business and legal entity alignment of $71 million, (vi) net losses on early retirement of debt of $999 million and (vii) other charges of $700 million. For additional information, see Note 2B, Note 3 and Note 4. For Earnings in 2016, certain significant items includes: (i) restructuring charges and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $1.4 billion, (ii) charges for certain legal matters of $494 million, (iii) an impairment charge related to the write-down of the HIS net assets to fair value less estimated costs to sell of $1.7 billion, (iv) certain asset impairment charges of $1.4 billion, (v) charges for business and legal entity alignment of $261 million, (vi) net losses on early retirement of debt of $312 million and (vii) other charges of $294 million. For additional information, see Note 3 and Note 4.
Reconciliation Of Depreciation And Amortization From Segments To Consolidated |
The following table provides selected income statement information by reportable segment:
|  | Revenues |  | Earnings(a) |  | Depreciation and Amortization(b)
|  | Year Ended December 31, |  | Year Ended December 31, |  | Year Ended December 31,
(MILLIONS OF DOLLARS) |  | 2018 |  |  | 2017 |  |  | 2016 |  |  | 2018 |  |  | 2017 |  |  | 2016 |  |  | 2018 |  |  | 2017 |  |  | 2016 |
Reportable Segments: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
IH(c) |  | $ | 33,426 |  |  | $ | 31,422 |  |  | $ | 29,197 |  |  | $ | 20,258 |  |  | $ | 18,809 |  |  | $ | 16,166 |  |  | $ | 629 |  |  | $ | 534 |  |  | $ | 583 |
EH(c) |  | 20,221 |  |  | 21,124 |  |  | 23,627 |  |  | 10,712 |  |  | 11,460 |  |  | 13,065 |  |  | 547 |  |  | 579 |  |  | 600 |
Total reportable segments |  | 53,647 |  |  | 52,546 |  |  | 52,824 |  |  | 30,970 |  |  | 30,269 |  |  | 29,231 |  |  | 1,175 |  |  | 1,113 |  |  | 1,183 |
Other business activities(d), (e) |  | — |  |  | — |  |  | — |  |  | (2,977 | ) |  | (3,137 | ) |  | (3,020 | ) |  | 93 |  |  | 90 |  |  | 85 |
Reconciling Items: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Corporate(c), (e) |  | — |  |  | — |  |  | — |  |  | (5,096 | ) |  | (5,452 | ) |  | (5,448 | ) |  | 363 |  |  | 337 |  |  | 356 |
Purchase accounting adjustments(e) |  | — |  |  | — |  |  | — |  |  | (4,786 | ) |  | (4,758 | ) |  | (4,185 | ) |  | 4,620 |  |  | 4,565 |  |  | 3,890 |
Acquisition-related costs(e) |  | — |  |  | — |  |  | — |  |  | (318 | ) |  | (456 | ) |  | (785 | ) |  | 12 |  |  | 39 |  |  | 7 |
Certain significant items(f) |  | — |  |  | — |  |  | — |  |  | (4,305 | ) |  | (2,647 | ) |  | (5,888 | ) |  | 38 |  |  | 52 |  |  | 200 |
Other unallocated(c), (e) |  | — |  |  | — |  |  | — |  |  | (1,603 | ) |  | (1,514 | ) |  | (1,554 | ) |  | 82 |  |  | 72 |  |  | 35 |
|  | $ | 53,647 |  |  | $ | 52,546 |  |  | $ | 52,824 |  |  | $ | 11,885 |  |  | $ | 12,305 |  |  | $ | 8,351 |  |  | $ | 6,384 |  |  | $ | 6,269 |  |  | $ | 5,757 |
(a) | Income from continuing operations before provision/(benefit) for taxes on income. IH’s earnings include d ividend income from our investment in ViiV of $253 million in 2018 and $266 million in 2017. For additional information, see Note 4.
(b) | Certain production facilities are shared. Depreciation is allocated based on estimates of physical production. Amounts here relate solely to the depreciation and amortization associated with continuing operations.
(c) | In connection with the StratCO reporting change, in 2017, we reclassified approximately $468 million of costs from IH, approximately $176 million of costs from EH and approximately $70 million of costs from Corporate to Other unallocated costs, and in 2016, we reclassified approximately $312 million of costs from IH, approximately $167 million of costs from EH and approximately $43 million of costs from Corporate to Other unallocated costs to conform to the current period presentation.
(d) | Other business activities includes the costs managed by our WRD and GPD organizations.
(e) | For a description, see the “Other Costs and Business Activities” section above.
(f) | Certain significant items are substantive and/or unusual, and in some cases recurring, items (such as restructuring or legal charges) that, either as a result of their nature or size, would not be expected to occur as part of our normal business on a regular basis.
For Earnings in 2018, certain significant items includes: (i) restructuring charges and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $977 million, (ii) net charges for certain legal matters of $157 million, (iii) income of $1 million, representing an adjustment to amounts previously recorded to write down the HIS net assets to fair value less costs to sell, (iv) certain asset impairment charges of $3.1 billion, (v) charges for business and legal entity alignment of $4 million, (vi) net losses on early retirement of debt of $3 million and (vii) other charges of $65 million, which includes, among other things, a non-cash $343 million pre-tax gain in Other (income)/deductions––net associated with our transaction with Bain Capital to create a new biopharmaceutical company, Cerevel, to continue development of a portfolio of clinical and preclinical stage neuroscience assets primarily targeting disorders of the central nervous system, a $119 million charge, in the aggregate, in Selling, informational and administrative expenses, for a special one-time bonus paid to virtually all Pfizer colleagues, excluding executives, which was one of several actions taken by us after evaluating the expected positive net impact of the December 2017 enactment of the legislation commonly referred to as the TCJA, $59 million of incremental costs associated with the design, planning and implementation of the new organizational structure, effective in the beginning of 2019, and primarily including consulting, legal, tax, and advisory services and a non-cash $50 million pre-tax gain in Other (income)/deductions––net as a result of the contribution of our allogeneic CAR T cell therapy development program assets in connection with our contribution agreement entered into with Allogene. For additional information, see Note 2B, Note 3 and Note 4. For Earnings in 2017, certain significant items includes: (i) restructuring charges and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $204 million, (ii) charges for certain legal matters of $237 million, (iii) charges of $55 million, representing adjustments to amounts previously recorded to write-down the HIS net assets to fair value less costs to sell, (iv) certain asset impairment charges of $379 million, (v) charges for business and legal entity alignment of $71 million, (vi) net losses on early retirement of debt of $999 million and (vii) other charges of $700 million. For additional information, see Note 2B, Note 3 and Note 4. For Earnings in 2016, certain significant items includes: (i) restructuring charges and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $1.4 billion, (ii) charges for certain legal matters of $494 million, (iii) an impairment charge related to the write-down of the HIS net assets to fair value less estimated costs to sell of $1.7 billion, (iv) certain asset impairment charges of $1.4 billion, (v) charges for business and legal entity alignment of $261 million, (vi) net losses on early retirement of debt of $312 million and (vii) other charges of $294 million. For additional information, see Note 3 and Note 4.
Revenue from External Customers by Geographic Areas | As described in Note 1A, the February 3, 2017 sale of HIS impacted our results of operations in 2018, 2017 and 2016.
The following table provides revenues by geographic area:
| Year Ended December 31,
(MILLIONS OF DOLLARS) | 2018 |  |  | 2017 |  |  | 2016 |
United States | $ | 25,329 |  |  | $ | 26,026 |  |  | $ | 26,369 |
Developed Europe(a) | 9,116 |  |  | 8,508 |  |  | 9,306 |
Developed Rest of World(b) | 6,551 |  |  | 6,612 |  |  | 6,729 |
Emerging Markets (c) | 12,651 |  |  | 11,399 |  |  | 10,420 |
Revenues | $ | 53,647 |  |  | $ | 52,546 |  |  | $ | 52,824 |
(a) | Developed Europe region includes the following markets: Western Europe, Scandinavian countries and Finland. Revenues denominated in euros were $7.3 billion in 2018, $6.8 billion in 2017 and $7.2 billion in 2016.
(b) | Developed Rest of World region includes the following markets: Japan, Canada, South Korea, Australia and New Zealand.
(c) | Emerging Markets region includes, but is not limited to, the following markets: Asia (excluding Japan and South Korea), Latin America, Eastern Europe, Africa, the Middle East, Central Europe and Turkey.
Long-lived Assets by Geographic Areas |
The following table provides long-lived assets by geographic area:
|  | As of December 31,
(MILLIONS OF DOLLARS) |  | 2018 |  |  | 2017 |  |  | 2016 |
Property, plant and equipment, net |  |  |  |  |  |
United States |  | $ | 7,089 |  |  | $ | 6,971 |  |  | $ | 6,649 |
Developed Europe(a) |  | 4,204 |  |  | 4,345 |  |  | 4,228 |
Developed Rest of World(b) |  | 490 |  |  | 632 |  |  | 643 |
Emerging Markets(c) |  | 1,602 |  |  | 1,917 |  |  | 1,797 |
Property, plant and equipment, net |  | $ | 13,385 |  |  | $ | 13,865 |  |  | $ | 13,318 |
(a) | Developed Europe region includes the following markets: Western Europe, Scandinavian countries and Finland.
(b) | Developed Rest of World region includes the following markets: Japan, Canada, South Korea, Australia and New Zealand.
(c) | Emerging Markets region includes, but is not limited to, the following markets: Asia (excluding Japan and South Korea), Latin America, Eastern Europe, Africa, the Middle East, Central Europe and Turkey.
Schedule of Significant Product Revenues | As described in Note 1A, acquisitions and divestitures have impacted our results of operations in 2018, 2017 and 2016.
The following table provides detailed revenue information for several of our major products:
(MILLIONS OF DOLLARS) |  |  |  | Year Ended December 31,
PRODUCT |  | PRIMARY INDICATION OR CLASS |  | 2018 |  |  | 2017 |  |  | 2016 |
TOTAL REVENUES |  |  |  | $ | 53,647 |  |  | $ | 52,546 |  |  | $ | 52,824 |
PFIZER INNOVATIVE HEALTH (IH)(a) |  | $ | 33,426 |  |  | $ | 31,422 |  |  | $ | 29,197 |
Internal Medicine |  | $ | 9,996 |  |  | $ | 9,684 |  |  | $ | 8,858 |
Lyrica IH(b) |  | Epilepsy, post-herpetic neuralgia and diabetic peripheral neuropathy, fibromyalgia, neuropathic pain due to spinal cord injury |  | 4,622 |  |  | 4,511 |  |  | 4,165 |
Eliquis alliance revenues and direct sales |  | Atrial fibrillation, deep vein thrombosis, pulmonary embolism |  | 3,434 |  |  | 2,523 |  |  | 1,713 |
Chantix/Champix |  | An aid to smoking cessation treatment in adults 18 years of age or older |  | 1,085 |  |  | 997 |  |  | 842 |
BMP2 |  | Development of bone and cartilage |  | 279 |  |  | 261 |  |  | 251 |
Toviaz |  | Overactive bladder |  | 271 |  |  | 257 |  |  | 258 |
Viagra IH(c) |  | Erectile dysfunction |  | — |  |  | 823 |  |  | 1,181 |
All other Internal Medicine |  | Various |  | 306 |  |  | 312 |  |  | 447 |
Vaccines |  | $ | 6,332 |  |  | $ | 6,001 |  |  | $ | 6,071 |
Prevnar 13/Prevenar 13 |  | Vaccines for prevention of pneumococcal disease |  | 5,802 |  |  | 5,601 |  |  | 5,718 |
FSME/IMMUN-TicoVac |  | Tick-borne encephalitis vaccine |  | 184 |  |  | 134 |  |  | 114 |
Trumenba |  | Meningococcal Group B vaccine |  | 116 |  |  | 88 |  |  | 84 |
All other Vaccines |  | Various |  | 230 |  |  | 177 |  |  | 155 |
Oncology |  | $ | 7,202 |  |  | $ | 6,056 |  |  | $ | 4,563 |
Ibrance |  | Advanced breast cancer |  | 4,118 |  |  | 3,126 |  |  | 2,135 |
Sutent |  | Advanced and/or metastatic RCC, adjuvant RCC, refractory GIST (after disease progression on, or intolerance to, imatinib mesylate) and advanced pancreatic neuroendocrine tumor |  | 1,049 |  |  | 1,081 |  |  | 1,095 |
Xtandi alliance revenues |  | Castration-resistant prostate cancer |  | 699 |  |  | 590 |  |  | 140 |
Xalkori |  | ALK-positive and ROS1-positive advanced NSCLC |  | 524 |  |  | 594 |  |  | 561 |
Inlyta |  | Advanced RCC |  | 298 |  |  | 339 |  |  | 401 |
Bosulif |  | Philadelphia chromosome–positive chronic myelogenous leukemia |  | 296 |  |  | 233 |  |  | 167 |
All other Oncology |  | Various |  | 219 |  |  | 93 |  |  | 63 |
Inflammation & Immunology (I&I) |  | $ | 4,080 |  |  | $ | 3,968 |  |  | $ | 3,928 |
Enbrel (Outside the U.S. and Canada) |  | RA, juvenile idiopathic arthritis, PsA, plaque psoriasis, pediatric plaque psoriasis, ankylosing spondylitis and nonradiographic axial spondyloarthritis |  | 2,112 |  |  | 2,452 |  |  | 2,909 |
Xeljanz |  | RA, PsA, ulcerative colitis |  | 1,774 |  |  | 1,345 |  |  | 927 |
Eucrisa |  | Mild-to-moderate atopic dermatitis (eczema) |  | 147 |  |  | 67 |  |  | — |
All other I&I |  | Various |  | 46 |  |  | 103 |  |  | 93 |
Rare Disease |  | $ | 2,211 |  |  | $ | 2,240 |  |  | $ | 2,369 |
Genotropin |  | Replacement of human growth hormone |  | 558 |  |  | 532 |  |  | 579 |
BeneFIX |  | Hemophilia |  | 554 |  |  | 604 |  |  | 712 |
Refacto AF/Xyntha |  | Hemophilia |  | 514 |  |  | 551 |  |  | 554 |
Somavert |  | Acromegaly |  | 267 |  |  | 254 |  |  | 232 |
All other Rare Disease |  | Various |  | 318 |  |  | 300 |  |  | 292 |
Consumer Healthcare |  |  |  | $ | 3,605 |  |  | $ | 3,472 |  |  | $ | 3,407 |
PFIZER ESSENTIAL HEALTH (EH)(d) |  | $ | 20,221 |  |  | $ | 21,124 |  |  | $ | 23,627 |
Legacy Established Products (LEP)(e) |  | $ | 10,540 |  |  | $ | 10,894 |  |  | $ | 11,197 |
Lipitor |  | Reduction of LDL cholesterol |  | 2,062 |  |  | 1,915 |  |  | 1,758 |
Norvasc |  | Hypertension |  | 1,024 |  |  | 926 |  |  | 962 |
Premarin family |  | Symptoms of menopause |  | 832 |  |  | 977 |  |  | 1,017 |
Xalatan/Xalacom |  | Glaucoma and ocular hypertension |  | 318 |  |  | 335 |  |  | 363 |
Effexor |  | Depression and certain anxiety disorders |  | 311 |  |  | 297 |  |  | 278 |
EpiPen |  | Epinephrine injection used in treatment of life-threatening allergic reactions |  | 303 |  |  | 290 |  |  | 386 |
Zoloft |  | Depression and certain anxiety disorders |  | 298 |  |  | 291 |  |  | 304 |
Zithromax |  | Bacterial infections |  | 290 |  |  | 270 |  |  | 272 |
Xanax |  | Anxiety disorders |  | 223 |  |  | 225 |  |  | 222 |
Sildenafil Citrate |  | Erectile dysfunction |  | 56 |  |  | 56 |  |  | — |
All other LEP |  | Various |  | 4,822 |  |  | 5,313 |  |  | 5,636 |
(MILLIONS OF DOLLARS) |  |  |  | Year Ended December 31,
PRODUCT |  | PRIMARY INDICATION OR CLASS |  | 2018 |  |  | 2017 |  |  | 2016 |
Sterile Injectable Pharmaceuticals (SIP)(f) |  | $ | 5,214 |  |  | $ | 5,673 |  |  | $ | 6,014 |
Sulperazon |  | Treatment of infections |  | 613 |  |  | 471 |  |  | 396 |
Medrol |  | Steroid anti-inflammatory |  | 427 |  |  | 483 |  |  | 450 |
Fragmin |  | Slows blood clotting |  | 293 |  |  | 306 |  |  | 318 |
Tygacil |  | Tetracycline class antibiotic |  | 249 |  |  | 260 |  |  | 274 |
Zosyn/Tazocin |  | Antibiotic |  | 229 |  |  | 194 |  |  | 146 |
Precedex |  | Sedation agent in surgery or intensive care |  | 213 |  |  | 243 |  |  | 264 |
All other SIP |  | Various |  | 3,191 |  |  | 3,715 |  |  | 4,166 |
Peri-LOE Products(g) |  | $ | 2,944 |  |  | $ | 3,223 |  |  | $ | 4,220 |
Celebrex |  | Arthritis pain and inflammation, acute pain |  | 686 |  |  | 775 |  |  | 733 |
Viagra EH(c) |  | Erectile dysfunction |  | 636 |  |  | 382 |  |  | 383 |
Vfend |  | Fungal infections |  | 392 |  |  | 421 |  |  | 590 |
Lyrica EH(b) |  | Epilepsy, neuropathic pain and generalized anxiety disorder |  | 347 |  |  | 553 |  |  | 801 |
Zyvox |  | Bacterial infections |  | 236 |  |  | 281 |  |  | 421 |
Revatio |  | Pulmonary arterial hypertension |  | 227 |  |  | 252 |  |  | 285 |
Pristiq |  | Depression |  | 206 |  |  | 303 |  |  | 732 |
All other Peri-LOE Products |  | Various |  | 213 |  |  | 257 |  |  | 276 |
Biosimilars(h) |  | Various |  | $ | 769 |  |  | $ | 531 |  |  | $ | 319 |
Inflectra/Remsima |  | Inflammatory diseases |  | 642 |  |  | 419 |  |  | 192 |
All other Biosimilars |  | Various |  | 127 |  |  | 112 |  |  | 127 |
Pfizer CentreOne(i) |  |  |  | $ | 755 |  |  | $ | 706 |  |  | $ | 718 |
Hospira Infusion Systems (HIS)(j) |  | Various |  | $ | — |  |  | $ | 97 |  |  | $ | 1,158 |
Total Lyrica(b) |  | Epilepsy, post-herpetic neuralgia and diabetic peripheral neuropathy, fibromyalgia, neuropathic pain due to spinal cord injury |  | $ | 4,970 |  |  | $ | 5,065 |  |  | $ | 4,966 |
Total Viagra(c) |  | Erectile dysfunction |  | $ | 636 |  |  | $ | 1,204 |  |  | $ | 1,564 |
Total Alliance revenues |  | Various |  | $ | 3,838 |  |  | $ | 2,927 |  |  | $ | 1,746 |
(a) | The IH business encompasses Internal Medicine, Vaccines, Oncology, Inflammation & Immunology, Rare Disease and Consumer Healthcare. Through December 31, 2016, includes Duavive/Duavee and Viviant (recorded in All other Internal Medicine in 2016), which were transferred from Innovative Health to Essential Health effective January 1, 2017 (recorded in All other LEP (EH) beginning January 1, 2017), in order to align these products with our management of the women’s health portfolio within EH.
(b) | Lyrica revenues from all of Europe, Russia, Turkey, Israel and Central Asia countries are included in Lyrica EH. All other Lyrica revenues are included in Lyrica IH. Total Lyrica revenues represent the aggregate of worldwide revenues from Lyrica IH and Lyrica EH.
(c) | Viagra lost exclusivity in the U.S. in December 2017. In 2018, revenues for Viagra in the U.S. and Canada, which were reported in IH through 2017, were reported in EH (which reported all other Viagra revenues excluding the U.S. and Canada through 2017). Therefore, in 2018, total Viagra worldwide revenues were reported in EH. Total Viagra revenues in 2017 and 2016 represented the aggregate of worldwide revenues from Viagra IH and Viagra EH.
(d) | The EH business encompasses Legacy Established Products, Sterile Injectable Pharmaceuticals, Peri-LOE Products, Biosimilars, Pfizer CentreOne and HIS (through February 2, 2017).
(e) | Legacy Established Products primarily include products that have lost patent protection (excluding Sterile Injectable Pharmaceuticals and Peri-LOE Products). In the fourth quarter of 2017, we sold our equity share in Hisun Pfizer. As a result, effective in the first quarter of 2018, Hisun Pfizer-related revenues, previously reported in emerging markets within All Other LEP and All Other SIP, are reported in emerging markets within Pfizer CentreOne.
Effective January 1, 2017, All other LEP includes Duavive/Duavee and Viviant, which were transferred from Innovative Health (recorded in All other Internal Medicine (IH) in 2016), in order to align these products with our management of the women’s health portfolio within EH. See note (a) above.
(f) | Sterile Injectable Pharmaceuticals includes branded and generic injectables (excluding Peri-LOE Products). In the fourth quarter of 2017, we sold our equity share in Hisun Pfizer. As a result, effective in the first quarter of 2018, Hisun Pfizer-related revenues, previously reported in emerging markets within All Other LEP and All Other SIP, are reported in emerging markets within Pfizer CentreOne.
(g) | Peri-LOE Products include products that have recently lost or are anticipated to soon lose patent protection. These products primarily include: Lyrica in Europe, Russia, Turkey, Israel and Central Asia; and worldwide revenues for Celebrex, Pristiq, Zyvox, Vfend, Revatio and Inspra; and in 2018, Viagra revenues for all countries (and Viagra revenues for all countries other than the U.S. and Canada in 2017 and 2016), see note (c) above.
(h) | Biosimilars include Inflectra/Remsima (biosimilar infliximab) in the U.S. and certain international markets, Nivestim (biosimilar filgrastim) in certain European, Asian and Africa/Middle Eastern markets and in the U.S. and Retacrit (biosimilar epoetin zeta) in the U.S. and certain European and Africa/Middle Eastern markets.
(i) | Pfizer CentreOne includes revenues from our contract manufacturing and active pharmaceutical ingredient sales operation, including sterile injectables contract manufacturing, and revenues related to our manufacturing and supply agreements, including with Zoetis Inc. In the fourth quarter of 2017, we sold our equity share in Hisun Pfizer. As a result, effective in the first quarter of 2018, Hisun Pfizer-related revenues, previously reported in emerging markets within All Other LEP and All Other SIP, are reported in emerging markets within Pfizer CentreOne.
(j) | HIS (through February 2, 2017) includes Medication Management Systems products composed of infusion pumps and related software and services, as well as IV Infusion Products, including large volume IV solutions and their associated administration sets.

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