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Restructuring Charges and Other Costs Associated with Acquisitions and Cost-Reduction/Productivity Initiatives - Schedule of Components and Changes in Restructuring Accruals (Detail) - USD ($) $ in Millions | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 28, 2025 | Sep. 29, 2024 | Sep. 28, 2025 | Sep. 29, 2024
Restructuring Reserve [Roll Forward] |  |  |  |  |
Balance, beginning | [1] |  |  | $ 2,120 |
Provision | [2] | $ 237 | $ 217 | 784 | $ 1,331
Utilization and other | [3] |  |  | (1,067) |
Balance, ending | [4] | 1,836 |  | 1,836 |
Other Current Liabilities [Member] |  |  |  |  |
Restructuring Reserve [Roll Forward] |  |  |  |  |
Balance, beginning |  |  |  | 1,700 |
Balance, ending |  | 1,300 |  | 1,300 |
Other Noncurrent Liabilities [Member] |  |  |  |  |
Restructuring Reserve [Roll Forward] |  |  |  |  |
Balance, beginning |  |  |  | 437 |
Balance, ending |  | 532 |  | 532 |
Employee Termination Costs [Member] |  |  |  |  |
Restructuring Reserve [Roll Forward] |  |  |  |  |
Balance, beginning | [1] |  |  | 2,046 |
Provision |  |  |  | 360 |
Utilization and other | [3] |  |  | (724) |
Balance, ending | [4] | 1,682 |  | 1,682 |
Asset Impairment Charges [Member] |  |  |  |  |
Restructuring Reserve [Roll Forward] |  |  |  |  |
Balance, beginning | [1] |  |  | 0 |
Provision |  |  |  | 328 |
Utilization and other | [3] |  |  | (328) |
Balance, ending | [4] | 0 |  | 0 |
Exit Costs [Member] |  |  |  |  |
Restructuring Reserve [Roll Forward] |  |  |  |  |
Balance, beginning | [1] |  |  | 74 |
Provision |  |  |  | 96 |
Utilization and other | [3] |  |  | (15) |
Balance, ending | [4] | $ 155 |  | $ 155 |
[1] | Included in Other current liabilities ($1.7 billion) and Other noncurrent liabilities ($437 million).
[2] | Primarily represents cost-reduction initiatives. Amounts associated with our Biopharma segment: (i) charges of $240 million for the three months ended September 28, 2025 (including charges of $117 million for our Manufacturing Optimization Program and charges of $107 million for our Realigning our Cost Base Program), (ii) charges of $451 million for the nine months ended September 28, 2025 (including charges of $669 million for our Realigning our Cost Base Program and credits of $295 million for our Manufacturing Optimization Program), (iii) charges of $141 million for the three months ended September 29, 2024 (primarily including charges for our Realigning our Cost Base Program) and (iv) charges of $1.2 billion for the nine months ended September 29, 2024 (including charges of $1.3 billion for our Manufacturing Optimization Program and credits of $69 million for our Realigning our Cost Base Program). For the nine months ended September 28, 2025 and September 29, 2024, Employee terminations include revisions of estimates of previously recorded accruals for severance benefits, driven in large part by higher-than-expected voluntary attrition.
[3] | Other activity includes adjustments for foreign currency translation that are not material to our condensed consolidated financial statements.
[4] | Included in Other current liabilities ($1.3 billion) and Other noncurrent liabilities ($532 million).

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