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Acquisitions, Divestitures, Assets and Liabilities Held for Sale, Licensing Arrangements, Research and Development and Collaborative Arrangements, Equity-Method Investments and Privately Held Investment - AstraZeneca (Details) - USD ($) |  | 1 Months Ended | 3 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | ---
Dec. 22, 2016 | Jan. 31, 2019 | Apr. 01, 2018 | Jul. 02, 2017 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Business Acquisition [Line Items] |  |  |  |  |  |  |  |  |
Goodwill |  |  |  |  | $ 53,411,000,000 | [1] | $ 55,952,000,000 | [1] | $ 54,449,000,000
AstraZeneca [Member] |  |  |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |  |  |
Payments to acquire businesses, cash portion | $ 555,000,000 |  |  |  |  |  | $ 605,000,000 |  |
Milestone payment |  |  | $ 125,000,000 | $ 50,000,000 |  |  |  |  |
Potential milestone payments |  |  |  |  | 75,000,000 |  |  |  |
Maximum amount of sales-related payments |  |  |  |  | 600,000,000 |  |  |  |
Consideration transferred | 1,040,000,000 |  |  |  |  |  |  |  |
Fair value of contingent consideration | 485,000,000 |  |  |  |  |  |  |  |
Intangible assets | 894,000,000 |  |  |  |  |  |  |  |
Other current assets | 92,000,000 |  |  |  |  |  |  |  |
Goodwill | 73,000,000 |  |  |  |  |  |  |  |
Net deferred tax liabilities | 19,000,000 |  |  |  |  |  |  |  |
Minimum [Member] | AstraZeneca [Member] |  |  |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |  |  |
Royalty payments |  |  |  |  | 327,000,000 |  |  |  |
Maximum [Member] | AstraZeneca [Member] |  |  |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |  |  |
Royalty payments |  |  |  |  | $ 553,000,000 |  |  |  |
Developed Technology Rights [Member] | AstraZeneca [Member] |  |  |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |  |  |
Intangible assets | 728,000,000 |  |  |  |  |  |  |  |
In Process Research and Development [Member] | AstraZeneca [Member] |  |  |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |  |  |
Intangible assets | $ 166,000,000 |  |  |  |  |  |  |  |
Subsequent Event [Member] | AstraZeneca [Member] |  |  |  |  |  |  |  |  |
Business Acquisition [Line Items] |  |  |  |  |  |  |  |  |
Deferred payment |  | $ 175,000,000 |  |  |  |  |  |  |
[1] | Amounts may not add due to rounding.

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