<SEC-DOCUMENT>0001193125-25-291406.txt : 20251121
<SEC-HEADER>0001193125-25-291406.hdr.sgml : 20251121
<ACCEPTANCE-DATETIME>20251121161649
ACCESSION NUMBER:		0001193125-25-291406
CONFORMED SUBMISSION TYPE:	8-K
PUBLIC DOCUMENT COUNT:		19
CONFORMED PERIOD OF REPORT:	20251118
ITEM INFORMATION:		Other Events
ITEM INFORMATION:		Financial Statements and Exhibits
FILED AS OF DATE:		20251121
DATE AS OF CHANGE:		20251121

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PFIZER INC
		CENTRAL INDEX KEY:			0000078003
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				135315170
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		8-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-03619
		FILM NUMBER:		251508195

	BUSINESS ADDRESS:	
		STREET 1:		66 HUDSON BOULEVARD EAST
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10001-2192
		BUSINESS PHONE:		2127332323

	MAIL ADDRESS:	
		STREET 1:		66 HUDSON BOULEVARD EAST
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10001-2192

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PFIZER CHARLES & CO INC
		DATE OF NAME CHANGE:	19710908
</SEC-HEADER>
<DOCUMENT>
<TYPE>8-K
<SEQUENCE>1
<FILENAME>d80089d8k.htm
<DESCRIPTION>8-K
<TEXT>
<XBRL>
<?xml version='1.0' encoding='ASCII'?>
<html xmlns:dei="http://xbrl.sec.gov/dei/2025" xmlns:us-types="http://fasb.org/us-types/2025" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:pfe="http://www.pfizer.com/20251118" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:utr="http://www.xbrl.org/2009/utr" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:ix="http://www.xbrl.org/2013/inlineXBRL" xmlns:ixt="http://www.xbrl.org/inlineXBRL/transformation/2015-02-26" xmlns:ixt-sec="http://www.sec.gov/inlineXBRL/transformation/2015-08-31" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:us-gaap="http://fasb.org/us-gaap/2025" xmlns="http://www.w3.org/1999/xhtml">
<head>
<title>8-K</title>
<meta http-equiv="Content-Type" content="text/html"/>
</head>
   <body><div style="display:none"> <ix:header> <ix:hidden> <ix:nonNumeric id="Hidden_dei_EntityRegistrantName" name="dei:EntityRegistrantName" contextRef="duration_2025-11-18_to_2025-11-18">PFIZER INC</ix:nonNumeric> <ix:nonNumeric name="dei:AmendmentFlag" contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-439">false</ix:nonNumeric> <ix:nonNumeric id="Hidden_dei_EntityCentralIndexKey" name="dei:EntityCentralIndexKey" contextRef="duration_2025-11-18_to_2025-11-18">0000078003</ix:nonNumeric> </ix:hidden> <ix:references> <link:schemaRef xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:link="http://www.xbrl.org/2003/linkbase" xlink:type="simple" xlink:href="pfe-20251118.xsd" xlink:arcrole="http://www.xbrl.org/2003/linkbase"/> </ix:references> <ix:resources> <xbrli:context id="duration_2025-11-18_to_2025-11-18"> <xbrli:entity> <xbrli:identifier scheme="http://www.sec.gov/CIK">0000078003</xbrli:identifier> </xbrli:entity> <xbrli:period> <xbrli:startDate>2025-11-18</xbrli:startDate> <xbrli:endDate>2025-11-18</xbrli:endDate> </xbrli:period> </xbrli:context> <xbrli:context id="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_us-gaap-CommonStockMember"> <xbrli:entity> <xbrli:identifier scheme="http://www.sec.gov/CIK">0000078003</xbrli:identifier> <xbrli:segment> <xbrldi:explicitMember dimension="us-gaap:StatementClassOfStockAxis">us-gaap:CommonStockMember</xbrldi:explicitMember> </xbrli:segment> </xbrli:entity> <xbrli:period> <xbrli:startDate>2025-11-18</xbrli:startDate> <xbrli:endDate>2025-11-18</xbrli:endDate> </xbrli:period> </xbrli:context> <xbrli:context id="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M1.000NotesDue20275Member"> <xbrli:entity> <xbrli:identifier scheme="http://www.sec.gov/CIK">0000078003</xbrli:identifier> <xbrli:segment> <xbrldi:explicitMember dimension="us-gaap:StatementClassOfStockAxis">pfe:M1.000NotesDue20275Member</xbrldi:explicitMember> </xbrli:segment> </xbrli:entity> <xbrli:period> <xbrli:startDate>2025-11-18</xbrli:startDate> <xbrli:endDate>2025-11-18</xbrli:endDate> </xbrli:period> </xbrli:context> <xbrli:context id="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M2.875NotesDue20291Member"> <xbrli:entity> <xbrli:identifier scheme="http://www.sec.gov/CIK">0000078003</xbrli:identifier> <xbrli:segment> <xbrldi:explicitMember dimension="us-gaap:StatementClassOfStockAxis">pfe:M2.875NotesDue20291Member</xbrldi:explicitMember> </xbrli:segment> </xbrli:entity> <xbrli:period> <xbrli:startDate>2025-11-18</xbrli:startDate> <xbrli:endDate>2025-11-18</xbrli:endDate> </xbrli:period> </xbrli:context> <xbrli:context id="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M3.250NotesDue20322Member"> <xbrli:entity> <xbrli:identifier scheme="http://www.sec.gov/CIK">0000078003</xbrli:identifier> <xbrli:segment> <xbrldi:explicitMember dimension="us-gaap:StatementClassOfStockAxis">pfe:M3.250NotesDue20322Member</xbrldi:explicitMember> </xbrli:segment> </xbrli:entity> <xbrli:period> <xbrli:startDate>2025-11-18</xbrli:startDate> <xbrli:endDate>2025-11-18</xbrli:endDate> </xbrli:period> </xbrli:context> <xbrli:context id="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M3.875NotesDue20373Member"> <xbrli:entity> <xbrli:identifier scheme="http://www.sec.gov/CIK">0000078003</xbrli:identifier> <xbrli:segment> <xbrldi:explicitMember dimension="us-gaap:StatementClassOfStockAxis">pfe:M3.875NotesDue20373Member</xbrldi:explicitMember> </xbrli:segment> </xbrli:entity> <xbrli:period> <xbrli:startDate>2025-11-18</xbrli:startDate> <xbrli:endDate>2025-11-18</xbrli:endDate> </xbrli:period> </xbrli:context> <xbrli:context id="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M4.250NotesDue20454Member"> <xbrli:entity> <xbrli:identifier scheme="http://www.sec.gov/CIK">0000078003</xbrli:identifier> <xbrli:segment> <xbrldi:explicitMember dimension="us-gaap:StatementClassOfStockAxis">pfe:M4.250NotesDue20454Member</xbrldi:explicitMember> </xbrli:segment> </xbrli:entity> <xbrli:period> <xbrli:startDate>2025-11-18</xbrli:startDate> <xbrli:endDate>2025-11-18</xbrli:endDate> </xbrli:period> </xbrli:context> </ix:resources> </ix:header> </div> <div style="text-align:center"> <div style="width:8.5in;text-align:left;margin-left: auto;margin-right: auto"> <div style="line-height:1.0pt;margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #000000">&#160;</div> <div style="line-height:3.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1px solid #000000">&#160;</div> <p style="margin-top:8pt; margin-bottom:0pt; font-size:18pt; font-family:Times New Roman;font-weight:bold;text-align:center">UNITED STATES</p> <p style="margin-top:0pt; margin-bottom:0pt; font-size:18pt; font-family:Times New Roman;font-weight:bold;text-align:center">SECURITIES AND EXCHANGE COMMISSION</p> <p style="margin-top:0pt; margin-bottom:0pt; font-size:12pt; font-family:Times New Roman;font-weight:bold;text-align:center">Washington, D.C. 20549</p> <p style="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&#160;</p> <div style="text-align:center"> <div style="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000;width:21%;text-align:center;margin-left: auto;margin-right: auto">&#160;</div></div> <p style="margin-top:12pt; margin-bottom:0pt; font-size:18pt; font-family:Times New Roman;font-weight:bold;text-align:center">FORM <span style="white-space:nowrap"><ix:nonNumeric name="dei:DocumentType" contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-498">8-K</ix:nonNumeric></span></p> <p style="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&#160;</p> <div style="text-align:center"> <div style="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000;width:21%;text-align:center;margin-left: auto;margin-right: auto">&#160;</div></div> <p style="margin-top:12pt; margin-bottom:0pt; font-size:12pt; font-family:Times New Roman;font-weight:bold;text-align:center">CURRENT REPORT</p> <p style="margin-top:0pt; margin-bottom:0pt; font-size:12pt; font-family:Times New Roman;font-weight:bold;text-align:center">PURSUANT TO SECTION 13 OR 15(d)</p> <p style="margin-top:0pt; margin-bottom:0pt; font-size:12pt; font-family:Times New Roman;font-weight:bold;text-align:center">OF THE SECURITIES EXCHANGE ACT OF 1934</p> <p style="margin-top:12pt; margin-bottom:0pt; font-size:12pt; font-family:Times New Roman;font-weight:bold;text-align:center">Date of report (Date of earliest event reported): <ix:nonNumeric name="dei:DocumentPeriodEndDate" contextRef="duration_2025-11-18_to_2025-11-18" format="ixt:datemonthdayyearen" id="ixv-499">November&#160;18, 2025</ix:nonNumeric></p> <p style="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&#160;</p> <div style="text-align:center"> <div style="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000;width:21%;text-align:center;margin-left: auto;margin-right: auto">&#160;</div></div> <p style="margin-top:12pt; margin-bottom:0pt; font-size:24pt; font-family:Times New Roman;font-weight:bold;text-align:center"> <span style=" -sec-ix-hidden:Hidden_dei_EntityRegistrantName">PFIZER INC.</span> </p> <p style="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;font-weight:bold;text-align:center">(Exact name of registrant as specified in its charter)</p> <p style="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&#160;</p> <div style="text-align:center"> <div style="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000;width:21%;text-align:center;margin-left: auto;margin-right: auto">&#160;</div></div> <p style="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&#160;</p>
<table cellspacing="0" cellpadding="0" style="border-collapse:collapse; font-family:Times New Roman; font-size:8pt;width:100%;border-spacing:0;margin:0 auto">
<tr>
<td style="width:34%"/>
<td style="vertical-align:bottom"/>
<td style="width:32%"/>
<td style="vertical-align:bottom;width:1%"/>
<td style="width:32%"/></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;text-align:center"><span style="font-weight:bold"><ix:nonNumeric name="dei:EntityIncorporationStateCountryCode" contextRef="duration_2025-11-18_to_2025-11-18" format="ixt-sec:stateprovnameen" id="ixv-500">Delaware</ix:nonNumeric></span></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:top;text-align:center"><span style="font-weight:bold"><span style="white-space:nowrap"><ix:nonNumeric name="dei:EntityFileNumber" contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-501">1-3619</ix:nonNumeric></span></span></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:top;text-align:center"><span style="font-weight:bold"><span style="white-space:nowrap"><ix:nonNumeric name="dei:EntityTaxIdentificationNumber" contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-502">13-5315170</ix:nonNumeric></span></span></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<td style="vertical-align:top;text-align:center"><span style="font-weight:bold">(State or other jurisdiction<br/>of incorporation)</span></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:top;text-align:center"> <p style="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman;font-weight:bold;text-align:center">(Commission</p> <p style="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman;font-weight:bold;text-align:center">File Number)</p></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:top;text-align:center"> <p style="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman;font-weight:bold;text-align:center">(I.R.S. Employer</p> <p style="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman;font-weight:bold;text-align:center">Identification No.)</p></td></tr></table> <p style="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&#160;</p>
<table cellspacing="0" cellpadding="0" style="border-collapse:collapse; font-family:Times New Roman; font-size:10pt;width:100%;border-spacing:0;margin:0 auto">
<tr>
<td style="width:50%"/>
<td style="vertical-align:bottom;width:1%"/>
<td style="width:48%"/></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:bottom;text-align:center"><span style="font-weight:bold"><ix:nonNumeric name="dei:EntityAddressAddressLine1" contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-503">66 Hudson Boulevard East</ix:nonNumeric></span></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:bottom"/></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;text-align:center"><span style="font-weight:bold"><ix:nonNumeric name="dei:EntityAddressCityOrTown" contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-504">New York</ix:nonNumeric>, <ix:nonNumeric name="dei:EntityAddressStateOrProvince" contextRef="duration_2025-11-18_to_2025-11-18" format="ixt-sec:stateprovnameen" id="ixv-505">New York</ix:nonNumeric></span></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:top;text-align:center"><span style="font-weight:bold"><ix:nonNumeric name="dei:EntityAddressPostalZipCode" contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-506">10001-2192</ix:nonNumeric></span></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<td style="vertical-align:top;text-align:center"><span style="font-weight:bold">(Address of principal executive offices)</span></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:top;text-align:center"><span style="font-weight:bold">(Zip Code)</span></td></tr></table> <p style="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;font-weight:bold;text-align:center">Registrant&#8217;s telephone number, including area code:</p> <p style="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;font-weight:bold;text-align:center"><ix:nonNumeric name="dei:CityAreaCode" contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-507">(212)</ix:nonNumeric> <span style="white-space:nowrap"><ix:nonNumeric name="dei:LocalPhoneNumber" contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-508">733-2323</ix:nonNumeric></span></p> <p style="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman;font-weight:bold;text-align:center">(Former name or former address, if changed since last report)</p> <p style="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&#160;</p> <div style="text-align:center"> <div style="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000;width:21%;text-align:center;margin-left: auto;margin-right: auto">&#160;</div></div> <p style="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Check the appropriate box below if the Form <span style="white-space:nowrap">8-K</span> filing is intended to simultaneously satisfy the obligation of the registrant under any of the following provisions (see General Instruction A.2. below):</p> <p style="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&#160;</p>
<table style="border-collapse:collapse; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%" cellpadding="0" cellspacing="0">
<tr style="page-break-inside:avoid">
<td style="width:4%;vertical-align:top;text-align:left"><ix:nonNumeric name="dei:WrittenCommunications" contextRef="duration_2025-11-18_to_2025-11-18" format="ixt-sec:boolballotbox" id="ixv-509">&#9744;</ix:nonNumeric></td>
<td style="vertical-align:top;text-align:left"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;text-align:left">Written communication pursuant to Rule 425 under the Securities Act (17 CFR 230.425)</p></td></tr></table> <p style="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&#160;</p>
<table style="border-collapse:collapse; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%" cellpadding="0" cellspacing="0">
<tr style="page-break-inside:avoid">
<td style="width:4%;vertical-align:top;text-align:left"><ix:nonNumeric name="dei:SolicitingMaterial" contextRef="duration_2025-11-18_to_2025-11-18" format="ixt-sec:boolballotbox" id="ixv-510">&#9744;</ix:nonNumeric></td>
<td style="vertical-align:top;text-align:left"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;text-align:left">Soliciting material pursuant to Rule <span style="white-space:nowrap">14a-12</span> under the Exchange Act (17 CFR <span style="white-space:nowrap">240.14a-12)</span></p></td></tr></table> <p style="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&#160;</p>
<table style="border-collapse:collapse; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%" cellpadding="0" cellspacing="0">
<tr style="page-break-inside:avoid">
<td style="width:4%;vertical-align:top;text-align:left"><ix:nonNumeric name="dei:PreCommencementTenderOffer" contextRef="duration_2025-11-18_to_2025-11-18" format="ixt-sec:boolballotbox" id="ixv-511">&#9744;</ix:nonNumeric></td>
<td style="vertical-align:top;text-align:left"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;text-align:left"><span style="white-space:nowrap">Pre-commencement</span> communications pursuant to Rule <span style="white-space:nowrap">14d-2(b)</span> under the Exchange Act (17 CFR <span style="white-space:nowrap">240.14d-2</span> (b))</p></td></tr></table> <p style="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&#160;</p>
<table style="border-collapse:collapse; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%" cellpadding="0" cellspacing="0">
<tr style="page-break-inside:avoid">
<td style="width:4%;vertical-align:top;text-align:left"><ix:nonNumeric name="dei:PreCommencementIssuerTenderOffer" contextRef="duration_2025-11-18_to_2025-11-18" format="ixt-sec:boolballotbox" id="ixv-512">&#9744;</ix:nonNumeric></td>
<td style="vertical-align:top;text-align:left"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;text-align:left"><span style="white-space:nowrap">Pre-commencement</span> communications pursuant to Rule <span style="white-space:nowrap">13e-4(c)</span> under the Exchange Act (17 CFR <span style="white-space:nowrap">240.13e-4(c))</span></p></td></tr></table> <p style="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Securities registered pursuant to Section&#160;12(b) of the Act:</p> <p style="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&#160;</p>
<table cellspacing="0" cellpadding="0" style="border-collapse:collapse; font-family:Times New Roman; font-size:10pt;width:100%;border-spacing:0;margin:0 auto">
<tr>
<td style="width:34%"/>
<td style="vertical-align:bottom"/>
<td style="width:32%"/>
<td style="vertical-align:bottom;width:1%"/>
<td style="width:32%"/></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;white-space:nowrap;text-align:center"> <p style="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman;font-weight:bold;text-align:center">Title of each class</p></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"> <p style="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman;font-weight:bold;text-align:center">Trading<br/>Symbol(s)</p></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;text-align:center"> <p style="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman;font-weight:bold;text-align:center">Name of each exchange<br/>on which registered</p></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;text-align:center"><ix:nonNumeric name="dei:Security12bTitle" contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_us-gaap-CommonStockMember" id="ixv-513">Common Stock, $0.05 par value</ix:nonNumeric></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:top;text-align:center"><ix:nonNumeric name="dei:TradingSymbol" contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_us-gaap-CommonStockMember" id="ixv-514">PFE</ix:nonNumeric></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:top;text-align:center"><ix:nonNumeric name="dei:SecurityExchangeName" contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_us-gaap-CommonStockMember" format="ixt-sec:exchnameen" id="ixv-515">New York Stock Exchange</ix:nonNumeric></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;text-align:center"><ix:nonNumeric name="dei:Security12bTitle" contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M1.000NotesDue20275Member" id="ixv-516">1.000% Notes due 2027</ix:nonNumeric></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:top;text-align:center"><ix:nonNumeric name="dei:TradingSymbol" contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M1.000NotesDue20275Member" id="ixv-517">PFE/27</ix:nonNumeric></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:top;text-align:center"><ix:nonNumeric name="dei:SecurityExchangeName" contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M1.000NotesDue20275Member" format="ixt-sec:exchnameen" id="ixv-518">New York Stock Exchange</ix:nonNumeric></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;text-align:center"><ix:nonNumeric name="dei:Security12bTitle" contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M2.875NotesDue20291Member" id="ixv-519">2.875% Notes due 2029</ix:nonNumeric></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:top;text-align:center"><ix:nonNumeric name="dei:TradingSymbol" contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M2.875NotesDue20291Member" id="ixv-520">PFE/29</ix:nonNumeric></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:top;text-align:center"><ix:nonNumeric name="dei:SecurityExchangeName" contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M2.875NotesDue20291Member" format="ixt-sec:exchnameen" id="ixv-521">New York Stock Exchange</ix:nonNumeric></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;text-align:center"><ix:nonNumeric name="dei:Security12bTitle" contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M3.250NotesDue20322Member" id="ixv-522">3.250% Notes due 2032</ix:nonNumeric></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:top;text-align:center"><ix:nonNumeric name="dei:TradingSymbol" contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M3.250NotesDue20322Member" id="ixv-523">PFE/32</ix:nonNumeric></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:top;text-align:center"><ix:nonNumeric name="dei:SecurityExchangeName" contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M3.250NotesDue20322Member" format="ixt-sec:exchnameen" id="ixv-524">New York Stock Exchange</ix:nonNumeric></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;text-align:center"><ix:nonNumeric name="dei:Security12bTitle" contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M3.875NotesDue20373Member" id="ixv-525">3.875% Notes due 2037</ix:nonNumeric></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:top;text-align:center"><ix:nonNumeric name="dei:TradingSymbol" contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M3.875NotesDue20373Member" id="ixv-526">PFE/37A</ix:nonNumeric></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:top;text-align:center"><ix:nonNumeric name="dei:SecurityExchangeName" contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M3.875NotesDue20373Member" format="ixt-sec:exchnameen" id="ixv-527">New York Stock Exchange</ix:nonNumeric></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;text-align:center"><ix:nonNumeric name="dei:Security12bTitle" contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M4.250NotesDue20454Member" id="ixv-528">4.250% Notes due 2045</ix:nonNumeric></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:top;text-align:center"><ix:nonNumeric name="dei:TradingSymbol" contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M4.250NotesDue20454Member" id="ixv-529">PFE/45</ix:nonNumeric></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:top;text-align:center"><ix:nonNumeric name="dei:SecurityExchangeName" contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M4.250NotesDue20454Member" format="ixt-sec:exchnameen" id="ixv-530">New York Stock Exchange</ix:nonNumeric></td></tr></table> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (&#167;230.405 of this chapter) or Rule <span style="white-space:nowrap">12b-2</span> of the Securities Exchange Act of 1934 <span style="white-space:nowrap">(&#167;240.12b-2</span> of this chapter).</p> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Emerging growth company &#8194;<ix:nonNumeric name="dei:EntityEmergingGrowthCompany" contextRef="duration_2025-11-18_to_2025-11-18" format="ixt-sec:boolballotbox" id="ixv-531">&#9744;</ix:nonNumeric></p> <p style="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section&#160;13(a) of the Exchange Act. &#8194;&#9744;</p> <p style="font-size:10pt;margin-top:0pt;margin-bottom:0pt">&#160;</p> <div style="line-height:1.0pt;margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #000000">&#160;</div> <div style="line-height:3.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1px solid #000000">&#160;</div></div></div>

<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<hr style="color:#999999;height:3px;width:100%;clear:both"/>

<div style="text-align:center"><div style="width:8.5in;text-align:left;margin-left: auto;margin-right: auto">

<table style="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%" cellpadding="0" cellspacing="0">
<tr style="page-break-inside:avoid">
<td style="width:11%;vertical-align:top;text-align:left"><span style="font-weight:bold">Item&#8201;8.01</span></td>
<td style="vertical-align:top;text-align:left"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;font-weight:bold;text-align:left">Other Events. </p></td></tr></table> <p style="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">On November&#160;21, 2025, Pfizer Inc. (the &#8220;Company&#8221;) completed a public offering of $500,000,000 aggregate principal amount of Floating Rate Notes due 2027 (the &#8220;Floating Rate Notes&#8221;), $1,000,000,000 aggregate principal amount of 3.875% Notes due 2027 (the &#8220;2027 Notes&#8221;), $1,000,000,000 aggregate principal amount of 4.200% Notes due 2030 (the &#8220;2030 Notes&#8221;), $1,250,000,000 aggregate principal amount of 4.500% Notes due 2032 (the &#8220;2032 Notes&#8221;), $1,250,000,000 aggregate principal amount of 4.875% Notes due 2035 (the &#8220;2035 Notes&#8221;), $500,000,000 aggregate principal amount of 5.600% Notes due 2055 (the &#8220;2055 Notes&#8221;) and $500,000,000 aggregate principal amount of 5.700% Notes due 2065 (the &#8220;2065 Notes&#8221; and, together with the Floating Rate Notes, the 2027 Notes, the 2030 Notes, the 2032 Notes, the 2035 Notes and the 2055 Notes, the &#8220;Notes&#8221;). </p> <p style="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The offering of the Notes was made pursuant to the shelf registration statement on Form <span style="white-space:nowrap">S-3</span> (Registration <span style="white-space:nowrap">No.&#160;333-277323)</span> of the Company, Pfizer Investment Enterprises Pte. Ltd. and Pfizer Netherlands International Finance B.V., originally filed with the Securities and Exchange Commission (the &#8220;Commission&#8221;) on February&#160;23, 2024, as amended by the Post-Effective Amendment No.&#160;1 thereto, filed with the Commission on May 13, 2025. </p> <p style="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The Notes were issued pursuant to an indenture (the &#8220;Base Indenture&#8221;), dated as of September&#160;7, 2018, between the Company and The Bank of New&#160;York Mellon, as trustee (the &#8220;Trustee&#8221;), as supplemented by the sixth supplemental indenture (the &#8220;Sixth Supplemental Indenture&#8221; and, the Base Indenture as supplemented by the Sixth Supplemental Indenture, the &#8220;Indenture&#8221;), dated as of November&#160;21, 2025, between the Company and the Trustee. </p> <p style="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The Sixth Supplemental Indenture is filed herewith as Exhibit 4.2 to this Current Report on Form <span style="white-space:nowrap">8-K</span> and is incorporated herein by reference. Each of the form of Floating Rate Notes, the form of 2027 Notes, the form of 2030 Notes, the form of 2032 Notes, the form of 2035 Notes, the form of 2055 Notes and the form of 2065 Notes are filed herewith as Exhibit 4.3, Exhibit 4.4, Exhibit 4.5, Exhibit 4.6, Exhibit 4.7, Exhibit 4.8 and Exhibit 4.9 to this Current Report on Form <span style="white-space:nowrap">8-K,</span> respectively, and are incorporated herein by reference. </p> <p style="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">In connection with the offering of the Notes, the Company entered into an underwriting agreement (the &#8220;Underwriting Agreement&#8221;) and related pricing agreement (the &#8220;Pricing Agreement&#8221;), each dated November&#160;18, 2025, with Citigroup Global Markets Inc., Deutsche Bank Securities Inc., J.P. Morgan Securities LLC and Mizuho Securities USA LLC, as representatives of the several underwriters listed on Schedule I to the Pricing Agreement. </p> <p style="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The Underwriting Agreement and the Pricing Agreement are filed herewith as Exhibit 1.1 and Exhibit 1.2 to this Current Report on Form <span style="white-space:nowrap">8-K,</span> respectively, and are incorporated herein by reference. </p> <p style="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">In addition, in connection with the offering of the Notes, the Company is filing a legal opinion regarding the validity of the Notes, which is filed herewith as Exhibit 5.1 to this Current Report on Form <span style="white-space:nowrap">8-K.</span> </p> <p style="font-size:18pt; margin-top:0pt; margin-bottom:0pt">&#160;</p>
</div></div>



<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<hr style="color:#999999;height:3px;width:100%;clear:both"/>

<div style="text-align:center"><div style="width:8.5in;text-align:left;margin-left: auto;margin-right: auto">

<table style="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;border-spacing:0;width:100%" cellpadding="0" cellspacing="0">
<tr style="page-break-inside:avoid">
<td style="width:11%;vertical-align:top;text-align:left"><span style="font-weight:bold">Item&#8201;9.01</span></td>
<td style="vertical-align:top;text-align:left"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;font-weight:bold;text-align:left">Financial Statements and Exhibits. </p></td></tr></table> <p style="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">(d)&#160;Exhibits </p> <p style="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&#160;</p>
<table cellspacing="0" cellpadding="0" style="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;width:100%;border-spacing:0;margin:0 auto">


<tr>

<td/>

<td style="vertical-align:bottom;width:4%"/>
<td style="width:93%"/></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<td style="vertical-align:bottom;white-space:nowrap;text-align:center"> <p style=" margin-top:0pt ; margin-bottom:0pt; border-bottom:1.00pt solid #000000; display:inline-block; font-size:8pt; font-family:Times New Roman;text-align:center">Exhibit<br/>No.</p></td>
<td style="vertical-align:bottom">&#160;&#160;</td>
<td style="border-bottom:1.00pt solid #000000;vertical-align:bottom;white-space:nowrap;text-align:center"> <p style="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman;text-align:center">Exhibit Description</p></td></tr>


<tr style="font-size:1pt">
<td style="height:6pt"/>
<td style="height:6pt" colspan="2"/></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;white-space:nowrap">1.1</td>
<td style="vertical-align:bottom">&#160;&#160;</td>
<td style="vertical-align:top"><a href="d80089dex11.htm">Underwriting Agreement, dated November&#160;18, 2025. </a></td></tr>
<tr style="font-size:1pt">
<td style="height:6pt"/>
<td style="height:6pt" colspan="2"/></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;white-space:nowrap">1.2</td>
<td style="vertical-align:bottom">&#160;&#160;</td>
<td style="vertical-align:top"><a href="d80089dex12.htm">Pricing Agreement, dated November&#160;18, 2025. </a></td></tr>
<tr style="font-size:1pt">
<td style="height:6pt"/>
<td style="height:6pt" colspan="2"/></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;white-space:nowrap">4.1</td>
<td style="vertical-align:bottom">&#160;&#160;</td>
<td style="vertical-align:top"><a href="http://www.sec.gov/Archives/edgar/data/78003/000119312518269276/d618110d8k.htm">Indenture, dated as of September&#160;7, 2018 (incorporated by reference from the Company&#8217;s Current Report on Form <span style="white-space:nowrap">8-K</span> filed on September&#160;7, 2018). </a></td></tr>
<tr style="font-size:1pt">
<td style="height:6pt"/>
<td style="height:6pt" colspan="2"/></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;white-space:nowrap">4.2</td>
<td style="vertical-align:bottom">&#160;&#160;</td>
<td style="vertical-align:top"><a href="d80089dex42.htm">Sixth Supplemental Indenture, dated as of November&#160;21, 2025, between Pfizer Inc. and The Bank of New York Mellon, as trustee. </a></td></tr>
<tr style="font-size:1pt">
<td style="height:6pt"/>
<td style="height:6pt" colspan="2"/></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;white-space:nowrap">4.3</td>
<td style="vertical-align:bottom">&#160;&#160;</td>
<td style="vertical-align:top"><a href="d80089dex42.htm">Form of Floating Rate Notes due 2027 (included in Exhibit&#160;4.2). </a></td></tr>
<tr style="font-size:1pt">
<td style="height:6pt"/>
<td style="height:6pt" colspan="2"/></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;white-space:nowrap">4.4</td>
<td style="vertical-align:bottom">&#160;&#160;</td>
<td style="vertical-align:top"><a href="d80089dex42.htm">Form of 3.875% Notes due 2027 (included in Exhibit&#160;4.2). </a></td></tr>
<tr style="font-size:1pt">
<td style="height:6pt"/>
<td style="height:6pt" colspan="2"/></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;white-space:nowrap">4.5</td>
<td style="vertical-align:bottom">&#160;&#160;</td>
<td style="vertical-align:top"><a href="d80089dex42.htm">Form of 4.200% Notes due 2030 (included in Exhibit&#160;4.2). </a></td></tr>
<tr style="font-size:1pt">
<td style="height:6pt"/>
<td style="height:6pt" colspan="2"/></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;white-space:nowrap">4.6</td>
<td style="vertical-align:bottom">&#160;&#160;</td>
<td style="vertical-align:top"><a href="d80089dex42.htm">Form of 4.500% Notes due 2032 (included in Exhibit&#160;4.2). </a></td></tr>
<tr style="font-size:1pt">
<td style="height:6pt"/>
<td style="height:6pt" colspan="2"/></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;white-space:nowrap">4.7</td>
<td style="vertical-align:bottom">&#160;&#160;</td>
<td style="vertical-align:top"><a href="d80089dex42.htm">Form of 4.875% Notes due 2035 (included in Exhibit&#160;4.2). </a></td></tr>
<tr style="font-size:1pt">
<td style="height:6pt"/>
<td style="height:6pt" colspan="2"/></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;white-space:nowrap">4.8</td>
<td style="vertical-align:bottom">&#160;&#160;</td>
<td style="vertical-align:top"><a href="d80089dex42.htm">Form of 5.600% Notes due 2055 (included in Exhibit&#160;4.2). </a></td></tr>
<tr style="font-size:1pt">
<td style="height:6pt"/>
<td style="height:6pt" colspan="2"/></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;white-space:nowrap">4.9</td>
<td style="vertical-align:bottom">&#160;&#160;</td>
<td style="vertical-align:top"><a href="d80089dex42.htm">Form of 5.700% Notes due 2065 (included in Exhibit&#160;4.2). </a></td></tr>
<tr style="font-size:1pt">
<td style="height:6pt"/>
<td style="height:6pt" colspan="2"/></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;white-space:nowrap">5.1</td>
<td style="vertical-align:bottom">&#160;&#160;</td>
<td style="vertical-align:top"><a href="d80089dex51.htm">Opinion of Margaret M. Madden, Senior Vice President and Corporate Secretary, Chief Governance Counsel of the Company. </a></td></tr>
<tr style="font-size:1pt">
<td style="height:6pt"/>
<td style="height:6pt" colspan="2"/></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;white-space:nowrap">23.1</td>
<td style="vertical-align:bottom">&#160;&#160;</td>
<td style="vertical-align:top"><a href="d80089dex51.htm">Consent of Margaret M. Madden, Senior Vice President and Corporate Secretary, Chief Governance Counsel of the Company (included in Exhibit&#160;5.1). </a></td></tr>
<tr style="font-size:1pt">
<td style="height:6pt"/>
<td style="height:6pt" colspan="2"/></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top;white-space:nowrap">104</td>
<td style="vertical-align:bottom">&#160;&#160;</td>
<td style="vertical-align:top">Cover Page Interactive Data File (embedded within the Inline XBRL document).</td></tr>
</table> <p style="font-size:18pt; margin-top:0pt; margin-bottom:0pt">&#160;</p>
</div></div>



<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<hr style="color:#999999;height:3px;width:100%;clear:both"/>

<div style="text-align:center"><div style="width:8.5in;text-align:left;margin-left: auto;margin-right: auto">
 <p style="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman;text-align:center">SIGNATURE </p> <p style="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. </p> <p style="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&#160;</p>
<table cellspacing="0" cellpadding="0" style="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt;width:100%;border-spacing:0">


<tr>

<td style="width:45%"/>

<td style="vertical-align:bottom;width:1%"/>
<td style="width:4%"/>

<td style="vertical-align:bottom"/>
<td style="width:3%"/>

<td style="vertical-align:bottom;width:1%"/>
<td style="width:45%"/></tr>


<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:bottom"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-size:0pt">&#160;</p></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:bottom"/>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:bottom" colspan="3">PFIZER INC.</td></tr>
<tr style="font-size:1pt">
<td style="height:12pt"/>
<td style="height:12pt" colspan="2"/>
<td style="height:12pt" colspan="2"/>
<td style="height:12pt" colspan="2"/></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:bottom"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-size:0pt">&#160;</p></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:bottom"/>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:top">By:</td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:bottom"> <p style="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Margaret M. Madden</p></td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:bottom"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-size:0pt">&#160;</p></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:bottom"/>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:bottom"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-size:0pt">&#160;</p></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:bottom">Margaret M. Madden</td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:bottom"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-size:0pt">&#160;</p></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:bottom"/>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:bottom"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-size:0pt">&#160;</p></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:bottom">Senior Vice President and Corporate Secretary,</td></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:bottom"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-size:0pt">&#160;</p></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:bottom"/>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:bottom"> <p style=" margin-top:0pt ; margin-bottom:0pt; font-size:0pt">&#160;</p></td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:bottom">Chief Governance Counsel</td></tr>
<tr style="font-size:1pt">
<td style="height:12pt"/>
<td style="height:12pt" colspan="2"/>
<td style="height:12pt" colspan="2"/>
<td style="height:12pt" colspan="2"/></tr>
<tr style="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<td style="vertical-align:top">Dated: November&#160;21, 2025</td>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:bottom"/>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:bottom"/>
<td style="vertical-align:bottom">&#160;</td>
<td style="vertical-align:bottom"/></tr>
</table>
</div></div>

</body></html>
</XBRL>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-1.1
<SEQUENCE>2
<FILENAME>d80089dex11.htm
<DESCRIPTION>EX-1.1
<TEXT>
<HTML><HEAD>
<TITLE>EX-1.1</TITLE>
</HEAD>
 <BODY BGCOLOR="WHITE" STYLE="line-height:Normal">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right"><B>Exhibit 1.1 </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">Pfizer Inc. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">Debt Securities </P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><center><DIV STYLE="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000;width:21%">&nbsp;</DIV></center>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">Underwriting Agreement </P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><center><DIV STYLE="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #000000;width:21%">&nbsp;</DIV></center>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right">November&nbsp;18, 2025 </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">To the Representatives of
the </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">several Underwriters named in the </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">respective Pricing
Agreements </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">hereinafter described. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Ladies and Gentlemen:
</P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">From time to time Pfizer Inc., a Delaware corporation (the &#8220;Company&#8221;), proposes to enter into one or more Pricing Agreements
(each a &#8220;Pricing Agreement&#8221;) in the form of Annex I hereto, with such additions and deletions as the parties thereto may determine, and subject to the terms and conditions stated herein and therein, to issue and sell to the firms named
in Schedule I to the applicable Pricing Agreement (such firms constituting the &#8220;Underwriters&#8221; with respect to such Pricing Agreement and the securities specified therein) certain of its debt securities (the &#8220;Securities&#8221;)
specified in Schedule II to such Pricing Agreement (with respect to such Pricing Agreement, the &#8220;Designated Securities&#8221;). </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">The
terms and rights of any particular issuance of Designated Securities shall be as specified in the Pricing Agreement relating thereto and in or pursuant to the indenture (the &#8220;Indenture&#8221;) identified in such Pricing Agreement. References
in this Agreement to the &#8220;Pricing Agreement&#8221; are to the applicable Pricing Agreement relating to the particular issuance and sale of Designated Securities specified therein. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">1. Particular sales of Designated Securities may be made from time to time to the Underwriters of such Designated Securities, for whom the
firms designated as representatives of the Underwriters of such Designated Securities in the Pricing Agreement will act as representatives (the &#8220;Representatives&#8221;). The term &#8220;Representatives&#8221; also refers to a single firm
acting as sole representative of the Underwriters and to Underwriters who act without any firm being designated as their representative. This Underwriting Agreement shall not be construed as an obligation of the Company to sell any of the Securities
or as an obligation of any of the Underwriters to purchase the Securities. The obligation of the Company to issue and sell any of the </P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">
Securities and the obligations of any of the Underwriters to purchase any of the Securities shall be evidenced by the Pricing Agreement with respect to the Designated Securities specified
therein. Each Pricing Agreement shall specify the aggregate principal amount of such Designated Securities, the initial public offering price of such Designated Securities, the purchase price to the Underwriters of such Designated Securities, the
names of the Underwriters of such Designated Securities, the names of the Representatives of such Underwriters and the principal amount of such Designated Securities to be purchased by each Underwriter and shall set forth the date, time and manner
of delivery of such Designated Securities and payment therefor. The Pricing Agreement shall also specify (to the extent not set forth in the Indenture and the registration statement and prospectus with respect thereto) the terms of such Designated
Securities. A Pricing Agreement shall be in the form of an executed writing (which may be in counterparts), and may be evidenced by an exchange of facsimile or <FONT STYLE="white-space:nowrap">e-mail</FONT> communications or any other rapid
transmission device designed to produce a written record of communications transmitted. The obligations of the Underwriters under this Agreement and each Pricing Agreement shall be several and not joint. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">2. The Company represents and warrants to, and agrees with, each of the Underwriters that: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) A registration statement on Form <FONT STYLE="white-space:nowrap">S-3</FONT> identified by the Securities and Exchange
Commission (the &#8220;Commission&#8221;) file number appearing in Schedule II to the Pricing Agreement (the &#8220;Initial Registration Statement&#8221;) has been filed with the Commission; such Initial Registration Statement and any post-effective
amendment thereto, each in the form heretofore delivered or to be delivered to the Representatives, excluding exhibits to the Initial Registration Statement, but including all documents incorporated by reference in the prospectus contained therein,
is an &#8220;automatic shelf registration statement&#8221; as defined under Rule 405 of the Securities Act of 1933, as amended (the &#8220;Act&#8221;); and no notice of objection of the Commission to the use of the Initial Registration Statement or
any post-effective amendment thereto pursuant to Rule 401(g)(2) under the Act has been received by the Company; and no stop order suspending the effectiveness of the Initial Registration Statement or any post-effective amendment thereto has been
issued and no proceeding for that purpose has been initiated or threatened by the Commission (the base prospectus filed as part of the Initial Registration Statement, in the form in which it has most recently been filed with the Commission on or
prior to the date of this Agreement relating to the Securities, is hereinafter called the &#8220;Basic Prospectus&#8221;; any preliminary prospectus included in such registration statement or filed with the Commission pursuant to Rule 424(b) of the
rules and regulations of the Commission under the Act, being hereinafter called a &#8220;Preliminary Prospectus&#8221;; the various parts of the Initial Registration Statement, including all exhibits thereto and including any prospectus supplement
relating to the Designated Securities that is filed with the Commission and deemed by virtue of Rule 430B under the Act to be part of the Initial Registration Statement, each as amended at the time such part of the Initial Registration Statement
became effective (but excluding Form <FONT STYLE="white-space:nowrap">T-1),</FONT> are hereinafter collectively called the &#8220;Registration Statement&#8221;; the Basic Prospectus, as amended and supplemented
</P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">2 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">
immediately prior to the Applicable Time (as defined in Section&nbsp;2(c) hereof), is hereinafter called the &#8220;Pricing Prospectus&#8221;; the prospectus relating to the Securities, in the
form in which it is first filed or transmitted for filing, with the Commission after the date and time that this Agreement is executed, including such information as is incorporated by reference, being hereinafter called the
&#8220;Prospectus&#8221;; any reference herein to the Basic Prospectus, the Pricing Prospectus, any Preliminary Prospectus or the Prospectus shall be deemed to refer to and include the documents incorporated by reference therein pursuant to the
applicable form under the Act, as of the date of such prospectus; any reference to any amendment or supplement to the Basic Prospectus, any Preliminary Prospectus or the Prospectus shall be deemed to refer to and include any post-effective amendment
to the Registration Statement, any prospectus supplement relating to the Designated Securities filed with the Commission pursuant to Rule 424(b) under the Act and any documents filed after the date of such Basic Prospectus, Preliminary Prospectus or
Prospectus, as the case may be, under the Securities Exchange Act of 1934, as amended (the &#8220;Exchange Act&#8221;), and incorporated by reference in such Preliminary Prospectus or Prospectus, as the case may be; any reference to any amendment to
the Registration Statement shall be deemed to refer to and include any annual report of the Company filed pursuant to Section&nbsp;13(a) or 15(d) of the Exchange Act after the effective date of the Registration Statement that is incorporated by
reference in the Registration Statement; any &#8220;issuer free writing prospectus&#8221;, as defined in Rule 433 under the Act relating to the Securities is hereinafter called an &#8220;Issuer Free Writing Prospectus&#8221;; and any reference to
the Prospectus as amended or supplemented shall be deemed to refer to the Prospectus as amended or supplemented in relation to the applicable Designated Securities in the form in which it is filed with the Commission pursuant to Rule 424(b) under
the Act in accordance with Section&nbsp;5(a) hereof, including any documents incorporated by reference therein as of the date of such filing); </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) No order preventing or suspending the use of any Preliminary Prospectus or any Issuer Free Writing Prospectus has been
issued by the Commission, and each Preliminary Prospectus, at the time of filing thereof, conformed in all material respects to the requirements of the Act and the Trust Indenture Act of 1939, as amended (the &#8220;Trust Indenture Act&#8221;), and
the rules and regulations of the Commission thereunder, and did not contain an untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein, in the light of the
circumstances under which they were made, not misleading; <U>provided</U>, <U>however</U>, that this representation and warranty shall not apply to any statements or omissions made in reliance upon and in conformity with information furnished in
writing to the Company by an Underwriter through the Representatives expressly for use therein as set forth in Schedule II to the applicable Pricing Agreement; </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">3 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(c) For the purposes of this Agreement, the &#8220;Applicable Time&#8221; is
the time set forth as such in Schedule II of the Pricing Agreement on the date of the Pricing Agreement; the Pricing Prospectus as supplemented by the final term sheet prepared and filed pursuant to Section&nbsp;5(a) hereof, taken together
(collectively, the &#8220;Pricing Disclosure Package&#8221;) as of the Applicable Time, did not include any untrue statement of a material fact or omit to state any material fact necessary in order to make the statements therein, in the light of the
circumstances under which they were made, not misleading; and each Issuer Free Writing Prospectus listed on Schedule II to the Pricing Agreement does not conflict with the information contained in the Registration Statement, the Pricing Prospectus
or the Prospectus and each such Issuer Free Writing Prospectus, as supplemented by and taken together with the Pricing Disclosure Package as of the Applicable Time, did not include any untrue statement of a material fact or omit to state any
material fact necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading; <U>provided</U>, <U>however</U>, that this representation and warranty shall not apply to statements or
omissions made in the Pricing Disclosure Package or an Issuer Free Writing Prospectus in reliance upon and in conformity with information furnished in writing to the Company by an Underwriter through the Representatives expressly for use therein as
set forth in Schedule II to the applicable Pricing Agreement; </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(d) The documents incorporated by reference in the Pricing
Prospectus and the Prospectus, when they became effective or were filed with the Commission, as the case may be, conformed in all material respects to the requirements of the Act or the Exchange Act, as applicable and the rules and regulations of
the Commission thereunder, and none of such documents contained an untrue statement of a material fact or omitted to state a material fact required to be stated therein or necessary to make the statements therein, in light of the circumstances under
which they were made, not misleading when read together with the other information in the Pricing Prospectus and the Prospectus, at the time the Registration Statement became effective; and any further documents so filed and incorporated by
reference in the Prospectus or any further amendment or supplement thereto, when such documents become effective or are filed with the Commission, as the case may be, will conform in all material respects to the requirements of the Act or the
Exchange Act, as applicable, and the rules and regulations of the Commission thereunder and will not contain an untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements
therein, in light of the circumstances under which they were made, not misleading when read together with the other information in the Prospectus at the time the Registration Statement became effective; <U>provided</U>, <U>however</U>, that this
representation and warranty shall not apply to any statements or omissions made in reliance upon and in conformity with information furnished in writing to the Company by an Underwriter of Designated Securities through the Representatives expressly
for use in the Prospectus as amended or supplemented relating to such Securities as set forth in Schedule II to the applicable Pricing Agreement; and no such documents were filed with the Commission since the Commission&#8217;s close of business on
the date of the applicable Pricing Agreement and prior to the execution of such Pricing Agreement, except as set forth on Schedule II to the applicable Pricing Agreement; </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">4 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(e) The Registration Statement and the Prospectus conform, and any further
amendments or supplements to the Registration Statement or the Prospectus will conform, in all material respects to the requirements of the Act and the Trust Indenture Act, and the rules and regulations of the Commission thereunder and do not and
will not, (i)&nbsp;as of the applicable effective date as to the Registration Statement and any amendment thereto contain an untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the
statements therein not misleading and (ii)&nbsp;as of the applicable filing date as to the Prospectus and any amendment or supplement thereto and as of the Time of Delivery (as defined in Section&nbsp;4 hereof) for the Designated Securities, contain
an untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein, in the light of the circumstances under which they were made, not misleading when read together with
the other information in the Prospectus at the time the Registration Statement became effective; <U>provided</U>, <U>however</U>, that this representation and warranty shall not apply to any statements or omissions made in reliance upon and in
conformity with information furnished in writing to the Company by an Underwriter of Designated Securities through the Representatives expressly for use in the Prospectus as amended or supplemented relating to such Securities as set forth in
Schedule II to the applicable Pricing Agreement; </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(f) (i) At the time of filing the Initial Registration Statement,
(ii)&nbsp;at the time of the most recent amendment thereto for the purposes of complying with Section&nbsp;10(a)(3) of the Act (whether such amendment was by post-effective amendment, incorporated report filed pursuant to Sections 13 or 15(d) of the
Exchange Act or form of prospectus), (iii) at the time the Company or any person acting on its behalf (within the meaning, for this clause only, of Rule 163(c)) made any offer relating to the Securities in reliance on the exemption in Rule 163, and
(iv)&nbsp;at the Applicable Time (with such date being used as the determination date for purposes of this clause (iv)), the Company was or is (as the case may be) a &#8220;well-known seasoned issuer&#8221; as defined in Rule 405; </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(g) (i) At the earliest time after the filing of the Initial Registration Statement that the Company or another offering
participant made a bona fide offer (within the meaning of Rule 164(h)(2) of the Act) and (ii)&nbsp;as of the Applicable Time (with such date being used as the determination date for purposes of this clause (ii)), the Company was not and is not an
&#8220;ineligible issuer&#8221; (as defined in Rule 405), without taking account of any determination by the Commission pursuant to Rule 405 that it is not necessary that the Company be considered an &#8220;ineligible issuer&#8221;; </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">5 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(h) Neither the Company nor any significant subsidiary of the Company (as
used in this Agreement, the term &#8220;significant subsidiary&#8221; shall have the meaning defined in Rule <FONT STYLE="white-space:nowrap">1-02(w)</FONT> of Regulation <FONT STYLE="white-space:nowrap">S-X)</FONT> has sustained since the date of
the latest financial statements included or incorporated by reference in the Pricing Prospectus any loss or interference with its business from fire, explosion, flood or other calamity, whether or not covered by insurance, or from any labor dispute
or court or governmental action, order or decree, that is material to the Company and its subsidiaries taken as a whole, otherwise than as set forth or contemplated in the Pricing Prospectus; and, since the respective dates as of which information
is given in the Registration Statement and the Pricing Prospectus, there has not been any material change in the capital stock of the Company (except for the issuance of shares of common stock pursuant to any plan sponsored by the Company and
registered pursuant to a registration statement on Form <FONT STYLE="white-space:nowrap">S-8)</FONT> or any material increase in the consolidated long-term debt of the Company and its subsidiaries taken as a whole or any material adverse change, or
any development involving a prospective material adverse change, in the consolidated financial position or results of operations of the Company and its consolidated subsidiaries taken as a whole, otherwise than as set forth or contemplated in the
Registration Statement and the Pricing Prospectus; </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(i) The Company has been duly incorporated in Delaware and is validly
existing as a corporation in good standing under the laws of Delaware, with corporate power and authority to own or lease, as the case may be, its properties and conduct its business as described in the Pricing Prospectus; </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(j) Each of the significant subsidiaries of the Company has been duly organized or incorporated, as the case may be, is validly
existing in good standing (or equivalent concept) under the laws of the jurisdiction of its organization or incorporation (as the case may be) and is duly qualified to transact business and is in good standing (or equivalent concept) in each
jurisdiction in which the conduct of its business or the ownership or leasing of its property requires such qualification, except where failure to qualify or be in good standing would not have a materially adverse effect upon the consolidated
financial position or results of operations of the Company and its consolidated subsidiaries taken as a whole (&#8220;Material Adverse Effect&#8221;); </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(k) This Agreement and the Pricing Agreement with respect to the Designated Securities have been duly authorized, executed and
delivered by the Company. The Securities have been duly authorized, and, when Designated Securities are issued and delivered pursuant to this Agreement and the Pricing Agreement with respect to such Designated Securities, such Designated Securities
will have been duly executed, authenticated, issued and delivered and will constitute valid and legally binding obligations of the Company entitled to the benefits provided by the Indenture, which will be substantially in the form filed as an
exhibit to the Registration Statement; the Indenture has been duly authorized and duly qualified under the Trust Indenture Act and, at the Time of Delivery of such Designated Securities, the Indenture will constitute a valid and legally binding
instrument, enforceable in accordance with its terms, subject to bankruptcy, insolvency, fraudulent transfer, reorganization, moratorium and similar laws of general applicability relating to or affecting creditors&#8217; rights and to general equity
principles; and the Indenture conforms, and the Designated Securities will conform, to the descriptions thereof contained in the Pricing Disclosure Package and the Prospectus as amended or supplemented with respect to such Designated Securities in
all material respects; </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">6 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(l) The issue and sale of the Securities and the compliance by the Company
with all of the provisions of the Securities, the Indenture, this Agreement and any Pricing Agreement, and the consummation of the transactions herein and therein contemplated will not: (i)&nbsp;conflict with or result in a breach or violation of
any of the terms or provisions of, or constitute a default under, or result in the creation or imposition of any lien, charge or encumbrance upon any of the property or assets of the Company or any of its significant subsidiaries pursuant to the
terms of any indenture, mortgage, deed of trust, loan agreement or other agreement or instrument to which the Company or any of its significant subsidiaries is a party or by which the Company or any of its significant subsidiaries is bound or to
which any of the property or assets of the Company or any of its significant subsidiaries is subject, (ii)&nbsp;result in any violation of (A)&nbsp;the provisions of the certificate of incorporation or <FONT STYLE="white-space:nowrap">by-laws</FONT>
of the Company, as amended, or (B)&nbsp;any statute, order, rule or regulation known to the General Counsel of the Company of any court or governmental agency or body having jurisdiction over the Company or any of its significant subsidiaries or any
of their properties, except in the case of (i)&nbsp;and (ii)(B) where such breach, conflict, default, lien, charge, encumbrance or violation would not have a Material Adverse Effect; and no consent, approval, authorization, order, registration or
qualification of or in any such court or governmental agency or body is required for the issue and sale of the Securities or the consummation by the Company of the transactions contemplated by this Agreement, any Pricing Agreement or the Indenture,
except (x)&nbsp;such as have been, or will have been prior to the Time of Delivery of the Designated Securities, obtained under the Act and the Trust Indenture Act, (y)&nbsp;for such consents, approvals, authorizations, orders, registrations or
qualifications the failure of which to obtain would not have a material adverse effect on the transactions contemplated under this Agreement and (z)&nbsp;such consents, approvals, authorizations, orders, registrations or qualifications as may be
required under state securities or Blue Sky laws or other applicable laws in connection with the purchase and distribution of the Securities by the Underwriters; </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(m) There are no legal or governmental proceedings to which the Company or any of its significant subsidiaries is a party or of
which any property of the Company or any of its significant subsidiaries is the subject other than as set forth in the Pricing Prospectus and other than litigation incident to the kind of business conducted by the Company and its significant
subsidiaries which, if determined adversely to the Company or any of its significant subsidiaries, would individually or in the aggregate have a Material Adverse Effect; and, to the Company&#8217;s knowledge, no such proceedings are threatened or
contemplated by governmental authorities or threatened by others; </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">7 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(n) KPMG LLP, who have certified certain financial statements of the Company
and its subsidiaries, is an independent registered public accounting firm with respect to the Company and its subsidiaries within the applicable rules and regulations adopted by the Commission and the Public Company Accounting Oversight Board
(United States) and as required by the Act; </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(o) The consolidated financial statements (including the related notes
thereto) of the Company and its consolidated subsidiaries included in the Registration Statement, the Pricing Disclosure Package and the Prospectus present fairly in all material respects the financial position of the Company and its consolidated
subsidiaries as of the dates indicated and the results of their operations and cash flows for the periods specified; such financial statements have been prepared in conformity with generally accepted accounting principles in the United States
applied on a consistent basis throughout the periods covered thereby; </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(p) The Company is not and, after giving effect to
the offering and sale of the Securities and the application of the proceeds thereof as described in the Registration Statement, the Pricing Disclosure Package and the Prospectus, will not be required to register as an &#8220;investment
company&#8221; within the meaning of the Investment Company Act of 1940, as amended, and the rules and regulations of the Commission thereunder; and </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(q) The Company confirms that it is acting as principal for its own account and not on behalf of any other person in relation
to the issue of the Securities or the entry into of the documents. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">3. Upon the execution of the Pricing Agreement applicable to any
Designated Securities and authorization by the Representatives of the release of such Designated Securities, the Underwriters propose to offer such Designated Securities for sale upon the terms and conditions set forth in the Pricing Prospectus and
Prospectus as amended or supplemented. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">4. Designated Securities to be purchased by each Underwriter pursuant to the Pricing Agreement
relating thereto, in definitive form to the extent practicable, and in such authorized denominations and registered in such names as the Representatives may request upon at least forty-eight hours prior notice to the Company, shall be delivered by
or on behalf of the Company to the Representatives for the account of such Underwriter, against payment by such Underwriter or on its behalf of the purchase price therefor by wire transfer of Federal (same day) funds or other immediately available
funds to the account specified by the Company to the Representatives at least forty-eight hours in advance or at such other place and time and date as the Representatives and the Company may agree upon in writing, such time and date being herein
called the &#8220;Time of Delivery&#8221; for such Securities. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">8 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">5. The Company agrees with each of the Underwriters of any Designated Securities: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) To prepare the Prospectus as amended and supplemented in relation to the applicable Designated Securities in a form
approved by the Representatives and to file such Prospectus pursuant to Rule 424(b) under the Act, to pay the registration fees for this offering within the time period required by Rule 456(b)(1)(i) under the Act (without giving effect to the
proviso therein) and in any event prior to the Time of Delivery of the Designated Securities, to make no further amendment or any supplement to the Registration Statement, the Basic Prospectus or Prospectus as amended or supplemented after the date
of the Pricing Agreement relating to such Securities and prior to the Time of Delivery of such Securities which shall be disapproved by the Representatives for such Securities promptly after reasonable notice thereof; to advise the Representatives
promptly of any such amendment or supplement after such Time of Delivery and furnish the Representatives with copies thereof as they shall reasonably request; to prepare a final term sheet, containing solely a description of the Designated
Securities, in a form approved by the Representatives and to file such term sheet pursuant to Rule 433(d) under the Act within the time required by such Rule; to file promptly all other material required to be filed by the Company with the
Commission pursuant to Rule 433(d) under the Act; to file promptly all reports and any definitive proxy or information statements required to be filed by the Company with the Commission pursuant to Section&nbsp;13(a), 13(c), 14 or 15(d) of the
Exchange Act for so long as the delivery of a prospectus (or in lieu thereof, the notice referred to in Rule 173(a) under the Act) is required in connection with the offering or sale of such Securities, and during such same period to advise the
Representatives, promptly after it receives notice thereof, of the time when any amendment to the Registration Statement has been filed or becomes effective or any supplement to the Prospectus or any amended Prospectus has been filed with the
Commission, of the issuance by the Commission of any stop order or of any order preventing or suspending the use of any prospectus relating to the Securities, of the receipt by the Company of any notice of objection of the Commission to the use of
the Registration Statement or any post-effective amendment thereto pursuant to Rule 401(g)(2) under the Act, of the suspension of the qualification of such Securities for offering or sale in any jurisdiction, of the initiation or threatening of any
proceeding for any such purpose, or of any request by the Commission for the amending or supplementing of the Registration Statement or Prospectus or for additional information; and, in the event of the issuance of any such stop order or of any such
order preventing or suspending the use of any prospectus relating to the Securities or suspending any such qualification, to use promptly its reasonable best efforts to obtain its withdrawal; </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) Promptly from time to time to take such action, in cooperation with the Representatives, to qualify such Securities for
offering and sale under the securities laws of such jurisdictions as the Representatives may reasonably request and to comply with such laws so as to permit the continuance of sales and dealings therein in such jurisdictions for as long as may be
necessary to complete the distribution of such Securities, provided that in connection therewith the Company shall not be required to qualify as a foreign corporation or to file a general consent to service of process in any jurisdiction or to
subject itself to taxation in respect of doing business in any jurisdiction in which it is not otherwise so subject; </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">9 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(c) To furnish the Underwriters with copies of the Prospectus as amended or
supplemented in such quantities as the Representatives may from time to time reasonably request, and, if the delivery of a prospectus (or in lieu thereof, the notice referred to in Rule 173(a) under the Act) is required at any time in connection
with the offering or sale of the Securities and if at such time any event shall have occurred as a result of which the Prospectus as then amended or supplemented would include an untrue statement of a material fact or omit to state any material fact
necessary in order to make the statements therein, in light of the circumstances under which they were made when such Prospectus (or in lieu thereof, the notice referred to in Rule 173(a) under the Act) is delivered, not misleading, or, if for any
other reason it shall be necessary during such same period to amend or supplement the Prospectus or to file under the Exchange Act any document incorporated by reference in the Prospectus in order to comply with the Act, the Exchange Act or the
Trust Indenture Act, to notify the Representatives and upon their reasonable request to file such document and to prepare and furnish without charge to each Underwriter and to any dealer in securities as many copies as the Representatives may from
time to time reasonably request of an amended Prospectus or a supplement to the Prospectus which will correct such statement or omission or effect such compliance; </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(d) To make generally available to its securityholders as soon as practicable, but in any event not later than eighteen months
after the effective date of the Registration Statement (as defined in Rule 158(c) under the Act), an earning statement of the Company and its subsidiaries (which need not be audited) complying with the last paragraph of Section&nbsp;11(a) of the Act
and the rules and regulations of the Commission thereunder (including, at the option of the Company, Rule 158); and </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(e)
During the period beginning from the date of the Pricing Agreement for such Designated Securities and continuing to and including the earlier of (i)&nbsp;the termination of trading restrictions for such Designated Securities, as notified to the
Company by the Representatives and (ii)&nbsp;the Time of Delivery of such Designated Securities, not to offer, sell, contract to sell or otherwise dispose of any debt securities of the Company which mature more than one year after such Time of
Delivery and which are substantially similar to such Designated Securities, without the prior written consent of the Representatives, which consent shall not be unreasonably withheld. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">10 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">6. The Company covenants and agrees with the several Underwriters that the Company will pay
or cause to be paid the following: (i)&nbsp;the reasonable fees, disbursements and expenses of the Company&#8217;s counsel and accountants in connection with the registration of the Designated Securities under the Act and all other expenses in
connection with the preparation, printing and filing of the Registration Statement, the Basic Prospectus, any Preliminary Prospectus, any Issuer Free Writing Prospectus and the Prospectus and amendments and supplements thereto and the mailing and
delivering of copies thereof to the Underwriters and dealers; (ii)&nbsp;the cost of printing or producing any agreement among Underwriters, this Agreement, any Pricing Agreement, any Indenture, any Blue Sky and Legal Investment Memoranda and any
other documents in connection with the offering, purchase, sale and delivery of the Securities; (iii)&nbsp;all expenses in connection with the qualification of the Securities for offering and sale under state securities laws as provided in
Section&nbsp;5(b) hereof, including the reasonable fees and disbursements of counsel for the Underwriters in connection with such qualification and in connection with the Blue Sky and legal investment surveys; (iv)&nbsp;any fees charged by
securities rating services for rating the Securities; (v)&nbsp;any filing fees incident to any required review by the Financial Industry Regulatory Authority, Inc. of the terms of the sale of the Securities; (vi)&nbsp;the cost of preparing, issuing
and delivering the certificate for the Securities; (vii)&nbsp;the fees and expenses of any trustee, any paying agent (the &#8220;Paying Agent&#8221;) and any agent of any trustee or any Paying Agent and the reasonable fees and disbursements of
counsel for any trustee or any Paying Agent in connection with any Indenture and the Securities; and (viii)&nbsp;all other costs and expenses incident to the performance of its obligations hereunder which are not otherwise specifically provided for
in this Section; but the Company shall not in any event be liable to any of the Underwriters for damages on account of loss of anticipated profits from the sale by them of the Securities. It is understood, however, that except as provided in this
Section&nbsp;6, Section&nbsp;8 and Section&nbsp;11 hereof, the Underwriters will pay all of their own costs and expenses, including but not limited to expenses connected with any offers they may make and the fees, disbursements and expenses of their
counsel and transfer taxes on resale of any of the Securities by them. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">7. The obligations of the Underwriters of any Designated
Securities under the Pricing Agreement relating to such Designated Securities shall be subject, in the discretion of the Representatives, to the condition that all representations and warranties and other statements of the Company in or incorporated
by reference in the Pricing Agreement relating to such Designated Securities are, at and as of the Applicable Time and the Time of Delivery of such Designated Securities, true and correct in all material respects (except for such representations and
warranties that are qualified by materiality, which shall be true and correct in all respects), the condition that the Company shall have performed all of its obligations hereunder shall have theretofore been satisfied, and the following additional
conditions: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) The Prospectus as amended or supplemented in relation to the applicable Designated Securities shall have
been filed with the Commission pursuant to Rule 424(b) within the applicable time period prescribed for such filing by the rules and regulations under the Act and in accordance with Section&nbsp;5(a) hereof; the final term sheet contemplated by
Section&nbsp;5(a) hereof, and any other material required to be filed by the Company pursuant to Rule 433(d) under the Act, shall have been filed with the Commission within the applicable time period prescribed for such filings by Rule 433; no stop
order suspending the effectiveness of the Registration Statement or any part thereof shall have been issued and no proceeding for that purpose shall have been initiated or threatened by the Commission; no stop order suspending or preventing the use
of the Prospectus or any Issuer Free Writing Prospectus shall have been initiated or threatened by the Commission; and all requests for additional information on the part of the Commission shall have been complied with to the Representatives&#8217;
reasonable satisfaction; </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">11 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) Counsel for the Underwriters shall have furnished to the Representatives
such opinion or opinions, dated the Time of Delivery of such Designated Securities, with respect to the issuance and sale of the Designated Securities, the Indenture, the Registration Statement, the Pricing Disclosure Package, the Prospectus
(together with any supplement thereto) and other related matters as the Representatives may reasonably request, and such counsel shall have received such papers and information as they may reasonably request to enable them to pass upon such matters;
</P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(c) Margaret M. Madden, the Senior Vice President and Corporate Secretary, Chief Governance Counsel of the Company (or
such other internal legal counsel or outside legal firm reasonably satisfactory to the Representatives at such Time of Delivery), shall have furnished to the Representatives a written opinion and a negative assurance letter, each dated the Time of
Delivery of such Designated Securities, in form and substance satisfactory to the Representatives; </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(d) On the date of the
Pricing Agreement for such Designated Securities and at the Time of Delivery of such Designated Securities, the independent accountants of the Company who have certified the financial statements of the Company and its subsidiaries included or
incorporated by reference in the Registration Statement shall have furnished to the Representatives a letter, dated (A)&nbsp;the date of such Pricing Agreement, (B)&nbsp;the effective date of the Registration Statement or (C)&nbsp;the date of the
most recent report filed with the Commission containing financial statements and incorporated by reference in the Registration Statement, if the date of such report is later than such effective date, and a letter dated such Time of Delivery,
respectively, to the effect set forth in Annex II hereto, and with respect, as to such other matters as the Representatives may reasonably request and in form and substance satisfactory to the Representatives; </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(e) (i) Neither the Company nor any of its significant subsidiaries shall have sustained since the date of the latest financial
statements included or incorporated by reference in the Pricing Prospectus and Prospectus as amended or supplemented any loss or interference with its business from fire, explosion, flood or other calamity, whether or not covered by insurance, or
from any labor dispute or court or governmental action, order or decree, otherwise than as set forth or contemplated in the Pricing Prospectus and Prospectus as amended or supplemented, and (ii)&nbsp;since the respective dates as of which
information is given in the Pricing Prospectus and Prospectus as amended or supplemented there shall not have been any change in the capital stock of the Company (except for the issuance of shares of common stock pursuant to any plan sponsored by
the Company and registered pursuant to a registration statement on Form <FONT STYLE="white-space:nowrap">S-8)</FONT> or any increase in the consolidated long-term debt of the Company and its subsidiaries or any material change, or any development
involving a prospective material change, in the consolidated financial position or results of operations of the Company and its consolidated subsidiaries taken as a whole, otherwise than as set forth or contemplated in the Pricing Prospectus and
Prospectus as amended or supplemented, the effect of which is in any such case described in clause (i)&nbsp;or (ii) is in the judgment of the Representatives so material and adverse as to make it impracticable or inadvisable to proceed with the
public offering or the delivery of the Designated Securities on the terms and in the manner contemplated in the Prospectus as amended or supplemented; </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">12 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(f) On or after the Applicable Time (i)&nbsp;no downgrading shall have
occurred in the rating accorded the Company&#8217;s debt securities by any &#8220;nationally recognized statistical rating organization,&#8221; as that term is defined by the Commission for purposes of Section&nbsp;3(a)(62) of the Exchange Act and
(ii)&nbsp;no such organization shall have publicly announced that it has under surveillance or review, with possible negative implications, its rating of any of the Company&#8217;s debt securities; </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(g) On or after the Applicable Time there shall not have occurred any of the following: (i)&nbsp;a suspension of trading of the
Company&#8217;s common stock by the Commission or the NYSE precipitated by the announcement by the Company of a material adverse event with respect to the Company&#8217;s business or financial position; (ii)&nbsp;a suspension or material limitation
in trading in securities generally on the NYSE, (iii)&nbsp;a general moratorium on commercial banking activities in New York declared by either Federal or New York State authorities; (iv)&nbsp;the outbreak or escalation of hostilities directly
involving the United States or the declaration by the United States of a national emergency or war, if the effect of any such event specified in this clause (iv)&nbsp;in the reasonable judgment of the Representatives makes it impracticable or
inadvisable to proceed with the public offering or the delivery of the Designated Securities on the terms and in the manner contemplated by the Prospectus as amended and supplemented; or (v)&nbsp;if in the opinion of the Representatives there shall
have occurred such a change in national or international financial, political or economic conditions or currency exchange rates or exchange controls as would in their view be likely to prejudice materially the success of the offering and
distribution of the Designated Securities or dealings in the Designated Securities in the secondary markets; and </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(h) The
Company shall have furnished or caused to be furnished at the Time of Delivery of the Designated Securities a certificate or certificates of officers or directors, as applicable, of the Company reasonably satisfactory to the Representatives as to
the accuracy of the representations and warranties of the Company herein at and as of such Time of Delivery, as to the performance by the Company of all of its obligations hereunder to be performed at or prior to such Time of Delivery, as to the
matters set forth in subsections (a)&nbsp;and (e) of this Section and as to such other matters as the Representatives may reasonably request. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">13 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">8. (a) The Company will indemnify and hold harmless each Underwriter and its respective
affiliates, selling agents, directors and officers and each person, if any, who controls such Underwriter within the meaning of Section&nbsp;15 of the Act or Section&nbsp;20 of the Exchange Act against any losses, claims, damages or liabilities,
joint or several, to which such indemnified party may become subject, under the Act or otherwise, insofar as such losses, claims, damages or liabilities (or actions in respect thereof) arise out of or are based upon an untrue statement or alleged
untrue statement of a material fact contained in any Preliminary Prospectus, any preliminary prospectus supplement, the Basic Prospectus, the Pricing Prospectus, the Registration Statement, the Prospectus as amended or supplemented and any other
prospectus relating to the Securities, or any amendment or supplement thereto, any Issuer Free Writing Prospectus or any &#8220;issuer information&#8221; filed or required to be filed pursuant to Rule 433(d) under the Act, or arise out of or are
based upon the omission or alleged omission to state therein a material fact required to be stated therein or necessary to make the statements therein not misleading, and will reimburse each such indemnified party for any legal or other expenses
reasonably incurred by such indemnified party in connection with investigating or defending any such action or claim as such expenses are incurred; <U>provided</U>, <U>however</U>, that the Company shall not be liable in any such case to the extent
that any such loss, claim, damage or liability arises out of or is based upon an untrue statement or alleged untrue statement or omission or alleged omission made in any Preliminary Prospectus, any preliminary prospectus supplement, the Basic
Prospectus, the Pricing Prospectus, the Registration Statement, the Prospectus as amended or supplemented and any other prospectus, in each case, relating to the Securities, or any such amendment or supplement thereto, or any Issuer Free Writing
Prospectus in reliance upon and in conformity with written information furnished to the Company by any Underwriter of Designated Securities through the Representatives expressly for use in the Prospectus as amended or supplemented relating to such
Securities as set forth in Schedule II to the applicable Pricing Agreement. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) Each Underwriter will severally and not
jointly indemnify and hold harmless the Company, its directors and officers who signed the Registration Statement and each person, if any, who controls the Company within the meaning of Section&nbsp;15 of the Act or Section&nbsp;20 of the Exchange
Act against any losses, claims, damages or liabilities to which such indemnified party may become subject, under the Act or otherwise, insofar as such losses, claims, damages or liabilities (or actions in respect thereof) arise out of or are based
upon an untrue statement or alleged untrue statement of a material fact contained in any Preliminary Prospectus, any preliminary prospectus supplement, the Basic Prospectus, the Pricing Prospectus, the Registration Statement, the Prospectus as
amended or supplemented and any other prospectus relating to the Securities, or any amendment or supplement thereto, or any Issuer Free Writing Prospectus, or arise out of or are based upon the omission or alleged omission to state therein a
material fact required to be stated therein or necessary to make the statements therein not misleading, in each case to the extent, but only to the extent, that such untrue statement or alleged untrue statement or omission or alleged omission was
made in any Preliminary Prospectus, any preliminary prospectus supplement, the Basic Prospectus, the Pricing Prospectus, the Registration Statement, the </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">14 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">
Prospectus as amended or supplemented and any other prospectus relating to the Securities, or any such amendment or supplement thereto, or any Issuer Free Writing Prospectus in reliance upon and
in conformity with written information furnished to the Company by such Underwriter through the Representatives expressly for use therein as set forth in Schedule II to the applicable Pricing Agreement; and will reimburse such indemnified party for
any legal or other expenses reasonably incurred by such indemnified party in connection with investigating or defending any such action or claim as such expenses are incurred. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(c) Promptly after receipt by an indemnified party under subsection (a)&nbsp;or (b) above of notice of the commencement of any
action, such indemnified party shall, if a claim in respect thereof is to be made against the indemnifying party under such subsection, notify the indemnifying party in writing of the commencement thereof; but the omission so to notify the
indemnifying party shall not relieve it from any liability which it may have to any indemnified party otherwise than under such subsection. In case any such action shall be brought against any indemnified party and it shall notify the indemnifying
party of the commencement thereof, the indemnifying party shall be entitled to participate therein and, to the extent that it shall wish, jointly with any other indemnifying party similarly notified, to assume the defense thereof, with counsel
reasonably satisfactory to such indemnified party (who shall not, except with the consent of the indemnified party, be counsel to the indemnifying party), and, after notice from the indemnifying party to such indemnified party of its election so to
assume the defense thereof, the indemnifying party shall not be liable to such indemnified party under such subsection for any legal expenses of other counsel or any other expenses, in each case subsequently incurred by such indemnified party, in
connection with the defense thereof other than reasonable costs of investigation. No indemnifying party shall, without the written consent of the indemnified party, effect any settlement of any pending or threatened proceeding in respect of which
any indemnified party is or could have been a party and indemnification could have been sought hereunder by such indemnified party, unless such settlement (x)&nbsp;includes an unconditional release of such indemnified party, in form and substance
reasonably satisfactory to such indemnified party, from all liability on claims that are the subject matter of such proceeding and (y)&nbsp;does not include any statement as to or any admission of fault, culpability or a failure to act by or on
behalf of any indemnified party. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(d) If the indemnification provided for in this Section&nbsp;8 is unavailable or
insufficient to hold harmless an indemnified party under subsection (a)&nbsp;or (b) above in respect of any losses, claims, damages or liabilities (or actions in respect thereof) referred to therein, then each indemnifying party shall contribute to
the amount paid or payable by such indemnified party as a result of such losses, claims, damages or liabilities (or actions in respect thereof) in such proportion as is appropriate to reflect the relative benefits received by the Company on the one
hand and the Underwriters of the Designated Securities on the other from the offering of the Designated Securities to which such loss, claim, damage or liability (or action in respect thereof) relates. If however, the allocation provided by the
immediately preceding sentence is not permitted by </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">15 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">
applicable law or if the indemnified party failed to give the notice required under subsection (c)&nbsp;above, then each indemnifying party shall contribute to such amount paid or payable by such
indemnified party in such proportion as is appropriate to reflect not only such relative benefits but also the relative fault of the Company on the one hand and the Underwriters of the Designated Securities on the other in connection with the
statements or omissions which resulted in such losses, claims, damages or liabilities (or actions in respect thereof), as well as any other relevant equitable considerations. The relative benefits received by the Company on the one hand and such
Underwriters on the other shall be deemed to be in the same proportion as the total net proceeds from such offering (before deducting expenses) received by the Company bear to the total underwriting discounts and commissions received by such
Underwriters. The relative fault shall be determined by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission or alleged omission to state a material fact relates to information supplied
by the Company on the one hand or such Underwriters on the other and the parties&#8217; relative intent, knowledge, access to information and opportunity to correct or prevent such statement or omission. The Company and the Underwriters agree that
it would not be just and equitable if contribution pursuant to this subsection (d)&nbsp;were determined by pro rata allocation (even if the Underwriters were treated as one entity for such purpose) or by any other method of allocation which does not
take account of the equitable considerations referred to above in this subsection (d). The amount paid or payable by an indemnified party as a result of the losses, claims, damages or liabilities (or actions in respect thereof) referred to above in
this subsection (d)&nbsp;shall be deemed to include any legal or other expenses reasonably incurred by such indemnified party in connection with investigating or defending any such action or claim. Notwithstanding the provisions of this subsection
(d), no Underwriter shall be required to contribute any amount in excess of the amount by which the total price at which the applicable Designated Securities underwritten by it and distributed to the public in such offering exceeds the amount of any
damages which such Underwriter has otherwise been required to pay by reason of such untrue or alleged untrue statement or omission or alleged omission. No person guilty of fraudulent misrepresentation (within the meaning of Section&nbsp;11(f) of the
Act) shall be entitled to contribution from any person who was not guilty of such fraudulent misrepresentation. The obligations of the Underwriters of Designated Securities in this subsection (d)&nbsp;to contribute are several in proportion to their
respective underwriting obligations with respect to such Securities and not joint. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(e) The obligations of the Company
under this Section&nbsp;8 shall be in addition to any liability which the Company may otherwise have and shall extend, upon the same terms and conditions, to each officer and director of such Underwriter and to each person, if any, who controls any
Underwriter within the meaning of the Act; and the obligations of the Underwriters under this Section&nbsp;8 shall be in addition to any liability which the respective Underwriters may otherwise have and shall extend, upon the same terms and
conditions, to each officer and director of the Company and to each person, if any, who controls the Company within the meaning of the Act. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">16 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">9. (a) If any Underwriter shall default in its obligation to purchase the Designated
Securities which it has agreed to purchase under the Pricing Agreement relating to such Designated Securities, the Representatives may in their discretion arrange for themselves or another party or other parties to purchase such Designated
Securities on the terms contained herein. If within <FONT STYLE="white-space:nowrap">thirty-six</FONT> hours after such default by any Underwriter the Representatives do not arrange for the purchase of such Designated Securities, then the Company
shall be entitled to a further period of <FONT STYLE="white-space:nowrap">thirty-six</FONT> hours within which to procure another party or other parties satisfactory to the Representatives to purchase such Designated Securities on such terms. In the
event that, within the respective prescribed period, the Representatives notify the Company that they have so arranged for the purchase of such Designated Securities, or the Company notifies the Representatives that it has so arranged for the
purchase of such Designated Securities, the Representatives or the Company shall have the right to postpone the Time of Delivery of such Designated Securities for a period of not more than seven days, in order effect whatever changes may thereby be
made necessary in the Registration Statement or the Prospectus as amended or supplemented, or in any other documents or arrangements, and the Company agrees to file promptly any amendments or supplements to the Registration Statement or the
Prospectus which in the opinion of the Representatives may thereby be made necessary. The term &#8220;Underwriter&#8221; as used in this Agreement shall include any person substituted under this Section with like effect as if such person had
originally been a party to the Pricing Agreement with respect to such Designated Securities. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) If, after giving effect
to any arrangements for the purchase of the Designated Securities of a defaulting Underwriter or Underwriters by the Representatives and the Company as provided in subsection (a)&nbsp;above, the aggregate principal amount of such Designated
Securities which remains unpurchased does not exceed <FONT STYLE="white-space:nowrap">one-eleventh</FONT> of the aggregate principal amount of the Designated Securities, then the Company shall have the right to require each <FONT
STYLE="white-space:nowrap">non-defaulting</FONT> Underwriter to purchase the principal amount of Designated Securities which such Underwriter agreed to purchase under the Pricing Agreement relating to such Designated Securities and, in addition, to
require each <FONT STYLE="white-space:nowrap">non-defaulting</FONT> Underwriter to purchase its pro rata share (based on the principal amount of Designated Securities which such Underwriter agreed to purchase under such Pricing Agreement) of the
Designated Securities of such defaulting Underwriter or Underwriters for which such arrangements have not been made; but nothing herein shall relieve a defaulting Underwriter from liability for its default. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(c) If, after giving effect to any arrangements for the purchase of the Designated Securities of a defaulting Underwriter or
Underwriters by the Representatives and the Company as provided in subsection (a)&nbsp;above, the aggregate principal amount of Designated Securities which remains unpurchased exceeds <FONT STYLE="white-space:nowrap">one-eleventh</FONT> of the
aggregate principal amount of the Designated Securities, as referred to in subsection (b)&nbsp;above, or if the Company shall not exercise the right described in subsection (b)&nbsp;above to require
<FONT STYLE="white-space:nowrap">non-defaulting</FONT> Underwriters to purchase Designated Securities of a defaulting Underwriter or Underwriters, then the Pricing Agreement relating to such Designated Securities shall thereupon terminate, without
liability on the part of any <FONT STYLE="white-space:nowrap">non-defaulting</FONT> Underwriter or the Company, except for the expenses to be borne by the Company and the Underwriters as provided in Section&nbsp;6 hereof and the indemnity and
contribution agreements in Section&nbsp;8 hereof; but nothing herein shall relieve a defaulting Underwriter from liability for its default. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">17 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">10. The respective indemnities, agreements, representations, warranties and other statements
of the Company and the several Underwriters, as set forth in this Agreement or made by or on behalf of them, respectively, pursuant to this Agreement, shall remain in full force and effect regardless of any investigation (or any statement as to the
results thereof) made by or on behalf of any Underwriter or any controlling person of any Underwriter, or the Company, or any officer or director or controlling person of the Company, and shall survive delivery of and payment for the Securities.
</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">11. If any Pricing Agreement shall be terminated pursuant to Section&nbsp;9 hereof, the Company shall not then be under any liability to
any Underwriter with respect to the Designated Securities covered by such Pricing Agreement except as provided in Section&nbsp;6 and Section&nbsp;8 hereof; but, if for any other reason Designated Securities are not delivered by or on behalf of the
Company as provided herein, the Company will reimburse the Underwriters through the Representatives for all <FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">out-of-pocket</FONT></FONT> expenses approved in writing by the
Representatives, including fees and disbursements of counsel, reasonably incurred by the Underwriters in making preparations for the purchase, sale and delivery of such Designated Securities, but the Company shall then be under no further liability
to any Underwriter with respect to such Designated Securities except as provided in Section&nbsp;6 and Section&nbsp;8 hereof. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">12. In all
dealings hereunder, the Representatives of the Underwriters of Designated Securities shall act on behalf of each such Underwriters, and the parties hereto shall be entitled to act and rely upon any statement, request, notice or agreement on behalf
of any Underwriter made or given by such Representatives jointly or by such of the Representatives, if any, as may be designated for such purpose in the Pricing Agreement. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">All statements, requests, notices and agreements hereunder shall be in writing, and if to the Underwriters shall be delivered or sent by mail,
<FONT STYLE="white-space:nowrap">e-mail</FONT> or facsimile transmission to the address of the Representatives as set forth in Schedule II to the Pricing Agreement; and if to the Company shall be delivered or sent by mail, <FONT
STYLE="white-space:nowrap">e-mail</FONT> or facsimile transmission to the address of the Company set forth in the Registration Statement, Attention: Secretary. Any such statements, requests, notices or agreements shall take effect upon receipt
thereof. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">18 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">13. This Agreement and each Pricing Agreement shall be binding upon, and inure solely to the
benefit of, the Underwriters, the Company and, to the extent provided in Section&nbsp;8 and Section&nbsp;10 hereof, the officers and directors of the Company and any Underwriter and each person who controls the Company or any Underwriter, and their
respective heirs, executors, administrators, successors and assigns, and no other person shall acquire or have any right under or by virtue of this Agreement or any such Pricing Agreement. No purchaser of any of the Securities from any Underwriter
shall be deemed a successor or assign by reason merely of such purchase. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">14. Time shall be of the essence of each Pricing Agreement. As
used herein &#8220;business day&#8221; shall mean each Monday, Tuesday, Wednesday, Thursday and Friday which is not a day on which banking institutions in New York City are generally authorized or obligated by law or executive order to close. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">15. This Agreement and each Pricing Agreement shall be governed by and construed in accordance with the laws of the State of New York. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">16. (a)&nbsp;(i) The Company represents and agrees that, other than the final term sheet prepared and filed pursuant to Section&nbsp;5(a)
hereof, without the prior consent of the Representatives, it has not made and will not make any offer relating to the Designated Securities that would constitute a &#8220;free writing prospectus&#8221; as defined in Rule 405 under the Act; </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:9%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(ii) each Underwriter represents and agrees that, without the prior consent of the Company and the Representatives, other than
one or more term sheets relating to the Designated Securities containing customary information and conveyed to purchasers of Designated Securities, it has not made and will not make any offer relating to the Designated Securities that would
constitute an issuer free writing prospectus (as defined by Rule 433 under the Securities Act) or a free writing prospectus that would otherwise be required to be filed with the Commission; and </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:9%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(iii) any such free writing prospectus the use of which has been consented to by the Company and the Representatives (including
the final term sheet prepared and filed pursuant to Section&nbsp;5(a) hereof) is listed on Schedule II to the Pricing Agreement; </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) The Company has complied and will comply with the requirements of Rule 433 under the Act applicable to any Issuer Free
Writing Prospectus, including timely filing with the Commission or retention where required and legending; and </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(c) The
Company agrees that if at any time following issuance of an Issuer Free Writing Prospectus any event occurred or occurs as a result of which such Issuer Free Writing Prospectus would conflict with the information in the Registration Statement, the
Pricing Prospectus or the Prospectus as amended and supplemented or would include an untrue statement or a material fact or omit to state any material fact necessary in order to make the statements therein, in the light of the circumstances under
which they were made, not misleading, the Company will give prompt notice thereof to the Representatives and, if requested by the Representatives, will prepare and furnish without charge to each Underwriter an Issuer Free Writing Prospectus or other
document which will correct such conflict, statement or omission; <U>provided</U>, <U>however</U>, that this representation and warranty shall not apply to any statements or omissions in an Issuer Free Writing Prospectus made in reliance upon and in
conformity with information furnished in writing to the Company by an Underwriter through the Representatives expressly for use therein as set forth in Schedule II to the applicable Pricing Agreement. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">19 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">17. The Company acknowledges and agrees that (i)&nbsp;the purchase and sale of any
Designated Securities pursuant to this Agreement and the applicable Pricing Agreement is an <FONT STYLE="white-space:nowrap">arm&#8217;s-length</FONT> commercial transaction between the Company, on the one hand, and the several Underwriters for such
Designated Securities, on the other, (ii)&nbsp;in connection therewith and with the process leading to any such transaction each Underwriter is acting solely as a principal and not the agent or fiduciary of the Company, and the Company&#8217;s
engagement of the Underwriters in any offering of Designated Securities and the process leading up to such offering is as independent contractor and not in any other capacity, (iii)&nbsp;no Underwriter has assumed an advisory or fiduciary
responsibility in favor of the Company with respect to the offering contemplated hereby or the process leading thereto (irrespective of whether such Underwriter has advised or is currently advising the Company on other matters) or any other
obligation to the Company except the obligations expressly set forth in this Agreement and the applicable Pricing Agreement and (iv)&nbsp;the Company has consulted its own legal and financial advisors to the extent it deemed appropriate. The Company
agrees that it will not claim that the Underwriters, or any of them, has rendered advisory services of any nature or respect, or owes a fiduciary or similar duty to the Company, in connection with the offering contemplated hereby or the process
leading thereto. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">18. In accordance with the requirements of the USA Patriot Act (Title III of Pub. L.
<FONT STYLE="white-space:nowrap">107-56</FONT> (signed into law October&nbsp;26, 2001)), the Underwriters are required to obtain, verify and record information that identifies their respective clients, including the Company, which information may
include the name and address of their respective clients, as well as other information that will allow the Underwriters to properly identify their respective clients. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">19. (a) In the event that any Underwriter that is a Covered Entity becomes subject to a proceeding under a U.S. Special Resolution Regime, the
transfer from such Underwriter of this Agreement, and any interest and obligation in or under this Agreement, will be effective to the same extent as the transfer would be effective under the U.S. Special Resolution Regime if this Agreement, and any
such interest and obligation, were governed by the laws of the United States or a state of the United States. (b)&nbsp;In the event that any Underwriter that is a Covered Entity or a BHC Act Affiliate of such Underwriter becomes subject to a
proceeding under a U.S. Special Resolution Regime, Default Rights under this Agreement that may be exercised against such Underwriter are permitted to be exercised to no greater extent than such Default Rights could be exercised under the U.S.
Special Resolution Regime if this Agreement were governed by the laws of the United States or a state of the United States. &#8220;BHC Act </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">20 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">
Affiliate&#8221; has the meaning assigned to the term &#8220;affiliate&#8221; in, and shall be interpreted in accordance with, 12 U.S.C. &#167; 1841(k). &#8220;Covered Entity&#8221; means any of
the following: (i)&nbsp;a &#8220;covered entity&#8221; as that term is defined in, and interpreted in accordance with, 12 C.F.R. &#167;&nbsp;252.82(b); (ii) a &#8220;covered bank&#8221; as that term is defined in, and interpreted in accordance with,
12 C.F.R. &#167;&nbsp;47.3(b); or (iii)&nbsp;a &#8220;covered FSI&#8221; as that term is defined in, and interpreted in accordance with, 12 C.F.R. &#167;&nbsp;382.2(b). &#8220;Default Right&#8221; has the meaning assigned to that term in, and shall
be interpreted in accordance with, 12 C.F.R. &#167;&#167; 252.81, 47.2 or 382.1, as applicable. &#8220;U.S. Special Resolution Regime&#8221; means each of (i)&nbsp;the Federal Deposit Insurance Act and the regulations promulgated thereunder and
(ii)&nbsp;Title II of the Dodd-Frank Wall Street Reform and Consumer Protection Act and the regulations promulgated thereunder. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">20. (a)
Notwithstanding and to the exclusion of any other term of this Agreement or any other agreements, arrangements or understanding between the parties to this Agreement, each of the parties acknowledges and accepts that a BRRD liability arising under
this Agreement may be subject to the exercise of <FONT STYLE="white-space:nowrap">Bail-in</FONT> Powers by the Relevant Resolution Authority and acknowledges, accepts, and agrees to be bound by: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:9%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(i) the effect of the exercise of <FONT STYLE="white-space:nowrap">Bail-in</FONT> Powers by the Relevant Resolution Authority
in relation to any BRRD Liability of the Underwriters to the Company under this Agreement, that (without limitation) may include and result in any of the following, or some combination thereof: (w)&nbsp;the reduction of all, or a portion, of the
BRRD Liability or outstanding amounts due thereon; (x)&nbsp;the conversion of all, or a portion, of the BRRD Liability into shares, other securities or other obligations of the Underwriters or another person and the issue to or conferral on the
Company of such shares, securities or obligations; (y)&nbsp;the cancellation of the BRRD Liability; or (z)&nbsp;the amendment or alteration of any interest, if applicable, thereon, the maturity or the dates on which any payments are due, including
by suspending payment for a temporary period; and </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:9%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(ii) the variation of the terms of this Agreement, as deemed necessary
by the Relevant Resolution Authority, to give effect to the exercise of <FONT STYLE="white-space:nowrap">Bail-in</FONT> Powers by the Relevant Resolution Authority. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) As used in this Section&nbsp;20, </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:9%; font-size:10pt; font-family:Times New Roman"><FONT STYLE="white-space:nowrap">&#8220;Bail-in</FONT> Legislation&#8221; means in relation to a member state of the European Economic Area
which has implemented, or which at any time implements, the BRRD, the relevant implementing law, regulation, rule or requirement as described in the EU <FONT STYLE="white-space:nowrap">Bail-in</FONT> Legislation Schedule from time to time. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:9%; font-size:10pt; font-family:Times New Roman"><FONT STYLE="white-space:nowrap">&#8220;Bail-in</FONT> Powers&#8221; means any Write-down and Conversion Powers as defined in the EU <FONT
STYLE="white-space:nowrap">Bail-in</FONT> Legislation Schedule, in relation to the relevant <FONT STYLE="white-space:nowrap">Bail-in</FONT> Legislation. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">21 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:9%; font-size:10pt; font-family:Times New Roman">&#8220;BRRD&#8221; means Directive 2014/59/EU establishing a framework for the recovery and
resolution of credit institutions and investment firms. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:9%; font-size:10pt; font-family:Times New Roman">&#8220;BRRD Liability&#8221; means a liability in respect of which the relevant
Write Down and Conversion Powers in the applicable <FONT STYLE="white-space:nowrap">Bail-in</FONT> Legislation may be exercised. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:9%; font-size:10pt; font-family:Times New Roman">&#8220;EU
<FONT STYLE="white-space:nowrap">Bail-in</FONT> Legislation Schedule&#8221; means the document described as such, then in effect, and published by the Loan Market Association (or any successor person) from time to time at http://www.lma.eu.com/.
</P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:9%; font-size:10pt; font-family:Times New Roman">&#8220;Relevant Resolution Authority&#8221; means the resolution authority with the ability to exercise any
<FONT STYLE="white-space:nowrap">Bail-in</FONT> Powers in relation to the Underwriters. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">21. (a) Notwithstanding and to the exclusion of
any other term of this Agreement or any other agreements, arrangements or understanding between the parties to this Agreement, each of the parties acknowledges and accepts that a UK <FONT STYLE="white-space:nowrap">Bail-in</FONT> Liability arising
under this Agreement may be subject to the exercise of UK <FONT STYLE="white-space:nowrap">Bail-in</FONT> Powers by the relevant United Kingdom (&#8220;UK&#8221;) resolution authority and acknowledges, accepts, and agrees to be bound by: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:9%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(i) the effect of the exercise of UK <FONT STYLE="white-space:nowrap">Bail-in</FONT> Powers by the relevant UK resolution
authority in relation to any UK <FONT STYLE="white-space:nowrap">Bail-in</FONT> Liability of the Underwriters to the Company under this Agreement, that (without limitation) may include and result in any of the following, or some combination thereof:
(w)&nbsp;the reduction of all, or a portion, of the UK <FONT STYLE="white-space:nowrap">Bail-in</FONT> Liability or outstanding amounts due thereon; (x)&nbsp;the conversion of all, or a portion, of the UK
<FONT STYLE="white-space:nowrap">Bail-in</FONT> Liability into shares, other securities or other obligations of the Underwriters or another person (and the issue to or conferral on the Company of such shares, securities or obligations); (y) the
cancellation of the UK <FONT STYLE="white-space:nowrap">Bail-in</FONT> Liability; or (z)&nbsp;the amendment or alteration of any interest, if applicable, thereon, the maturity or the dates on which any payments are due, including by suspending
payment for a temporary period; and </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:9%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(ii) the variation of the terms of this Agreement, as deemed necessary by the relevant
UK resolution authority, to give effect to the exercise of UK <FONT STYLE="white-space:nowrap">Bail-in</FONT> Powers by the relevant UK resolution authority. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) As used in this Section&nbsp;21, </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:9%; font-size:10pt; font-family:Times New Roman">&#8220;UK <FONT STYLE="white-space:nowrap">Bail-in</FONT> Legislation&#8221; means Part I of the UK Banking Act 2009 and any other law or
regulation applicable in the UK relating to the resolution of unsound or failing banks, investment firms or other financial institutions or their affiliates (otherwise than through liquidation, administration or other insolvency proceedings). </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">22 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:9%; font-size:10pt; font-family:Times New Roman">&#8220;UK <FONT STYLE="white-space:nowrap">Bail-in</FONT> Liability&#8221; means a liability
in respect of which the UK <FONT STYLE="white-space:nowrap">Bail-in</FONT> Powers may be exercised. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:9%; font-size:10pt; font-family:Times New Roman">&#8220;UK <FONT
STYLE="white-space:nowrap">Bail-in</FONT> Powers&#8221; means the powers under the UK <FONT STYLE="white-space:nowrap">Bail-In</FONT> Legislation to cancel, transfer or dilute shares issued by a person that is a bank or investment firm or affiliate
of a bank or investment firm, to cancel, reduce, modify or change the form of a liability of such a person or any contract or instrument under which that liability arises, to convert all or part of that liability into shares, securities or
obligations of that person or any other person, to provide that any such contract or instrument is to have effect as if a right had been exercised under it or to suspend any obligation in respect of that liability. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">22. This Agreement and each Pricing Agreement may be executed in two or more counterparts, each of which shall be deemed an original and all
of which together shall constitute one instrument. Delivery of this Agreement and any Pricing Agreement by one party to the other may be made by facsimile, electronic mail (including any electronic signature complying with the New York Electronic
Signatures and Records Act (N.Y. State Tech. &#167;&#167; <FONT STYLE="white-space:nowrap">301-309),</FONT> as amended from time to time, or other applicable law) or other transmission method, and the parties hereto agree that any counterpart so
delivered shall be deemed to have been duly and validly delivered and be valid and effective for all purposes. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">23. The words
&#8220;execution,&#8221; &#8220;signed,&#8221; &#8220;signature,&#8221; &#8220;delivery,&#8221; and words of like import in or relating to this Agreement, each Pricing Agreement or any document to be signed in connection with this Agreement shall be
deemed to include electronic signatures, deliveries or the keeping of records in electronic form, each of which shall be of the same legal effect, validity or enforceability as a manually executed signature, physical delivery thereof or the use of a
paper-based recordkeeping system, as the case may be, and the parties hereto consent to conduct the transactions contemplated hereunder by electronic means. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">[<I>Signatures follow</I>] </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">23 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="92%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Very truly yours,</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">PFIZER INC. </TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Brian Byala</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name: Brian Byala</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title: &#8194;Senior Vice President and Treasurer</TD></TR>
</TABLE></DIV>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">

<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="92%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Accepted as of the date hereof:</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">CITIGROUP GLOBAL MARKETS INC., as a Representative of the Underwriters</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Adam D. Bordner</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name: Adam D. Bordner</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title:&#8194; Managing Director</TD></TR>
</TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">2 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">

<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="92%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">DEUTSCHE BANK SECURITIES INC., as a Representative of the Underwriters</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Kevin Prior</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name: Kevin Prior</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title: &#8194;Managing Director</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ John Han</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name: John Han</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title: &#8194;Managing Director</TD></TR>
</TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">3 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">

<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="92%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">J.P. MORGAN SECURITIES LLC, as a Representative of the Underwriters</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Som Bhattacharyya</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name: Som Bhattacharyya</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title: &#8194;Executive Director</TD></TR>
</TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">4 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">

<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="92%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">MIZUHO SECURITIES USA LLC, as a Representative of the Underwriters</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Moshe Tomkiewicz</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name: Moshe Tomkiewicz</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title: &#8194;Managing Director</TD></TR>
</TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">5 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ANNEX I </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Form of Pricing Agreement </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">PRICING AGREEMENT </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right">November&nbsp;18, 2025 </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Citigroup Global Markets
Inc. </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">388 Greenwich Street </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">New York, New York 10013 </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Deutsche Bank Securities Inc. </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">1 Columbus Circle </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">New York, New York 10019 </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">J.P. Morgan Securities LLC </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">270 Park Ave </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">New York, New York 10017 </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Mizuho Securities USA LLC </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">1271 Avenue of the Americas </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">New York, New York 10020 </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">As Representatives of the several
Underwriters </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Ladies and Gentlemen: </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Pfizer
Inc., a Delaware corporation (the &#8220;Company&#8221;), proposes, subject to the terms and conditions stated herein and in the Underwriting Agreement, dated November&nbsp;18, 2025 (the &#8220;Underwriting Agreement&#8221;), between the Company and
the Representatives of the several Underwriters to issue and sell to each of the Underwriters named in Schedule I hereto (the &#8220;Underwriters&#8221;) the Securities specified in Schedule II hereto (the &#8220;Designated Securities&#8221;). Each
of the provisions of the Underwriting Agreement is incorporated herein by reference in its entirety, and shall be deemed to be a part of this Agreement to the same extent as if such provisions had been set forth in full herein; and each of the
representations and warranties set forth therein shall be deemed to have been made at and as of the date of this Pricing Agreement, except that each representation and warranty which refers to the Prospectus in Section&nbsp;2 of the Underwriting
Agreement shall be deemed to be a representation or warranty as of the date of the Underwriting Agreement in relation to the Prospectus (as therein defined), and also a representation and warranty as of the Applicable Time in relation to the Pricing
Disclosure Package and Prospectus as amended or supplemented relating to the Designated Securities which are the subject of this Pricing </P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">
Agreement. Each reference to the &#8220;Representatives&#8221; herein and in the provisions of the Underwriting Agreement so incorporated by reference shall be deemed to refer to you. Unless
otherwise defined herein, terms defined in the Underwriting Agreement are used herein as therein defined. The Representatives designated to act on behalf of the Representatives and on behalf of each of the Underwriters of the Designated Securities
pursuant to Section&nbsp;12 of the Underwriting Agreement and the address of the Representatives referred to in such Section&nbsp;12 are set forth at the end of Schedule II hereto. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">An amendment to the Registration Statement, or a supplement to the Prospectus, as the case may be, relating to the Designated Securities, in
the form heretofore delivered to you is now proposed to be filed with the Commission. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Subject to the terms and conditions set forth
herein and in the Underwriting Agreement incorporated herein by reference, the Company agrees to issue and sell to each of the Underwriters, and each of the Underwriters agrees, severally and not jointly, to purchase from the Company, at the time
and place and at the purchase price to the Underwriters set forth in Schedule II hereto, the principal amount of Designated Securities set forth opposite the name of such Underwriter in Schedule I hereto, plus any additional principal amount of
Designated Securities which such Underwriter may become obligated to purchase pursuant to the provisions of Section&nbsp;9 of the Underwriting Agreement. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">If the foregoing is in accordance with your understanding, please sign and return to us four counterparts hereof, and upon acceptance hereof
by you, on behalf of each of the Underwriters this letter and such acceptance hereof, including the provisions of the Underwriting Agreement incorporated herein by reference, shall constitute a binding agreement between each of the Underwriters and
the Company. It is understood that your acceptance of this letter on behalf of each of the Underwriters is or will be pursuant to the authority set forth in an agreement among Underwriters, the form of which shall be submitted to the Company for
examination upon request, but without warranty on the part of the Representatives as to the authority of the signers thereof. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">[<I>Signatures follow</I>] </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">2 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="92%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Very truly yours,</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">PFIZER INC.</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name:</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title:</TD></TR>
</TABLE></DIV> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><I>[Signature Page to the Pricing Agreement] </I></P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">

<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="92%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Accepted as of the date hereof:</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">CITIGROUP GLOBAL MARKETS INC., as a Representative of the Underwriters</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name:</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title:</TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><I>[Signature Page to the Pricing Agreement] </I></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">2 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">

<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="92%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">DEUTSCHE BANK SECURITIES INC., as a Representative of the Underwriters</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name:</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title:</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name:</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title:</TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><I>[Signature Page to the Pricing Agreement] </I></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">3 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">

<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="92%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">J.P. MORGAN SECURITIES LLC, as a Representative of the Underwriters</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name:</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title:</TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><I>[Signature Page to the Pricing Agreement] </I></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">4 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">

<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="92%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">MIZUHO SECURITIES USA LLC, as a Representative of the Underwriters</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name:</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title:</TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><I>[Signature Page to the Pricing Agreement] </I></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">5 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">SCHEDULE I </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">


<TR>

<TD WIDTH="79%"></TD>

<TD VALIGN="bottom"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>

<TD VALIGN="bottom"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>

<TD VALIGN="bottom"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>

<TD VALIGN="bottom"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>

<TD VALIGN="bottom"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>

<TD VALIGN="bottom"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>

<TD VALIGN="bottom"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<TD VALIGN="bottom" NOWRAP> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-bottom:1.00pt solid #000000; display:table-cell; font-size:8pt; font-family:Times New Roman; "><B>Underwriters</B></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"><B>Principal</B><br><B>Amount of</B><br><B>Floating Rate</B><br><B>Notes&nbsp;due&nbsp;2027</B></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"><B>Principal</B><br><B>Amount of</B><br><B>3.875% Notes</B><br><B>due 2027</B></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"><B>Principal</B><br><B>Amount of</B><br><B>4.200% Notes</B><br><B>due 2030</B></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"><B>Principal</B><br><B>Amount of</B><br><B>4.500% Notes</B><br><B>due 2032</B></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"><B>Principal</B><br><B>Amount of</B><br><B>4.875% Notes</B><br><B>due 2035</B></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"><B>Principal</B><br><B>Amount of</B><br><B>5.600%&nbsp;Notes</B><br><B>due 2055</B></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"><B>Principal</B><br><B>Amount of</B><br><B>5.700%&nbsp;Notes</B><br><B>due 2065</B></TD>
<TD VALIGN="bottom">&nbsp;</TD></TR>


<TR BGCOLOR="#cceeff" STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Citigroup Global Markets Inc.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">92,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">185,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">185,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">231,250,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">231,250,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">92,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">92,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Deutsche Bank Securities Inc.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">87,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">175,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">175,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">218,750,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">218,750,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">87,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">87,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR BGCOLOR="#cceeff" STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">J.P. Morgan Securities LLC</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">87,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">175,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">175,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">218,750,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">218,750,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">87,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">87,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Mizuho Securities USA LLC</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">87,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">175,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">175,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">218,750,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">218,750,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">87,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">87,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR BGCOLOR="#cceeff" STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Barclays Capital Inc.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">30,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">60,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">60,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">75,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">75,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">30,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">30,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">HSBC Securities (USA) Inc.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">30,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">60,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">60,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">75,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">75,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">30,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">30,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR BGCOLOR="#cceeff" STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">UBS Securities LLC</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">30,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">60,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">60,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">75,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">75,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">30,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">30,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">BNP Paribas Securities Corp.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">20,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">40,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">40,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">50,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">50,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">20,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">20,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR BGCOLOR="#cceeff" STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">RBC Capital Markets, LLC</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">20,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">40,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">40,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">50,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">50,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">20,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">20,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Academy Securities, Inc.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">7,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">15,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">15,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">18,750,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">18,750,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">7,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">7,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR BGCOLOR="#cceeff" STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Siebert Williams Shank&nbsp;&amp; Co., LLC</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">7,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">15,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">15,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">18,750,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">18,750,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">7,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">7,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="font-size:1px; ">
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Total</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">500,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">1,000,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">1,000,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">1,250,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">1,250,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">500,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">500,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="font-size:1px; ">
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD></TR>
</TABLE>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">SCHEDULE II </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Title of Designated Securities: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Floating Rate
Notes due 2027 (the &#8220;Floating Rate Notes&#8221;) </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">3.875% Notes due 2027 (the &#8220;2027 Notes&#8221;) </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">4.200% Notes due 2030 (the &#8220;2030 Notes&#8221;) </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">4.500% Notes due 2032 (the &#8220;2032 Notes&#8221;) </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">4.875% Notes due 2035 (the &#8220;2035 Notes&#8221;) </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">5.600% Notes due 2055 (the &#8220;2055 Notes&#8221;) </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">5.700% Notes due 2065 (the &#8220;2065 Notes&#8221; and, collectively with the 2027, the 2030 Notes, the 2032, the 2035 Notes and the 2055
Notes, the &#8220;Fixed Rate Notes,&#8221; and the Fixed Rate Notes, together with the Floating Rate Notes, the &#8220;Notes&#8221;) </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Commission File
Number of Initial Registration Statement: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><FONT STYLE="white-space:nowrap">333-277323</FONT> and Post-Effective Amendment No.&nbsp;1
thereto </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Aggregate Principal Amount: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">$500,000,000 for the Floating Rate Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">$1,000,000,000 for the 2027 Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">$1,000,000,000 for the 2030 Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">$1,250,000,000 for the 2032 Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">$1,250,000,000 for the 2035 Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">$500,000,000 for the 2055 Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">$500,000,000 for the 2065 Notes </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Price to
Public: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the Floating Rate Notes, 100.000% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the 2027 Notes, 99.989% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the 2030 Notes, 99.921% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the 2032 Notes, 99.781% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the 2035 Notes, 99.985% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the 2055 Notes, 99.655% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the 2065 Notes, 99.237% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Purchase Price by Underwriters: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the Floating Rate Notes, 99.800% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the 2027 Notes, 99.789% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the 2030 Notes, 99.571% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the 2032 Notes, 99.381% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the 2035 Notes, 99.535% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the 2055 Notes, 98.905% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the 2065 Notes, 98.487% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Form of Designated Securities: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Book-entry only
form represented by one or more global securities deposited with the depositary or its designated custodian, to be made available for checking by the Representative at least twenty-four hours prior to the Time of Delivery at the office of the
depositary. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Specified Funds for Payment of Purchase Price: </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Wire transfer of immediately available funds. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Indenture: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Indenture dated September&nbsp;7,
2018, between the Company and The Bank of New York Mellon as supplemented by the sixth supplemental indenture to be dated November 21, 2025 between the Company and The Bank of New York Mellon. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Maturity: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">November&nbsp;15, 2027 for the
Floating Rate Notes </P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">November&nbsp;15, 2027 for the 2027 Notes </P>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">November&nbsp;15, 2030 for the 2030 Notes </P>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">November&nbsp;15, 2032 for the 2032 Notes </P>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">November&nbsp;15, 2035 for the 2035 Notes </P>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">November&nbsp;15, 2055 for the 2055 Notes </P>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">November&nbsp;15, 2065 for the 2065 Notes </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">2 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Interest Rate: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Compounded SOFR (as defined in the Preliminary Prospectus Supplement) plus 0.500%, reset quarterly for the Floating Rate Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">3.875% per annum for the 2027 Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">4.200% per annum for the 2030 Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">4.500% per annum for the 2032 Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">4.875% per annum for the 2035 Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">5.600% per annum for the 2055 Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">5.700% per annum for the 2065 Notes </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Interest
Payment Dates: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">February&nbsp;15, May&nbsp;15, August&nbsp;15 and November&nbsp;15 of each year, beginning on February&nbsp;15, 2026 for
the Floating Rate Notes </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">May&nbsp;15 and November&nbsp;15 of each year, beginning on May&nbsp;15, 2026 for the Fixed Rate Notes </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Record Dates: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">February&nbsp;1, May&nbsp;1,
August&nbsp;1 and November&nbsp;1 immediately preceding the relevant Interest Payment Date for the Floating Rate Notes </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">May&nbsp;1 or
November&nbsp;1 immediately preceding the relevant Interest Payment Date for the Fixed Rate Notes </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Redemption Provisions: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">The Floating Rate Notes may not be redeemed prior to maturity. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">The Fixed Rate Notes may be redeemed in whole or in part at the price(s) described in the Prospectus relating to the Notes. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Sinking Fund Provisions: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">None. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Defeasance Provisions: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">As described in the
Basic Prospectus dated May&nbsp;13, 2025. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Applicable Time: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">5:20 P.M. New York City time on November&nbsp;18, 2025 </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">3 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Issuer Free Writing Prospectuses: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Pricing Term Sheet dated November&nbsp;18, 2025, as filed under Rule 433 </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Recently Filed Documents for Section&nbsp;2(d) of the Underwriting Agreement: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">None. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Time of Delivery: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">10:00 A.M. New York City time on November&nbsp;21, 2025 </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Closing Location: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Simpson Thacher&nbsp;&amp;
Bartlett LLP, 425 Lexington Avenue, New York, NY 10017. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Additional Agreements of the Underwriters: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Each of the Underwriters has agreed that it will not offer, sell or deliver any of the Designated Securities, directly or indirectly, or
distribute the Prospectus or any other offering material relating to the Designated Securities, in or from any jurisdiction except under circumstances that will, to the best of the Underwriters&#8217; knowledge and belief, result in compliance with
the applicable laws and regulations and which will not impose any obligations on the Company. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Each of the Underwriters agrees to abide by
the offering restrictions as set forth under the following captions in the Prospectus: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;Underwriting&#8212;Notice to Prospective
Investors in the European Economic Area&#8221;, </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;Underwriting&#8212;Notice to Prospective Investors in the United Kingdom&#8221;,
&#8220;Underwriting&#8212;Notice to Prospective Investors in France&#8221;, </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;Underwriting&#8212;Notice to Prospective Investors in
Switzerland&#8221;, </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;Underwriting&#8212;Notice to Prospective Investors in Hong Kong&#8221;, &#8220;Underwriting&#8212;Notice to
Prospective Investors in Japan&#8221;, </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;Underwriting&#8212;Notice to Prospective Investors in Singapore&#8221;, </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;Underwriting&#8212;Notice to Prospective Investors in Canada&#8221;, </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;Underwriting&#8212;Notice to Prospective Investors in Taiwan&#8221;, </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;Underwriting&#8212;Notice to Prospective Investors in Korea&#8221;, </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;Underwriting&#8212;Notice to Prospective Investors in the United Arab Emirates </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">(excluding the Dubai International Financial Centre)&#8221; and </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;Underwriting&#8212;Dubai International Financial Centre.&#8221; </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">4 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Contact Information for Representatives for purposes of Section&nbsp;12 of the Underwriting Agreement: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Citigroup Global Markets Inc. </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">388 Greenwich Street </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">New York,
New York 10013 </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Attention: General Counsel </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Deutsche Bank Securities Inc. </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">1
Columbus Circle </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">New York, New York 10019 </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Attention: Debt Capital Markets Syndicate </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Email: dbcapmarkets.gcnotices@list.db.com </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">J.P. Morgan Securities LLC </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">270
Park Ave </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">New York, New York 10017 </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Attention:&nbsp;Investment Grade Syndicate Desk </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Fax: (212) <FONT STYLE="white-space:nowrap">834-6081</FONT> </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Mizuho Securities USA LLC </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">1271
Avenue of the Americas </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">New York, New York 10020 </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Attention: Debt Capital Markets; </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Email: ba_dcm_notices@mizuhogroup.com </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Information furnished by the Underwriters for purposes of Sections 2(b), 2(c), 2(d), 2(e), 8(a), 8(b) and 16(c) of the Underwriting Agreement: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">The information in the last paragraph of the cover page of the Prospectus. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">The information set forth in the third, fourth and eighth paragraphs under the caption &#8220;Underwriting&#8221;. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">The information in the third sentence of the tenth paragraph and the second sentence of the thirteenth paragraph under the caption
&#8220;Underwriting&#8221;. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">No other information in the Prospectus has been furnished by the Underwriters for use therein. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">5 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ANNEX II </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Form of Comfort Letter-KPMG LLP </B></P>
</DIV></Center>

</BODY></HTML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-1.2
<SEQUENCE>3
<FILENAME>d80089dex12.htm
<DESCRIPTION>EX-1.2
<TEXT>
<HTML><HEAD>
<TITLE>EX-1.2</TITLE>
</HEAD>
 <BODY BGCOLOR="WHITE" STYLE="line-height:Normal">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right"><B>Exhibit 1.2 </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">PRICING AGREEMENT </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right">November&nbsp;18, 2025 </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Citigroup Global Markets
Inc. </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">388 Greenwich Street </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">New York, New York 10013 </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Deutsche Bank Securities Inc. </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">1 Columbus Circle </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">New York, New York 10019 </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">J.P. Morgan Securities LLC </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">270 Park Ave </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">New York, New York 10017 </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Mizuho Securities USA LLC </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">1271 Avenue of the Americas </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">New York, New York 10020 </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">As Representatives of the several
Underwriters </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Ladies and Gentlemen: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Pfizer
Inc., a Delaware corporation (the &#8220;Company&#8221;), proposes, subject to the terms and conditions stated herein and in the Underwriting Agreement, dated November&nbsp;18, 2025 (the &#8220;Underwriting Agreement&#8221;), between the Company and
the Representatives of the several Underwriters to issue and sell to each of the Underwriters named in Schedule I hereto (the &#8220;Underwriters&#8221;) the Securities specified in Schedule II hereto (the &#8220;Designated Securities&#8221;). Each
of the provisions of the Underwriting Agreement is incorporated herein by reference in its entirety, and shall be deemed to be a part of this Agreement to the same extent as if such provisions had been set forth in full herein; and each of the
representations and warranties set forth therein shall be deemed to have been made at and as of the date of this Pricing Agreement, except that each representation and warranty which refers to the Prospectus in Section&nbsp;2 of the Underwriting
Agreement shall be deemed to be a representation or warranty as of the date of the Underwriting Agreement in relation to the Prospectus (as therein defined), and also a representation and warranty as of the Applicable Time in relation to the Pricing
Disclosure Package and Prospectus as amended or supplemented relating to the Designated Securities which are the subject of this Pricing Agreement. Each reference to the &#8220;Representatives&#8221; herein and in the provisions of the Underwriting
Agreement so incorporated by reference shall be deemed to refer to you. Unless otherwise defined herein, terms defined in the Underwriting Agreement are used herein as therein defined. The Representatives designated to act on behalf of the
Representatives and on behalf of each of the Underwriters of the Designated Securities pursuant to Section&nbsp;12 of the Underwriting Agreement and the address of the Representatives referred to in such Section&nbsp;12 are set forth at the end of
Schedule II hereto. </P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">An amendment to the Registration Statement, or a supplement to the Prospectus, as the case
may be, relating to the Designated Securities, in the form heretofore delivered to you is now proposed to be filed with the Commission. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Subject to the terms and conditions set forth herein and in the Underwriting Agreement incorporated herein by reference, the Company agrees to
issue and sell to each of the Underwriters, and each of the Underwriters agrees, severally and not jointly, to purchase from the Company, at the time and place and at the purchase price to the Underwriters set forth in Schedule II hereto, the
principal amount of Designated Securities set forth opposite the name of such Underwriter in Schedule I hereto, plus any additional principal amount of Designated Securities which such Underwriter may become obligated to purchase pursuant to the
provisions of Section&nbsp;9 of the Underwriting Agreement. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">If the foregoing is in accordance with your understanding, please sign and
return to us four counterparts hereof, and upon acceptance hereof by you, on behalf of each of the Underwriters this letter and such acceptance hereof, including the provisions of the Underwriting Agreement incorporated herein by reference, shall
constitute a binding agreement between each of the Underwriters and the Company. It is understood that your acceptance of this letter on behalf of each of the Underwriters is or will be pursuant to the authority set forth in an agreement among
Underwriters, the form of which shall be submitted to the Company for examination upon request, but without warranty on the part of the Representatives as to the authority of the signers thereof. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">[<I>Signatures follow</I>] </P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="16%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="83%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Very truly yours,</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">PFIZER INC. </TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">&#8195;&#8195;By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Brian Byala</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name: Brian Byala</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title: &#8194;Senior Vice President and Treasurer</TD></TR>
</TABLE></DIV> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><I>[Signature Page to the Pricing Agreement] </I></P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">

<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="92%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">Accepted as of the date hereof:</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">CITIGROUP GLOBAL MARKETS INC., as a Representative of the Underwriters</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Adam D. Bordner</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name: Adam D. Bordner</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title: &#8194;Managing Director</TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><I>[Signature Page to the Pricing Agreement] </I></P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">

<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="92%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">DEUTSCHE BANK SECURITIES INC.,</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:2.00em; font-size:10pt; font-family:Times New Roman">as a Representative of the Underwriters</P></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Kevin Prior</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name: Kevin Prior</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title: &#8194;Managing Director</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ John Han</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name: John Han</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title: &#8194;Managing Director</TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><I>[Signature Page to the Pricing Agreement] </I></P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">

<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="92%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">J.P. MORGAN SECURITIES LLC,</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:2.00em; font-size:10pt; font-family:Times New Roman">as a Representative of the Underwriters</P></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Som Bhattacharyya</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name: Som Bhattacharyya</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title: &#8194;Executive Director</TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><I>[Signature Page to the Pricing Agreement] </I></P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">

<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="92%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">MIZUHO SECURITIES USA LLC,</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:2.00em; font-size:10pt; font-family:Times New Roman">as a Representative of the Underwriters</P></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Moshe Tomkiewicz</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name: Moshe Tomkiewicz</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title: &#8194;Managing Director</TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><I>[Signature Page to the Pricing Agreement] </I></P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">SCHEDULE I </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">


<TR>

<TD WIDTH="79%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD></TD>
<TD></TD>
<TD></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD></TD>
<TD></TD>
<TD></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD></TD>
<TD></TD>
<TD></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD></TD>
<TD></TD>
<TD></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD></TD>
<TD></TD>
<TD></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD></TD>
<TD></TD>
<TD></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD></TD>
<TD></TD>
<TD></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<TD VALIGN="bottom" NOWRAP> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-bottom:1.00pt solid #000000; display:table-cell; font-size:8pt; font-family:Times New Roman; "><B>Underwriters</B></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"><B>Principal</B><br><B>Amount of</B><br><B>Floating Rate<BR>Notes&nbsp;due&nbsp;2027</B></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"><B>Principal</B><br><B>Amount of</B><br><B>3.875% Notes</B><br><B>due 2027</B></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"><B>Principal</B><br><B>Amount of</B><br><B>4.200% Notes</B><br><B>due 2030</B></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"><B>Principal</B><br><B>Amount of</B><br><B>4.500% Notes</B><br><B>due 2032</B></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"><B>Principal</B><br><B>Amount of</B><br><B>4.875% Notes</B><br><B>due 2035</B></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"><B>Principal</B><br><B>Amount of</B><br><B>5.600%&nbsp;Notes<BR>due 2055</B></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"><B>Principal</B><br><B>Amount of</B><br><B>5.700%&nbsp;Notes<BR>due 2065</B></TD>
<TD VALIGN="bottom">&nbsp;</TD></TR>


<TR BGCOLOR="#cceeff" STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Citigroup Global Markets Inc.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">92,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">185,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">185,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">231,250,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">231,250,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">92,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">92,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Deutsche Bank Securities Inc.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">87,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">175,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">175,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">218,750,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">218,750,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">87,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">87,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR BGCOLOR="#cceeff" STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">J.P. Morgan Securities LLC</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">87,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">175,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">175,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">218,750,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">218,750,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">87,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">87,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Mizuho Securities USA LLC</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">87,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">175,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">175,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">218,750,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">218,750,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">87,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">87,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR BGCOLOR="#cceeff" STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Barclays Capital Inc.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">30,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">60,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">60,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">75,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">75,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">30,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">30,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">HSBC Securities (USA) Inc.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">30,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">60,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">60,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">75,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">75,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">30,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">30,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR BGCOLOR="#cceeff" STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">UBS Securities LLC</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">30,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">60,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">60,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">75,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">75,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">30,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">30,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">BNP Paribas Securities Corp.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">20,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">40,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">40,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">50,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">50,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">20,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">20,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR BGCOLOR="#cceeff" STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">RBC Capital Markets, LLC</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">20,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">40,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">40,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">50,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">50,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">20,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">20,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Academy Securities, Inc.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">7,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">15,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">15,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">18,750,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">18,750,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">7,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">7,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR BGCOLOR="#cceeff" STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Siebert Williams Shank&nbsp;&amp; Co., LLC</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">7,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">15,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">15,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">18,750,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">18,750,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">7,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">7,500,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="font-size:1px; ">
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:1.00px solid #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Total</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">500,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">1,000,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">1,000,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">1,250,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">1,250,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">500,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">$</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">500,000,000</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="font-size:1px; ">
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; border-top:3.00px double #000000">&nbsp;</P></TD>
<TD>&nbsp;</TD></TR>
</TABLE>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">SCHEDULE II </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Title of Designated Securities: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Floating Rate
Notes due 2027 (the &#8220;Floating Rate Notes&#8221;) </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">3.875% Notes due 2027 (the &#8220;2027 Notes&#8221;) </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">4.200% Notes due 2030 (the &#8220;2030 Notes&#8221;) </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">4.500% Notes due 2032 (the &#8220;2032 Notes&#8221;) </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">4.875% Notes due 2035 (the &#8220;2035 Notes&#8221;) </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">5.600% Notes due 2055 (the &#8220;2055 Notes&#8221;) </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">5.700% Notes due 2065 (the &#8220;2065 Notes&#8221; and, collectively with the 2027, the 2030 Notes, the 2032, the 2035 Notes and the 2055
Notes, the &#8220;Fixed Rate Notes,&#8221; and the Fixed Rate Notes, together with the Floating Rate Notes, the &#8220;Notes&#8221;) </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Commission File
Number of Initial Registration Statement: </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><FONT STYLE="white-space:nowrap">333-277323</FONT> and Post-Effective Amendment No.&nbsp;1
thereto </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Aggregate Principal Amount: </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">$500,000,000 for the Floating Rate Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">$1,000,000,000 for the 2027 Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">$1,000,000,000 for the 2030 Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">$1,250,000,000 for the 2032 Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">$1,250,000,000 for the 2035 Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">$500,000,000 for the 2055 Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">$500,000,000 for the 2065 Notes </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Price to
Public: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the Floating Rate Notes, 100.000% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the 2027 Notes, 99.989% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the 2030 Notes, 99.921% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the 2032 Notes, 99.781% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the 2035 Notes, 99.985% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the 2055 Notes, 99.655% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the 2065 Notes, 99.237% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Purchase Price by Underwriters: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the Floating Rate Notes, 99.800% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the 2027 Notes, 99.789% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the 2030 Notes, 99.571% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the 2032 Notes, 99.381% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the 2035 Notes, 99.535% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the 2055 Notes, 98.905% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">For the 2065 Notes, 98.487% of the principal amount, plus accrued interest, from November&nbsp;21, 2025 </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Form of Designated Securities: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Book-entry only
form represented by one or more global securities deposited with the depositary or its designated custodian, to be made available for checking by the Representative at least twenty-four hours prior to the Time of Delivery at the office of the
depositary. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Specified Funds for Payment of Purchase Price: </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Wire transfer of immediately available funds. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Indenture: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Indenture dated September&nbsp;7,
2018, between the Company and The Bank of New York Mellon as supplemented by the sixth supplemental indenture to be dated November 21, 2025 between the Company and The Bank of New York Mellon. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Maturity: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">November&nbsp;15, 2027 for the
Floating Rate Notes </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">November&nbsp;15, 2027 for the 2027 Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">November&nbsp;15, 2030 for the 2030 Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">November&nbsp;15, 2032 for the 2032 Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">November&nbsp;15, 2035 for the 2035 Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">November&nbsp;15, 2055 for the 2055 Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">November&nbsp;15, 2065 for the 2065 Notes </P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Interest Rate: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Compounded SOFR (as defined in the Preliminary Prospectus Supplement) plus 0.500%, reset quarterly for the Floating Rate Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">3.875% per annum for the 2027 Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">4.200% per annum for the 2030 Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">4.500% per annum for the 2032 Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">4.875% per annum for the 2035 Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">5.600% per annum for the 2055 Notes </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">5.700% per annum for the 2065 Notes </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Interest
Payment Dates: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">February&nbsp;15, May&nbsp;15, August&nbsp;15 and November&nbsp;15 of each year, beginning on February&nbsp;15, 2026 for
the Floating Rate Notes </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">May&nbsp;15 and November&nbsp;15 of each year, beginning on May&nbsp;15, 2026 for the Fixed Rate Notes </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Record Dates: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">February&nbsp;1, May&nbsp;1,
August&nbsp;1 and November&nbsp;1 immediately preceding the relevant Interest Payment Date for the Floating Rate Notes </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">May&nbsp;1 or
November&nbsp;1 immediately preceding the relevant Interest Payment Date for the Fixed Rate Notes </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Redemption Provisions: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">The Floating Rate Notes may not be redeemed prior to maturity. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">The Fixed Rate Notes may be redeemed in whole or in part at the price(s) described in the Prospectus relating to the Notes. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Sinking Fund Provisions: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">None. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Defeasance Provisions: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">As described in the
Basic Prospectus dated May&nbsp;13, 2025. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Applicable Time: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">5:20 P.M. New York City time on November&nbsp;18, 2025 </P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Issuer Free Writing Prospectuses: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Pricing Term Sheet dated November&nbsp;18, 2025, as filed under Rule 433 </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Recently Filed Documents for Section&nbsp;2(d) of the Underwriting Agreement: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">None. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Time of Delivery: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">10:00 A.M. New York City time on November&nbsp;21, 2025 </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Closing Location: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Simpson Thacher&nbsp;&amp;
Bartlett LLP, 425 Lexington Avenue, New York, NY 10017. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Additional Agreements of the Underwriters: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Each of the Underwriters has agreed that it will not offer, sell or deliver any of the Designated Securities, directly or indirectly, or
distribute the Prospectus or any other offering material relating to the Designated Securities, in or from any jurisdiction except under circumstances that will, to the best of the Underwriters&#8217; knowledge and belief, result in compliance with
the applicable laws and regulations and which will not impose any obligations on the Company. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Each of the Underwriters agrees to abide by
the offering restrictions as set forth under the following captions in the Prospectus: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;Underwriting&#8212;Notice to Prospective
Investors in the European Economic Area&#8221;, </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;Underwriting&#8212;Notice to Prospective Investors in the United Kingdom&#8221;,
&#8220;Underwriting&#8212;Notice to Prospective Investors in France&#8221;, </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;Underwriting&#8212;Notice to Prospective Investors in
Switzerland&#8221;, </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;Underwriting&#8212;Notice to Prospective Investors in Hong Kong&#8221;, &#8220;Underwriting&#8212;Notice to
Prospective Investors in Japan&#8221;, </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;Underwriting&#8212;Notice to Prospective Investors in Singapore&#8221;, </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;Underwriting&#8212;Notice to Prospective Investors in Canada&#8221;, </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;Underwriting&#8212;Notice to Prospective Investors in Taiwan&#8221;, </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;Underwriting&#8212;Notice to Prospective Investors in Korea&#8221;, </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;Underwriting&#8212;Notice to Prospective Investors in the United Arab Emirates (excluding the Dubai International Financial
Centre)&#8221; and </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">&#8220;Underwriting&#8212;Dubai International Financial Centre.&#8221; </P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Contact Information for Representatives for purposes of Section&nbsp;12 of the Underwriting Agreement: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Citigroup Global Markets Inc. </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">388 Greenwich Street </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">New York,
New York 10013 </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Attention: General Counsel </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Deutsche Bank Securities Inc. </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">1
Columbus Circle </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">New York, New York 10019 </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Attention: Debt Capital Markets Syndicate </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Email: dbcapmarkets.gcnotices@list.db.com </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">J.P. Morgan Securities LLC </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">270
Park Ave </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">New York, New York 10017 </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Attention:&nbsp;Investment Grade Syndicate Desk </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Fax: (212) <FONT STYLE="white-space:nowrap">834-6081</FONT> </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">Mizuho Securities USA LLC </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">1271
Avenue of the Americas </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">New York, New York 10020 </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Attention: Debt Capital Markets; </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Email: ba_dcm_notices@mizuhogroup.com </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Information furnished by the Underwriters for purposes of Sections 2(b), 2(c), 2(d), 2(e), 8(a), 8(b) and 16(c) of the Underwriting Agreement: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">The information in the last paragraph of the cover page of the Prospectus. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">The information set forth in the third, fourth and eighth paragraphs under the caption &#8220;Underwriting&#8221;. </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">The information in the third sentence of the tenth paragraph and the second sentence of the thirteenth paragraph under the caption
&#8220;Underwriting&#8221;. </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:Times New Roman">No other information in the Prospectus has been furnished by the Underwriters for use therein. </P>
</DIV></Center>

</BODY></HTML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.2
<SEQUENCE>4
<FILENAME>d80089dex42.htm
<DESCRIPTION>EX-4.2
<TEXT>
<HTML><HEAD>
<TITLE>EX-4.2</TITLE>
</HEAD>
 <BODY BGCOLOR="WHITE" STYLE="line-height:Normal">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right"><B>Exhibit 4.2 </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">PFIZER INC. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">and </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">THE BANK OF NEW YORK MELLON, </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">Trustee </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">SIXTH SUPPLEMENTAL
INDENTURE </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">Dated as of November&nbsp;21, 2025 </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">to </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">INDENTURE </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">Dated as of September&nbsp;7, 2018 </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">Floating Rate Notes due 2027 </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">3.875% Notes due 2027 </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">4.200% Notes
due 2030 </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">4.500% Notes due 2032 </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">4.875% Notes due 2035 </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">5.600% Notes
due 2055 </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">5.700% Notes due 2065 </P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>TABLE OF CONTENTS </B></P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">


<TR>

<TD WIDTH="96%"></TD>

<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>
<TD></TD>
<TD></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"><B>Page</B></TD>
<TD VALIGN="bottom">&nbsp;</TD></TR>


<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center">ARTICLE ONE</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center">DEFINITIONS</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;101. Definition of Terms</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">2</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center">ARTICLE TWO</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center">GENERAL TERMS AND CONDITIONS OF THE FLOATING RATE NOTES</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;201. Designation and Principal Amount</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">8</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;202. Maturity</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">8</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;203. Further Issues</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">8</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;204. Global Notes</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">8</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;205. Interest</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">8</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;206. SOFR Index Unavailable</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">10</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;207. Effect of a Benchmark Transition Event</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">10</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;208. Authorized Denominations</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">11</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;209. Redemption</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">11</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;210. Appointment of Agents</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">11</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center">ARTICLE THREE</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center">GENERAL TERMS AND CONDITIONS OF THE 2027 NOTES</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;301. Designation and Principal Amount</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">11</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;302. Maturity</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">12</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;303. Further Issues</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">12</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;304. Global Notes</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">12</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;305. Interest</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">12</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;306. Authorized Denominations</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">12</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;307. Redemption</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">12</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;308. Appointment of Agents</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">12</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center">ARTICLE FOUR</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center">GENERAL TERMS AND CONDITIONS OF THE 2030 NOTES</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;401. Designation and Principal Amount</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">13</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;402. Maturity</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">13</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;403. Further Issues</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">13</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;404. Global Notes</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">13</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;405. Interest</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">13</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;406. Authorized Denominations</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">13</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-i- </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">

<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">


<TR>

<TD WIDTH="97%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD></TD>
<TD></TD>
<TD></TD></TR>

<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;407. Redemption</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">13</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;408. Appointment of Agents</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">14</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center">ARTICLE FIVE</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center">GENERAL TERMS AND CONDITIONS OF THE 2032 NOTES</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;501. Designation and Principal Amount</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">14</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;502. Maturity</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">14</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;503. Further Issues</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">14</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;504. Global Notes</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">14</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;505. Interest</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">14</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;506. Authorized Denominations</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">15</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;507. Redemption</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">15</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;508. Appointment of Agents</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">15</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center">ARTICLE SIX</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center">GENERAL TERMS AND CONDITIONS OF THE 2035 NOTES</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;601. Designation and Principal Amount</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">15</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;602. Maturity</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">15</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;603. Further Issues</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">15</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;604. Global Notes</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">15</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;605. Interest</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">15</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;606. Authorized Denominations</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">16</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;607. Redemption</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">16</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;608. Appointment of Agents</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">16</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center">ARTICLE SEVEN</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center">GENERAL TERMS AND CONDITIONS OF THE 2055 NOTES</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;701. Designation and Principal Amount</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">16</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;702. Maturity</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">16</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;703. Further Issues</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">16</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;704. Global Notes</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">16</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;705. Interest</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">17</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;706. Authorized Denominations</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">17</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;707. Redemption</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">17</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;708. Appointment of Agents</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">17</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center">ARTICLE EIGHT</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center">GENERAL TERMS AND CONDITIONS OF THE 2065 NOTES</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;801. Designation and Principal Amount</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">17</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;802. Maturity</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">17</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">ii </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">

<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">


<TR>

<TD WIDTH="97%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD></TD>
<TD></TD>
<TD></TD></TR>

<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;803. Further Issues</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">17</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;804. Global Notes</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">17</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;805. Interest</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">18</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;806. Authorized Denominations</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">18</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;807. Redemption</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">18</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;808. Appointment of Agents</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">18</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center">ARTICLE NINE</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center">OPTIONAL REDEMPTION; NO SINKING FUND</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;901. Optional Redemption by Company</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">18</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;902. Par Call</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">19</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;903. No Sinking Fund</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">19</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center">ARTICLE TEN</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center">FORM OF NOTES</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;1001. Form of Floating Rate Note</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">19</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;1002. Form of 2027 Note</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">20</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;1003. Form of 2030 Note</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">20</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;1004. Form of 2032 Note</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">20</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;1005. Form of 2035 Note</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">20</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;1006. Form of 2055 Note</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">20</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;1007. Form of 2065 Note</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">20</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center">ARTICLE ELEVEN</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center">ORIGINAL ISSUE AMOUNT OF NOTES</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;1101. Original Issue Amount of the Floating Rate Notes</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">20</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;1102. Original Issue Amount of the 2027 Notes</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">20</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;1103. Original Issue Amount of the 2030 Notes</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">20</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;1104. Original Issue Amount of the 2032 Notes</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">21</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;1105. Original Issue Amount of the 2035 Notes</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">21</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;1106. Original Issue Amount of the 2055 Notes</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">21</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;1107. Original Issue Amount of the 2065 Notes</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">21</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center">ARTICLE TWELVE</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" ALIGN="center">MISCELLANEOUS</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;1201. Ratification of Indenture</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">21</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;1202. Trustee Not Responsible for Recitals</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">21</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;1203. Governing Law</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">21</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;1204. Separability</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">21</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;1205. Counterparts</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">22</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;1206. Trust Indenture Act</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">22</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Section&nbsp;1207. Signatures</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right">22</TD>
<TD NOWRAP VALIGN="bottom">&nbsp;</TD></TR>
</TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">iii </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">

<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">


<TR>

<TD WIDTH="9%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="90%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Exhibits</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Exhibit A</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">Form of Floating Rate Note</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Exhibit B</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">Form of 2027 Note</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Exhibit C</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">Form of 2030 Note</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Exhibit D</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">Form of 2032 Note</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Exhibit E</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">Form of 2035 Note</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Exhibit F</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">Form of 2055 Note</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Exhibit G</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">Form of 2065 Note</TD></TR>
</TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">iv </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">SIXTH SUPPLEMENTAL INDENTURE, dated as of November&nbsp;21, 2025 (the &#8220;Sixth
Supplemental Indenture&#8221;), between Pfizer Inc., a Delaware corporation (the &#8220;Company&#8221;), and The Bank of New York Mellon, a New York banking corporation, as trustee (the &#8220;Trustee&#8221;). </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">WHEREAS, the Company executed and delivered the indenture, dated as of September&nbsp;7, 2018, to the Trustee (the &#8220;Indenture&#8221;),
to provide for the issuance of the Company&#8217;s unsecured debentures, notes, bonds or other evidences of indebtedness (the &#8220;Securities&#8221;) in an unlimited aggregate principal amount to be issued from time to time in one or more series
as provided therein; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">WHEREAS, pursuant to Section&nbsp;14.01 of the Indenture, the Company desires to provide for the issuance of a new
series of its Securities to be known as its Floating Rate Notes due 2027 (the &#8220;Floating Rate Notes&#8221;), 3.875% Notes due 2027 (the &#8220;2027 Notes&#8221;), 4.200% Notes due 2030 (the &#8220;2030 Notes&#8221;), 4.500% Notes due 2032 (the
&#8220;2032 Notes&#8221;), 4.875% Notes due 2035 (the &#8220;2035 Notes&#8221;), 5.600% Notes due 2055 (the &#8220;2055 Notes&#8221;) and 5.700% Notes due 2065 (the &#8220;2065 Notes&#8221; and, together with the 2027 Notes, the 2030 Notes, the 2032
Notes, the 2035 Notes, the 2055 Notes, the &#8220;Fixed Rate Notes&#8221; and, the Fixed Rate Notes together with the Floating Rate Notes, the &#8220;Notes&#8221;) and to establish the forms and to set forth the terms of the Notes thereof, as
provided in Section&nbsp;3.01 of the Indenture; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">WHEREAS, the Board of Directors of the Company, pursuant to resolutions duly adopted, has
duly authorized the issuance of the Company&#8217;s debt securities and the Securities Issuance Committee of the Company, pursuant to a resolution duly adopted on November&nbsp;18, 2025, has duly authorized the issuance of $500,000,000 aggregate
principal amount of the Floating Rate Notes, $1,000,000,000 aggregate principal amount of 2027 Notes, $1,000,000,000 aggregate principal amount of 2030 Notes, $1,250,000,000 aggregate principal amount of 2032 Notes, $1,250,000,000 aggregate
principal amount of 2035 Notes, $500,000,000 aggregate principal amount of 2055 Notes and $500,000,000 aggregate principal amount of 2065 Notes and has authorized the proper officers of the Company to execute any and all appropriate documents
necessary or appropriate to effect such issuance; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">WHEREAS, the Company has requested that the Trustee execute and deliver this Sixth
Supplemental Indenture; and </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">WHEREAS, all things necessary to make this Sixth Supplemental Indenture a valid agreement of the Company, in
accordance with its terms, and to make the Notes, when executed by the Company and authenticated and delivered by the Trustee, the valid obligations of the Company, have been done; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">NOW THEREFORE, in consideration of the premises and the purchase and acceptance of the Notes by the Holders thereof, and for the purpose of
setting forth, as provided in the Indenture, the forms and terms of the Notes, it is mutually covenanted and agreed, for the equal and proportionate benefit of all Holders of the Notes, as follows: </P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE ONE </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>DEFINITIONS </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;101. <U>Definition of Terms</U>. Unless the context otherwise requires: </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) each term defined in the Indenture has the same meaning when used in this Sixth Supplemental Indenture; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) each term defined anywhere in this Sixth Supplemental Indenture has the same meaning throughout; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) the singular includes the plural and vice versa; and </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(d) headings are for convenience of reference only and do not affect interpretation. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(e) the following terms have the meanings given to them in this Section&nbsp;101(e): </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;Benchmark&#8221; means, initially, Compounded SOFR; provided that if the Company or its designee determine on or prior to the Reference
Time that a Benchmark Transition Event and its related Benchmark Replacement Date have occurred with respect to Compounded SOFR (or the published daily SOFR Index used in the calculation thereof) or the then-current Benchmark, then
&#8220;Benchmark&#8221; means the applicable Benchmark Replacement. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;Benchmark Replacement&#8221; means the first alternative set
forth in the order below that can be determined by the Company or its designee as of the Benchmark Replacement Date: </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(1) the sum of
(a)&nbsp;the alternate rate of interest that has been selected or recommended by the Relevant Governmental Body as the replacement for the then-current Benchmark and (b)&nbsp;the Benchmark Replacement Adjustment; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(2) the sum of (a)&nbsp;the ISDA Fallback Rate and (b)&nbsp;the Benchmark Replacement Adjustment; or </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(3) the sum of (a)&nbsp;the alternate rate of interest that has been selected by the Company or its designee as the replacement for the
then-current Benchmark giving due consideration to any industry-accepted rate of interest as a replacement for the then-current Benchmark for U.S. dollar-denominated floating rate notes at such time and (b)&nbsp;the Benchmark Replacement Adjustment.
</P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-2- </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;Benchmark Replacement Adjustment&#8221; means the first alternative set forth in the
order below that can be determined by the Company or its designee as of the Benchmark Replacement Date: </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(1) the spread adjustment, or
method for calculating or determining such spread adjustment (which may be a positive or negative value or zero), that has been selected or recommended by the Relevant Governmental Body for the applicable Unadjusted Benchmark Replacement; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(2) if the applicable Unadjusted Benchmark Replacement is equivalent to the ISDA Fallback Rate, the ISDA Fallback Adjustment; or </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(3) the spread adjustment (which may be a positive or negative value or zero) that has been selected by the Company or its designee giving due
consideration to any industry-accepted spread adjustment, or method for calculating or determining such spread adjustment, for the replacement of the then-current Benchmark with the applicable Unadjusted Benchmark Replacement for U.S.
dollar-denominated floating rate notes at such time. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;Benchmark Replacement Conforming Changes&#8221; means, with respect to any
Benchmark Replacement, any technical, administrative or operational changes (including changes to the definition of the Interest Period, timing and frequency of determining rates and making payments of interest, rounding of amounts or tenors and
other administrative matters) that the Company or its designee decide may be appropriate to reflect the adoption of such Benchmark Replacement in a manner substantially consistent with market practice (or, if the Company or its designee decide that
adoption of any portion of such market practice is not administratively feasible or if the Company or its designee determine that no market practice for use of the Benchmark Replacement exists, in such other manner as the Company or its designee
determine is reasonably necessary). </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;Benchmark Replacement Date&#8221; means the earliest to occur of the following events with
respect to the then-current Benchmark (including the daily published component used in the calculation thereof): </P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="9%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left">(1)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">in the case of clause (1)&nbsp;or (2) of the definition of &#8220;Benchmark Transition Event,&#8221; the later
of (a)&nbsp;the date of the public statement or publication of information referenced therein and (b)&nbsp;the date on which the administrator of the Benchmark permanently or indefinitely ceases to provide the Benchmark (or such component); or
</P></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="9%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left">(2)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">in the case of clause (3)&nbsp;of the definition of &#8220;Benchmark Transition Event,&#8221; the date of the
public statement or publication of information referenced therein. </P></TD></TR></TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;Benchmark Transition Event&#8221; means the
occurrence of one or more of the following events with respect to the then-current Benchmark (including the daily published component used in the calculation thereof): </P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="9%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left">(1)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">a public statement or publication of information by or on behalf of the administrator of the Benchmark (or such
component) announcing that such administrator has ceased or will cease to provide the Benchmark (or such component), permanently or indefinitely; provided that, at the time of such statement or publication, there is no successor administrator that
will continue to provide the Benchmark (or such component); </P></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-3- </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">

<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="9%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left">(2)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">a public statement or publication of information by the regulatory supervisor for the administrator of the
Benchmark (or such component), the central bank for the currency of the Benchmark (or such component), an insolvency official with jurisdiction over the administrator for the Benchmark (or such component), a resolution authority with jurisdiction
over the administrator for the Benchmark (or such component) or a court or an entity with similar insolvency or resolution authority over the administrator for the Benchmark, which states that the administrator of the Benchmark (or such component)
has ceased or will cease to provide the Benchmark (or such component) permanently or indefinitely; provided that, at the time of such statement or publication, there is no successor administrator that will continue to provide the Benchmark (or such
component); or </P></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="9%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left">(3)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">a public statement or publication of information by the regulatory supervisor for the administrator of the
Benchmark announcing that the Benchmark is no longer representative. </P></TD></TR></TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;Compounded SOFR&#8221; means, with respect
to any Interest Period, the rate computed in accordance with the following formula set forth below (and the resulting percentage will be rounded, if necessary, to the nearest one hundred-thousandth of a percentage point (e.g., 9.753973% (or
.09753973) being rounded down to 9.75397% (or .0975397) and 9.753978% (or .09753978) being rounded up to 9.75398% (or .0975398)): </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt;margin-bottom:0pt; text-indent:9%">


<IMG SRC="g80089g1121085102404.jpg" ALT="LOGO">
 </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;dc&#8221; is the actual number of calendar days from (and including) SOFR IndexStart to (but
excluding) SOFR IndexEnd (the actual number of calendar days in the applicable Observation Period). </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;Initial Interest Period&#8221;
means the period from and including the date of this Supplemental Indenture to, but excluding, the first Floating Rate Interest Payment Date. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;Interest Determination Date&#8221; means, with respect to any Interest Period, the second U.S. Government Securities Business Day
preceding such Floating Rate Interest Payment Date. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-4- </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;Interest Period&#8221; means, after the Initial Interest Period, the period from and
including a Floating Rate Interest Payment Date for the Floating Rate Notes to, but excluding, the immediately succeeding Floating Rate Interest Payment Date for such Floating Rate Notes (such succeeding Floating Rate Interest Payment Date, the
&#8220;Latter Floating Rate Interest Payment Date&#8221;); provided that the final Interest Period for the Floating Rate Notes will be the period from and including the Floating Rate Interest Payment Date immediately preceding the maturity date of
the Floating Rate Notes to, but excluding, the maturity date. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;ISDA Definitions&#8221; means the 2006 ISDA Definitions published by
the International Swaps and Derivatives Association, Inc. or any successor thereto, as amended or supplemented from time to time, or any successor definitional booklet for interest rate derivatives published from time to time. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;ISDA Fallback Adjustment&#8221; means the spread adjustment (which may be a positive or negative value or zero) that would apply for
derivatives transactions referencing the ISDA Definitions to be determined upon the occurrence of an index cessation event with respect to the Benchmark for the applicable tenor. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;ISDA Fallback Rate&#8221; means the rate that would apply for derivatives transactions referencing the ISDA Definitions to be effective
upon the occurrence of an index cessation date with respect to the Benchmark for the applicable tenor excluding the applicable ISDA Fallback Adjustment. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;New York Federal Reserve&#8221; means the Federal Reserve Bank of New York (or a successor administrator of the Secured Overnight
Financing Rate). </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;New York Federal Reserve&#8217;s Website&#8221; means the website of the New York Federal Reserve, currently at
http://www.newyorkfed.org, or any successor source. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;Observation Period&#8221; means, in respect of each Interest Period, the
period from and including two U.S. Government Securities Business Days preceding the first date of such relevant Interest Period to but excluding two U.S. Government Securities Business Days preceding the Latter Floating Rate Interest Payment Date;
provided that the first Observation Period shall be the period from and including two U.S. Government Securities Business Days preceding the date hereof to, but excluding, the two U.S. Government Securities Business Days preceding the first Floating
Rate Interest Payment Date. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;Par Call Date&#8221; means (i)&nbsp;in the case of the 2030 Notes, October&nbsp;15, 2030, (ii) in the
case of the 2032 Notes, September&nbsp;15, 2032, (iii) in the case of the 2035 Notes, August&nbsp;15, 2035, (iv) in the case of the 2055 Notes, May&nbsp;15, 2055 and (v)&nbsp;in the case of the 2065 Notes, May&nbsp;15, 2065. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;Reference Time&#8221; with respect to any determination of the Benchmark means (1)&nbsp;if the Benchmark is Compounded SOFR, the SOFR
Determination Time, and (2)&nbsp;if the Benchmark is not Compounded SOFR, the time determined by the Company or its designee after giving effect to the Benchmark Replacement Conforming Changes. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-5- </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;Relevant Governmental Body&#8221; means the Federal Reserve Board and/or the Federal
Reserve Bank of New York, or a committee officially endorsed or convened by the Federal Reserve Board and/or the Federal Reserve Bank of New York or any successor thereto. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;Secured Overnight Financing Rate&#8221; or &#8220;SOFR&#8221; means the daily secured overnight financing rate as provided by the New
York Federal Reserve on the New York Federal Reserve&#8217;s Website. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;SOFR Index&#8221; means, with respect to any U.S. Government
Securities Business Day: </P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="9%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left">(1)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">SOFR Index value as published by the New York Federal Reserve as such index appears on the New York Federal
Reserve&#8217;s Website at 3:00 p.m. (New York time) on such U.S. Government Securities Business Day (the &#8220;SOFR Determination Time&#8221;); provided that: </P></TD></TR></TABLE>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="9%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left">(2)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">if a SOFR Index value does not so appear as specified in clause (1)&nbsp;above at the SOFR Determination Time,
then: </P></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="13%">&nbsp;</TD>
<TD WIDTH="5%" VALIGN="top" ALIGN="left">(i)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">a Benchmark Transition Event and its related Benchmark Replacement Date have not occurred with respect to SOFR,
then Compounded SOFR shall be the rate determined pursuant to Section&nbsp;206; or </P></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="13%">&nbsp;</TD>
<TD WIDTH="5%" VALIGN="top" ALIGN="left">(ii)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">a Benchmark Transition Event and its related Benchmark Replacement Date have occurred with respect to SOFR,
then Compounded SOFR shall be the rate determined pursuant to Section&nbsp;207. </P></TD></TR></TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;SOFR IndexStart&#8221; is the
SOFR Index value for the day that is two U.S. Government Securities Business Days preceding the first date of the relevant Interest Period; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;SOFR IndexEnd&#8221; is the SOFR Index value for the day that is two U.S. Government Securities Business Days preceding the Latter
Floating Rate Interest Payment Date relating to such Interest Period; and </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;Treasury Rate&#8221; means, with respect to any
Redemption Date, the yield determined by the Company in accordance with the following two paragraphs: </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-6- </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">The Treasury Rate shall be determined by the Company after 4:15 p.m., New York City time (or
after such time as yields on U.S. government securities are posted daily by the Board of Governors of the Federal Reserve System), on the third Business Day preceding the Redemption Date based upon the yield or yields for the most recent day that
appear after such time on such day in the most recent statistical release published by the Board of Governors of the Federal Reserve System designated as &#8220;Selected Interest Rates (Daily)&#8212;H.15&#8221; (or any successor designation or
publication) (&#8220;H.15&#8221;) under the caption &#8220;U.S. government securities&#8211;Treasury constant maturities&#8211;Nominal&#8221; (or any successor caption or heading). In determining the Treasury Rate, the Company shall select, as
applicable: (1)&nbsp;the yield for the Treasury constant maturity on H.15 exactly equal to the period from the Redemption Date to the applicable Par Call Date (or in the case of the 2027 Notes their Stated Maturity) (the &#8220;Remaining
Life&#8221;); (2) if there is no such Treasury constant maturity on H.15 exactly equal to the applicable Remaining Life, the two yields &#8211; one yield corresponding to the Treasury constant maturity on H.15 immediately shorter than and one yield
corresponding to the Treasury constant maturity on H.15 immediately longer than the applicable Remaining Life &#8211; and shall interpolate to the applicable Par Call Date (or in the case of the 2027 Notes their Stated Maturity) on a straight-line
basis (using the actual number of days) using such yields and rounding the result to three decimal places; or (3)&nbsp;if there is no such Treasury constant maturity on H.15 shorter than or longer than the applicable Remaining Life, the yield for
the single Treasury constant maturity on H.15 closest to the applicable Remaining Life. For purposes of this paragraph, the applicable Treasury constant maturity or maturities on H.15 shall be deemed to have a maturity date equal to the relevant
number of months or years, as applicable, of such Treasury constant maturity from the Redemption Date. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">If on the third Business Day
preceding the Redemption Date H.15 TCM is no longer published, the Company shall calculate the applicable Treasury Rate based on the rate per annum equal to the semi-annual equivalent yield to maturity at 11:00 a.m., New York City time, on the
second Business Day preceding such Redemption Date of the United States Treasury security maturing on, or with a maturity that is closest to, the applicable Par Call Date or, in the case of the 2027 Notes, their Stated Maturity, as applicable. If
there is no United States Treasury security maturing on the applicable Par Call Date (or in the case of the 2027 Notes their Stated Maturity) but there are two or more United States Treasury securities with a maturity date equally distant from the
applicable Par Call Date or such Stated Maturity, as applicable, one with a maturity date preceding the applicable Par Call Date or such Stated Maturity, as applicable, and one with a maturity date following the applicable Par Call Date or such
Stated Maturity, as applicable,, the Company shall select the United States Treasury security with a maturity date preceding the applicable Par Call Date or such Stated Maturity, as applicable. If there are two or more United States Treasury
securities maturing on the applicable Par Call Date (or in the case of the 2027 Notes their Stated Maturity) or two or more United States Treasury securities meeting the criteria of the preceding sentence, the Company shall select from among these
two or more United States Treasury securities the United States Treasury security that is trading closest to par based upon the average of the bid and asked prices for such United States Treasury securities at 11:00 a.m., New York City time. In
determining the applicable Treasury Rate in accordance with the terms of this paragraph, the semi-annual yield to maturity of the applicable United States Treasury security shall be based upon the average of the bid and asked prices (expressed as a
percentage of principal amount) at 11:00 a.m., New York City time, of such United States Treasury security, and rounded to three decimal places. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;Unadjusted Benchmark Replacement&#8221; means the Benchmark Replacement excluding the Benchmark Replacement Adjustment. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-7- </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">&#8220;U.S. Government Securities Business Day&#8221; means any day except for a Saturday,
Sunday or a day on which the Securities Industry and Financial Markets Association recommends that the fixed income departments of its members be closed for the entire day for purposes of trading in U.S. government securities. </P>
<P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE TWO </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>GENERAL
TERMS AND CONDITIONS OF THE FLOATING RATE NOTES </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;201. <U>Designation and Principal Amount</U>. There is hereby authorized
and established a series of Securities under the Indenture, designated as the &#8220;Floating Rate Notes due 2027&#8221;, which is not limited in aggregate principal amount. The aggregate principal amount of the Floating Rate Notes to be issued on
the date hereof is set forth in Article Eleven herein. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;202. <U>Maturity</U>. The Stated Maturity of principal of the
Floating Rate Notes is November 15, 2027. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;203. <U>Further Issues</U>. The Company may from time to time, without the consent
of the Holders of the Floating Rate Notes, issue additional Floating Rate Notes. Any such additional Floating Rate Notes will have the same ranking, interest rate, maturity date and other terms as the Floating Rate Notes herein provided for. Any
such additional Floating Rate Notes, together with the Floating Rate Notes herein provided for, will constitute a single series of Securities under the Indenture. No additional Floating Rate Notes may be issued if an Event of Default has occurred
and is continuing with respect to the Floating Rate Notes. The Company will not issue any additional Floating Rate Notes intended to form a single series with the Floating Rate Notes herein provided for unless such additional Notes will be fungible
with the Floating Rate Notes herein provided for U.S. federal income tax purposes. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;204. <U>Global Notes</U>. Upon their
original issuance, the Floating Rate Notes will be represented by one or more Global Securities registered in the name of Cede&nbsp;&amp; Co., the nominee of The Depository Trust Company (&#8220;DTC&#8221;). The Company will deposit the Global
Securities with DTC or its custodian and register the Global Securities in the name of Cede&nbsp;&amp; Co. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;205.
<U>Interest</U>. The Floating Rate Notes will bear interest (computed on the basis of the actual number of days elapsed over a <FONT STYLE="white-space:nowrap">360-day</FONT> year) at a floating rate, reset quarterly on each Floating Rate Interest
Payment Date, equal to Compounded SOFR, plus 0.500% per annum. In no event will the interest on the Floating Rate Notes be less than zero. Interest on the Floating Rate Notes will be payable quarterly in arrears on each Floating Rate Interest
Payment Date, to holders of record on the applicable Record Date; the dates on which such interest shall be payable are February&nbsp;15, May&nbsp;15, August&nbsp;15 and November&nbsp;15 in each year, beginning on February&nbsp;15, 2026 (each, a
&#8220;Floating Rate Interest Payment Date&#8221;); and the Record Date for the interest payable on any Floating Rate Interest Payment Date is the close of business on the February&nbsp;1, May&nbsp;1, August&nbsp;1 and
</P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-8- </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">
November&nbsp;1 (whether or not a Business Day) immediately preceding the relevant Floating Rate Interest Payment Date. Interest on the Floating Rate Notes will accrue from and including the most
recent Floating Rate Interest Payment Date or, if no interest has been paid, from the date hereof. If the Floating Rate Interest Payment Date is not a Business Day, then the next succeeding Business Day will be the applicable Floating Rate Interest
Payment Date and interest accrued and payable on the Floating Rate Notes will be paid on such next succeeding Business Day (unless such next succeeding Business Day falls in the succeeding calendar month, in which case the applicable Floating Rate
Interest Payment Date will be the Business Day immediately preceding such Floating Rate Interest Payment Date and interest on the Floating Rate Notes will be paid on such immediately preceding Business Day). If the maturity date of the Floating Rate
Notes is not a Business Day, the payment of principal of, and interest on, the Floating Rate Notes will be made on the next succeeding Business Day, and no interest will accrue for the period from and after the maturity date. The amount of interest
accrued and payable on the Floating Rate Notes for each Interest Period will be equal to the product of (i)&nbsp;the outstanding principal amount of the Floating Rate Notes multiplied by (ii)&nbsp;the product of (a)&nbsp;the interest rate for the
relevant Interest Period multiplied by (b)&nbsp;the quotient of the actual number of calendar days in such Interest Period divided by 360. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">The interest rate and amount of interest to be paid on the Floating Rate Notes for each interest period will be determined by the Calculation
Agent. The Bank of New York Mellon will initially serve as the Calculation Agent. All determinations made by the Calculation Agent shall, in the absence of willful misconduct or manifest error, be conclusive for all purposes and binding on the
Company and the Holders of the Floating Rate Notes. So long as Compounded SOFR is required to be determined with respect to the Floating Rate Notes, there will at all times be a calculation agent. In the event that any then acting calculation agent
shall be unable or unwilling to act, or that such calculation agent shall fail duly to establish Compounded SOFR for any interest period, or the Company proposes to remove such calculation agent, the Company shall appoint another calculation agent.
None of the Trustee, the Paying Agent, nor the Calculation Agent shall have any duty or liability in connection with the determination of any Benchmark Transition Event, Benchmark Replacement, Benchmark Replacement Conforming Changes, or any other
related matter as provided in this Article Two. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">None of the Trustee, the Paying Agent, or the Calculation Agent shall be under any
obligation (i)&nbsp;to monitor, determine or verify the unavailability or cessation of SOFR or the SOFR Index or any other Benchmark, or whether or when there has occurred, or to give notice to any other transaction party of the occurrence of, any
Benchmark Transition Event or related Benchmark Replacement Date, (ii)&nbsp;to select, determine or designate any Benchmark Replacement, or other successor or replacement benchmark index, or to determine whether any conditions to the designation of
such a rate or index have been satisfied, (iii)&nbsp;to select, determine or designate any Benchmark Replacement Adjustment or Unadjusted Benchmark Replacement, or other modifier to any replacement or successor index, or (iv)&nbsp;to determine
whether or what Benchmark Replacement Conforming Changes are necessary or advisable, if any, in connection with any of the foregoing, including, but not limited to, as to any spread adjustment thereon, the business day convention, interest
determination dates or any other relevant methodology applicable to such substitute or successor Benchmark. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-9- </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">
In connection with the foregoing, each of the Trustee, the Paying Agent and the Calculation Agent shall be entitled to conclusively rely on any determinations made by the Company or its designee
without independent investigation, and none will have any liability for actions taken at the Company&#8217;s direction in connection therewith. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">None of the Trustee, the Paying Agent or the Calculation Agent shall be liable for any inability, failure or delay on its part to perform any
of its duties set forth in this Sixth Supplemental Indenture as a result of the unavailability of SOFR, the SOFR Index or other applicable Benchmark Replacement, including as a result of any failure, inability, delay, error or inaccuracy on the part
of any other transaction party in providing any direction, instruction, notice or information required or contemplated by the terms of this Sixth Supplemental Indenture and reasonably required for the performance of such duties. In connection with
any determination made hereunder, none of the Trustee, the Paying Agent or the Calculation Agent shall be responsible or liable for the Company&#8217;s actions or omissions or those of its designee, or for any failure or delay in the performance by
Pfizer or its designee, nor shall any of the Trustee, the Paying Agent or the Calculation Agent be under any obligation to oversee or monitor the Company&#8217;s performance or that of its designee. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;206. <U>SOFR Index Unavailable</U>. If a SOFR IndexStart or SOFR IndexEnd is not published on the associated Interest
Determination Date and a Benchmark Transition Event and its related Benchmark Replacement Date have not occurred with respect to the Secured Overnight Financing Rate, &#8220;Compounded SOFR&#8221; means, for the applicable Interest Period for which
such index is not available, the rate of return on a daily compounded interest investment calculated in accordance with the formula for SOFR Averages, and definitions required for such formula, published on the New York Federal Reserve&#8217;s
Website at https://www.newyorkfed.org/markets/treasury-repo-reference-rates-information. For the purposes of this provision, references in the SOFR Averages compounding formula and related definitions to &#8220;calculation period&#8221; shall be
replaced with &#8220;Observation Period&#8221; and the words &#8220;that is, <FONT STYLE="white-space:nowrap">30-,</FONT> <FONT STYLE="white-space:nowrap">90-,</FONT> or <FONT STYLE="white-space:nowrap">180-calendar</FONT> days&#8221; shall be
removed. If the daily Secured Overnight Financing Rate (&#8220;SOFRi&#8221;) does not so appear for any day, &#8220;i&#8221; in the Observation Period, SOFRi for such day &#8220;i&#8221; shall be SOFR published in respect of the first preceding U.S.
Government Securities Business Day for which the Secured Overnight Financing Rate was published on the New York Federal Reserve&#8217;s Website. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;207. <U>Effect of a Benchmark Transition Event</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) If the Company or its designee determine on or prior to the relevant Reference Time that a Benchmark Transition Event and its related
Benchmark Replacement Date have occurred with respect to the then-current Benchmark, the Benchmark Replacement will replace the then-current Benchmark for all purposes relating to the Floating Rate Notes in respect of all determinations on such date
and for all determinations on all subsequent dates. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-10- </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) In connection with the implementation of a Benchmark Replacement, the Company or its
designee will have the right to make Benchmark Replacement Conforming Changes from time to time. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) Any determination, decision or
election that may be made by the Company or its designee pursuant to this Section&nbsp;207, including a determination with respect to a tenor, rate or adjustment or of the occurrence or <FONT STYLE="white-space:nowrap">non-occurrence</FONT> of an
event, circumstance or date and any decision to take or refrain from taking any action or any selection: </P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="13%">&nbsp;</TD>
<TD WIDTH="5%" VALIGN="top" ALIGN="left">(i)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">will be conclusive and binding absent manifest error; </P></TD></TR></TABLE>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="13%">&nbsp;</TD>
<TD WIDTH="5%" VALIGN="top" ALIGN="left">(ii)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">will be made in the sole discretion of the Company or its designee; and </P></TD></TR></TABLE>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="13%">&nbsp;</TD>
<TD WIDTH="5%" VALIGN="top" ALIGN="left">(iii)</TD>
<TD ALIGN="left" VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman; " ALIGN="left">notwithstanding anything to the contrary in the documentation relating to the Floating Rate Notes, shall become
effective without consent from the holders of the Floating Rate Notes or any other party. </P></TD></TR></TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(d) If the event that gives
rise to the Benchmark Replacement Date occurs on the same day as, but earlier than, the Reference Time in respect of any determination, the Benchmark Replacement Date will be deemed to have occurred prior to the Reference Time for such
determination. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(e) For purposes of the definitions of Benchmark Replacement Date and Benchmark Transition Event, references to Benchmark
also include any reference rate underlying such Benchmark. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;208. <U>Authorized Denominations</U>. The Notes shall be issuable
in denominations of $2,000 and integral multiples of $1,000 in excess thereof. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;209. <U>Redemption</U>. The Floating Rate
Notes are not subject to redemption at the option of the Company. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;210. <U>Appointment of Agents</U>. The Trustee will
initially be the Registrar and Paying Agent for the Notes and will act as such only at its corporate trust offices in the Borough of Manhattan, City of New York. </P>
<P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE THREE </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>GENERAL
TERMS AND CONDITIONS OF THE 2027 NOTES </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;301. <U>Designation and Principal Amount</U>. There is hereby authorized and
established a series of Securities under the Indenture, designated as the &#8220;3.875% Notes due 2027&#8221;, which is not limited in aggregate principal amount. The aggregate principal amount of the 2027 Notes to be issued on the date hereof is
set forth in Article Eleven herein. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-11- </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;302. <U>Maturity</U>. The Stated Maturity of principal of the 2027 Notes is
November&nbsp;15, 2027. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;303. <U>Further Issues</U>. The Company may from time to time, without the consent of the Holders of
the 2027 Notes, issue additional 2027 Notes. Any such additional 2027 Notes will have the same ranking, interest rate, maturity date and other terms as the 2027 Notes herein provided for. Any such additional 2027 Notes, together with the 2027 Notes
herein provided for, will constitute a single series of Securities under the Indenture. No additional 2027 Notes may be issued if an Event of Default has occurred and is continuing with respect to the 2027 Notes. The Company will not issue any
additional 2027 Notes intended to form a single series with the 2027 Notes herein provided for unless such additional 2027 Notes will be fungible with the Notes herein provided for U.S. federal income tax purposes. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;304. <U>Global Notes</U>. Upon their original issuance, the 2027 Notes will be represented by one or more Global Securities
registered in the name of Cede&nbsp;&amp; Co., the nominee of The Depository Trust Company (&#8220;DTC&#8221;). The Company will deposit the Global Securities with DTC or its custodian and register the Global Securities in the name of
Cede&nbsp;&amp; Co. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;305. <U>Interest</U>. The 2027 Notes will bear interest (computed on the basis of a <FONT
STYLE="white-space:nowrap">360-day</FONT> year consisting of twelve <FONT STYLE="white-space:nowrap">30-day</FONT> months) from November 21, 2025 at the rate of 3.875% per annum, payable semiannually in arrears; interest payable on each Interest
Payment Date will include interest accrued from November 21, 2025, or from the most recent Interest Payment Date to which interest has been paid or duly provided for; the Interest Payment Dates on which such interest shall be payable are May 15 and
November 15, beginning on May 15, 2026; and the Record Date for the interest payable on any Interest Payment Date is the close of business on the May 1 and November 1 (whether or not a Business Day) immediately preceding the relevant Interest
Payment Date. If any Interest Payment Date falls on a day that is not a Business Day, the required payment on that day will be due on the next succeeding Business Day as if made on the date the payment was due, and no interest will accrue on that
payment for the period from and after that Interest Payment Date to the date of payment on the next succeeding Business Day. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;306. <U>Authorized Denominations</U>. The Notes shall be issuable in denominations of $2,000 and integral multiples of $1,000 in
excess thereof. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;307. <U>Redemption</U>. The 2027 Notes are subject to redemption at the option of the Company as described
in Article Nine hereof. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;308. <U>Appointment of Agents</U>. The Trustee will initially be the Registrar and Paying Agent for
the Notes and will act as such only at its corporate trust offices in the Borough of Manhattan, City of New York. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-12- </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE FOUR </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>GENERAL TERMS AND CONDITIONS OF THE 2030 NOTES </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;401. <U>Designation and Principal Amount</U>. There is hereby authorized and established a series of Securities under the
Indenture, designated as the &#8220;4.200% Notes due 2030&#8221;, which is not limited in aggregate principal amount. The aggregate principal amount of the 2030 Notes to be issued on the date hereof is set forth in Article Eleven herein. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;402. <U>Maturity</U>. The Stated Maturity of principal of the 2030 Notes is November&nbsp;15, 2030. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;403. <U>Further Issues</U>. The Company may from time to time, without the consent of the Holders of the 2030 Notes, issue
additional 2030 Notes. Any such additional 2030 Notes will have the same ranking, interest rate, maturity date and other terms as the 2030 Notes herein provided for. Any such additional 2030 Notes, together with the 2030 Notes herein provided for,
will constitute a single series of Securities under the Indenture. No additional 2030 Notes may be issued if an Event of Default has occurred and is continuing with respect to the 2030 Notes. The Company will not issue any additional 2030 Notes
intended to form a single series with the 2030 Notes herein provided for unless such additional 2030 Notes will be fungible with the Notes herein provided for U.S. federal income tax purposes. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;404. <U>Global Notes</U>. Upon their original issuance, the 2030 Notes will be represented by one or more Global Securities
registered in the name of Cede&nbsp;&amp; Co., the nominee of The Depository Trust Company (&#8220;DTC&#8221;). The Company will deposit the Global Securities with DTC or its custodian and register the Global Securities in the name of
Cede&nbsp;&amp; Co. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;405. <U>Interest</U>. The 2030 Notes will bear interest (computed on the basis of a <FONT
STYLE="white-space:nowrap">360-day</FONT> year consisting of twelve <FONT STYLE="white-space:nowrap">30-day</FONT> months) from November 21, 2025 at the rate of 4.200% per annum, payable semiannually in arrears; interest payable on each Interest
Payment Date will include interest accrued from November 21, 2025, or from the most recent Interest Payment Date to which interest has been paid or duly provided for; the Interest Payment Dates on which such interest shall be payable are May 15 and
November 15, beginning on May 15, 2026; and the Record Date for the interest payable on any Interest Payment Date is the close of business on the May 1 and November 1 (whether or not a Business Day) immediately preceding the relevant Interest
Payment Date. If any Interest Payment Date falls on a day that is not a Business Day, the required payment on that day will be due on the next succeeding Business Day as if made on the date the payment was due, and no interest will accrue on that
payment for the period from and after that Interest Payment Date to the date of payment on the next succeeding Business Day. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;406. <U>Authorized Denominations</U>. The Notes shall be issuable in denominations of $2,000 and integral multiples of $1,000 in
excess thereof. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;407. <U>Redemption</U>. The 2030 Notes are subject to redemption at the option of the Company as described
in Article Nine hereof. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-13- </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;408. <U>Appointment of Agents</U>. The Trustee will initially be the Registrar
and Paying Agent for the Notes and will act as such only at its corporate trust offices in the Borough of Manhattan, City of New York. </P>
<P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE FIVE </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>GENERAL
TERMS AND CONDITIONS OF THE 2032 NOTES </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;501. <U>Designation and Principal Amount</U>. There is hereby authorized and
established a series of Securities under the Indenture, designated as the &#8220;4.500% Notes due 2032&#8221;, which is not limited in aggregate principal amount. The aggregate principal amount of the 2032 Notes to be issued on the date hereof is
set forth in Article Eleven herein. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;502. <U>Maturity</U>. The Stated Maturity of principal of the 2032 Notes is
November&nbsp;15, 2032. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;503. <U>Further Issues</U>. The Company may from time to time, without the consent of the Holders of
the 2032 Notes, issue additional 2032 Notes. Any such additional 2032 Notes will have the same ranking, interest rate, maturity date and other terms as the 2032 Notes herein provided for. Any such additional 2032 Notes, together with the 2032 Notes
herein provided for, will constitute a single series of Securities under the Indenture. No additional 2032 Notes may be issued if an Event of Default has occurred and is continuing with respect to the 2032 Notes. The Company will not issue any
additional 2032 Notes intended to form a single series with the 2032 Notes herein provided for unless such additional 2032 Notes will be fungible with the Notes herein provided for U.S. federal income tax purposes. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;504. <U>Global Notes</U>. Upon their original issuance, the 2032 Notes will be represented by one or more Global Securities
registered in the name of Cede&nbsp;&amp; Co., the nominee of The Depository Trust Company (&#8220;DTC&#8221;). The Company will deposit the Global Securities with DTC or its custodian and register the Global Securities in the name of
Cede&nbsp;&amp; Co. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;505. <U>Interest</U>. The 2032 Notes will bear interest (computed on the basis of a <FONT
STYLE="white-space:nowrap">360-day</FONT> year consisting of twelve <FONT STYLE="white-space:nowrap">30-day</FONT> months) from November 21, 2025 at the rate of 4.500% per annum, payable semiannually in arrears; interest payable on each Interest
Payment Date will include interest accrued from November 21, 2025, or from the most recent Interest Payment Date to which interest has been paid or duly provided for; the Interest Payment Dates on which such interest shall be payable are May 15 and
November 15, beginning on May 15, 2026; and the Record Date for the interest payable on any Interest Payment Date is the close of business on the May 1 and November 1 (whether or not a Business Day) immediately preceding the relevant Interest
Payment Date. If any Interest Payment Date falls on a day that is not a Business Day, the required payment on that day will be due on the next succeeding Business Day as if made on the date the payment was due, and no interest will accrue on that
payment for the period from and after that Interest Payment Date to the date of payment on the next succeeding Business Day. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-14- </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;506. <U>Authorized Denominations</U>. The Notes shall be issuable in
denominations of $2,000 and integral multiples of $1,000 in excess thereof. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;507. <U>Redemption</U>. The 2032 Notes are
subject to redemption at the option of the Company as described in Article Nine hereof. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;508. <U>Appointment of Agents</U>.
The Trustee will initially be the Registrar and Paying Agent for the Notes and will act as such only at its corporate trust offices in the Borough of Manhattan, City of New York. </P>
<P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE SIX </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>GENERAL
TERMS AND CONDITIONS OF THE 2035 NOTES </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;601. <U>Designation and Principal Amount</U>. There is hereby authorized and
established a series of Securities under the Indenture, designated as the &#8220;4.875% Notes due 2035&#8221;, which is not limited in aggregate principal amount. The aggregate principal amount of the 2035 Notes to be issued on the date hereof is
set forth in Article Eleven herein. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;602. <U>Maturity</U>. The Stated Maturity of principal of the 2035 Notes is
November&nbsp;15, 2035. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;603. <U>Further Issues</U>. The Company may from time to time, without the consent of the Holders of
the 2035 Notes, issue additional 2035 Notes. Any such additional 2035 Notes will have the same ranking, interest rate, maturity date and other terms as the 2035 Notes herein provided for. Any such additional 2035 Notes, together with the 2035 Notes
herein provided for, will constitute a single series of Securities under the Indenture. No additional 2035 Notes may be issued if an Event of Default has occurred and is continuing with respect to the 2035 Notes. The Company will not issue any
additional 2035 Notes intended to form a single series with the 2035 Notes herein provided for unless such additional 2035 Notes will be fungible with the Notes herein provided for U.S. federal income tax purposes. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;604. <U>Global Notes</U>. Upon their original issuance, the 2035 Notes will be represented by one or more Global Securities
registered in the name of Cede&nbsp;&amp; Co., the nominee of The Depository Trust Company (&#8220;DTC&#8221;). The Company will deposit the Global Securities with DTC or its custodian and register the Global Securities in the name of
Cede&nbsp;&amp; Co. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;605. <U>Interest</U>. The 2035 Notes will bear interest (computed on the basis of a <FONT
STYLE="white-space:nowrap">360-day</FONT> year consisting of twelve <FONT STYLE="white-space:nowrap">30-day</FONT> months) from November 21, 2025 at the rate of 4.875% per annum, payable semiannually in arrears; interest payable on each Interest
Payment Date will include interest accrued from November 21, 2025, or from the most recent Interest Payment Date to which interest has been paid or duly provided for; the Interest Payment Dates on which such interest shall be payable are May 15 and
November 15, beginning on May 15, 2026; and the Record Date for the interest payable on any Interest Payment Date is the close of business on the May 1 and November 1 (whether or not a Business Day) immediately preceding the relevant Interest
Payment Date. If any Interest Payment Date falls on a day that is not a Business Day, the required payment on that day will be due on the next succeeding Business Day as if made on the date the payment was due, and no interest will accrue on that
payment for the period from and after that Interest Payment Date to the date of payment on the next succeeding Business Day. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-15- </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;606. <U>Authorized Denominations</U>. The Notes shall be issuable in
denominations of $2,000 and integral multiples of $1,000 in excess thereof. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;607. <U>Redemption</U>. The 2035 Notes are
subject to redemption at the option of the Company as described in Article Nine hereof. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;608. <U>Appointment of Agents</U>.
The Trustee will initially be the Registrar and Paying Agent for the Notes and will act as such only at its corporate trust offices in the Borough of Manhattan, City of New York. </P>
<P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE SEVEN </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>GENERAL
TERMS AND CONDITIONS OF THE 2055 NOTES </B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;701. <U>Designation and Principal Amount</U>. There is hereby authorized and
established a series of Securities under the Indenture, designated as the &#8220;5.600% Notes due 2055&#8221;, which is not limited in aggregate principal amount. The aggregate principal amount of the 2055 Notes to be issued on the date hereof is
set forth in Article Eleven herein. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;702. <U>Maturity</U>. The Stated Maturity of principal of the 2055 Notes is
November&nbsp;15, 2055. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;703. <U>Further Issues</U>. The Company may from time to time, without the consent of the Holders of
the 2055 Notes, issue additional 2055 Notes. Any such additional 2055 Notes will have the same ranking, interest rate, maturity date and other terms as the 2055 Notes herein provided for. Any such additional 2055 Notes, together with the 2055 Notes
herein provided for, will constitute a single series of Securities under the Indenture. No additional 2055 Notes may be issued if an Event of Default has occurred and is continuing with respect to the 2055 Notes. The Company will not issue any
additional 2055 Notes intended to form a single series with the 2055 Notes herein provided for unless such additional 2055 Notes will be fungible with the Notes herein provided for U.S. federal income tax purposes. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;704. <U>Global Notes</U>. Upon their original issuance, the 2055 Notes will be represented by one or more Global Securities
registered in the name of Cede&nbsp;&amp; Co., the nominee of The Depository Trust Company (&#8220;DTC&#8221;). The Company will deposit the Global Securities with DTC or its custodian and register the Global Securities in the name of
Cede&nbsp;&amp; Co. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-16- </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;705. <U>Interest</U>. The 2055 Notes will bear interest (computed on the basis
of a <FONT STYLE="white-space:nowrap">360-day</FONT> year consisting of twelve <FONT STYLE="white-space:nowrap">30-day</FONT> months) from November 21, 2025 at the rate of 5.600% per annum, payable semiannually in arrears; interest payable on each
Interest Payment Date will include interest accrued from November 21, 2025, or from the most recent Interest Payment Date to which interest has been paid or duly provided for; the Interest Payment Dates on which such interest shall be payable are
May 15 and November 15, beginning on May 15, 2026; and the Record Date for the interest payable on any Interest Payment Date is the close of business on the May 1 and November 1 (whether or not a Business Day) immediately preceding the relevant
Interest Payment Date. If any Interest Payment Date falls on a day that is not a Business Day, the required payment on that day will be due on the next succeeding Business Day as if made on the date the payment was due, and no interest will accrue
on that payment for the period from and after that Interest Payment Date to the date of payment on the next succeeding Business Day. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;706. <U>Authorized Denominations</U>. The Notes shall be issuable in denominations of $2,000 and integral multiples of $1,000 in
excess thereof. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;707. <U>Redemption</U>. The 2055 Notes are subject to redemption at the option of the Company as described
in Article Nine hereof. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;708. <U>Appointment of Agents</U>. The Trustee will initially be the Registrar and Paying Agent for
the Notes and will act as such only at its corporate trust offices in the Borough of Manhattan, City of New York. </P> <P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE EIGHT
</B></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>GENERAL TERMS AND CONDITIONS OF THE 2065 NOTES </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;801. <U>Designation and Principal Amount</U>. There is hereby authorized and established a series of Securities under the
Indenture, designated as the &#8220;5.700% Notes due 2065&#8221;, which is not limited in aggregate principal amount. The aggregate principal amount of the 2065 Notes to be issued on the date hereof is set forth in Article Eleven herein. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;802. <U>Maturity</U>. The Stated Maturity of principal of the 2065 Notes is November&nbsp;15, 2065. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;803. <U>Further Issues</U>. The Company may from time to time, without the consent of the Holders of the 2065 Notes, issue
additional 2065 Notes. Any such additional 2065 Notes will have the same ranking, interest rate, maturity date and other terms as the 2065 Notes herein provided for. Any such additional 2065 Notes, together with the 2065 Notes herein provided for,
will constitute a single series of Securities under the Indenture. No additional 2065 Notes may be issued if an Event of Default has occurred and is continuing with respect to the 2065 Notes. The Company will not issue any additional 2065 Notes
intended to form a single series with the 2065 Notes herein provided for unless such additional 2065 Notes will be fungible with the Notes herein provided for U.S. federal income tax purposes. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;804. <U>Global Notes</U>. Upon their original issuance, the 2065 Notes will be represented by one or more Global Securities
registered in the name of Cede&nbsp;&amp; Co., the nominee of The Depository Trust Company (&#8220;DTC&#8221;). The Company will deposit the Global Securities with DTC or its custodian and register the Global Securities in the name of
Cede&nbsp;&amp; Co. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-17- </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;805. <U>Interest</U>. The 2065 Notes will bear interest (computed on the basis
of a <FONT STYLE="white-space:nowrap">360-day</FONT> year consisting of twelve <FONT STYLE="white-space:nowrap">30-day</FONT> months) from November 21, 2025 at the rate of 5.700% per annum, payable semiannually in arrears; interest payable on each
Interest Payment Date will include interest accrued from November 21, 2025, or from the most recent Interest Payment Date to which interest has been paid or duly provided for; the Interest Payment Dates on which such interest shall be payable are
May 15 and November 15, beginning on May 15, 2026; and the Record Date for the interest payable on any Interest Payment Date is the close of business on the May 1 and November 1 (whether or not a Business Day) immediately preceding the relevant
Interest Payment Date. If any Interest Payment Date falls on a day that is not a Business Day, the required payment on that day will be due on the next succeeding Business Day as if made on the date the payment was due, and no interest will accrue
on that payment for the period from and after that Interest Payment Date to the date of payment on the next succeeding Business Day. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;806. <U>Authorized Denominations</U>. The Notes shall be issuable in denominations of $2,000 and integral multiples of $1,000 in
excess thereof. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;807. <U>Redemption</U>. The 2065 Notes are subject to redemption at the option of the Company as described
in Article Nine hereof. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;808. <U>Appointment of Agents</U>. The Trustee will initially be the Registrar and Paying Agent for
the Notes and will act as such only at its corporate trust offices in the Borough of Manhattan, City of New York. </P> <P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE NINE </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>OPTIONAL REDEMPTION; NO SINKING FUND </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;901. <U>Optional Redemption by Company</U>. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(a) The Company may not redeem the Floating Rate Notes at the Company&#8217;s option prior to maturity. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) At the Company&#8217;s option, the Fixed Rate Notes may be redeemed, in whole or in part, at any time and from time to time, prior to the
applicable Par Call Date (the date of any such redemption a &#8220;Redemption Date&#8221;) at a redemption price (expressed as a percentage of principal amount and rounded to three decimal places) to be calculated on the basis of a <FONT
STYLE="white-space:nowrap">360-day</FONT> year consisting of twelve <FONT STYLE="white-space:nowrap">30-day</FONT> months (the &#8220;Redemption Price&#8221;) equal to the greater of the following amounts: </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-18- </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(i) (x) the sum of the present values of the remaining scheduled payments of
principal and interest thereon discounted to the Redemption Date (assuming such Fixed Rate Notes matured on their Stated Maturity, in the case of the 2027 Notes, or the applicable Par Call Date, in the case of the 2030 Notes, the 2032 Notes, the
2035 Notes, the 2055 Notes and the 2065 Notes to be redeemed) on a semi-annual basis at the Treasury Rate plus 5 basis points with respect to the 2027 notes, the Treasury Rate plus 10 basis points with respect to the 2030 Notes, the Treasury Rate
plus 10 basis points with respect to the 2032 Notes, the Treasury Rate plus 15 basis points with respect to the 2035 Notes, the Treasury Rate plus 15 basis points with respect to the 2055 Notes and the Treasury Rate plus 15 basis points with respect
to the 2065 Notes less (y)&nbsp;interest accrued to, but excluding, the Redemption Date, and </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; text-indent:4%; font-size:10pt; font-family:Times New Roman">(ii) 100% of the principal
amount of the Fixed Rate Notes being redeemed on the relevant Redemption Date, </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><I>plus</I>, in each of the cases of (b)(i) and (b)(ii) above, accrued and
unpaid interest on the Notes being redeemed to, but excluding, such Redemption Date. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(c) Notice of any redemption of the Fixed Rate Notes
shall be given in the manner and otherwise in accordance with the provisions of Section&nbsp;4.03 of the Indenture. If the Company has given notice of redemption as provided in the Indenture and funds for the redemption of the Fixed Rate Notes
called for redemption have been made available on the Redemption Date referred to in that notice, unless the Company defaults in the payment of the Redemption Price and accrued and unpaid interest, on and after the Redemption Date, interest will
cease to accrue on the Fixed Rate Notes or portions thereof called for redemption. Any interest accrued to such Redemption Date will be paid as specified in such notice. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(d) The Company will notify the Trustee of the Redemption Price promptly after the calculation thereof. Neither the Trustee nor the
Calculation Agent shall have any responsibility for any calculation or determination in respect of the Redemption Price of any Notes, or any component thereof. The Trustee shall be entitled to receive, and fully-protected in relying upon, an
Officer&#8217;s Certificate from the Company that states such Redemption Price. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;902. <U>Par Call</U>. Any time on or after
the applicable Par Call Date, the Company may redeem the 2030 Notes, the 2032 Notes, the 2035 Notes, the 2055 Notes or the 2065 Notes, in whole or in part, at a redemption price equal to 100% of the principal amount of such Notes to be redeemed,
plus, accrued and unpaid interest on such Notes being redeemed to, but excluding, such Redemption Date. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;903. <U>No Sinking
Fund</U>. None of the Notes are entitled to the benefit of any sinking fund. </P> <P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE TEN </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>FORM OF NOTES </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1001. <U>Form of Floating Rate Note</U>. The Notes and the Trustee&#8217;s Certificate of Authentication to be endorsed thereon
are to be substantially in the forms set forth in Exhibit A hereto. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-19- </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1002. <U>Form of 2027 Note</U>. The 2027 Notes and the Trustee&#8217;s
Certificate of Authentication to be endorsed thereon are to be substantially in the forms set forth in Exhibit B hereto. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1003. <U>Form of 2030 Note</U>. The 2030 Notes and the Trustee&#8217;s Certificate of Authentication to be endorsed thereon are
to be substantially in the forms set forth in Exhibit C hereto. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1004. <U>Form of 2032 Note</U>. The 2032 Notes and the
Trustee&#8217;s Certificate of Authentication to be endorsed thereon are to be substantially in the forms set forth in Exhibit D hereto. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1005. <U>Form of 2035 Note</U>. The 2035 Notes and the Trustee&#8217;s Certificate of Authentication to be endorsed thereon are
to be substantially in the forms set forth in Exhibit E hereto. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1006. <U>Form of 2055 Note</U>. The 2055 Notes and the
Trustee&#8217;s Certificate of Authentication to be endorsed thereon are to be substantially in the forms set forth in Exhibit F hereto. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1007. <U>Form of 2065 Note</U>. The 2065 Notes and the Trustee&#8217;s Certificate of Authentication to be endorsed thereon are
to be substantially in the forms set forth in Exhibit G hereto. </P> <P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE ELEVEN </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ORIGINAL ISSUE AMOUNT OF NOTES </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1101. <U>Original Issue Amount of the</U><U> Floating Rate Notes</U>. Floating Rate Notes in the aggregate principal amount of
$500,000,000 may, upon execution of this Sixth Supplemental Indenture, be executed by the Company and delivered to the Trustee for authentication, and the Trustee shall, upon receipt of a Company Order, authenticate and deliver said Floating Rate
Notes as provided in said Company Order. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1102. <U>Original Issue Amount of the 2027 Notes</U>. 2027 Notes in the aggregate
principal amount of $1,000,000,000 may, upon execution of this Sixth Supplemental Indenture, be executed by the Company and delivered to the Trustee for authentication, and the Trustee shall, upon receipt of a Company Order, authenticate and deliver
said 2027 Notes as provided in said Company Order. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1103. <U>Original Issue Amount of the 2030 Notes</U>. 2030 Notes in the
aggregate principal amount of $1,000,000,000 may, upon execution of this Sixth Supplemental Indenture, be executed by the Company and delivered to the Trustee for authentication, and the Trustee shall, upon receipt of a Company Order, authenticate
and deliver said 2030 Notes as provided in said Company Order. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-20- </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1104. <U>Original Issue Amount of the 2032 Notes</U>. 2032 Notes in the
aggregate principal amount of $1,250,000,000 may, upon execution of this Sixth Supplemental Indenture, be executed by the Company and delivered to the Trustee for authentication, and the Trustee shall, upon receipt of a Company Order, authenticate
and deliver said 2032 Notes as provided in said Company Order. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1105. <U>Original Issue Amount of the 2035 Notes</U>. 2035
Notes in the aggregate principal amount of $1,250,000,000 may, upon execution of this Sixth Supplemental Indenture, be executed by the Company and delivered to the Trustee for authentication, and the Trustee shall, upon receipt of a Company Order,
authenticate and deliver said 2035 Notes as provided in said Company Order. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1106. <U>Original Issue Amount of the 2055
Notes</U>. 2055 Notes in the aggregate principal amount of $500,000,000 may, upon execution of this Sixth Supplemental Indenture, be executed by the Company and delivered to the Trustee for authentication, and the Trustee shall, upon receipt of a
Company Order, authenticate and deliver said 2055 Notes as provided in said Company Order. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1107. <U>Original Issue Amount of
the 2065 Notes</U>. 2065 Notes in the aggregate principal amount of $500,000,000 may, upon execution of this Sixth Supplemental Indenture, be executed by the Company and delivered to the Trustee for authentication, and the Trustee shall, upon
receipt of a Company Order, authenticate and deliver said 2065 Notes as provided in said Company Order. </P> <P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>ARTICLE TWELVE </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>MISCELLANEOUS </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1201. <U>Ratification of Indenture</U>. The Indenture, as supplemented by this Sixth Supplemental Indenture, is in all respects
ratified and confirmed, and this Sixth Supplemental Indenture shall be deemed part of the Indenture in the manner and to the extent herein and therein provided. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1202. <U>Trustee Not Responsible for Recitals</U>. The recitals and statements herein contained are made by the Company and not
by the Trustee, and the Trustee assumes no responsibility for the correctness thereof. The Trustee makes no representation as to the validity or sufficiency of this Sixth Supplemental Indenture. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1203. <U>Governing Law</U>. This Sixth Supplemental Indenture and each Note shall be governed by and construed in accordance with
the laws of the State of New York. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1204. <U>Separability</U>. In case any one or more of the provisions contained in this
Sixth Supplemental Indenture or in the Notes shall for any reason be held to be invalid, illegal or unenforceable in any respect, such invalidity, illegality or unenforceability shall not affect any other provisions of this Sixth Supplemental
Indenture or of the Notes, but this Sixth Supplemental Indenture and the Notes shall be construed as if such invalid or illegal or unenforceable provision had never been contained herein or therein. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-21- </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1205. <U>Counterparts</U>. This Sixth Supplemental Indenture, and each of the
other documents executed on the date hereof in connection with this Sixth Supplemental Indenture and the authentication and delivery of the Notes, may be executed in any number of counterparts each of which shall be an original; but such
counterparts shall together constitute but one and the same instrument. The exchange of copies of this Sixth Supplemental Indenture, such other documents and of signature pages&nbsp;by electronic format (<I>i.e.</I>, &#8220;pdf&#8221; or
&#8220;tif&#8221;) transmission shall constitute effective execution and delivery of this Sixth Supplemental Indenture and such other documents as to the parties hereto and may be used in lieu of the original Sixth Supplemental Indenture and such
other documents for all purposes. Signatures of the parties hereto transmitted by electronic format (<I>i.e.</I>, &#8220;pdf&#8221; or &#8220;tif&#8221;) shall be deemed to be their original signatures for all purposes. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1206. <U>Trust Indenture Act</U>. This Sixth Supplemental Indenture is subject to the provisions of the Trust Indenture Act that
are required to be part of the Indenture and shall, to the extent applicable, be governed by such provisions. If any provision in this Sixth Supplemental Indenture limits, qualifies or conflicts with another provision of hereof which is required to
be included herein by any provisions of the Trust Indenture Act, such required provision shall control. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1207.
<U>Signatures</U>. The words &#8220;execution,&#8221; &#8220;signed,&#8221; &#8220;signature,&#8221; &#8220;delivery,&#8221; and words of like import in or relating to this Sixth Supplemental Indenture or any document to be signed in connection with
this Sixth Supplemental Indenture shall be deemed to include electronic signatures, deliveries or the keeping of records in electronic form, each of which shall be of the same legal effect, validity or enforceability as a manually executed
signature, physical delivery thereof or the use of a paper-based recordkeeping system, as the case may be, to the extent and as provided for in any applicable law, including the federal Electronic Signatures in Global and National Commerce Act, the
New York State Electronic Signatures and Records Act, or any other state laws based on the Uniform Electronic Transactions Act, and the parties hereto consent to conduct the transactions contemplated hereunder by electronic means. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">Section&nbsp;1208. <U>Office of Foreign Assets Control Sanctions Representations</U>. (a)&nbsp;The Company represents that neither it nor any
of its Subsidiaries, directors or officers are the target or subject of any sanctions enforced by the Office of Foreign Assets Control of the US Department of the Treasury, the US Department of State, the United Nations Security Council, the
European Union or His Majesty&#8217;s Treasury (collectively &#8220;Sanctions&#8221;); and </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:9%; font-size:10pt; font-family:Times New Roman">(b) The Company covenants that neither it nor
any of its Subsidiaries, directors or officers will directly or knowingly indirectly use any payments made pursuant to this Sixth Supplemental Indenture, (i)&nbsp;to fund or facilitate any activities of or business with any person who, at the time
of such funding or facilitation, is the subject or target of Sanctions, in violation of applicable Sanctions, (ii)&nbsp;to fund or facilitate any activities of or business with any country or territory that is the target or subject of Sanctions, in
violation of applicable Sanctions, or (iii)&nbsp;in any other manner that will result in a violation of Sanctions by any person. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-22- </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">IN WITNESS WHEREOF, the parties hereto have caused this Sixth Supplemental Indenture to be duly executed as
of the day and year first above written. </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="92%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">PFIZER INC.</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Brian Byala</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name: Brian Byala</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title: &#8194;Senior Vice President and Treasurer</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">THE BANK OF NEW YORK MELLON, as</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman">Trustee</P></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name:</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title:</TD></TR>
</TABLE></DIV> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">[<I>Signature Page to Sixth Supplemental Indenture</I>] </P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">IN WITNESS WHEREOF, the parties hereto have caused this Sixth Supplemental Indenture to be duly executed as
of the day and year first above written. </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="92%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3">PFIZER INC.</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name:</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title:</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16" COLSPAN="3"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="3"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">THE BANK OF NEW YORK MELLON, as</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman">Trustee</P></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">/s/ Leslie Morales</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name: Leslie Morales</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title: &#8194;Vice President</TD></TR>
</TABLE></DIV> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">[<I>Signature Page to Sixth Supplemental Indenture</I>] </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">-2- </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">EXHIBIT A </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">FORM OF NOTE </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">THIS SECURITY IS A
GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS
SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right">CUSIP No.&nbsp;717081 FC2 </P>
<P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Pfizer Inc. </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>FLOATING
RATE NOTES DUE 2027 </B></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">


<TR>

<TD WIDTH="84%"></TD>

<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD WIDTH="14%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">No.<U>&#8195;&#8194;</U></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">$<U>&#8195;&#8195;&#8195;&#8195;&#8195;&#8195;&#8195;</U></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">As revised by the</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Schedule
of&nbsp;Increases</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">or Decreases in</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Global Security</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman">attached hereto</P></TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><I>Interest. </I>Pfizer Inc., a Delaware corporation (herein called the &#8220;Company&#8221;, which term includes any
successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede&nbsp;&amp; Co. or registered assigns, the principal sum of [&#149;] DOLLARS ($[&#149;]), as revised by the Schedule of Increases or
Decreases in Global Security attached hereto, on November&nbsp;15, 2027. The interest rate for the Initial Interest Period shall be Compounded SOFR as determined on February&nbsp;12, 2026 plus 0.500% per annum. Thereafter, the interest rate for any
Interest Period will be Compounded SOFR, as determined on the applicable Interest Determination Date plus 0.500% per annum. The interest rate shall be reset quarterly on each day on which interest on the Floating Rate Notes will be paid, which will
be quarterly in arrears on February&nbsp;15, May&nbsp;15, August&nbsp;15 and November&nbsp;15 in each year, commencing February&nbsp;15, 2026 (each an &#8220;Floating Rate Interest Payment Date&#8221;), until the principal hereof is paid or made
available for payment. If February&nbsp;15, May&nbsp;15, August&nbsp;15 and November&nbsp;15 of any year is not a Business Day, then the next succeeding Business Day will be the applicable Floating Rate Interest Payment Date and interest on the
Floating Rate Notes will be paid on such next succeeding Business Day (unless such next succeeding Business Day falls in the succeeding calendar month, in which case the applicable Floating Rate Interest Payment Date will be the Business Day
immediately preceding such February&nbsp;15, May&nbsp;15, August&nbsp;15 and November&nbsp;15, and interest on the Floating Rate Notes will be paid on such immediately preceding Business Day). If the maturity date of the Floating Rate Notes is not a
Business Day, the payment of principal of, and interest on, the Floating Rate Notes will be made on the next succeeding Business Day, and no interest will accrue for the period from and after the maturity date. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><I>Method of Payment. </I>The interest so payable, and punctually paid or duly provided for, on any Floating Rate Interest Payment Date will, as provided in
such Indenture, be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Record Date for such interest, which shall be the February&nbsp;1, May&nbsp;1, August&nbsp;1 and
November&nbsp;1 immediately preceding such Floating Rate Interest Payment Date. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Record Date and may either be paid to the Person
in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice thereof
</P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">A-1 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">
having been given to Holders of Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the
requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the
same effect as if set forth at this place. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><I>Authentication. </I>Unless the certificate of authentication hereon has been executed by the Trustee
referred to on the reverse hereof by manual or electronic signature of one of its authorized signatories, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">A-2 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed under its corporate seal.
</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Dated: <U>&#8195;</U><U>&#8195;</U><U>&#8195;</U><U>&#8195;</U>, 20<U>&#8195;</U> </P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="14%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="77%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="5">PFIZER INC.</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" COLSPAN="3"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
</TABLE></DIV> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">TRUSTEE&#8217;S CERTIFICATE OF AUTHENTICATION </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">This is one of the Securities of the series designated therein referred to in the within-mentioned Indenture. </P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="45%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="4%"></TD>

<TD VALIGN="bottom"></TD>
<TD WIDTH="3%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="45%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Date of authentication:<U>&#8195;&#8195;&#8195;&#8195;</U></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" COLSPAN="3">THE BANK OF NEW YORK MELLON,</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" COLSPAN="3">as Trustee</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Authorized Signatory</TD></TR>
</TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">A-3 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>[Reverse of Security] </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Indenture. </I>This Security is one of a duly authorized issue of securities of the Company (herein called the &#8220;Securities&#8221;),
issued and to be issued in one or more series under an Indenture, dated as of September&nbsp;7, 2018, as supplemented by a Sixth Supplemental Indenture, dated as of November&nbsp;21, 2025 (as so supplemented, herein called the
&#8220;Indenture&#8221;), between the Company and The Bank of New York Mellon (herein called the &#8220;Trustee&#8221;, which term includes any successor trustee under the Indenture), to which Indenture and all indentures supplemental thereto
reference is hereby made for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be,
authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited in aggregate principal amount to $500,000,000. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Optional Redemption. </I>The Company may not redeem the Securities at the Company&#8217;s option prior to maturity and the Securities will
not be entitled to the benefit of any sinking fund. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Defaults and Remedies</I>. If an Event of Default with respect to Securities of
this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in the manner and with the effect provided in the Indenture. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Amendment, Modification and Waiver</I>. The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the
modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a majority in
principal amount of all series at the time Outstanding affected thereby (voting as one class). The Indenture contains provisions permitting the Holders of not less than a majority in principal amount of the Outstanding Securities of all series, with
respect to which any default under the Indenture shall have occurred and be continuing (voting as one class), on behalf of the Holders of all the Outstanding Securities of such series, to waive, with certain exceptions, such past default with
respect to such series and its consequences. The Indenture also permits the Holders of not less than a majority in principal amount of the Outstanding Securities of any series, on behalf of the Holders of all Outstanding Securities of such series,
to waive compliance by the Company with certain provisions of the Indenture. Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security
issued upon the registration of transfer hereof or in exchange therefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Security. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Restrictive Covenants</I>. The Indenture does not limit unsecured debt of the Company or any of its Subsidiaries. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Denominations, Transfer and Exchange</I>. The Securities of this series are issuable only in registered form without coupons in
denominations of $2,000 and in integral multiples of $1,000 in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate principal amount of
Securities of like tenor of a different authorized denomination, as requested by the Holder surrendering the same. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">As provided in the
Indenture and subject to certain limitations therein set forth, the transfer of this Security is registerable in the Security Register, upon surrender of this Security for registration of transfer at the Registrar accompanied by a written request
for transfer in form satisfactory to the Company and the Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing, and thereupon one or more new Securities of this series and of like tenor, of authorized denominations
and for the same aggregate principal amount, will be issued to the designated transferee or transferees. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">No service charge shall be made
for any such registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">A-4 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Persons Deemed Owners</I>. Prior to due presentment of this Security for registration of
transfer, the Company, the Trustee and any agent of the Company or the Trustee may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the
Trustee nor any such agent shall be affected by notice to the contrary. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Miscellaneous</I>. The Indenture and this Security shall be
governed by and construed in accordance with the law of the State of New York. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">All terms used in this Security and not defined herein
shall have the meanings assigned to them in the Indenture. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The words &#8220;execution,&#8221; &#8220;signed,&#8221;
&#8220;signature,&#8221; &#8220;delivery,&#8221; and words of like import in or relating to this Security or any document to be signed in connection with this Security shall be deemed to include electronic signatures, deliveries or the keeping of
records in electronic form, each of which shall be of the same legal effect, validity or enforceability as a manually executed signature, physical delivery thereof or the use of a paper-based recordkeeping system, as the case may be, to the extent
and as provided for in any applicable law, including the federal Electronic Signatures in Global and National Commerce Act, the New York State Electronic Signatures and Records Act, or any other state laws based on the Uniform Electronic
Transactions Act, and the parties hereto consent to conduct the transactions contemplated hereunder by electronic means. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">A-5 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">SCHEDULE OF INCREASES OR DECREASES IN GLOBAL SECURITY </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The following increases or decreases in this Global Security have been made: </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:8pt" ALIGN="center">


<TR>

<TD WIDTH="18%"></TD>

<TD VALIGN="bottom"></TD>
<TD WIDTH="19%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="20%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="20%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="19%"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<TD VALIGN="bottom" NOWRAP> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman"><B>Date of</B></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1.00pt solid #000000; display:table-cell; font-size:8pt; font-family:Times New Roman; "><B>Exchange</B></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Amount of increase in</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Principal Amount of</B></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>this
Global Security</B></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Amount of decrease</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>in Principal Amount</B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>of this
Global</B></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Security</B></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Principal&nbsp;Amount&nbsp;of</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>this Global&nbsp;Security</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>following each</B></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>decrease or
increase</B></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Signature&nbsp;of</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>authorized&nbsp;signatory</B></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>of Trustee</B></P></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">A-6 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">EXHIBIT B </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">FORM OF NOTE </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">THIS SECURITY IS A
GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS
SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right">CUSIP No.&nbsp;717081 FJ7 </P>
<P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Pfizer Inc. </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>3.875%
NOTES DUE 2027 </B></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">


<TR>

<TD WIDTH="84%"></TD>

<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD WIDTH="14%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">No.<U>&#8195;&#8194;</U></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">$<U>&#8195;&#8195;&#8195;&#8195;&#8195;&#8195;&#8195;</U></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">As revised by the</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Schedule
of&nbsp;Increases</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">or Decreases in</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Global Security</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman">attached hereto</P></TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><I>Interest. </I>Pfizer Inc., a Delaware corporation (herein called the &#8220;Company&#8221;, which term includes any
successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede&nbsp;&amp; Co. or registered assigns, the principal sum of [&#149;] DOLLARS ($[&#149;]), as revised by the Schedule of Increases or
Decreases in Global Security attached hereto, on November&nbsp;15, 2027 and to pay interest thereon from November&nbsp;21, 2025 or from the most recent Interest Payment Date to which interest has been paid or duly provided for, semi-annually in
arrears on May&nbsp;15 and November&nbsp;15 in each year, commencing May&nbsp;15, 2026, at the rate of 3.875% per annum, until the principal hereof is paid or made available for payment. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><I>Method of Payment. </I>The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture,
be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Record Date for such interest, which shall be the May&nbsp;1 and November&nbsp;1 immediately preceding such
Interest Payment Date. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor
Securities) is registered at the close of business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice thereof having been given to Holders of Securities of this series not less than 10 days prior
to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such
exchange, all as more fully provided in said Indenture. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Reference is hereby made to the further provisions of this Security set forth on the reverse
hereof, which further provisions shall for all purposes have the same effect as if set forth at this place. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><I>Authentication. </I>Unless the certificate
of authentication hereon has been executed by the Trustee referred to on the reverse hereof by manual or electronic signature of one of its authorized signatories, this Security shall not be entitled to any benefit under the Indenture or be valid or
obligatory for any purpose. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">B-1 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed under its corporate seal.
</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Dated: <U>&#8195;</U><U>&#8195;</U><U>&#8195;</U><U>&#8195;</U>, 20<U>&#8195;</U> </P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="14%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="77%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="5">PFIZER INC.</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" COLSPAN="3"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
</TABLE></DIV> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">TRUSTEE&#8217;S CERTIFICATE OF AUTHENTICATION </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">This is one of the Securities of the series designated therein referred to in the within-mentioned Indenture. </P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="45%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="4%"></TD>

<TD VALIGN="bottom"></TD>
<TD WIDTH="3%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="45%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Date of authentication:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" COLSPAN="3">THE BANK OF NEW YORK MELLON,</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" COLSPAN="3">as Trustee</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Authorized Signatory</TD></TR>
</TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">B-2 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>[Reverse of Security] </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Indenture. </I>This Security is one of a duly authorized issue of securities of the Company (herein called the &#8220;Securities&#8221;),
issued and to be issued in one or more series under an Indenture, dated as of September&nbsp;7, 2018, as supplemented by a Sixth Supplemental Indenture, dated as of November&nbsp;21, 2025 (as so supplemented, herein called the
&#8220;Indenture&#8221;), between the Company and The Bank of New York Mellon (herein called the &#8220;Trustee&#8221;, which term includes any successor trustee under the Indenture), to which Indenture and all indentures supplemental thereto
reference is hereby made for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be,
authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited in aggregate principal amount to $1,000,000,000. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Optional Redemption. </I>At the Company&#8217;s option, the Securities of this series may be redeemed in whole or in part, at any time and
from time to time prior to their Stated Maturity. The redemption price (the &#8220;Redemption Price&#8221;) of the Securities will be equal to the greater of the following amounts: </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) 100% of the principal amount of the Securities being redeemed on the applicable Redemption Date, and </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) the sum of the present values of the remaining scheduled payments of principal and interest thereon discounted to the Redemption Date
(assuming such Securities matured on their Stated Maturity) on a semi-annual basis (assuming a <FONT STYLE="white-space:nowrap">360-day</FONT> year consisting of twelve <FONT STYLE="white-space:nowrap">30-day</FONT> months) at the Treasury Rate (as
defined below) plus 5 basis points less interest accrued to, but excluding, the Redemption Date, </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>plus</I>, in each case, accrued and
unpaid interest on the Securities being redeemed to, but excluding, such Redemption Date. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Redemption Price will be calculated on the
basis of a <FONT STYLE="white-space:nowrap">360-day</FONT> year consisting of twelve <FONT STYLE="white-space:nowrap">30-day</FONT> months. Once notice of redemption is delivered by the Company, the Securities called for redemption will become due
and payable on the applicable Redemption Date at the applicable Redemption Price, plus accrued and unpaid interest applicable to the Securities to, but excluding, the Redemption Date. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">For purposes of determining the Redemption Price, the following definitions are applicable: </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;Treasury Rate&#8221; means, with respect to any Redemption Date, the yield determined by the Company in accordance with the following
two paragraphs. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Treasury Rate shall be determined by the Company after 4:15 p.m., New York City time (or after such time as yields on
U.S. government securities are posted daily by the Board of Governors of the Federal Reserve System), on the third Business Day preceding the Redemption Date based upon the yield or yields for the most recent day that appear after such time on such
day in the most recent statistical release published by the Board of Governors of the Federal Reserve System designated as &#8220;Selected Interest Rates (Daily)&#8212;H.15&#8221; (or any successor designation or publication) (&#8220;H.15&#8221;)
under the caption &#8220;U.S. government securities&#8211;Treasury constant maturities&#8211;Nominal&#8221; (or any successor caption or heading). In determining the Treasury Rate, the Company shall select, as applicable: (1)&nbsp;the yield for the
Treasury constant maturity on H.15 exactly equal to the period from the Redemption Date to the Stated Maturity of the Securities (the &#8220;Remaining Life&#8221;); (2) if there is no such Treasury constant maturity on H.15 exactly equal to the
applicable Remaining Life, the two yields &#8211; one yield corresponding to the Treasury constant maturity on H.15 immediately shorter than and one yield corresponding to the Treasury constant maturity on H.15 immediately longer than the applicable
Remaining Life &#8211; and shall interpolate to the Stated Maturity of the Securities on a straight-line basis (using the actual number of days) using such yields and rounding the result to three decimal places; or (3)&nbsp;if there is no such
Treasury constant maturity on H.15 shorter than or longer than the applicable Remaining Life, the yield for the single Treasury constant maturity on H.15 closest to the applicable Remaining Life. For purposes of this paragraph, the applicable
Treasury constant maturity or maturities on H.15 shall be deemed to have a maturity date equal to the relevant number of months or years, as applicable, of such Treasury constant maturity from the Redemption Date. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">B-3 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">If on the third Business Day preceding the Redemption Date H.15 TCM is no longer published,
the Company shall calculate the applicable Treasury Rate based on the rate per annum equal to the semi-annual equivalent yield to maturity at 11:00 a.m., New York City time, on the second Business Day preceding such Redemption Date of the United
States Treasury security maturing on, or with a maturity that is closest to, the Stated Maturity of the Securities. If there is no United States Treasury security maturing on the Stated Maturity of the Securities but there are two or more United
States Treasury securities with a maturity date equally distant from the Stated Maturity of the Securities, one with a maturity date preceding the Stated Maturity of the Securities and one with a maturity date following the Stated Maturity of the
Securities, the Company shall select the United States Treasury security with a maturity date preceding the Stated Maturity of the Securities. If there are two or more United States Treasury securities maturing on Stated Maturity of the Securities
or two or more United States Treasury securities meeting the criteria of the preceding sentence, the Company shall select from among these two or more United States Treasury securities the United States Treasury security that is trading closest to
par based upon the average of the bid and asked prices for such United States Treasury securities at 11:00 a.m., New York City time. In determining the applicable Treasury Rate in accordance with the terms of this paragraph, the semi-annual yield to
maturity of the applicable United States Treasury security shall be based upon the average of the bid and asked prices (expressed as a percentage of principal amount) at 11:00 a.m., New York City time, of such United States Treasury security, and
rounded to three decimal places. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Company will notify the Trustee of the Redemption Price promptly after the calculation thereof.
Neither the Trustee nor the Calculation Agent shall have any responsibility for any calculation or determination in respect of the Redemption Price of any Notes, or any component thereof. The Trustee shall be entitled to receive, and fully-protected
in relying upon, an Officer&#8217;s Certificate from the Company that states such Redemption Price. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Notice of any redemption will be
mailed or electronically delivered (or otherwise transmitted in accordance with the depository&#8217;s procedures) at least 10 days but not more than 60 days before the Redemption Date to each Holder of the Securities to be redeemed. Unless the
Company defaults in payment of the Redemption Price, on and after the Redemption Date, interest will cease to accrue on the Securities or portions of the Securities called for redemption. If fewer than all of the Securities are to be redeemed, the
Trustee will select by lot. For so long as the Securities are held by DTC (or another depositary), the redemption of the Securities shall be done in accordance with the policies and procedures of the depositary. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Except as set forth above, the Securities will not be redeemable by the Company prior to maturity and will not be entitled to the benefit of
any sinking fund. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Defaults and Remedies</I>. If an Event of Default with respect to Securities of this series shall occur and be
continuing, the principal of the Securities of this series may be declared due and payable in the manner and with the effect provided in the Indenture. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Amendment, Modification and Waiver</I>. The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the
modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a majority in
principal amount of all series at the time Outstanding affected thereby (voting as one class). The Indenture contains provisions permitting the Holders of not less than a majority in principal amount of the Outstanding Securities of all series, with
respect to which any default under the Indenture shall have occurred and be continuing (voting as one class), on behalf of the Holders of all the Outstanding Securities of such series, to waive, with certain exceptions, such past default with
respect to such series and its consequences. The Indenture also permits the Holders of not less than a majority in principal amount of the Outstanding Securities of any series, on behalf of the Holders of all Outstanding Securities of such series,
to waive compliance by the Company with certain provisions of the Indenture. Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security
issued upon the registration of transfer hereof or in exchange therefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Security. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">B-4 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Restrictive Covenants</I>. The Indenture does not limit unsecured debt of the Company or
any of its Subsidiaries. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Denominations, Transfer and Exchange</I>. The Securities of this series are issuable only in registered form
without coupons in denominations of $2,000 and in integral multiples of $1,000 in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate
principal amount of Securities of like tenor of a different authorized denomination, as requested by the Holder surrendering the same. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">As
provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Security is registerable in the Security Register, upon surrender of this Security for registration of transfer at the Registrar accompanied by a
written request for transfer in form satisfactory to the Company and the Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing, and thereupon one or more new Securities of this series and of like tenor, of
authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">No
service charge shall be made for any such registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Persons Deemed Owners</I>. Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent
of the Company or the Trustee may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by
notice to the contrary. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Miscellaneous</I>. The Indenture and this Security shall be governed by and construed in accordance with the
law of the State of New York. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">All terms used in this Security and not defined herein shall have the meanings assigned to them in the
Indenture. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The words &#8220;execution,&#8221; &#8220;signed,&#8221; &#8220;signature,&#8221; &#8220;delivery,&#8221; and words of like
import in or relating to this Security or any document to be signed in connection with this Security shall be deemed to include electronic signatures, deliveries or the keeping of records in electronic form, each of which shall be of the same legal
effect, validity or enforceability as a manually executed signature, physical delivery thereof or the use of a paper-based recordkeeping system, as the case may be, to the extent and as provided for in any applicable law, including the federal
Electronic Signatures in Global and National Commerce Act, the New York State Electronic Signatures and Records Act, or any other state laws based on the Uniform Electronic Transactions Act, and the parties hereto consent to conduct the transactions
contemplated hereunder by electronic means. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">B-5 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">SCHEDULE OF INCREASES OR DECREASES IN GLOBAL SECURITY </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The following increases or decreases in this Global Security have been made: </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:8pt" ALIGN="center">


<TR>

<TD WIDTH="18%"></TD>

<TD VALIGN="bottom"></TD>
<TD WIDTH="19%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="20%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="20%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="19%"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<TD VALIGN="bottom" NOWRAP> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman"><B>Date of</B></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1.00pt solid #000000; display:table-cell; font-size:8pt; font-family:Times New Roman; "><B>Exchange</B></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Amount of increase in</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Principal Amount of</B></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>this
Global Security</B></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Amount of decrease</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>in Principal Amount</B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>of this
Global</B></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Security</B></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Principal&nbsp;Amount&nbsp;of</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>this Global&nbsp;Security</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>following each</B></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>decrease or
increase</B></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Signature&nbsp;of</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>authorized&nbsp;signatory</B></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>of Trustee</B></P></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">B-6 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">EXHIBIT C </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">FORM OF NOTE </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">THIS SECURITY IS A
GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS
SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right">CUSIP No.&nbsp;717081 FD0 </P>
<P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Pfizer Inc. </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>4.200%
NOTES DUE 2030 </B></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">


<TR>

<TD WIDTH="84%"></TD>

<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD WIDTH="14%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">No.<U>&#8195;&#8194;</U></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">$<U>&#8195;&#8195;&#8195;&#8195;&#8195;&#8195;&#8195;</U></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">As revised by the</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Schedule
of&nbsp;Increases</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">or Decreases in</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Global Security</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman">attached hereto</P></TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><I>Interest. </I>Pfizer Inc., a Delaware corporation (herein called the &#8220;Company&#8221;, which term includes any
successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede&nbsp;&amp; Co. or registered assigns, the principal sum of [&#149;] DOLLARS ($[&#149;]), as revised by the Schedule of Increases or
Decreases in Global Security attached hereto, on November&nbsp;15, 2030 and to pay interest thereon from November&nbsp;21, 2025 or from the most recent Interest Payment Date to which interest has been paid or duly provided for, semi-annually in
arrears on May&nbsp;15 and November&nbsp;15 in each year, commencing May&nbsp;15, 2026, at the rate of 4.200% per annum, until the principal hereof is paid or made available for payment. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><I>Method of Payment. </I>The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture,
be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Record Date for such interest, which shall be the May&nbsp;1 and November&nbsp;1 immediately preceding such
Interest Payment Date. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor
Securities) is registered at the close of business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice thereof having been given to Holders of Securities of this series not less than 10 days prior
to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such
exchange, all as more fully provided in said Indenture. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Reference is hereby made to the further provisions of this Security set forth on the reverse
hereof, which further provisions shall for all purposes have the same effect as if set forth at this place. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><I>Authentication. </I>Unless the certificate
of authentication hereon has been executed by the Trustee referred to on the reverse hereof by manual or electronic signature of one of its authorized signatories, this Security shall not be entitled to any benefit under the Indenture or be valid or
obligatory for any purpose. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">C-1 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed under its corporate seal.
</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Dated: <U>&#8195;</U><U>&#8195;</U><U>&#8195;</U><U>&#8195;</U>, 20<U>&#8195;</U> </P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="14%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="77%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="5">PFIZER INC.</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" COLSPAN="3"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
</TABLE></DIV> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">TRUSTEE&#8217;S CERTIFICATE OF AUTHENTICATION </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">This is one of the Securities of the series designated therein referred to in the within-mentioned Indenture. </P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="45%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="4%"></TD>

<TD VALIGN="bottom"></TD>
<TD WIDTH="3%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="45%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Date of authentication:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" COLSPAN="3">THE BANK OF NEW YORK MELLON,</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" COLSPAN="3">as Trustee</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Authorized Signatory</TD></TR>
</TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">C-2 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>[Reverse of Security] </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Indenture. </I>This Security is one of a duly authorized issue of securities of the Company (herein called the &#8220;Securities&#8221;),
issued and to be issued in one or more series under an Indenture, dated as of September&nbsp;7, 2018, as supplemented by a Sixth Supplemental Indenture, dated as of November&nbsp;21, 2025 (as so supplemented, herein called the
&#8220;Indenture&#8221;), between the Company and The Bank of New York Mellon (herein called the &#8220;Trustee&#8221;, which term includes any successor trustee under the Indenture), to which Indenture and all indentures supplemental thereto
reference is hereby made for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be,
authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited in aggregate principal amount to $1,000,000,000. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Optional Redemption. </I>At the Company&#8217;s option, the Securities of this series may be redeemed in whole or in part, at any time and
from time to time prior to October&nbsp;15, 2030 (one month prior to the Stated Maturity of the Securities (the &#8220;Par Call Date,&#8221; and the date of any such redemption a &#8220;Redemption Date&#8221;)). The redemption price (the
&#8220;Redemption Price&#8221;) of the Securities will be equal to the greater of the following amounts: </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) 100% of the principal amount
of the Securities being redeemed on the applicable Redemption Date, and </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) the sum of the present values of the remaining scheduled
payments of principal and interest thereon discounted to the Redemption Date (assuming such Securities matured on the Par Call Date) on a semi-annual basis (assuming a <FONT STYLE="white-space:nowrap">360-day</FONT> year consisting of twelve <FONT
STYLE="white-space:nowrap">30-day</FONT> months) at the Treasury Rate (as defined below) plus 10 basis points less interest accrued to, but excluding, the Redemption Date, </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>plus</I>, in each case, accrued and unpaid interest on the Securities being redeemed to, but excluding, such Redemption Date. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Any time on or after the Par Call Date, the Company may redeem the Securities, in whole or in part, at a Redemption Price equal to 100% of the
principal amount of the Securities to be redeemed, plus accrued and unpaid interest on the Securities being redeemed to, but excluding, the Redemption Date. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Redemption Price will be calculated on the basis of a <FONT STYLE="white-space:nowrap">360-day</FONT> year consisting of twelve <FONT
STYLE="white-space:nowrap">30-day</FONT> months. Once notice of redemption is delivered by the Company, the Securities called for redemption will become due and payable on the applicable Redemption Date at the applicable Redemption Price, plus
accrued and unpaid interest applicable to the Securities to, but excluding, the Redemption Date. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">For purposes of determining the
Redemption Price, the following definitions are applicable: </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;Treasury Rate&#8221; means, with respect to any Redemption Date, the
yield determined by the Company in accordance with the following two paragraphs. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Treasury Rate shall be determined by the Company
after 4:15 p.m., New York City time (or after such time as yields on U.S. government securities are posted daily by the Board of Governors of the Federal Reserve System), on the third Business Day preceding the Redemption Date based upon the yield
or yields for the most recent day that appear after such time on such day in the most recent statistical release published by the Board of Governors of the Federal Reserve System designated as &#8220;Selected Interest Rates (Daily)&#8212;H.15&#8221;
(or any successor designation or publication) (&#8220;H.15&#8221;) under the caption &#8220;U.S. government securities&#8211;Treasury constant maturities&#8211;Nominal&#8221; (or any successor caption or heading). In determining the Treasury Rate,
the Company shall select, as applicable: (1)&nbsp;the yield for the Treasury constant maturity on H.15 exactly equal to the period from the Redemption Date to the Par Call Date (the &#8220;Remaining Life&#8221;); (2) if there is no such Treasury
constant maturity on H.15 exactly equal to the applicable Remaining Life, the two yields &#8211; one yield corresponding to the Treasury constant maturity on H.15 immediately shorter than and one yield corresponding to the Treasury constant maturity
on H.15 immediately longer than the applicable Remaining Life &#8211; and shall interpolate to the Par Call Date on a straight-line basis (using the actual number </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">C-3 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">
of days) using such yields and rounding the result to three decimal places; or (3)&nbsp;if there is no such Treasury constant maturity on H.15 shorter than or longer than the applicable Remaining
Life, the yield for the single Treasury constant maturity on H.15 closest to the applicable Remaining Life. For purposes of this paragraph, the applicable Treasury constant maturity or maturities on H.15 shall be deemed to have a maturity date equal
to the relevant number of months or years, as applicable, of such Treasury constant maturity from the Redemption Date. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">If on the third
Business Day preceding the Redemption Date H.15 TCM is no longer published, the Company shall calculate the applicable Treasury Rate based on the rate per annum equal to the semi-annual equivalent yield to maturity at 11:00 a.m., New York City time,
on the second Business Day preceding such Redemption Date of the United States Treasury security maturing on, or with a maturity that is closest to, the Par Call Date. If there is no United States Treasury security maturing on the Par Call Date but
there are two or more United States Treasury securities with a maturity date equally distant from the Par Call Date, one with a maturity date preceding the Par Call Date and one with a maturity date following the Par Call Date, the Company shall
select the United States Treasury security with a maturity date preceding the Par Call Date. If there are two or more United States Treasury securities maturing on the Par Call Date or two or more United States Treasury securities meeting the
criteria of the preceding sentence, the Company shall select from among these two or more United States Treasury securities the United States Treasury security that is trading closest to par based upon the average of the bid and asked prices for
such United States Treasury securities at 11:00 a.m., New York City time. In determining the applicable Treasury Rate in accordance with the terms of this paragraph, the semi-annual yield to maturity of the applicable United States Treasury security
shall be based upon the average of the bid and asked prices (expressed as a percentage of principal amount) at 11:00 a.m., New York City time, of such United States Treasury security, and rounded to three decimal places. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Company will notify the Trustee of the Redemption Price promptly after the calculation thereof. Neither the Trustee nor the Calculation
Agent shall have any responsibility for any calculation or determination in respect of the Redemption Price of any Notes, or any component thereof. The Trustee shall be entitled to receive, and fully-protected in relying upon, an Officer&#8217;s
Certificate from the Company that states such Redemption Price. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Notice of any redemption will be mailed or electronically delivered (or
otherwise transmitted in accordance with the depository&#8217;s procedures) at least 10 days but not more than 60 days before the Redemption Date to each Holder of the Securities to be redeemed. Unless the Company defaults in payment of the
Redemption Price, on and after the Redemption Date, interest will cease to accrue on the Securities or portions of the Securities called for redemption. If fewer than all of the Securities are to be redeemed, the Trustee will select by lot. For so
long as the Securities are held by DTC (or another depositary), the redemption of the Securities shall be done in accordance with the policies and procedures of the depositary. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Except as set forth above, the Securities will not be redeemable by the Company prior to maturity and will not be entitled to the benefit of
any sinking fund. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Defaults and Remedies</I>. If an Event of Default with respect to Securities of this series shall occur and be
continuing, the principal of the Securities of this series may be declared due and payable in the manner and with the effect provided in the Indenture. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Amendment, Modification and Waiver</I>. The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the
modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a majority in
principal amount of all series at the time Outstanding affected thereby (voting as one class). The Indenture contains provisions permitting the Holders of not less than a majority in principal amount of the Outstanding Securities of all series, with
respect to which any default under the Indenture shall have occurred and be continuing (voting as one class), on behalf of the Holders of all the Outstanding Securities of such series, to waive, with certain exceptions, such past default with
respect to such series and its consequences. The Indenture also permits the Holders of not less than a majority in principal amount of the Outstanding Securities of any series, on behalf of the Holders of all Outstanding Securities of such series,
to waive compliance by the Company with certain provisions of the Indenture. Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security
issued upon the registration of transfer hereof or in exchange therefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Security. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">C-4 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Restrictive Covenants</I>. The Indenture does not limit unsecured debt of the Company or
any of its Subsidiaries. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Denominations, Transfer and Exchange</I>. The Securities of this series are issuable only in registered form
without coupons in denominations of $2,000 and in integral multiples of $1,000 in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate
principal amount of Securities of like tenor of a different authorized denomination, as requested by the Holder surrendering the same. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">As
provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Security is registerable in the Security Register, upon surrender of this Security for registration of transfer at the Registrar accompanied by a
written request for transfer in form satisfactory to the Company and the Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing, and thereupon one or more new Securities of this series and of like tenor, of
authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">No
service charge shall be made for any such registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Persons Deemed Owners</I>. Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent
of the Company or the Trustee may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by
notice to the contrary. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Miscellaneous</I>. The Indenture and this Security shall be governed by and construed in accordance with the
law of the State of New York. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">All terms used in this Security and not defined herein shall have the meanings assigned to them in the
Indenture. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The words &#8220;execution,&#8221; &#8220;signed,&#8221; &#8220;signature,&#8221; &#8220;delivery,&#8221; and words of like
import in or relating to this Security or any document to be signed in connection with this Security shall be deemed to include electronic signatures, deliveries or the keeping of records in electronic form, each of which shall be of the same legal
effect, validity or enforceability as a manually executed signature, physical delivery thereof or the use of a paper-based recordkeeping system, as the case may be, to the extent and as provided for in any applicable law, including the federal
Electronic Signatures in Global and National Commerce Act, the New York State Electronic Signatures and Records Act, or any other state laws based on the Uniform Electronic Transactions Act, and the parties hereto consent to conduct the transactions
contemplated hereunder by electronic means. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">C-5 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">SCHEDULE OF INCREASES OR DECREASES IN GLOBAL SECURITY </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The following increases or decreases in this Global Security have been made: </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:8pt" ALIGN="center">


<TR>

<TD WIDTH="22%"></TD>

<TD VALIGN="bottom"></TD>
<TD WIDTH="19%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="20%"></TD>

<TD VALIGN="bottom"></TD>
<TD WIDTH="17%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="16%"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<TD VALIGN="bottom" NOWRAP ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Date of</B></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Exchange</B></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Amount of increase in</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Principal Amount of</B></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>this
Global Security</B></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Amount of decrease</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>in Principal Amount</B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>of this
Global</B></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Security</B></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Principal&nbsp;Amount&nbsp;of</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>this Global&nbsp;Security</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>following each</B></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>decrease or
increase</B></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Signature&nbsp;of</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>authorized&nbsp;signatory</B></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>of Trustee</B></P></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">C-6 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">EXHIBIT D </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">FORM OF NOTE </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">THIS SECURITY IS A
GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS
SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right">CUSIP No.&nbsp;717081 FE8 </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Pfizer Inc. </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>4.500%
NOTES DUE 2032 </B></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">


<TR>

<TD WIDTH="25%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="25%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="25%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="22%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">No. <U>&#8195;&#8195;&#8195;</U></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">$<U>&#8195;&#8195;&#8195;&#8195;&#8195;&#8195;&#8195;</U></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">As revised by the Schedule of&nbsp;Increases or Decreases in Global Security attached hereto</TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><I>Interest. </I>Pfizer Inc., a Delaware corporation (herein called the &#8220;Company&#8221;, which term includes any
successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to&#8195;&#8195;&#8195;&#8195;Cede&nbsp;&amp; Co. or registered assigns, the principal sum of [&#149;] DOLLARS ($[&#149;]), as revised by the
Schedule of Increases or Decreases in Global Security attached hereto, on November&nbsp;15, 2032 and to pay interest thereon from November&nbsp;21, 2025 or from the most recent Interest Payment Date to which interest has been paid or duly provided
for, semi-annually in arrears on May&nbsp;15 and November&nbsp;15 in each year, commencing May&nbsp;15, 2026, at the rate of 4.500% per annum, until the principal hereof is paid or made available for payment. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><I>Method of Payment. </I>The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture,
be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Record Date for such interest, which shall be the May&nbsp;1 and November&nbsp;1 immediately preceding such
Interest Payment Date. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor
Securities) is registered at the close of business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice thereof having been given to Holders of Securities of this series not less than 10 days prior
to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such
exchange, all as more fully provided in said Indenture. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Reference is hereby made to the further provisions of this Security set forth on the reverse
hereof, which further provisions shall for all purposes have the same effect as if set forth at this place. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><I>Authentication. </I>Unless the certificate
of authentication hereon has been executed by the Trustee referred to on the reverse hereof by manual or electronic signature of one of its authorized signatories, this Security shall not be entitled to any benefit under the Indenture or be valid or
obligatory for any purpose. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">D-1 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed under its corporate seal.
</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Dated: <U>&#8195;</U><U>&#8195;</U><U>&#8195;</U><U>&#8195;</U>, 20<U>&#8195;</U> </P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="14%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="77%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="5">PFIZER INC.</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" COLSPAN="3"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
</TABLE></DIV> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">TRUSTEE&#8217;S CERTIFICATE OF AUTHENTICATION </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">This is one of the Securities of the series designated therein referred to in the within-mentioned Indenture. </P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="45%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="4%"></TD>

<TD VALIGN="bottom"></TD>
<TD WIDTH="3%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="45%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Date of authentication: <U>&#8195;&#8195;&#8195;&#8195;&#8195;&#8195;&#8195;&#8195;</U></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" COLSPAN="3">THE BANK OF NEW YORK MELLON,</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" COLSPAN="3">as Trustee</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Authorized Signatory</TD></TR>
</TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">D-2 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>[Reverse of Security] </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Indenture. </I>This Security is one of a duly authorized issue of securities of the Company (herein called the &#8220;Securities&#8221;),
issued and to be issued in one or more series under an Indenture, dated as of September&nbsp;7, 2018, as supplemented by a Sixth Supplemental Indenture, dated as of November&nbsp;21, 2025 (as so supplemented, herein called the
&#8220;Indenture&#8221;), between the Company and The Bank of New York Mellon (herein called the &#8220;Trustee&#8221;, which term includes any successor trustee under the Indenture), to which Indenture and all indentures supplemental thereto
reference is hereby made for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be,
authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited in aggregate principal amount to $1,250,000,000. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Optional Redemption. </I>At the Company&#8217;s option, the Securities of this series may be redeemed in whole or in part, at any time and
from time to time prior to September&nbsp;15, 2032 (two months prior to the Stated Maturity of the Securities (the &#8220;Par Call Date,&#8221; and the date of any such redemption a &#8220;Redemption Date&#8221;)). The redemption price (the
&#8220;Redemption Price&#8221;) of the Securities will be equal to the greater of the following amounts: </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) 100% of the principal amount
of the Securities being redeemed on the applicable Redemption Date, and </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) the sum of the present values of the remaining scheduled
payments of principal and interest thereon discounted to the Redemption Date (assuming such Securities matured on the Par Call Date) on a semi-annual basis (assuming a <FONT STYLE="white-space:nowrap">360-day</FONT> year consisting of twelve <FONT
STYLE="white-space:nowrap">30-day</FONT> months) at the Treasury Rate (as defined below) plus 10 basis points less interest accrued to, but excluding, the Redemption Date, </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>plus</I>, in each case, accrued and unpaid interest on the Securities being redeemed to, but excluding, such Redemption Date. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Any time on or after the Par Call Date, the Company may redeem the Securities, in whole or in part, at a Redemption Price equal to 100% of the
principal amount of the Securities to be redeemed, plus accrued and unpaid interest on the Securities being redeemed to, but excluding, the Redemption Date. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Redemption Price will be calculated on the basis of a <FONT STYLE="white-space:nowrap">360-day</FONT> year consisting of twelve <FONT
STYLE="white-space:nowrap">30-day</FONT> months. Once notice of redemption is delivered by the Company, the Securities called for redemption will become due and payable on the applicable Redemption Date at the applicable Redemption Price, plus
accrued and unpaid interest applicable to the Securities to, but excluding, the Redemption Date. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">For purposes of determining the
Redemption Price, the following definitions are applicable: </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;Treasury Rate&#8221; means, with respect to any Redemption Date, the
yield determined by the Company in accordance with the following two paragraphs. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Treasury Rate shall be determined by the Company
after 4:15 p.m., New York City time (or after such time as yields on U.S. government securities are posted daily by the Board of Governors of the Federal Reserve System), on the third Business Day preceding the Redemption Date based upon the yield
or yields for the most recent day that appear after such time on such day in the most recent statistical release published by the Board of Governors of the Federal Reserve System designated as &#8220;Selected Interest Rates (Daily)&#8212;H.15&#8221;
(or any successor designation or publication) (&#8220;H.15&#8221;) under the caption &#8220;U.S. government securities&#8211;Treasury constant maturities&#8211;Nominal&#8221; (or any successor caption or heading). In determining the Treasury Rate,
the Company shall select, as applicable: (1)&nbsp;the yield for the Treasury constant maturity on H.15 exactly equal to the period from the Redemption Date to the Par Call Date (the &#8220;Remaining Life&#8221;); (2) if there is no such Treasury
constant maturity on H.15 exactly equal to the applicable Remaining Life, the two yields &#8211; one yield corresponding to the Treasury constant maturity on H.15 immediately shorter than and one yield corresponding to the Treasury constant maturity
on H.15 immediately longer than the applicable Remaining Life &#8211; and shall interpolate to the Par Call Date on a straight-line basis (using the actual number of days) using such yields and rounding the result to three decimal places; or
(3)&nbsp;if there is no such Treasury constant maturity on H.15 shorter than or longer than the applicable Remaining Life, the yield for the single Treasury constant maturity on H.15 closest to the applicable Remaining Life. For purposes of this
paragraph, the applicable Treasury constant maturity or maturities on H.15 shall be deemed to have a maturity date equal to the relevant number of months or years, as applicable, of such Treasury constant maturity from the Redemption Date. </P>
<P STYLE="font-size:12pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">D-3 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">If on the third Business Day preceding the Redemption Date H.15 TCM is no longer published,
the Company shall calculate the applicable Treasury Rate based on the rate per annum equal to the semi-annual equivalent yield to maturity at 11:00 a.m., New York City time, on the second Business Day preceding such Redemption Date of the United
States Treasury security maturing on, or with a maturity that is closest to, the Par Call Date. If there is no United States Treasury security maturing on the Par Call Date but there are two or more United States Treasury securities with a maturity
date equally distant from the Par Call Date, one with a maturity date preceding the Par Call Date and one with a maturity date following the Par Call Date, the Company shall select the United States Treasury security with a maturity date preceding
the Par Call Date. If there are two or more United States Treasury securities maturing on the Par Call Date or two or more United States Treasury securities meeting the criteria of the preceding sentence, the Company shall select from among these
two or more United States Treasury securities the United States Treasury security that is trading closest to par based upon the average of the bid and asked prices for such United States Treasury securities at 11:00 a.m., New York City time. In
determining the applicable Treasury Rate in accordance with the terms of this paragraph, the semi-annual yield to maturity of the applicable United States Treasury security shall be based upon the average of the bid and asked prices (expressed as a
percentage of principal amount) at 11:00 a.m., New York City time, of such United States Treasury security, and rounded to three decimal places. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Company will notify the Trustee of the Redemption Price promptly after the calculation thereof. Neither the Trustee nor the Calculation
Agent shall have any responsibility for any calculation or determination in respect of the Redemption Price of any Notes, or any component thereof. The Trustee shall be entitled to receive, and fully-protected in relying upon, an Officer&#8217;s
Certificate from the Company that states such Redemption Price. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Notice of any redemption will be mailed or electronically delivered (or
otherwise transmitted in accordance with the depository&#8217;s procedures) at least 10 days but not more than 60 days before the Redemption Date to each Holder of the Securities to be redeemed. Unless the Company defaults in payment of the
Redemption Price, on and after the Redemption Date, interest will cease to accrue on the Securities or portions of the Securities called for redemption. If fewer than all of the Securities are to be redeemed, the Trustee will select by lot. For so
long as the Securities are held by DTC (or another depositary), the redemption of the Securities shall be done in accordance with the policies and procedures of the depositary. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Except as set forth above, the Securities will not be redeemable by the Company prior to maturity and will not be entitled to the benefit of
any sinking fund. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Defaults and Remedies</I>. If an Event of Default with respect to Securities of this series shall occur and be
continuing, the principal of the Securities of this series may be declared due and payable in the manner and with the effect provided in the Indenture. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Amendment, Modification and Waiver</I>. The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the
modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a majority in
principal amount of all series at the time Outstanding affected thereby (voting as one class). The Indenture contains provisions permitting the Holders of not less than a majority in principal amount of the Outstanding Securities of all series, with
respect to which any default under the Indenture shall have occurred and be continuing (voting as one class), on behalf of the Holders of all the Outstanding Securities of such series, to waive, with certain exceptions, such past default with
respect to such series and its consequences. The Indenture also permits the Holders of not less than a majority in principal amount of the Outstanding Securities of any series, on behalf of the Holders of all Outstanding Securities of such series,
to waive compliance by the Company with certain provisions of the Indenture. Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security
issued upon the registration of transfer hereof or in exchange therefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Security. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">D-4 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Restrictive Covenants</I>. The Indenture does not limit unsecured debt of the Company or
any of its Subsidiaries. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Denominations, Transfer and Exchange</I>. The Securities of this series are issuable only in registered form
without coupons in denominations of $2,000 and in integral multiples of $1,000 in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate
principal amount of Securities of like tenor of a different authorized denomination, as requested by the Holder surrendering the same. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">As
provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Security is registerable in the Security Register, upon surrender of this Security for registration of transfer at the Registrar accompanied by a
written request for transfer in form satisfactory to the Company and the Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing, and thereupon one or more new Securities of this series and of like tenor, of
authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">No
service charge shall be made for any such registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Persons Deemed Owners</I>. Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent
of the Company or the Trustee may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by
notice to the contrary. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Miscellaneous</I>. The Indenture and this Security shall be governed by and construed in accordance with the
law of the State of New York. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">All terms used in this Security and not defined herein shall have the meanings assigned to them in the
Indenture. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The words &#8220;execution,&#8221; &#8220;signed,&#8221; &#8220;signature,&#8221; &#8220;delivery,&#8221; and words of like
import in or relating to this Security or any document to be signed in connection with this Security shall be deemed to include electronic signatures, deliveries or the keeping of records in electronic form, each of which shall be of the same legal
effect, validity or enforceability as a manually executed signature, physical delivery thereof or the use of a paper-based recordkeeping system, as the case may be, to the extent and as provided for in any applicable law, including the federal
Electronic Signatures in Global and National Commerce Act, the New York State Electronic Signatures and Records Act, or any other state laws based on the Uniform Electronic Transactions Act, and the parties hereto consent to conduct the transactions
contemplated hereunder by electronic means. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">D-5 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">SCHEDULE OF INCREASES OR DECREASES IN GLOBAL SECURITY </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The following increases or decreases in this Global Security have been made: </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:8pt" ALIGN="center">


<TR>

<TD WIDTH="22%"></TD>

<TD VALIGN="bottom"></TD>
<TD WIDTH="19%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="20%"></TD>

<TD VALIGN="bottom"></TD>
<TD WIDTH="17%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="16%"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<TD VALIGN="bottom" NOWRAP ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Date of</B></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Exchange</B></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Amount of increase in</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Principal Amount of</B></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>this
Global Security</B></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Amount of decrease</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>in Principal Amount</B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>of this
Global</B></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Security</B></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Principal&nbsp;Amount&nbsp;of</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>this Global&nbsp;Security</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>following each</B></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>decrease or
increase</B></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Signature&nbsp;of</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>authorized&nbsp;signatory</B></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>of Trustee</B></P></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">D-6 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">EXHIBIT E </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">FORM OF NOTE </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">THIS SECURITY IS A
GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS
SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right">CUSIP No.&nbsp;717081 FF5 </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Pfizer Inc. </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>4.875%
NOTES DUE 2035 </B></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">


<TR>

<TD WIDTH="26%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="24%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="24%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="23%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">No. <U>&#8195;&#8195;&#8195;</U></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">$<U>&#8195;&#8195;&#8195;&#8195;&#8195;&#8195;&#8195;</U></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">As revised by the Schedule of&nbsp;Increases or Decreases in Global Security attached hereto</TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><I>Interest. </I>Pfizer Inc., a Delaware corporation (herein called the &#8220;Company&#8221;, which term includes any
successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to&#8195;&#8195;&#8195;&#8195;Cede&nbsp;&amp; Co. or registered assigns, the principal sum of [&#149;] DOLLARS ($[&#149;]), as revised by the
Schedule of Increases or Decreases in Global Security attached hereto, on November&nbsp;15, 2035 and to pay interest thereon from November&nbsp;21, 2025 or from the most recent Interest Payment Date to which interest has been paid or duly provided
for, semi-annually in arrears on May&nbsp;15 and November&nbsp;15 in each year, commencing May&nbsp;15, 2026, at the rate of 4.875% per annum, until the principal hereof is paid or made available for payment. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><I>Method of Payment. </I>The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture,
be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Record Date for such interest, which shall be the May&nbsp;1 and November&nbsp;1 immediately preceding such
Interest Payment Date. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor
Securities) is registered at the close of business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice thereof having been given to Holders of Securities of this series not less than 10 days prior
to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such
exchange, all as more fully provided in said Indenture. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Reference is hereby made to the further provisions of this Security set forth on the reverse
hereof, which further provisions shall for all purposes have the same effect as if set forth at this place. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><I>Authentication. </I>Unless the certificate
of authentication hereon has been executed by the Trustee referred to on the reverse hereof by manual or electronic signature of one of its authorized signatories, this Security shall not be entitled to any benefit under the Indenture or be valid or
obligatory for any purpose. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">E-1 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed under its corporate seal.
</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Dated: <U>&#8195;</U><U>&#8195;</U><U>&#8195;</U><U>&#8195;</U>, 20<U>&#8195;</U> </P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="14%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="77%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="5">PFIZER INC.</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" COLSPAN="3"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
</TABLE></DIV> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">TRUSTEE&#8217;S CERTIFICATE OF AUTHENTICATION </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">This is one of the Securities of the series designated therein referred to in the within-mentioned Indenture. </P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="45%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="4%"></TD>

<TD VALIGN="bottom"></TD>
<TD WIDTH="3%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="45%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Date of authentication: <U>&#8195;&#8195;&#8195;&#8195;&#8195;&#8195;&#8195;&#8195;</U></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" COLSPAN="3">THE BANK OF NEW YORK MELLON,</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" COLSPAN="3">as Trustee</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Authorized Signatory</TD></TR>
</TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">E-2 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>[Reverse of Security] </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Indenture. </I>This Security is one of a duly authorized issue of securities of the Company (herein called the &#8220;Securities&#8221;),
issued and to be issued in one or more series under an Indenture, dated as of September&nbsp;7, 2018, as supplemented by a Sixth Supplemental Indenture, dated as of November&nbsp;21, 2025 (as so supplemented, herein called the
&#8220;Indenture&#8221;), between the Company and The Bank of New York Mellon (herein called the &#8220;Trustee&#8221;, which term includes any successor trustee under the Indenture), to which Indenture and all indentures supplemental thereto
reference is hereby made for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be,
authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited in aggregate principal amount to $1,250,000,000. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Optional Redemption. </I>At the Company&#8217;s option, the Securities of this series may be redeemed in whole or in part, at any time and
from time to time prior to August&nbsp;15, 2035 (three months prior to the Stated Maturity of the Securities (the &#8220;Par Call Date,&#8221; and the date of any such redemption a &#8220;Redemption Date&#8221;)). The redemption price (the
&#8220;Redemption Price&#8221;) of the Securities will be equal to the greater of the following amounts: </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) 100% of the principal amount
of the Securities being redeemed on the applicable Redemption Date, and </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) the sum of the present values of the remaining scheduled
payments of principal and interest thereon discounted to the Redemption Date (assuming such Securities matured on the Par Call Date) on a semi-annual basis (assuming a <FONT STYLE="white-space:nowrap">360-day</FONT> year consisting of twelve <FONT
STYLE="white-space:nowrap">30-day</FONT> months) at the Treasury Rate (as defined below) plus 15 basis points less interest accrued to, but excluding, the Redemption Date, </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>plus</I>, in each case, accrued and unpaid interest on the Securities being redeemed to, but excluding, such Redemption Date. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Any time on or after the Par Call Date, the Company may redeem the Securities, in whole or in part, at a Redemption Price equal to 100% of the
principal amount of the Securities to be redeemed, plus accrued and unpaid interest on the Securities being redeemed to, but excluding, the Redemption Date. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Redemption Price will be calculated on the basis of a <FONT STYLE="white-space:nowrap">360-day</FONT> year consisting of twelve <FONT
STYLE="white-space:nowrap">30-day</FONT> months. Once notice of redemption is delivered by the Company, the Securities called for redemption will become due and payable on the applicable Redemption Date at the applicable Redemption Price, plus
accrued and unpaid interest applicable to the Securities to, but excluding, the Redemption Date. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">For purposes of determining the
Redemption Price, the following definitions are applicable: </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;Treasury Rate&#8221; means, with respect to any Redemption Date, the
yield determined by the Company in accordance with the following two paragraphs. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Treasury Rate shall be determined by the Company
after 4:15 p.m., New York City time (or after such time as yields on U.S. government securities are posted daily by the Board of Governors of the Federal Reserve System), on the third Business Day preceding the Redemption Date based upon the yield
or yields for the most recent day that appear after such time on such day in the most recent statistical release published by the Board of Governors of the Federal Reserve System designated as &#8220;Selected Interest Rates (Daily)&#8212;H.15&#8221;
(or any successor designation or publication) (&#8220;H.15&#8221;) under the caption &#8220;U.S. government securities&#8211;Treasury constant maturities&#8211;Nominal&#8221; (or any successor caption or heading). In determining the Treasury Rate,
the Company shall select, as applicable: (1)&nbsp;the yield for the Treasury constant maturity on H.15 exactly equal to the period from the Redemption Date to the Par Call Date (the &#8220;Remaining Life&#8221;); (2) if there is no such Treasury
constant maturity on H.15 exactly equal to the applicable Remaining Life, the two yields &#8211; one yield corresponding to the Treasury constant maturity on H.15 immediately shorter than and one yield corresponding to the Treasury constant maturity
on H.15 immediately longer than the applicable Remaining Life &#8211; and shall interpolate to the Par Call Date on a straight-line basis (using the actual number </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">E-3 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">
of days) using such yields and rounding the result to three decimal places; or (3)&nbsp;if there is no such Treasury constant maturity on H.15 shorter than or longer than the applicable Remaining
Life, the yield for the single Treasury constant maturity on H.15 closest to the applicable Remaining Life. For purposes of this paragraph, the applicable Treasury constant maturity or maturities on H.15 shall be deemed to have a maturity date equal
to the relevant number of months or years, as applicable, of such Treasury constant maturity from the Redemption Date. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">If on the third
Business Day preceding the Redemption Date H.15 TCM is no longer published, the Company shall calculate the applicable Treasury Rate based on the rate per annum equal to the semi-annual equivalent yield to maturity at 11:00 a.m., New York City time,
on the second Business Day preceding such Redemption Date of the United States Treasury security maturing on, or with a maturity that is closest to, the Par Call Date. If there is no United States Treasury security maturing on the Par Call Date but
there are two or more United States Treasury securities with a maturity date equally distant from the Par Call Date, one with a maturity date preceding the Par Call Date and one with a maturity date following the Par Call Date, the Company shall
select the United States Treasury security with a maturity date preceding the Par Call Date. If there are two or more United States Treasury securities maturing on the Par Call Date or two or more United States Treasury securities meeting the
criteria of the preceding sentence, the Company shall select from among these two or more United States Treasury securities the United States Treasury security that is trading closest to par based upon the average of the bid and asked prices for
such United States Treasury securities at 11:00 a.m., New York City time. In determining the applicable Treasury Rate in accordance with the terms of this paragraph, the semi-annual yield to maturity of the applicable United States Treasury security
shall be based upon the average of the bid and asked prices (expressed as a percentage of principal amount) at 11:00 a.m., New York City time, of such United States Treasury security, and rounded to three decimal places. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Company will notify the Trustee of the Redemption Price promptly after the calculation thereof. Neither the Trustee nor the Calculation
Agent shall have any responsibility for any calculation or determination in respect of the Redemption Price of any Notes, or any component thereof. The Trustee shall be entitled to receive, and fully-protected in relying upon, an Officer&#8217;s
Certificate from the Company that states such Redemption Price. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Notice of any redemption will be mailed or electronically delivered (or
otherwise transmitted in accordance with the depository&#8217;s procedures) at least 10 days but not more than 60 days before the Redemption Date to each Holder of the Securities to be redeemed. Unless the Company defaults in payment of the
Redemption Price, on and after the Redemption Date, interest will cease to accrue on the Securities or portions of the Securities called for redemption. If fewer than all of the Securities are to be redeemed, the Trustee will select by lot. For so
long as the Securities are held by DTC (or another depositary), the redemption of the Securities shall be done in accordance with the policies and procedures of the depositary. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Except as set forth above, the Securities will not be redeemable by the Company prior to maturity and will not be entitled to the benefit of
any sinking fund. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Defaults and Remedies</I>. If an Event of Default with respect to Securities of this series shall occur and be
continuing, the principal of the Securities of this series may be declared due and payable in the manner and with the effect provided in the Indenture. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Amendment, Modification and Waiver</I>. The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the
modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a majority in
principal amount of all series at the time Outstanding affected thereby (voting as one class). The Indenture contains provisions permitting the Holders of not less than a majority in principal amount of the Outstanding Securities of all series, with
respect to which any default under the Indenture shall have occurred and be continuing (voting as one class), on behalf of the Holders of all the Outstanding Securities of such series, to waive, with certain exceptions, such past default with
respect to such series and its consequences. The Indenture also permits the Holders of not less than a majority in principal amount of the Outstanding Securities of any series, on behalf of the Holders of all Outstanding Securities of such series,
to waive compliance by the Company with certain provisions of the Indenture. Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security
issued upon the registration of transfer hereof or in exchange therefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Security. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">E-4 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Restrictive Covenants</I>. The Indenture does not limit unsecured debt of the Company or
any of its Subsidiaries. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Denominations, Transfer and Exchange</I>. The Securities of this series are issuable only in registered form
without coupons in denominations of $2,000 and in integral multiples of $1,000 in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate
principal amount of Securities of like tenor of a different authorized denomination, as requested by the Holder surrendering the same. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">As
provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Security is registerable in the Security Register, upon surrender of this Security for registration of transfer at the Registrar accompanied by a
written request for transfer in form satisfactory to the Company and the Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing, and thereupon one or more new Securities of this series and of like tenor, of
authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">No
service charge shall be made for any such registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Persons Deemed Owners</I>. Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent
of the Company or the Trustee may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by
notice to the contrary. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Miscellaneous</I>. The Indenture and this Security shall be governed by and construed in accordance with the
law of the State of New York. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">All terms used in this Security and not defined herein shall have the meanings assigned to them in the
Indenture. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The words &#8220;execution,&#8221; &#8220;signed,&#8221; &#8220;signature,&#8221; &#8220;delivery,&#8221; and words of like
import in or relating to this Security or any document to be signed in connection with this Security shall be deemed to include electronic signatures, deliveries or the keeping of records in electronic form, each of which shall be of the same legal
effect, validity or enforceability as a manually executed signature, physical delivery thereof or the use of a paper-based recordkeeping system, as the case may be, to the extent and as provided for in any applicable law, including the federal
Electronic Signatures in Global and National Commerce Act, the New York State Electronic Signatures and Records Act, or any other state laws based on the Uniform Electronic Transactions Act, and the parties hereto consent to conduct the transactions
contemplated hereunder by electronic means. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">E-5 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">SCHEDULE OF INCREASES OR DECREASES IN GLOBAL SECURITY </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The following increases or decreases in this Global Security have been made: </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:8pt" ALIGN="center">


<TR>

<TD WIDTH="22%"></TD>

<TD VALIGN="bottom"></TD>
<TD WIDTH="19%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="20%"></TD>

<TD VALIGN="bottom"></TD>
<TD WIDTH="17%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="16%"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<TD VALIGN="bottom" NOWRAP ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Date of</B></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Exchange</B></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Amount of increase in</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Principal Amount of</B></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>this
Global Security</B></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Amount of decrease</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>in Principal Amount</B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>of this
Global</B></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Security</B></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Principal&nbsp;Amount&nbsp;of</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>this Global&nbsp;Security</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>following each</B></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>decrease or
increase</B></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Signature&nbsp;of</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>authorized&nbsp;signatory</B></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>of Trustee</B></P></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">E-6 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">EXHIBIT F </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">FORM OF NOTE </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">THIS SECURITY IS A
GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS
SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right">CUSIP No.&nbsp;717081 FG3 </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Pfizer Inc. </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>5.600%
NOTES DUE 2055 </B></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">


<TR>

<TD WIDTH="26%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="24%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="24%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="23%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">No. <U>&#8195;&#8195;&#8195;</U></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">$<U>&#8195;&#8195;&#8195;&#8195;&#8195;&#8195;&#8195;</U></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">As revised by the Schedule of&nbsp;Increases or Decreases in Global Security attached hereto</TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><I>Interest. </I>Pfizer Inc., a Delaware corporation (herein called the &#8220;Company&#8221;, which term includes any
successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to&#8195;&#8195;&#8195;&#8195;Cede&nbsp;&amp; Co. or registered assigns, the principal sum of [&#149;] DOLLARS ($[&#149;]), as revised by the
Schedule of Increases or Decreases in Global Security attached hereto, on November&nbsp;15, 2055 and to pay interest thereon from November&nbsp;21, 2025 or from the most recent Interest Payment Date to which interest has been paid or duly provided
for, semi-annually in arrears on May&nbsp;15 and November&nbsp;15 in each year, commencing May&nbsp;15, 2026, at the rate of 5.600% per annum, until the principal hereof is paid or made available for payment. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><I>Method of Payment. </I>The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture,
be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Record Date for such interest, which shall be the May&nbsp;1 and November&nbsp;1 immediately preceding such
Interest Payment Date. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor
Securities) is registered at the close of business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice thereof having been given to Holders of Securities of this series not less than 10 days prior
to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such
exchange, all as more fully provided in said Indenture. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Reference is hereby made to the further provisions of this Security set forth on the reverse
hereof, which further provisions shall for all purposes have the same effect as if set forth at this place. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><I>Authentication. </I>Unless the certificate
of authentication hereon has been executed by the Trustee referred to on the reverse hereof by manual or electronic signature of one of its authorized signatories, this Security shall not be entitled to any benefit under the Indenture or be valid or
obligatory for any purpose. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">F-1 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed under its corporate seal.
</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Dated: <U>&#8195;</U><U>&#8195;</U><U>&#8195;</U><U>&#8195;</U>, 20<U>&#8195;</U> </P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="14%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="77%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="5">PFIZER INC.</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" COLSPAN="3"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
</TABLE></DIV> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">TRUSTEE&#8217;S CERTIFICATE OF AUTHENTICATION </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">This is one of the Securities of the series designated therein referred to in the within-mentioned Indenture. </P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="45%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="4%"></TD>

<TD VALIGN="bottom"></TD>
<TD WIDTH="3%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="45%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Date of authentication: <U>&#8195;&#8195;&#8195;&#8195;&#8195;&#8195;&#8195;&#8195;&#8195;</U></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" COLSPAN="3">THE BANK OF NEW YORK MELLON,</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" COLSPAN="3">as Trustee</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Authorized Signatory</TD></TR>
</TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">F-2 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>[Reverse of Security] </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Indenture. </I>This Security is one of a duly authorized issue of securities of the Company (herein called the &#8220;Securities&#8221;),
issued and to be issued in one or more series under an Indenture, dated as of September&nbsp;7, 2018, as supplemented by a Sixth Supplemental Indenture, dated as of November&nbsp;21, 2025 (as so supplemented, herein called the
&#8220;Indenture&#8221;), between the Company and The Bank of New York Mellon (herein called the &#8220;Trustee&#8221;, which term includes any successor trustee under the Indenture), to which Indenture and all indentures supplemental thereto
reference is hereby made for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be,
authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited in aggregate principal amount to $500,000,000. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Optional Redemption. </I>At the Company&#8217;s option, the Securities of this series may be redeemed in whole or in part, at any time and
from time to time prior to May&nbsp;15, 2055 (six months prior to the Stated Maturity of the Securities (the &#8220;Par Call Date,&#8221; and the date of any such redemption a &#8220;Redemption Date&#8221;)). The redemption price (the
&#8220;Redemption Price&#8221;) of the Securities will be equal to the greater of the following amounts: </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) 100% of the principal amount
of the Securities being redeemed on the applicable Redemption Date, and </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) the sum of the present values of the remaining scheduled
payments of principal and interest thereon discounted to the Redemption Date (assuming such Securities matured on the Par Call Date) on a semi-annual basis (assuming a <FONT STYLE="white-space:nowrap">360-day</FONT> year consisting of twelve <FONT
STYLE="white-space:nowrap">30-day</FONT> months) at the Treasury Rate (as defined below) plus 15 basis points less interest accrued to, but excluding, the Redemption Date, </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>plus</I>, in each case, accrued and unpaid interest on the Securities being redeemed to, but excluding, such Redemption Date. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Any time on or after the Par Call Date, the Company may redeem the Securities, in whole or in part, at a Redemption Price equal to 100% of the
principal amount of the Securities to be redeemed, plus accrued and unpaid interest on the Securities being redeemed to, but excluding, the Redemption Date. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Redemption Price will be calculated on the basis of a <FONT STYLE="white-space:nowrap">360-day</FONT> year consisting of twelve <FONT
STYLE="white-space:nowrap">30-day</FONT> months. Once notice of redemption is delivered by the Company, the Securities called for redemption will become due and payable on the applicable Redemption Date at the applicable Redemption Price, plus
accrued and unpaid interest applicable to the Securities to, but excluding, the Redemption Date. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">For purposes of determining the
Redemption Price, the following definitions are applicable: </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;Treasury Rate&#8221; means, with respect to any Redemption Date, the
yield determined by the Company in accordance with the following two paragraphs. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Treasury Rate shall be determined by the Company
after 4:15 p.m., New York City time (or after such time as yields on U.S. government securities are posted daily by the Board of Governors of the Federal Reserve System), on the third Business Day preceding the Redemption Date based upon the yield
or yields for the most recent day that appear after such time on such day in the most recent statistical release published by the Board of Governors of the Federal Reserve System designated as &#8220;Selected Interest Rates (Daily)&#8212;H.15&#8221;
(or any successor designation or publication) (&#8220;H.15&#8221;) under the caption &#8220;U.S. government securities&#8211;Treasury constant maturities&#8211;Nominal&#8221; (or any successor caption or heading). In determining the Treasury Rate,
the Company shall select, as applicable: (1)&nbsp;the yield for the Treasury constant maturity on H.15 exactly equal to the period from the Redemption Date to the Par Call Date (the &#8220;Remaining Life&#8221;); (2) if there is no such Treasury
constant maturity on H.15 exactly equal to the applicable Remaining Life, the two yields &#8211; one yield corresponding to the Treasury constant maturity on H.15 immediately shorter than and one yield corresponding to the Treasury constant maturity
on H.15 immediately longer than the applicable Remaining Life &#8211; and shall interpolate to the Par Call Date on a straight-line basis (using the actual number </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">F-3 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">
of days) using such yields and rounding the result to three decimal places; or (3)&nbsp;if there is no such Treasury constant maturity on H.15 shorter than or longer than the applicable Remaining
Life, the yield for the single Treasury constant maturity on H.15 closest to the applicable Remaining Life. For purposes of this paragraph, the applicable Treasury constant maturity or maturities on H.15 shall be deemed to have a maturity date equal
to the relevant number of months or years, as applicable, of such Treasury constant maturity from the Redemption Date. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">If on the third
Business Day preceding the Redemption Date H.15 TCM is no longer published, the Company shall calculate the applicable Treasury Rate based on the rate per annum equal to the semi-annual equivalent yield to maturity at 11:00 a.m., New York City time,
on the second Business Day preceding such Redemption Date of the United States Treasury security maturing on, or with a maturity that is closest to, the Par Call Date. If there is no United States Treasury security maturing on the Par Call Date but
there are two or more United States Treasury securities with a maturity date equally distant from the Par Call Date, one with a maturity date preceding the Par Call Date and one with a maturity date following the Par Call Date, the Company shall
select the United States Treasury security with a maturity date preceding the Par Call Date. If there are two or more United States Treasury securities maturing on the Par Call Date or two or more United States Treasury securities meeting the
criteria of the preceding sentence, the Company shall select from among these two or more United States Treasury securities the United States Treasury security that is trading closest to par based upon the average of the bid and asked prices for
such United States Treasury securities at 11:00 a.m., New York City time. In determining the applicable Treasury Rate in accordance with the terms of this paragraph, the semi-annual yield to maturity of the applicable United States Treasury security
shall be based upon the average of the bid and asked prices (expressed as a percentage of principal amount) at 11:00 a.m., New York City time, of such United States Treasury security, and rounded to three decimal places. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Company will notify the Trustee of the Redemption Price promptly after the calculation thereof. Neither the Trustee nor the Calculation
Agent shall have any responsibility for any calculation or determination in respect of the Redemption Price of any Notes, or any component thereof. The Trustee shall be entitled to receive, and fully-protected in relying upon, an Officer&#8217;s
Certificate from the Company that states such Redemption Price. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Notice of any redemption will be mailed or electronically delivered (or
otherwise transmitted in accordance with the depository&#8217;s procedures) at least 10 days but not more than 60 days before the Redemption Date to each Holder of the Securities to be redeemed. Unless the Company defaults in payment of the
Redemption Price, on and after the Redemption Date, interest will cease to accrue on the Securities or portions of the Securities called for redemption. If fewer than all of the Securities are to be redeemed, the Trustee will select by lot. For so
long as the Securities are held by DTC (or another depositary), the redemption of the Securities shall be done in accordance with the policies and procedures of the depositary. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Except as set forth above, the Securities will not be redeemable by the Company prior to maturity and will not be entitled to the benefit of
any sinking fund. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Defaults and Remedies</I>. If an Event of Default with respect to Securities of this series shall occur and be
continuing, the principal of the Securities of this series may be declared due and payable in the manner and with the effect provided in the Indenture. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Amendment, Modification and Waiver</I>. The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the
modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a majority in
principal amount of all series at the time Outstanding affected thereby (voting as one class). The Indenture contains provisions permitting the Holders of not less than a majority in principal amount of the Outstanding Securities of all series, with
respect to which any default under the Indenture shall have occurred and be continuing (voting as one class), on behalf of the Holders of all the Outstanding Securities of such series, to waive, with certain exceptions, such past default with
respect to such series and its consequences. The Indenture also permits the Holders of not less than a majority in principal amount of the Outstanding Securities of any series, on behalf of the Holders of all Outstanding Securities of such series,
to waive compliance by the Company with certain provisions of the Indenture. Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security
issued upon the registration of transfer hereof or in exchange therefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Security. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">F-4 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Restrictive Covenants</I>. The Indenture does not limit unsecured debt of the Company or
any of its Subsidiaries. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Denominations, Transfer and Exchange</I>. The Securities of this series are issuable only in registered form
without coupons in denominations of $2,000 and in integral multiples of $1,000 in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate
principal amount of Securities of like tenor of a different authorized denomination, as requested by the Holder surrendering the same. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">As
provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Security is registerable in the Security Register, upon surrender of this Security for registration of transfer at the Registrar accompanied by a
written request for transfer in form satisfactory to the Company and the Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing, and thereupon one or more new Securities of this series and of like tenor, of
authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">No
service charge shall be made for any such registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Persons Deemed Owners</I>. Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent
of the Company or the Trustee may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by
notice to the contrary. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Miscellaneous</I>. The Indenture and this Security shall be governed by and construed in accordance with the
law of the State of New York. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">All terms used in this Security and not defined herein shall have the meanings assigned to them in the
Indenture. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The words &#8220;execution,&#8221; &#8220;signed,&#8221; &#8220;signature,&#8221; &#8220;delivery,&#8221; and words of like
import in or relating to this Security or any document to be signed in connection with this Security shall be deemed to include electronic signatures, deliveries or the keeping of records in electronic form, each of which shall be of the same legal
effect, validity or enforceability as a manually executed signature, physical delivery thereof or the use of a paper-based recordkeeping system, as the case may be, to the extent and as provided for in any applicable law, including the federal
Electronic Signatures in Global and National Commerce Act, the New York State Electronic Signatures and Records Act, or any other state laws based on the Uniform Electronic Transactions Act, and the parties hereto consent to conduct the transactions
contemplated hereunder by electronic means. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">F-5 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">SCHEDULE OF INCREASES OR DECREASES IN GLOBAL SECURITY </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The following increases or decreases in this Global Security have been made: </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:8pt" ALIGN="center">


<TR>

<TD WIDTH="22%"></TD>

<TD VALIGN="bottom"></TD>
<TD WIDTH="19%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="20%"></TD>

<TD VALIGN="bottom"></TD>
<TD WIDTH="17%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="16%"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<TD VALIGN="bottom" NOWRAP ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Date of</B></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Exchange</B></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Amount of increase in</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Principal Amount of</B></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>this
Global Security</B></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Amount of decrease</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>in Principal Amount</B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>of this
Global</B></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Security</B></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Principal&nbsp;Amount&nbsp;of</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>this Global&nbsp;Security</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>following each</B></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>decrease or
increase</B></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Signature&nbsp;of</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>authorized&nbsp;signatory</B></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>of Trustee</B></P></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">F-6 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">EXHIBIT G </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">FORM OF NOTE </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">THIS SECURITY IS A
GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS
SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right">CUSIP No.&nbsp;717081 FH1 </P>
<P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>Pfizer Inc. </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>5.700%
NOTES DUE 2065 </B></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt" ALIGN="center">


<TR>

<TD WIDTH="84%"></TD>

<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD WIDTH="14%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">No.<U>&#8195;&#8194;</U></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top">$<U>&#8195;&#8195;&#8195;&#8195;&#8195;&#8195;&#8195;</U></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">As revised by the</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Schedule
of&nbsp;Increases</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">or Decreases in</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Global Security</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman">attached hereto</P></TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><I>Interest. </I>Pfizer Inc., a Delaware corporation (herein called the &#8220;Company&#8221;, which term includes any
successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede&nbsp;&amp; Co. or registered assigns, the principal sum of [&#149;] DOLLARS ($[&#149;]), as revised by the Schedule of Increases or
Decreases in Global Security attached hereto, on November&nbsp;15, 2065 and to pay interest thereon from November&nbsp;21, 2025 or from the most recent Interest Payment Date to which interest has been paid or duly provided for, semi-annually in
arrears on May&nbsp;15 and November&nbsp;15 in each year, commencing May&nbsp;15, 2026, at the rate of 5.700% per annum, until the principal hereof is paid or made available for payment. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><I>Method of Payment. </I>The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture,
be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Record Date for such interest, which shall be the May&nbsp;1 and November&nbsp;1 immediately preceding such
Interest Payment Date. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor
Securities) is registered at the close of business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice thereof having been given to Holders of Securities of this series not less than 10 days prior
to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such
exchange, all as more fully provided in said Indenture. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Reference is hereby made to the further provisions of this Security set forth on the reverse
hereof, which further provisions shall for all purposes have the same effect as if set forth at this place. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><I>Authentication. </I>Unless the certificate
of authentication hereon has been executed by the Trustee referred to on the reverse hereof by manual or electronic signature of one of its authorized signatories, this Security shall not be entitled to any benefit under the Indenture or be valid or
obligatory for any purpose. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">G-1 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed under its corporate seal.
</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Dated: <U>&#8195;</U><U>&#8195;</U><U>&#8195;</U><U>&#8195;</U>, 20<U>&#8195;</U> </P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="7%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="14%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="77%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top" COLSPAN="5">PFIZER INC.</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="4"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" COLSPAN="3"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Name:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Title:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
</TABLE></DIV> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">TRUSTEE&#8217;S CERTIFICATE OF AUTHENTICATION </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">This is one of the Securities of the series designated therein referred to in the within-mentioned Indenture. </P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="45%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="4%"></TD>

<TD VALIGN="bottom"></TD>
<TD WIDTH="3%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="45%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Date of authentication:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" COLSPAN="3">THE BANK OF NEW YORK MELLON,</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" COLSPAN="3">as Trustee</TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD>
<TD HEIGHT="16" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">By:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1px solid #000000; font-size:10pt; font-family:Times New Roman">&nbsp;</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Authorized Signatory</TD></TR>
</TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">G-2 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>[Reverse of Security] </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Indenture. </I>This Security is one of a duly authorized issue of securities of the Company (herein called the &#8220;Securities&#8221;),
issued and to be issued in one or more series under an Indenture, dated as of September&nbsp;7, 2018, as supplemented by a Sixth Supplemental Indenture, dated as of November&nbsp;21, 2025 (as so supplemented, herein called the
&#8220;Indenture&#8221;), between the Company and The Bank of New York Mellon (herein called the &#8220;Trustee&#8221;, which term includes any successor trustee under the Indenture), to which Indenture and all indentures supplemental thereto
reference is hereby made for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be,
authenticated and delivered. This Security is one of the series designated on the face hereof, initially limited in aggregate principal amount to $500,000,000. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Optional Redemption. </I>At the Company&#8217;s option, the Securities of this series may be redeemed in whole or in part, at any time and
from time to time prior to May&nbsp;15, 2065 (six months prior to the Stated Maturity of the Securities (the &#8220;Par Call Date,&#8221; and the date of any such redemption a &#8220;Redemption Date&#8221;)). The redemption price (the
&#8220;Redemption Price&#8221;) of the Securities will be equal to the greater of the following amounts: </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) 100% of the principal amount
of the Securities being redeemed on the applicable Redemption Date, and </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) the sum of the present values of the remaining scheduled
payments of principal and interest thereon discounted to the Redemption Date (assuming such Securities matured on the Par Call Date) on a semi-annual basis (assuming a <FONT STYLE="white-space:nowrap">360-day</FONT> year consisting of twelve <FONT
STYLE="white-space:nowrap">30-day</FONT> months) at the Treasury Rate (as defined below) plus 15 basis points less interest accrued to, but excluding, the Redemption Date, </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>plus</I>, in each case, accrued and unpaid interest on the Securities being redeemed to, but excluding, such Redemption Date. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Any time on or after the Par Call Date, the Company may redeem the Securities, in whole or in part, at a Redemption Price equal to 100% of the
principal amount of the Securities to be redeemed, plus accrued and unpaid interest on the Securities being redeemed to, but excluding, the Redemption Date. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Redemption Price will be calculated on the basis of a <FONT STYLE="white-space:nowrap">360-day</FONT> year consisting of twelve <FONT
STYLE="white-space:nowrap">30-day</FONT> months. Once notice of redemption is delivered by the Company, the Securities called for redemption will become due and payable on the applicable Redemption Date at the applicable Redemption Price, plus
accrued and unpaid interest applicable to the Securities to, but excluding, the Redemption Date. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">For purposes of determining the
Redemption Price, the following definitions are applicable: </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">&#8220;Treasury Rate&#8221; means, with respect to any Redemption Date, the
yield determined by the Company in accordance with the following two paragraphs. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Treasury Rate shall be determined by the Company
after 4:15 p.m., New York City time (or after such time as yields on U.S. government securities are posted daily by the Board of Governors of the Federal Reserve System), on the third Business Day preceding the Redemption Date based upon the yield
or yields for the most recent day that appear after such time on such day in the most recent statistical release published by the Board of Governors of the Federal Reserve System designated as &#8220;Selected Interest Rates (Daily)&#8212;H.15&#8221;
(or any successor designation or publication) (&#8220;H.15&#8221;) under the caption &#8220;U.S. government securities&#8211;Treasury constant maturities&#8211;Nominal&#8221; (or any successor caption or heading). In determining the Treasury Rate,
the Company shall select, as applicable: (1)&nbsp;the yield for the Treasury constant maturity on H.15 exactly equal to the period from the Redemption Date to the Par Call Date (the &#8220;Remaining Life&#8221;); (2) if there is no such Treasury
constant maturity on H.15 exactly equal to the applicable Remaining Life, the two yields &#8211; one yield corresponding to the Treasury constant maturity on H.15 immediately shorter than and one yield corresponding to the Treasury constant maturity
on H.15 immediately longer than the applicable Remaining Life &#8211; and shall interpolate to the Par Call Date on a straight-line basis (using the actual number of days) using such yields and rounding the result to three decimal places; or
(3)&nbsp;if there is no such Treasury constant maturity on H.15 shorter than or longer than the applicable Remaining Life, the yield for the single Treasury constant maturity on H.15 closest to the applicable Remaining Life. For purposes of this
paragraph, the applicable Treasury constant maturity or maturities on H.15 shall be deemed to have a maturity date equal to the relevant number of months or years, as applicable, of such Treasury constant maturity from the Redemption Date. </P>
<P STYLE="font-size:12pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">G-3 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">If on the third Business Day preceding the Redemption Date H.15 TCM is no longer published,
the Company shall calculate the applicable Treasury Rate based on the rate per annum equal to the semi-annual equivalent yield to maturity at 11:00 a.m., New York City time, on the second Business Day preceding such Redemption Date of the United
States Treasury security maturing on, or with a maturity that is closest to, the Par Call Date. If there is no United States Treasury security maturing on the Par Call Date but there are two or more United States Treasury securities with a maturity
date equally distant from the Par Call Date, one with a maturity date preceding the Par Call Date and one with a maturity date following the Par Call Date, the Company shall select the United States Treasury security with a maturity date preceding
the Par Call Date. If there are two or more United States Treasury securities maturing on the Par Call Date or two or more United States Treasury securities meeting the criteria of the preceding sentence, the Company shall select from among these
two or more United States Treasury securities the United States Treasury security that is trading closest to par based upon the average of the bid and asked prices for such United States Treasury securities at 11:00 a.m., New York City time. In
determining the applicable Treasury Rate in accordance with the terms of this paragraph, the semi-annual yield to maturity of the applicable United States Treasury security shall be based upon the average of the bid and asked prices (expressed as a
percentage of principal amount) at 11:00 a.m., New York City time, of such United States Treasury security, and rounded to three decimal places. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The Company will notify the Trustee of the Redemption Price promptly after the calculation thereof. Neither the Trustee nor the Calculation
Agent shall have any responsibility for any calculation or determination in respect of the Redemption Price of any Notes, or any component thereof. The Trustee shall be entitled to receive, and fully-protected in relying upon, an Officer&#8217;s
Certificate from the Company that states such Redemption Price. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Notice of any redemption will be mailed or electronically delivered (or
otherwise transmitted in accordance with the depository&#8217;s procedures) at least 10 days but not more than 60 days before the Redemption Date to each Holder of the Securities to be redeemed. Unless the Company defaults in payment of the
Redemption Price, on and after the Redemption Date, interest will cease to accrue on the Securities or portions of the Securities called for redemption. If fewer than all of the Securities are to be redeemed, the Trustee will select by lot. For so
long as the Securities are held by DTC (or another depositary), the redemption of the Securities shall be done in accordance with the policies and procedures of the depositary. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Except as set forth above, the Securities will not be redeemable by the Company prior to maturity and will not be entitled to the benefit of
any sinking fund. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Defaults and Remedies</I>. If an Event of Default with respect to Securities of this series shall occur and be
continuing, the principal of the Securities of this series may be declared due and payable in the manner and with the effect provided in the Indenture. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Amendment, Modification and Waiver</I>. The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the
modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a majority in
principal amount of all series at the time Outstanding affected thereby (voting as one class). The Indenture contains provisions permitting the Holders of not less than a majority in principal amount of the Outstanding Securities of all series, with
respect to which any default under the Indenture shall have occurred and be continuing (voting as one class), on behalf of the Holders of all the Outstanding Securities of such series, to waive, with certain exceptions, such past default with
respect to such series and its consequences. The Indenture also permits the Holders of not less than a majority in principal amount of the Outstanding Securities of any series, on behalf of the Holders of all Outstanding Securities of such series,
to waive compliance by the Company with certain provisions of the Indenture. Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security
issued upon the registration of transfer hereof or in exchange therefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Security. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">G-4 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Restrictive Covenants</I>. The Indenture does not limit unsecured debt of the Company or
any of its Subsidiaries. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Denominations, Transfer and Exchange</I>. The Securities of this series are issuable only in registered form
without coupons in denominations of $2,000 and in integral multiples of $1,000 in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate
principal amount of Securities of like tenor of a different authorized denomination, as requested by the Holder surrendering the same. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">As
provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Security is registerable in the Security Register, upon surrender of this Security for registration of transfer at the Registrar accompanied by a
written request for transfer in form satisfactory to the Company and the Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing, and thereupon one or more new Securities of this series and of like tenor, of
authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">No
service charge shall be made for any such registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Persons Deemed Owners</I>. Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent
of the Company or the Trustee may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by
notice to the contrary. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman"><I>Miscellaneous</I>. The Indenture and this Security shall be governed by and construed in accordance with the
law of the State of New York. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">All terms used in this Security and not defined herein shall have the meanings assigned to them in the
Indenture. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The words &#8220;execution,&#8221; &#8220;signed,&#8221; &#8220;signature,&#8221; &#8220;delivery,&#8221; and words of like
import in or relating to this Security or any document to be signed in connection with this Security shall be deemed to include electronic signatures, deliveries or the keeping of records in electronic form, each of which shall be of the same legal
effect, validity or enforceability as a manually executed signature, physical delivery thereof or the use of a paper-based recordkeeping system, as the case may be, to the extent and as provided for in any applicable law, including the federal
Electronic Signatures in Global and National Commerce Act, the New York State Electronic Signatures and Records Act, or any other state laws based on the Uniform Electronic Transactions Act, and the parties hereto consent to conduct the transactions
contemplated hereunder by electronic means. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">G-5 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">SCHEDULE OF INCREASES OR DECREASES IN GLOBAL SECURITY </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">The following increases or decreases in this Global Security have been made: </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:8pt" ALIGN="center">


<TR>

<TD WIDTH="18%"></TD>

<TD VALIGN="bottom"></TD>
<TD WIDTH="19%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="20%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="20%"></TD>

<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="19%"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<TD VALIGN="bottom" NOWRAP> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman"><B>Date of</B></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; border-bottom:1.00pt solid #000000; display:table-cell; font-size:8pt; font-family:Times New Roman; "><B>Exchange</B></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Amount of increase in</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Principal Amount of</B></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>this
Global Security</B></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Amount of decrease</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>in Principal Amount</B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>of this
Global</B></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Security</B></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Principal&nbsp;Amount&nbsp;of</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>this Global&nbsp;Security</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>following each</B></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>decrease or
increase</B></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="border-bottom:1.00pt solid #000000"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>Signature&nbsp;of</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>authorized&nbsp;signatory</B></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B>of Trustee</B></P></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">G-6 </P>

</DIV></Center>

</BODY></HTML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>5
<FILENAME>d80089dex51.htm
<DESCRIPTION>EX-5.1
<TEXT>
<HTML><HEAD>
<TITLE>EX-5.1</TITLE>
</HEAD>
 <BODY BGCOLOR="WHITE" STYLE="line-height:Normal">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="right"><B>Exhibit 5.1 </B></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt;margin-bottom:0pt" ALIGN="right">


<IMG SRC="g80089g59u60.jpg" ALT="LOGO">
 </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><B>Pfizer Inc. </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">66 Hudson
Boulevard East </P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">New York, New York 10001 </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">November&nbsp;21,
2025 </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman">Ladies and Gentlemen:</P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Attorneys under
my supervision and I have acted as counsel for Pfizer Inc., a Delaware corporation (the &#8220;Company&#8221;), in connection with the issuance and sale of $500,000,000 aggregate principal amount of Floating Rate Notes due 2027, $1,000,000,000
aggregate principal amount of 3.875% Notes due 2027, $1,000,000,000 aggregate principal amount of 4.200% Notes due 2030, $1,250,000,000 aggregate principal amount of 4.500% Notes due 2032, $1,250,000,000 aggregate principal amount of 4.875% Notes
due 2035, $500,000,000 aggregate principal amount of 5.600% Notes due 2055 and $500,000,000 aggregate principal amount of 5.700% Notes due 2065 (collectively, the &#8220;Debt Securities&#8221;) of the Company. The Debt Securities will be issued
pursuant to the Indenture, dated as of September 7, 2018 (the &#8220;Base Indenture&#8221;), between the Company and The Bank of New York Mellon, as trustee (the &#8220;Trustee&#8221;), and the Sixth Supplemental Indenture, dated as of
November&nbsp;21, 2025, between the Company and the Trustee (the &#8220;Sixth Supplemental Indenture&#8221; and together with the Base Indenture, the &#8220;Indenture&#8221;). On November&nbsp;18, 2025, the Company entered into an Underwriting
Agreement, dated as of November&nbsp;18, 2025 (the &#8220;Underwriting Agreement&#8221;), and related Pricing Agreement, dated as of November&nbsp;18, 2025 (the &#8220;Pricing Agreement&#8221;), with Citigroup Global Markets Inc., Deutsche Bank
Securities Inc., J.P. Morgan Securities LLC and Mizuho Securities USA LLC, as representatives of the several underwriters named in the Pricing Agreement (the &#8220;Underwriters&#8221;), relating to the sale by the Company to the Underwriters of the
Debt Securities.&nbsp;The Underwriting Agreement, the Pricing Agreement, the Indenture and the Note Certificates (as defined below) are referred to herein collectively as the &#8220;Transaction Agreements.&#8221;</P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">This opinion is being furnished in accordance with the requirements of Item 601(b)(5) of Regulation
<FONT STYLE="white-space:nowrap">S-K</FONT> under the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;). </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">In rendering
the opinion stated herein, attorneys under my supervision and/or I have examined and relied upon the following: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(i) the registration
statement on Form <FONT STYLE="white-space:nowrap">S-3ASR</FONT> (File <FONT STYLE="white-space:nowrap">No.&nbsp;333-277323)</FONT> of the Company, Pfizer Investment Enterprises Pte. Ltd. (&#8220;Pfizer Singapore&#8221;) and Pfizer Netherlands
International Finance B.V. (&#8220;Pfizer Netherlands&#8221;) relating to the Debt Securities and other securities of the Company, Pfizer Singapore and Pfizer Netherlands filed with the Securities and Exchange Commission (the
&#8220;Commission&#8221;) on February&nbsp;23, 2024 under the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;), allowing for delayed offerings pursuant to Rule 415 of the General Rules and Regulations under the Securities Act
(the &#8220;Rules and Regulations&#8221;), as amended by Post-Effective Amendment No.&nbsp;1 thereto, filed with the Commission on May&nbsp;13, 2025, including information deemed to be a part of the registration statement pursuant to Rule 430B of
the Rules and Regulations (such registration statement being hereinafter referred to as the &#8220;Registration Statement&#8221;); </P>
</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(ii) the prospectus, dated May&nbsp;13, 2025 (the &#8220;Base Prospectus&#8221;), which
forms a part of and is included in the Registration Statement; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(iii) the preliminary prospectus supplement, dated November 18, 2025
(together with the Base Prospectus, the &#8220;Preliminary Prospectus&#8221;) relating to the offering of the Debt Securities in the form filed with the Commission pursuant to Rule 424(b) of the Rules and Regulations; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(iv) the prospectus supplement, dated November 18, 2025 (together with the Base Prospectus, the &#8220;Prospectus&#8221;), relating to the
offering of the Debt Securities, in the form filed with the Commission pursuant to Rule 424(b) of the Rules and Regulations; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(v) executed
copies of the Underwriting Agreement and the Pricing Agreement; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(vi) the global certificates evidencing the Debt Securities (the
&#8220;Note Certificates&#8221;) in the form delivered by the Company to the Trustee for authentication and delivery; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(vii) an executed
copy of the Base Indenture; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(viii) an executed copy of the Sixth Supplemental Indenture; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(ix) an executed copy of a secretary&#8217;s certificate of Madelyn D. Purcell, Assistant Secretary of the Company, dated the date hereof (the
&#8220;Secretary&#8217;s Certificate&#8221;); </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(x) a copy of the Restated Certificate of Incorporation of the Company, dated
December&nbsp;14, 2020, certified by the Secretary of State of the State of Delaware as of November&nbsp;18, 2025 and certified pursuant to the Secretary&#8217;s Certificate; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(xi) a copy of the <FONT STYLE="white-space:nowrap">By-laws</FONT> of the Company (the
<FONT STYLE="white-space:nowrap">&#8220;By-laws&#8221;),</FONT> as amended and in effect as of the date hereof and certified pursuant to the Secretary&#8217;s Certificate; and </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(xii) copies of certain resolutions of the Board of Directors of the Company and certain resolutions of the Securities Issuance Committee of
the Company, each certified pursuant to the Secretary&#8217;s Certificate. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Attorneys under my supervision and/or I have also examined
originals or copies, certified or otherwise identified to our satisfaction, of such records of the Company and such agreements, certificates and receipts of public officials, certificates of other officers or representatives of the Company and
others, and such other documents as we have deemed necessary or appropriate as a basis for the opinion stated below. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">2 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">In our examination, attorneys under my supervision and I have assumed the genuineness of all
signatures, including electronic signatures, the legal capacity and competency of all natural persons, the authenticity of all documents submitted to us as originals, the conformity to original documents of all documents submitted to us as
facsimile, electronic, certified or photocopied copies, and the authenticity of the originals of such copies. As to any facts relevant to the opinion stated herein that attorneys under my supervision and I did not independently establish or verify,
we have relied upon statements and representations of other officers and representatives of the Company and others and of public officials, including those in the Secretary&#8217;s Certificate and the factual representations and warranties contained
in the Underwriting Agreement. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">I am admitted to the bar in the State of New York, and I do not express any opinion as to the laws of any
jurisdiction other than Delaware corporate law and the laws of the State of New York, and I do not express any opinion as to the effect of any other laws on the opinion stated herein. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">Based upon the foregoing and subject to the qualifications and assumptions stated herein, I am of the opinion that the Note Certificates have
been duly authorized by all requisite action on the part of the Company and duly executed by the Company under the General Corporation Law of the State of Delaware, and, when duly authenticated by the Trustee and issued and delivered by the Company
against payment therefor in accordance with the terms of the Underwriting Agreement, the Pricing Agreement and the Indenture, the Note Certificates will constitute valid and binding obligations of the Company entitled to the benefits of the
Indenture and enforceable against the Company in accordance with their terms under the laws of the State of New York. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The opinion stated
herein is subject to the following qualifications: </P> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(a) the opinion stated herein is limited by applicable bankruptcy, insolvency,
reorganization, moratorium, fraudulent transfer, preference and other similar laws affecting creditors&#8217; rights generally, and by general principles of equity (regardless of whether enforcement is sought in equity or at law); </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(b) I do not express any opinion with respect to any law, rule or regulation that is applicable to any party to any of the Transaction
Agreements or the transactions contemplated thereby solely because such law, rule or regulation is part of a regulatory regime applicable to any such party or any of its affiliates as a result of the specific assets or business operations of such
party or such affiliates; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(c) except to the extent expressly stated in the opinion contained herein, I have assumed that each of the
Transaction Agreements constitutes the valid and binding obligation of each party to such Transaction Agreement, enforceable against such party in accordance with its terms; </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">3 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(d) I do not express any opinion with respect to the enforceability of any provision
contained in any Transaction Agreement relating to any indemnification, contribution, <FONT STYLE="white-space:nowrap">non-reliance,</FONT> exculpation, release, limitation or exclusion of remedies, waiver or other provisions having similar effect
that may be contrary to public policy or violative of federal or state securities laws, rules or regulations, or to the extent any such provision purports to, or has the effect of, waiving or alerting any statute of limitations; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(e) I do not express any opinion with respect to the enforceability of any provision of any Transaction Agreement to the extent that such
section purports to bind the Company to the exclusive jurisdiction of any particular federal court or courts; </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(f) I call to your
attention that irrespective of the agreement of the parties to any Transaction Agreement, a court may decline to hear a case on grounds of forum non conveniens or other doctrine limiting the availability of such court as a forum for resolution of
disputes; in addition, I call to your attention that I do not express any opinion with respect to the subject matter jurisdiction of the federal courts of the United States of America in any action arising out of or relating to any Transaction
Agreement; and </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(g) to the extent that the opinion relates to the enforceability of the choice of New York law and choice of New York
forum provisions contained in any Transaction Agreement, the opinion stated herein is subject to the qualification that such enforceability may be subject to, in each case, (i)&nbsp;the exceptions and limitations in New York General Obligations Law
sections <FONT STYLE="white-space:nowrap">5-1401</FONT> and <FONT STYLE="white-space:nowrap">5-1402</FONT> and (ii)&nbsp;principles of comity and constitutionality. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">In addition, in rendering the foregoing opinion, I have assumed that, at all applicable times: </P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(h) neither the execution and delivery by the Company of each of the Transaction Agreements, nor the performance by the Company of its
obligations under each of the Transaction Agreements: (i)&nbsp;constitutes or will constitute a violation of, or a default under, any lease, indenture, instrument or other agreement to which the Company or its property is subject,
(ii)&nbsp;contravenes or will contravene any order or decree of any governmental authority to which the Company or its property is subject, (iii)&nbsp;violates or will violate any law, rule or regulation to which the Company or its property is
subject or (iv)&nbsp;requires or will require the consent, approval, licensing or authorization of, or any filing, recording or registration with, any governmental authority under any law, rule or regulation of any jurisdiction; </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(i) neither the execution and delivery by the Company of the Transaction Agreements to which the Company is a party nor the performance by the
Company of its respective obligations thereunder, including the issuance and sale of the Debt Securities, required or will require the consent, approval, licensing or authorization of, or any filing, recording or registration with, any governmental
authority under any law, rule or regulation of any jurisdiction; and </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">4 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">(j) I do not express any opinion as to whether the execution or delivery of any Transaction
Agreement by the Company or the performance by the Company of its obligations under any Transaction Agreement will constitute a violation of, or a default under, any covenant, restriction or provision with respect to financial ratios or tests or any
aspect of the financial condition or results of operations of the Company or any of its subsidiaries. </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">I consent to the filing of this
opinion with the Commission as an exhibit to the Company&#8217;s Current Report on Form <FONT STYLE="white-space:nowrap">8-K</FONT> being filed on the date hereof, and incorporated by reference into the Registration Statement.&nbsp;I also hereby
consent to the reference to my name under the heading &#8220;Legal Matters&#8221; in the prospectus supplement dated November&nbsp;18, 2025 and filed with the Commission. In giving such consent, I do not thereby admit that I am in the category of
persons whose consent is required under Section&nbsp;7 of the Securities Act. This opinion is expressed as of the date hereof unless otherwise expressly stated, and I disclaim any undertaking to advise you of any subsequent changes in the facts
stated or assumed herein or of any subsequent changes in applicable laws. </P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">5 </P>

</DIV></Center>


<p style="margin-top:1em; margin-bottom:0em; page-break-before:always"> </p>
<HR SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

<Center><DIV STYLE="width:8.5in" align="left">
 <DIV ALIGN="right">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="40%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Times New Roman; font-size:10pt">


<TR>

<TD WIDTH="100%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Very truly yours,</P></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">/s/ Margaret M. Madden, Esq.</P></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="16"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:10pt; font-family:Times New Roman">Margaret M. Madden, Esq.</P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="top">Senior Vice President and Corporate Secretary, Chief Governance Counsel of Pfizer Inc.</TD></TR>
</TABLE></DIV>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center">[<I>Signature Page to
Exhibit 5 Opinion</I>] </P>

</DIV></Center>

</BODY></HTML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.SCH
<SEQUENCE>6
<FILENAME>pfe-20251118.xsd
<DESCRIPTION>XBRL TAXONOMY EXTENSION SCHEMA
<TEXT>
<XBRL>
<?xml version="1.0" encoding="us-ascii"?>
<!-- DFIN - https://www.dfinsolutions.com/ -->
<!-- CTU Version: Release 2512 Build:20250722.1 -->
<!-- Creation date: 11/22/2025 2:13:39 AM Eastern Time -->
<!-- Copyright (c) 2025 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
<xsd:schema
  xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric"
  xmlns:num="http://www.xbrl.org/dtr/type/numeric"
  xmlns:us-types="http://fasb.org/us-types/2025"
  xmlns:pfe="http://www.pfizer.com/20251118"
  xmlns:dei="http://xbrl.sec.gov/dei/2025"
  xmlns:xbrli="http://www.xbrl.org/2003/instance"
  xmlns:link="http://www.xbrl.org/2003/linkbase"
  xmlns:xlink="http://www.w3.org/1999/xlink"
  xmlns:xbrldt="http://xbrl.org/2005/xbrldt"
  xmlns:us-gaap="http://fasb.org/us-gaap/2025"
  attributeFormDefault="unqualified"
  elementFormDefault="qualified"
  targetNamespace="http://www.pfizer.com/20251118"
  xmlns:xsd="http://www.w3.org/2001/XMLSchema">
    <xsd:import schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" namespace="http://www.xbrl.org/2003/instance" />
    <xsd:import schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" namespace="http://www.xbrl.org/2003/linkbase" />
    <xsd:import schemaLocation="https://xbrl.sec.gov/dei/2025/dei-2025.xsd" namespace="http://xbrl.sec.gov/dei/2025" />
    <xsd:import schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd" namespace="http://www.xbrl.org/dtr/type/numeric" />
    <xsd:import schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd" namespace="http://www.xbrl.org/dtr/type/non-numeric" />
    <xsd:import schemaLocation="https://xbrl.sec.gov/naics/2025/naics-2025.xsd" namespace="http://xbrl.sec.gov/naics/2025" />
    <xsd:import schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" namespace="http://xbrl.org/2005/xbrldt" />
    <xsd:import schemaLocation="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd" namespace="http://fasb.org/us-gaap/2025" />
    <xsd:import schemaLocation="https://xbrl.fasb.org/us-gaap/2025/elts/us-types-2025.xsd" namespace="http://fasb.org/us-types/2025" />
  <xsd:annotation>
    <xsd:appinfo>
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="pfe-20251118_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:title="Label Links, all" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="pfe-20251118_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:title="Presentation Links, all" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="pfe-20251118_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:title="Definition Links, all" xlink:type="simple" />
      <link:roleType roleURI="http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation" id="Role_DocumentDocumentAndEntityInformation">
        <link:definition>100000 - Document - Document and Entity Information</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xsd:appinfo>
  </xsd:annotation>
  <xsd:element id="pfe_DocumentAndEntityInformationTable" name="DocumentAndEntityInformationTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="pfe_DocumentAndEntityInformationLineItems" name="DocumentAndEntityInformationLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="pfe_M1.000NotesDue20275Member" name="M1.000NotesDue20275Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="pfe_M2.875NotesDue20291Member" name="M2.875NotesDue20291Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="pfe_M3.250NotesDue20322Member" name="M3.250NotesDue20322Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="pfe_M3.875NotesDue20373Member" name="M3.875NotesDue20373Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="pfe_M4.250NotesDue20454Member" name="M4.250NotesDue20454Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
</xsd:schema>
</XBRL>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.DEF
<SEQUENCE>7
<FILENAME>pfe-20251118_def.xml
<DESCRIPTION>XBRL TAXONOMY EXTENSION DEFINITION LINKBASE
<TEXT>
<XBRL>
<?xml version="1.0" encoding="us-ascii"?>
<!-- DFIN - https://www.dfinsolutions.com/ -->
<!-- CTU Version: Release 2512 Build:20250722.1 -->
<!-- Creation date: 11/22/2025 2:13:41 AM Eastern Time -->
<!-- Copyright (c) 2025 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
<linkbase xmlns="http://www.xbrl.org/2003/linkbase" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all" arcroleURI="http://xbrl.org/int/dim/arcrole/all" />
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default" arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" />
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain" arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" />
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member" arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" />
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension" arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" />
  <link:roleRef roleURI="http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation" xlink:href="pfe-20251118.xsd#Role_DocumentDocumentAndEntityInformation" xlink:type="simple" />
  <link:definitionLink xlink:type="extended" xlink:role="http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation">
    <link:loc xlink:href="pfe-20251118.xsd#pfe_DocumentAndEntityInformationTable" xlink:type="locator" xlink:label="pfe_DocumentAndEntityInformationTable" />
    <link:loc xlink:href="pfe-20251118.xsd#pfe_DocumentAndEntityInformationLineItems" xlink:type="locator" xlink:label="pfe_DocumentAndEntityInformationLineItems" />
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis" xlink:type="locator" xlink:label="us-gaap_StatementClassOfStockAxis" />
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain" xlink:type="locator" xlink:label="us-gaap_ClassOfStockDomain" />
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain" xlink:type="locator" xlink:label="us-gaap_ClassOfStockDomain_2" />
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockMember" xlink:type="locator" xlink:label="us-gaap_CommonStockMember" />
    <link:loc xlink:href="pfe-20251118.xsd#pfe_M1.000NotesDue20275Member" xlink:type="locator" xlink:label="pfe_M1.000NotesDue20275Member" />
    <link:loc xlink:href="pfe-20251118.xsd#pfe_M2.875NotesDue20291Member" xlink:type="locator" xlink:label="pfe_M2.875NotesDue20291Member" />
    <link:loc xlink:href="pfe-20251118.xsd#pfe_M3.250NotesDue20322Member" xlink:type="locator" xlink:label="pfe_M3.250NotesDue20322Member" />
    <link:loc xlink:href="pfe-20251118.xsd#pfe_M3.875NotesDue20373Member" xlink:type="locator" xlink:label="pfe_M3.875NotesDue20373Member" />
    <link:loc xlink:href="pfe-20251118.xsd#pfe_M4.250NotesDue20454Member" xlink:type="locator" xlink:label="pfe_M4.250NotesDue20454Member" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName" xlink:type="locator" xlink:label="dei_EntityRegistrantName" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag" xlink:type="locator" xlink:label="dei_AmendmentFlag" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey" xlink:type="locator" xlink:label="dei_EntityCentralIndexKey" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType" xlink:type="locator" xlink:label="dei_DocumentType" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate" xlink:type="locator" xlink:label="dei_DocumentPeriodEndDate" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode" xlink:type="locator" xlink:label="dei_EntityIncorporationStateCountryCode" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber" xlink:type="locator" xlink:label="dei_EntityFileNumber" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber" xlink:type="locator" xlink:label="dei_EntityTaxIdentificationNumber" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1" xlink:type="locator" xlink:label="dei_EntityAddressAddressLine1" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown" xlink:type="locator" xlink:label="dei_EntityAddressCityOrTown" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince" xlink:type="locator" xlink:label="dei_EntityAddressStateOrProvince" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode" xlink:type="locator" xlink:label="dei_EntityAddressPostalZipCode" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode" xlink:type="locator" xlink:label="dei_CityAreaCode" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber" xlink:type="locator" xlink:label="dei_LocalPhoneNumber" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications" xlink:type="locator" xlink:label="dei_WrittenCommunications" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial" xlink:type="locator" xlink:label="dei_SolicitingMaterial" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer" xlink:type="locator" xlink:label="dei_PreCommencementTenderOffer" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer" xlink:type="locator" xlink:label="dei_PreCommencementIssuerTenderOffer" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle" xlink:type="locator" xlink:label="dei_Security12bTitle" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol" xlink:type="locator" xlink:label="dei_TradingSymbol" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName" xlink:type="locator" xlink:label="dei_SecurityExchangeName" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany" xlink:type="locator" xlink:label="dei_EntityEmergingGrowthCompany" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="pfe_DocumentAndEntityInformationTable" order="1" priority="2" use="optional" xbrldt:contextElement="segment" xbrldt:closed="true" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="pfe_DocumentAndEntityInformationTable" xlink:to="us-gaap_StatementClassOfStockAxis" order="1" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="us-gaap_StatementClassOfStockAxis" xlink:to="us-gaap_ClassOfStockDomain" order="23" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="us-gaap_StatementClassOfStockAxis" xlink:to="us-gaap_ClassOfStockDomain_2" order="23.0001" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockDomain" xlink:to="us-gaap_CommonStockMember" order="24" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockDomain" xlink:to="pfe_M1.000NotesDue20275Member" order="25" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockDomain" xlink:to="pfe_M2.875NotesDue20291Member" order="26" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockDomain" xlink:to="pfe_M3.250NotesDue20322Member" order="27" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockDomain" xlink:to="pfe_M3.875NotesDue20373Member" order="28" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="us-gaap_ClassOfStockDomain" xlink:to="pfe_M4.250NotesDue20454Member" order="29" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_EntityRegistrantName" order="31.001" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_AmendmentFlag" order="32.001" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_EntityCentralIndexKey" order="33.001" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_DocumentType" order="37.001" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_DocumentPeriodEndDate" order="38.001" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_EntityIncorporationStateCountryCode" order="39.001" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_EntityFileNumber" order="40.001" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_EntityTaxIdentificationNumber" order="41.001" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_EntityAddressAddressLine1" order="42.001" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_EntityAddressCityOrTown" order="43.001" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_EntityAddressStateOrProvince" order="44.001" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_EntityAddressPostalZipCode" order="45.001" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_CityAreaCode" order="46.001" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_LocalPhoneNumber" order="47.001" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_WrittenCommunications" order="48.001" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_SolicitingMaterial" order="49.001" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_PreCommencementTenderOffer" order="50.001" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_PreCommencementIssuerTenderOffer" order="51.001" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_Security12bTitle" order="52.001" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_TradingSymbol" order="53.001" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_SecurityExchangeName" order="54.001" priority="2" use="optional" />
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_EntityEmergingGrowthCompany" order="55.001" priority="2" use="optional" />
  </link:definitionLink>
</linkbase>
</XBRL>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.LAB
<SEQUENCE>8
<FILENAME>pfe-20251118_lab.xml
<DESCRIPTION>XBRL TAXONOMY EXTENSION LABEL LINKBASE
<TEXT>
<XBRL>
<?xml version="1.0" encoding="us-ascii" standalone="yes"?>
<!-- DFIN - https://www.dfinsolutions.com/ -->
<!-- CTU Version: Release 2512 Build:20250722.1 -->
<!-- Creation date: 11/22/2025 2:13:39 AM Eastern Time -->
<!-- Copyright (c) 2025 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
<link:linkbase
  xmlns:link="http://www.xbrl.org/2003/linkbase"
  xmlns:xlink="http://www.w3.org/1999/xlink"
  xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
  xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:labelLink xlink:role="http://www.xbrl.org/2003/role/link" xlink:type="extended">
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CoverAbstract" xlink:type="locator" xlink:label="dei_CoverAbstract" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_CoverAbstract" xlink:to="dei_CoverAbstract_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_CoverAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Cover [Abstract]</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_CoverAbstract_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Cover [Abstract]</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName" xlink:type="locator" xlink:label="dei_EntityRegistrantName" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityRegistrantName" xlink:to="dei_EntityRegistrantName_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_EntityRegistrantName_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Registrant Name</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_EntityRegistrantName_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Registrant Name</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag" xlink:type="locator" xlink:label="dei_AmendmentFlag" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_AmendmentFlag" xlink:to="dei_AmendmentFlag_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_AmendmentFlag_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Amendment Flag</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_AmendmentFlag_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Amendment Flag</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey" xlink:type="locator" xlink:label="dei_EntityCentralIndexKey" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityCentralIndexKey" xlink:to="dei_EntityCentralIndexKey_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_EntityCentralIndexKey_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Central Index Key</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_EntityCentralIndexKey_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Central Index Key</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType" xlink:type="locator" xlink:label="dei_DocumentType" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_DocumentType" xlink:to="dei_DocumentType_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_DocumentType_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Document Type</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_DocumentType_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Document Type</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate" xlink:type="locator" xlink:label="dei_DocumentPeriodEndDate" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_DocumentPeriodEndDate" xlink:to="dei_DocumentPeriodEndDate_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_DocumentPeriodEndDate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Document Period End Date</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_DocumentPeriodEndDate_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Document Period End Date</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode" xlink:type="locator" xlink:label="dei_EntityIncorporationStateCountryCode" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityIncorporationStateCountryCode" xlink:to="dei_EntityIncorporationStateCountryCode_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_EntityIncorporationStateCountryCode_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Incorporation State Country Code</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_EntityIncorporationStateCountryCode_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Incorporation State Country Code</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber" xlink:type="locator" xlink:label="dei_EntityFileNumber" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityFileNumber" xlink:to="dei_EntityFileNumber_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_EntityFileNumber_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity File Number</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_EntityFileNumber_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity File Number</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber" xlink:type="locator" xlink:label="dei_EntityTaxIdentificationNumber" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityTaxIdentificationNumber" xlink:to="dei_EntityTaxIdentificationNumber_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_EntityTaxIdentificationNumber_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Tax Identification Number</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_EntityTaxIdentificationNumber_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Tax Identification Number</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1" xlink:type="locator" xlink:label="dei_EntityAddressAddressLine1" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityAddressAddressLine1" xlink:to="dei_EntityAddressAddressLine1_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_EntityAddressAddressLine1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Address, Address Line One</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_EntityAddressAddressLine1_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Address, Address Line One</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown" xlink:type="locator" xlink:label="dei_EntityAddressCityOrTown" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityAddressCityOrTown" xlink:to="dei_EntityAddressCityOrTown_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_EntityAddressCityOrTown_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Address, City or Town</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_EntityAddressCityOrTown_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Address, City or Town</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince" xlink:type="locator" xlink:label="dei_EntityAddressStateOrProvince" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityAddressStateOrProvince" xlink:to="dei_EntityAddressStateOrProvince_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_EntityAddressStateOrProvince_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Address, State or Province</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_EntityAddressStateOrProvince_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Address, State or Province</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode" xlink:type="locator" xlink:label="dei_EntityAddressPostalZipCode" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityAddressPostalZipCode" xlink:to="dei_EntityAddressPostalZipCode_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_EntityAddressPostalZipCode_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Address, Postal Zip Code</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_EntityAddressPostalZipCode_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Address, Postal Zip Code</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode" xlink:type="locator" xlink:label="dei_CityAreaCode" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_CityAreaCode" xlink:to="dei_CityAreaCode_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_CityAreaCode_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">City Area Code</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_CityAreaCode_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">City Area Code</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber" xlink:type="locator" xlink:label="dei_LocalPhoneNumber" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_LocalPhoneNumber" xlink:to="dei_LocalPhoneNumber_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_LocalPhoneNumber_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Local Phone Number</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_LocalPhoneNumber_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Local Phone Number</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications" xlink:type="locator" xlink:label="dei_WrittenCommunications" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_WrittenCommunications" xlink:to="dei_WrittenCommunications_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_WrittenCommunications_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Written Communications</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_WrittenCommunications_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Written Communications</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial" xlink:type="locator" xlink:label="dei_SolicitingMaterial" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_SolicitingMaterial" xlink:to="dei_SolicitingMaterial_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_SolicitingMaterial_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Soliciting Material</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_SolicitingMaterial_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Soliciting Material</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer" xlink:type="locator" xlink:label="dei_PreCommencementTenderOffer" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_PreCommencementTenderOffer" xlink:to="dei_PreCommencementTenderOffer_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_PreCommencementTenderOffer_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Pre Commencement Tender Offer</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_PreCommencementTenderOffer_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Pre Commencement Tender Offer</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer" xlink:type="locator" xlink:label="dei_PreCommencementIssuerTenderOffer" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_PreCommencementIssuerTenderOffer" xlink:to="dei_PreCommencementIssuerTenderOffer_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_PreCommencementIssuerTenderOffer_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Pre Commencement Issuer Tender Offer</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_PreCommencementIssuerTenderOffer_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Pre Commencement Issuer Tender Offer</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle" xlink:type="locator" xlink:label="dei_Security12bTitle" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_Security12bTitle" xlink:to="dei_Security12bTitle_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_Security12bTitle_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Security 12b Title</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_Security12bTitle_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Security 12b Title</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol" xlink:type="locator" xlink:label="dei_TradingSymbol" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_TradingSymbol" xlink:to="dei_TradingSymbol_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_TradingSymbol_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Trading Symbol</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_TradingSymbol_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Trading Symbol</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName" xlink:type="locator" xlink:label="dei_SecurityExchangeName" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_SecurityExchangeName" xlink:to="dei_SecurityExchangeName_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_SecurityExchangeName_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Security Exchange Name</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_SecurityExchangeName_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Security Exchange Name</link:label>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany" xlink:type="locator" xlink:label="dei_EntityEmergingGrowthCompany" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityEmergingGrowthCompany" xlink:to="dei_EntityEmergingGrowthCompany_lbl" />
    <link:label xml:lang="en-US" xlink:label="dei_EntityEmergingGrowthCompany_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Entity Emerging Growth Company</link:label>
    <link:label xml:lang="en-US" xlink:label="dei_EntityEmergingGrowthCompany_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Entity Emerging Growth Company</link:label>
    <link:loc xlink:href="pfe-20251118.xsd#pfe_DocumentAndEntityInformationTable" xlink:type="locator" xlink:label="pfe_DocumentAndEntityInformationTable" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="pfe_DocumentAndEntityInformationTable" xlink:to="pfe_DocumentAndEntityInformationTable_lbl" />
    <link:label xml:lang="en-US" xlink:label="pfe_DocumentAndEntityInformationTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Document And Entity Information [Table]</link:label>
    <link:label xml:lang="en-US" xlink:label="pfe_DocumentAndEntityInformationTable_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Document And Entity Information [Table]</link:label>
    <link:loc xlink:href="pfe-20251118.xsd#pfe_DocumentAndEntityInformationLineItems" xlink:type="locator" xlink:label="pfe_DocumentAndEntityInformationLineItems" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="pfe_DocumentAndEntityInformationLineItems_lbl" />
    <link:label xml:lang="en-US" xlink:label="pfe_DocumentAndEntityInformationLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Document And Entity Information [Line Items]</link:label>
    <link:label xml:lang="en-US" xlink:label="pfe_DocumentAndEntityInformationLineItems_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Document And Entity Information [Line Items]</link:label>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis" xlink:type="locator" xlink:label="us-gaap_StatementClassOfStockAxis" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StatementClassOfStockAxis" xlink:to="us-gaap_StatementClassOfStockAxis_lbl" />
    <link:label xml:lang="en-US" xlink:label="us-gaap_StatementClassOfStockAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Class of Stock [Axis]</link:label>
    <link:label xml:lang="en-US" xlink:label="us-gaap_StatementClassOfStockAxis_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Class of Stock [Axis]</link:label>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain" xlink:type="locator" xlink:label="us-gaap_ClassOfStockDomain" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ClassOfStockDomain" xlink:to="us-gaap_ClassOfStockDomain_lbl" />
    <link:label xml:lang="en-US" xlink:label="us-gaap_ClassOfStockDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Class of Stock [Domain]</link:label>
    <link:label xml:lang="en-US" xlink:label="us-gaap_ClassOfStockDomain_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Class of Stock [Domain]</link:label>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockMember" xlink:type="locator" xlink:label="us-gaap_CommonStockMember" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CommonStockMember" xlink:to="us-gaap_CommonStockMember_lbl" />
    <link:label xml:lang="en-US" xlink:label="us-gaap_CommonStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">Common Stock [Member]</link:label>
    <link:label xml:lang="en-US" xlink:label="us-gaap_CommonStockMember_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Common Stock [Member]</link:label>
    <link:loc xlink:href="pfe-20251118.xsd#pfe_M1.000NotesDue20275Member" xlink:type="locator" xlink:label="pfe_M1.000NotesDue20275Member" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="pfe_M1.000NotesDue20275Member" xlink:to="pfe_M1.000NotesDue20275Member_lbl" />
    <link:label xml:lang="en-US" xlink:label="pfe_M1.000NotesDue20275Member_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">M 1.000 Notes Due 20275 [Member]</link:label>
    <link:label xml:lang="en-US" xlink:label="pfe_M1.000NotesDue20275Member_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">M 1.000 Notes Due 20275 [Member]</link:label>
    <link:loc xlink:href="pfe-20251118.xsd#pfe_M2.875NotesDue20291Member" xlink:type="locator" xlink:label="pfe_M2.875NotesDue20291Member" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="pfe_M2.875NotesDue20291Member" xlink:to="pfe_M2.875NotesDue20291Member_lbl" />
    <link:label xml:lang="en-US" xlink:label="pfe_M2.875NotesDue20291Member_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">M 2.875 Notes Due 20291 [Member]</link:label>
    <link:label xml:lang="en-US" xlink:label="pfe_M2.875NotesDue20291Member_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">M 2.875 Notes Due 20291 [Member]</link:label>
    <link:loc xlink:href="pfe-20251118.xsd#pfe_M3.250NotesDue20322Member" xlink:type="locator" xlink:label="pfe_M3.250NotesDue20322Member" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="pfe_M3.250NotesDue20322Member" xlink:to="pfe_M3.250NotesDue20322Member_lbl" />
    <link:label xml:lang="en-US" xlink:label="pfe_M3.250NotesDue20322Member_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">M 3.250 Notes Due 20322 [Member]</link:label>
    <link:label xml:lang="en-US" xlink:label="pfe_M3.250NotesDue20322Member_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">M 3.250 Notes Due 20322 [Member]</link:label>
    <link:loc xlink:href="pfe-20251118.xsd#pfe_M3.875NotesDue20373Member" xlink:type="locator" xlink:label="pfe_M3.875NotesDue20373Member" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="pfe_M3.875NotesDue20373Member" xlink:to="pfe_M3.875NotesDue20373Member_lbl" />
    <link:label xml:lang="en-US" xlink:label="pfe_M3.875NotesDue20373Member_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">M 3.875 Notes Due 20373 [Member]</link:label>
    <link:label xml:lang="en-US" xlink:label="pfe_M3.875NotesDue20373Member_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">M 3.875 Notes Due 20373 [Member]</link:label>
    <link:loc xlink:href="pfe-20251118.xsd#pfe_M4.250NotesDue20454Member" xlink:type="locator" xlink:label="pfe_M4.250NotesDue20454Member" />
    <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="pfe_M4.250NotesDue20454Member" xlink:to="pfe_M4.250NotesDue20454Member_lbl" />
    <link:label xml:lang="en-US" xlink:label="pfe_M4.250NotesDue20454Member_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label">M 4.250 Notes Due 20454 [Member]</link:label>
    <link:label xml:lang="en-US" xlink:label="pfe_M4.250NotesDue20454Member_lbl" xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel">M 4.250 Notes Due 20454 [Member]</link:label>
  </link:labelLink>
</link:linkbase>
</XBRL>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.PRE
<SEQUENCE>9
<FILENAME>pfe-20251118_pre.xml
<DESCRIPTION>XBRL TAXONOMY EXTENSION PRESENTATION LINKBASE
<TEXT>
<XBRL>
<?xml version="1.0" encoding="us-ascii" standalone="yes"?>
<!-- DFIN - https://www.dfinsolutions.com/ -->
<!-- CTU Version: Release 2512 Build:20250722.1 -->
<!-- Creation date: 11/22/2025 2:13:39 AM Eastern Time -->
<!-- Copyright (c) 2025 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
<link:linkbase
    xmlns:link="http://www.xbrl.org/2003/linkbase"
    xmlns:xlink="http://www.w3.org/1999/xlink"
    xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
    xmlns:xbrldt="http://xbrl.org/2005/xbrldt"
    xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation" xlink:href="pfe-20251118.xsd#Role_DocumentDocumentAndEntityInformation" xlink:type="simple" />
  <link:presentationLink xlink:type="extended" xlink:role="http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation">
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CoverAbstract" xlink:type="locator" xlink:label="dei_CoverAbstract" />
    <link:loc xlink:href="pfe-20251118.xsd#pfe_DocumentAndEntityInformationTable" xlink:type="locator" xlink:label="pfe_DocumentAndEntityInformationTable" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_CoverAbstract" xlink:to="pfe_DocumentAndEntityInformationTable" order="21" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="pfe-20251118.xsd#pfe_DocumentAndEntityInformationLineItems" xlink:type="locator" xlink:label="pfe_DocumentAndEntityInformationLineItems" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="pfe_DocumentAndEntityInformationTable" xlink:to="pfe_DocumentAndEntityInformationLineItems" order="22" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StatementClassOfStockAxis" xlink:type="locator" xlink:label="us-gaap_StatementClassOfStockAxis" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="pfe_DocumentAndEntityInformationTable" xlink:to="us-gaap_StatementClassOfStockAxis" order="1" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ClassOfStockDomain" xlink:type="locator" xlink:label="us-gaap_ClassOfStockDomain" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_StatementClassOfStockAxis" xlink:to="us-gaap_ClassOfStockDomain" order="23" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockMember" xlink:type="locator" xlink:label="us-gaap_CommonStockMember" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_ClassOfStockDomain" xlink:to="us-gaap_CommonStockMember" order="24" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="pfe-20251118.xsd#pfe_M1.000NotesDue20275Member" xlink:type="locator" xlink:label="pfe_M1.000NotesDue20275Member" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_ClassOfStockDomain" xlink:to="pfe_M1.000NotesDue20275Member" order="25" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="pfe-20251118.xsd#pfe_M2.875NotesDue20291Member" xlink:type="locator" xlink:label="pfe_M2.875NotesDue20291Member" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_ClassOfStockDomain" xlink:to="pfe_M2.875NotesDue20291Member" order="26" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="pfe-20251118.xsd#pfe_M3.250NotesDue20322Member" xlink:type="locator" xlink:label="pfe_M3.250NotesDue20322Member" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_ClassOfStockDomain" xlink:to="pfe_M3.250NotesDue20322Member" order="27" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="pfe-20251118.xsd#pfe_M3.875NotesDue20373Member" xlink:type="locator" xlink:label="pfe_M3.875NotesDue20373Member" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_ClassOfStockDomain" xlink:to="pfe_M3.875NotesDue20373Member" order="28" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="pfe-20251118.xsd#pfe_M4.250NotesDue20454Member" xlink:type="locator" xlink:label="pfe_M4.250NotesDue20454Member" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_ClassOfStockDomain" xlink:to="pfe_M4.250NotesDue20454Member" order="29" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName" xlink:type="locator" xlink:label="dei_EntityRegistrantName" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_EntityRegistrantName" order="31.001" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag" xlink:type="locator" xlink:label="dei_AmendmentFlag" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_AmendmentFlag" order="32.001" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey" xlink:type="locator" xlink:label="dei_EntityCentralIndexKey" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_EntityCentralIndexKey" order="33.001" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType" xlink:type="locator" xlink:label="dei_DocumentType" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_DocumentType" order="37.001" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate" xlink:type="locator" xlink:label="dei_DocumentPeriodEndDate" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_DocumentPeriodEndDate" order="38.001" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode" xlink:type="locator" xlink:label="dei_EntityIncorporationStateCountryCode" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_EntityIncorporationStateCountryCode" order="39.001" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber" xlink:type="locator" xlink:label="dei_EntityFileNumber" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_EntityFileNumber" order="40.001" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber" xlink:type="locator" xlink:label="dei_EntityTaxIdentificationNumber" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_EntityTaxIdentificationNumber" order="41.001" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1" xlink:type="locator" xlink:label="dei_EntityAddressAddressLine1" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_EntityAddressAddressLine1" order="42.001" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown" xlink:type="locator" xlink:label="dei_EntityAddressCityOrTown" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_EntityAddressCityOrTown" order="43.001" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince" xlink:type="locator" xlink:label="dei_EntityAddressStateOrProvince" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_EntityAddressStateOrProvince" order="44.001" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode" xlink:type="locator" xlink:label="dei_EntityAddressPostalZipCode" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_EntityAddressPostalZipCode" order="45.001" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode" xlink:type="locator" xlink:label="dei_CityAreaCode" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_CityAreaCode" order="46.001" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber" xlink:type="locator" xlink:label="dei_LocalPhoneNumber" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_LocalPhoneNumber" order="47.001" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications" xlink:type="locator" xlink:label="dei_WrittenCommunications" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_WrittenCommunications" order="48.001" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial" xlink:type="locator" xlink:label="dei_SolicitingMaterial" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_SolicitingMaterial" order="49.001" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer" xlink:type="locator" xlink:label="dei_PreCommencementTenderOffer" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_PreCommencementTenderOffer" order="50.001" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer" xlink:type="locator" xlink:label="dei_PreCommencementIssuerTenderOffer" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_PreCommencementIssuerTenderOffer" order="51.001" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle" xlink:type="locator" xlink:label="dei_Security12bTitle" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_Security12bTitle" order="52.001" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol" xlink:type="locator" xlink:label="dei_TradingSymbol" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_TradingSymbol" order="53.001" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName" xlink:type="locator" xlink:label="dei_SecurityExchangeName" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_SecurityExchangeName" order="54.001" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany" xlink:type="locator" xlink:label="dei_EntityEmergingGrowthCompany" />
    <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="pfe_DocumentAndEntityInformationLineItems" xlink:to="dei_EntityEmergingGrowthCompany" order="55.001" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" />
  </link:presentationLink>
</link:linkbase>
</XBRL>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>10
<FILENAME>g80089g1121085102404.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
begin 644 g80089g1121085102404.jpg
M_]C_X  02D9)1@ ! 0$ 8 !@  #_VP!#  @&!@<&!0@'!P<)"0@*#!0-# L+
M#!D2$P\4'1H?'AT:'!P@)"XG("(L(QP<*#<I+# Q-#0T'R<Y/3@R/"XS-#+_
MVP!# 0D)"0P+#!@-#1@R(1PA,C(R,C(R,C(R,C(R,C(R,C(R,C(R,C(R,C(R
M,C(R,C(R,C(R,C(R,C(R,C(R,C(R,C+_P  1" !* .T# 2(  A$! Q$!_\0
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M,D9&E:.'$8>,D8DE8C[QZ@= /4FK]MK^JVWB^UT'5(+.3[7:R7$<UH6_=["
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M^0$#[/#C<P)YZ\<5S47BG5(01%X&U.,$Y(01C/Y&NUIDDL<,;22NJ(HR68X
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MTK6_&][/;2RZHN%LH_+)S L65VG^[N+$^]>E%%.,J#CIQTI-BDDE1DC!..U
M'DSV#:=HG@"TDF,.F0Q--<3&(N@GV IN7_>9\9[BM:2/3I+"[LD2XO;[Q+(T
M+S7,95754QO_ -E5'3U->AF-"FPHI7T(XHV+D':,CIQTH X+PK)>6W@R_-O
MTOB.V9K>Y:8?--)&=JD$]05&0.E7[;Q/)') Z2F[L7@FNYYI!L>"-"%*D=R&
MW?EBNEO-/AO5C#ET,<@D5HVVG< 1V^IJ@WA7267:8&VF!H&4.<.K$DY]3EB<
M^] %1O%GEK-OL)A)&UNHC# LQF.%'U Y(JQIVLWU[KEQ9O8"&&WB0R,9 2LC
M;CCW^4*?QJ>'PYIT#[PCL_G).6=R271=JD_A5F'2[:#4;B_C#">XQYGS'!(
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M$C11@*H& * )J*** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH
M**** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ H
IHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH _]D!

end
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>11
<FILENAME>g80089g59u60.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
begin 644 g80089g59u60.jpg
M_]C_X  02D9)1@ ! 0$ 8 !@  #_VP!#  ," @," @,# P,$ P,$!0@%!00$
M!0H'!P8(# H,# L*"PL-#A(0#0X1#@L+$!80$1,4%145# \7&!84&!(4%13_
MVP!# 0,$! 4$!0D%!0D4#0L-%!04%!04%!04%!04%!04%!04%!04%!04%!04
M%!04%!04%!04%!04%!04%!04%!04%!3_P  1" !  (T# 1$  A$! Q$!_\0
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ME>.P/^\T917=IV^_8^RP>:X#'_[K6C-]DU?[MSI*\L]4* "@ H * "@ H *
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MEP76/PKI@A88*33/)D>AZ9_*OK(>'N&CK+$2OY)+_,^/J>(^*EI'#1MYMO\
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MC@1P:7.[$_0+7ZC/-,!37-.O!+SE'_,XE"3V1[S\(/\ @F_\:_BK,LEWX?\
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* * "@ H * /_V0$!

end
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>13
<FILENAME>R1.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="include/report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.25.3</span><table class="report" border="0" cellspacing="2" id="id2">
<tr>
<th class="tl" colspan="1" rowspan="1"><div style="width: 200px;"><strong>Document and Entity Information<br></strong></div></th>
<th class="th"><div>Nov. 18, 2025</div></th>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_pfe_DocumentAndEntityInformationLineItems', window );"><strong>Document And Entity Information [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityRegistrantName', window );">Entity Registrant Name</a></td>
<td class="text">PFIZER INC<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_AmendmentFlag', window );">Amendment Flag</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityCentralIndexKey', window );">Entity Central Index Key</a></td>
<td class="text">0000078003<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_DocumentType', window );">Document Type</a></td>
<td class="text">8-K<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_DocumentPeriodEndDate', window );">Document Period End Date</a></td>
<td class="text">Nov. 18,  2025<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityIncorporationStateCountryCode', window );">Entity Incorporation State Country Code</a></td>
<td class="text">DE<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityFileNumber', window );">Entity File Number</a></td>
<td class="text">1-3619<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityTaxIdentificationNumber', window );">Entity Tax Identification Number</a></td>
<td class="text">13-5315170<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressAddressLine1', window );">Entity Address, Address Line One</a></td>
<td class="text">66 Hudson Boulevard East<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressCityOrTown', window );">Entity Address, City or Town</a></td>
<td class="text">New York<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressStateOrProvince', window );">Entity Address, State or Province</a></td>
<td class="text">NY<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityAddressPostalZipCode', window );">Entity Address, Postal Zip Code</a></td>
<td class="text">10001-2192<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_CityAreaCode', window );">City Area Code</a></td>
<td class="text">(212)<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_LocalPhoneNumber', window );">Local Phone Number</a></td>
<td class="text">733-2323<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_WrittenCommunications', window );">Written Communications</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_SolicitingMaterial', window );">Soliciting Material</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_PreCommencementTenderOffer', window );">Pre Commencement Tender Offer</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_PreCommencementIssuerTenderOffer', window );">Pre Commencement Issuer Tender Offer</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_EntityEmergingGrowthCompany', window );">Entity Emerging Growth Company</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_us-gaap_StatementClassOfStockAxis=us-gaap_CommonStockMember', window );">Common Stock [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_pfe_DocumentAndEntityInformationLineItems', window );"><strong>Document And Entity Information [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_Security12bTitle', window );">Security 12b Title</a></td>
<td class="text">Common Stock, $0.05 par value<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_TradingSymbol', window );">Trading Symbol</a></td>
<td class="text">PFE<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_SecurityExchangeName', window );">Security Exchange Name</a></td>
<td class="text">NYSE<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_us-gaap_StatementClassOfStockAxis=pfe_M1.000NotesDue20275Member', window );">M 1.000 Notes Due 20275 [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_pfe_DocumentAndEntityInformationLineItems', window );"><strong>Document And Entity Information [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_Security12bTitle', window );">Security 12b Title</a></td>
<td class="text">1.000% Notes due 2027<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_TradingSymbol', window );">Trading Symbol</a></td>
<td class="text">PFE/27<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_SecurityExchangeName', window );">Security Exchange Name</a></td>
<td class="text">NYSE<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_us-gaap_StatementClassOfStockAxis=pfe_M2.875NotesDue20291Member', window );">M 2.875 Notes Due 20291 [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_pfe_DocumentAndEntityInformationLineItems', window );"><strong>Document And Entity Information [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_Security12bTitle', window );">Security 12b Title</a></td>
<td class="text">2.875% Notes due 2029<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_TradingSymbol', window );">Trading Symbol</a></td>
<td class="text">PFE/29<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_SecurityExchangeName', window );">Security Exchange Name</a></td>
<td class="text">NYSE<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_us-gaap_StatementClassOfStockAxis=pfe_M3.250NotesDue20322Member', window );">M 3.250 Notes Due 20322 [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_pfe_DocumentAndEntityInformationLineItems', window );"><strong>Document And Entity Information [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_Security12bTitle', window );">Security 12b Title</a></td>
<td class="text">3.250% Notes due 2032<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_TradingSymbol', window );">Trading Symbol</a></td>
<td class="text">PFE/32<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_SecurityExchangeName', window );">Security Exchange Name</a></td>
<td class="text">NYSE<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_us-gaap_StatementClassOfStockAxis=pfe_M3.875NotesDue20373Member', window );">M 3.875 Notes Due 20373 [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_pfe_DocumentAndEntityInformationLineItems', window );"><strong>Document And Entity Information [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_Security12bTitle', window );">Security 12b Title</a></td>
<td class="text">3.875% Notes due 2037<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_TradingSymbol', window );">Trading Symbol</a></td>
<td class="text">PFE/37A<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_SecurityExchangeName', window );">Security Exchange Name</a></td>
<td class="text">NYSE<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_us-gaap_StatementClassOfStockAxis=pfe_M4.250NotesDue20454Member', window );">M 4.250 Notes Due 20454 [Member]</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_pfe_DocumentAndEntityInformationLineItems', window );"><strong>Document And Entity Information [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_Security12bTitle', window );">Security 12b Title</a></td>
<td class="text">4.250% Notes due 2045<span></span>
</td>
</tr>
<tr class="re">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_TradingSymbol', window );">Trading Symbol</a></td>
<td class="text">PFE/45<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="Show.showAR( this, 'defref_dei_SecurityExchangeName', window );">Security Exchange Name</a></td>
<td class="text">NYSE<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_AmendmentFlag">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the XBRL content amends previously-filed or accepted submission.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_AmendmentFlag</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_CityAreaCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Area code of city</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_CityAreaCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentPeriodEndDate">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>For the EDGAR submission types of Form 8-K: the date of the report, the date of the earliest event reported; for the EDGAR submission types of Form N-1A: the filing date; for all other submission types: the end of the reporting or transition period. The format of the date is YYYY-MM-DD.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentPeriodEndDate</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:dateItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentType">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The type of document being provided (such as 10-K, 10-Q, 485BPOS, etc). The document type is limited to the same value as the supporting SEC submission type, or the word 'Other'.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentType</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:submissionTypeItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressAddressLine1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Address Line 1 such as Attn, Building Name, Street Name</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressAddressLine1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressCityOrTown">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the City or Town</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressCityOrTown</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressPostalZipCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Code for the postal or zip code</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressPostalZipCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressStateOrProvince">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the state or province.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressStateOrProvince</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:stateOrProvinceItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityCentralIndexKey">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>A unique 10-digit SEC-issued value to identify entities that have filed disclosures with the SEC. It is commonly abbreviated as CIK.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityCentralIndexKey</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:centralIndexKeyItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityEmergingGrowthCompany">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Indicate if registrant meets the emerging growth company criteria.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityEmergingGrowthCompany</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityFileNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Commission file number. The field allows up to 17 characters. The prefix may contain 1-3 digits, the sequence number may contain 1-8 digits, the optional suffix may contain 1-4 characters, and the fields are separated with a hyphen.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityFileNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:fileNumberItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityIncorporationStateCountryCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Two-character EDGAR code representing the state or country of incorporation.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityIncorporationStateCountryCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:edgarStateCountryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityRegistrantName">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The exact name of the entity filing the report as specified in its charter, which is required by forms filed with the SEC.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityRegistrantName</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityTaxIdentificationNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>The Tax Identification Number (TIN), also known as an Employer Identification Number (EIN), is a unique 9-digit value assigned by the IRS.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityTaxIdentificationNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:employerIdItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_LocalPhoneNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Local phone number for entity.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_LocalPhoneNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_PreCommencementIssuerTenderOffer">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 13e<br> -Subsection 4c<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_PreCommencementIssuerTenderOffer</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_PreCommencementTenderOffer">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 14d<br> -Subsection 2b<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_PreCommencementTenderOffer</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_Security12bTitle">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Title of a 12(b) registered security.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_Security12bTitle</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:securityTitleItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_SecurityExchangeName">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Name of the Exchange on which a security is registered.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection d1-1<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_SecurityExchangeName</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:edgarExchangeCodeItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_SolicitingMaterial">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as soliciting material pursuant to Rule 14a-12 under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 14a<br> -Subsection 12<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_SolicitingMaterial</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_TradingSymbol">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Trading symbol of an instrument as listed on an exchange.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_TradingSymbol</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:tradingSymbolItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_WrittenCommunications">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as written communications pursuant to Rule 425 under the Securities Act.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Securities Act<br> -Number 230<br> -Section 425<br></p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_WrittenCommunications</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_pfe_DocumentAndEntityInformationLineItems">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">pfe_DocumentAndEntityInformationLineItems</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>pfe_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StatementClassOfStockAxis=us-gaap_CommonStockMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StatementClassOfStockAxis=us-gaap_CommonStockMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StatementClassOfStockAxis=pfe_M1.000NotesDue20275Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StatementClassOfStockAxis=pfe_M1.000NotesDue20275Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StatementClassOfStockAxis=pfe_M2.875NotesDue20291Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StatementClassOfStockAxis=pfe_M2.875NotesDue20291Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StatementClassOfStockAxis=pfe_M3.250NotesDue20322Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StatementClassOfStockAxis=pfe_M3.250NotesDue20322Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StatementClassOfStockAxis=pfe_M3.875NotesDue20373Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StatementClassOfStockAxis=pfe_M3.875NotesDue20373Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StatementClassOfStockAxis=pfe_M4.250NotesDue20454Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StatementClassOfStockAxis=pfe_M4.250NotesDue20454Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>14
<FILENAME>Show.js
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
// Edgar(tm) Renderer was created by staff of the U.S. Securities and Exchange Commission.  Data and content created by government employees within the scope of their employment are not subject to domestic copyright protection. 17 U.S.C. 105.
var Show={};Show.LastAR=null,Show.showAR=function(a,r,w){if(Show.LastAR)Show.hideAR();var e=a;while(e&&e.nodeName!='TABLE')e=e.nextSibling;if(!e||e.nodeName!='TABLE'){var ref=((window)?w.document:document).getElementById(r);if(ref){e=ref.cloneNode(!0);
e.removeAttribute('id');a.parentNode.appendChild(e)}}
if(e)e.style.display='block';Show.LastAR=e};Show.hideAR=function(){Show.LastAR.style.display='none'};Show.toggleNext=function(a){var e=a;while(e.nodeName!='DIV')e=e.nextSibling;if(!e.style){}else if(!e.style.display){}else{var d,p_;if(e.style.display=='none'){d='block';p='-'}else{d='none';p='+'}
e.style.display=d;if(a.textContent){a.textContent=p+a.textContent.substring(1)}else{a.innerText=p+a.innerText.substring(1)}}}
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>15
<FILENAME>report.css
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
/* Updated 2009-11-04 */
/* v2.2.0.24 */

/* DefRef Styles */
.report table.authRefData{
	background-color: #def;
	border: 2px solid #2F4497;
	font-size: 1em;
	position: absolute;
}

.report table.authRefData a {
	display: block;
	font-weight: bold;
}

.report table.authRefData p {
	margin-top: 0px;
}

.report table.authRefData .hide {
	background-color: #2F4497;
	padding: 1px 3px 0px 0px;
	text-align: right;
}

.report table.authRefData .hide a:hover {
	background-color: #2F4497;
}

.report table.authRefData .body {
	height: 150px;
	overflow: auto;
	width: 400px;
}

.report table.authRefData table{
	font-size: 1em;
}

/* Report Styles */
.pl a, .pl a:visited {
	color: black;
	text-decoration: none;
}

/* table */
.report {
	background-color: white;
	border: 2px solid #acf;
	clear: both;
	color: black;
	font: normal 8pt Helvetica, Arial, san-serif;
	margin-bottom: 2em;
}

.report hr {
	border: 1px solid #acf;
}

/* Top labels */
.report th {
	background-color: #acf;
	color: black;
	font-weight: bold;
	text-align: center;
}

.report th.void	{
	background-color: transparent;
	color: #000000;
	font: bold 10pt Helvetica, Arial, san-serif;
	text-align: left;
}

.report .pl {
	text-align: left;
	vertical-align: top;
	white-space: normal;
	width: 200px;
	white-space: normal; /* word-wrap: break-word; */
}

.report td.pl a.a {
	cursor: pointer;
	display: block;
	width: 200px;
	overflow: hidden;
}

.report td.pl div.a {
	width: 200px;
}

.report td.pl a:hover {
	background-color: #ffc;
}

/* Header rows... */
.report tr.rh {
	background-color: #acf;
	color: black;
	font-weight: bold;
}

/* Calendars... */
.report .rc {
	background-color: #f0f0f0;
}

/* Even rows... */
.report .re, .report .reu {
	background-color: #def;
}

.report .reu td {
	border-bottom: 1px solid black;
}

/* Odd rows... */
.report .ro, .report .rou {
	background-color: white;
}

.report .rou td {
	border-bottom: 1px solid black;
}

.report .rou table td, .report .reu table td {
	border-bottom: 0px solid black;
}

/* styles for footnote marker */
.report .fn {
	white-space: nowrap;
}

/* styles for numeric types */
.report .num, .report .nump {
	text-align: right;
	white-space: nowrap;
}

.report .nump {
	padding-left: 2em;
}

.report .nump {
	padding: 0px 0.4em 0px 2em;
}

/* styles for text types */
.report .text {
	text-align: left;
	white-space: normal;
}

.report .text .big {
	margin-bottom: 1em;
	width: 17em;
}

.report .text .more {
	display: none;
}

.report .text .note {
	font-style: italic;
	font-weight: bold;
}

.report .text .small {
	width: 10em;
}

.report sup {
	font-style: italic;
}

.report .outerFootnotes {
	font-size: 1em;
}
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>17
<FILENAME>FilingSummary.xml
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<XML>
<?xml version='1.0' encoding='utf-8'?>
<FilingSummary>
  <Version>3.25.3</Version>
  <ProcessingTime/>
  <ReportFormat>html</ReportFormat>
  <ContextCount>7</ContextCount>
  <ElementCount>22</ElementCount>
  <EntityCount>1</EntityCount>
  <FootnotesReported>false</FootnotesReported>
  <SegmentCount>6</SegmentCount>
  <ScenarioCount>0</ScenarioCount>
  <TuplesReported>false</TuplesReported>
  <UnitCount>0</UnitCount>
  <MyReports>
    <Report instance="d80089d8k.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R1.htm</HtmlFileName>
      <LongName>100000 - Document - Document and Entity Information</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation</Role>
      <ShortName>Document and Entity Information</ShortName>
      <MenuCategory>Cover</MenuCategory>
      <Position>1</Position>
    </Report>
    <Report>
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <LongName>All Reports</LongName>
      <ReportType>Book</ReportType>
      <ShortName>All Reports</ShortName>
    </Report>
  </MyReports>
  <InputFiles>
    <File doctype="8-K" isOnlyDei="true" isUsgaap="true" original="d80089d8k.htm">d80089d8k.htm</File>
    <File>pfe-20251118.xsd</File>
    <File>pfe-20251118_def.xml</File>
    <File>pfe-20251118_lab.xml</File>
    <File>pfe-20251118_pre.xml</File>
  </InputFiles>
  <SupplementalFiles/>
  <BaseTaxonomies>
    <BaseTaxonomy items="37">http://xbrl.sec.gov/dei/2025</BaseTaxonomy>
  </BaseTaxonomies>
  <HasPresentationLinkbase>true</HasPresentationLinkbase>
  <HasCalculationLinkbase>false</HasCalculationLinkbase>
</FilingSummary>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>JSON
<SEQUENCE>20
<FILENAME>MetaLinks.json
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
{
 "version": "2.2",
 "instance": {
  "d80089d8k.htm": {
   "nsprefix": "pfe",
   "nsuri": "http://www.pfizer.com/20251118",
   "dts": {
    "inline": {
     "local": [
      "d80089d8k.htm"
     ]
    },
    "schema": {
     "local": [
      "pfe-20251118.xsd"
     ],
     "remote": [
      "http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd",
      "http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd",
      "http://www.xbrl.org/2003/xl-2003-12-31.xsd",
      "http://www.xbrl.org/2003/xlink-2003-12-31.xsd",
      "http://www.xbrl.org/2005/xbrldt-2005.xsd",
      "http://www.xbrl.org/2006/ref-2006-02-27.xsd",
      "http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd",
      "http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd",
      "https://www.xbrl.org/2020/extensible-enumerations-2.0.xsd",
      "https://www.xbrl.org/dtr/type/2020-01-21/types.xsd",
      "https://www.xbrl.org/dtr/type/2024-01-31/types.xsd",
      "https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd",
      "https://xbrl.fasb.org/srt/2025/elts/srt-roles-2025.xsd",
      "https://xbrl.fasb.org/srt/2025/elts/srt-types-2025.xsd",
      "https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd",
      "https://xbrl.fasb.org/us-gaap/2025/elts/us-roles-2025.xsd",
      "https://xbrl.fasb.org/us-gaap/2025/elts/us-types-2025.xsd",
      "https://xbrl.sec.gov/country/2025/country-2025.xsd",
      "https://xbrl.sec.gov/dei/2025/dei-2025.xsd",
      "https://xbrl.sec.gov/naics/2025/naics-2025.xsd",
      "https://xbrl.sec.gov/stpr/2025/stpr-2025.xsd"
     ]
    },
    "definitionLink": {
     "local": [
      "pfe-20251118_def.xml"
     ]
    },
    "labelLink": {
     "local": [
      "pfe-20251118_lab.xml"
     ]
    },
    "presentationLink": {
     "local": [
      "pfe-20251118_pre.xml"
     ]
    }
   },
   "keyStandard": 22,
   "keyCustom": 0,
   "axisStandard": 1,
   "axisCustom": 0,
   "memberStandard": 1,
   "memberCustom": 5,
   "hidden": {
    "total": 3,
    "http://xbrl.sec.gov/dei/2025": 3
   },
   "contextCount": 7,
   "entityCount": 1,
   "segmentCount": 6,
   "elementCount": 33,
   "unitCount": 0,
   "baseTaxonomies": {
    "http://xbrl.sec.gov/dei/2025": 37
   },
   "report": {
    "R1": {
     "role": "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation",
     "longName": "100000 - Document - Document and Entity Information",
     "shortName": "Document and Entity Information",
     "isDefault": "true",
     "groupType": "document",
     "subGroupType": "",
     "menuCat": "Cover",
     "order": "1",
     "firstAnchor": {
      "contextRef": "duration_2025-11-18_to_2025-11-18",
      "name": "dei:DocumentType",
      "unitRef": null,
      "xsiNil": "false",
      "lang": "en-US",
      "decimals": null,
      "ancestors": [
       "span",
       "p",
       "div",
       "div",
       "body",
       "html"
      ],
      "reportCount": 1,
      "baseRef": "d80089d8k.htm",
      "first": true,
      "unique": true
     },
     "uniqueAnchor": {
      "contextRef": "duration_2025-11-18_to_2025-11-18",
      "name": "dei:DocumentType",
      "unitRef": null,
      "xsiNil": "false",
      "lang": "en-US",
      "decimals": null,
      "ancestors": [
       "span",
       "p",
       "div",
       "div",
       "body",
       "html"
      ],
      "reportCount": 1,
      "baseRef": "d80089d8k.htm",
      "first": true,
      "unique": true
     }
    }
   },
   "tag": {
    "dei_AmendmentFlag": {
     "xbrltype": "booleanItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "AmendmentFlag",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Amendment Flag",
        "terseLabel": "Amendment Flag",
        "documentation": "Boolean flag that is true when the XBRL content amends previously-filed or accepted submission."
       }
      }
     },
     "auth_ref": []
    },
    "dei_CityAreaCode": {
     "xbrltype": "normalizedStringItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "CityAreaCode",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "City Area Code",
        "terseLabel": "City Area Code",
        "documentation": "Area code of city"
       }
      }
     },
     "auth_ref": []
    },
    "us-gaap_ClassOfStockDomain": {
     "xbrltype": "domainItemType",
     "nsuri": "http://fasb.org/us-gaap/2025",
     "localname": "ClassOfStockDomain",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Class of Stock [Domain]",
        "terseLabel": "Class of Stock [Domain]"
       }
      }
     },
     "auth_ref": []
    },
    "us-gaap_CommonStockMember": {
     "xbrltype": "domainItemType",
     "nsuri": "http://fasb.org/us-gaap/2025",
     "localname": "CommonStockMember",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Common Stock [Member]",
        "terseLabel": "Common Stock [Member]"
       }
      }
     },
     "auth_ref": []
    },
    "dei_CoverAbstract": {
     "xbrltype": "stringItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "CoverAbstract",
     "lang": {
      "en-us": {
       "role": {
        "label": "Cover [Abstract]",
        "terseLabel": "Cover [Abstract]",
        "documentation": "Cover page."
       }
      }
     },
     "auth_ref": []
    },
    "pfe_DocumentAndEntityInformationLineItems": {
     "xbrltype": "stringItemType",
     "nsuri": "http://www.pfizer.com/20251118",
     "localname": "DocumentAndEntityInformationLineItems",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Document And Entity Information [Line Items]",
        "terseLabel": "Document And Entity Information [Line Items]"
       }
      }
     },
     "auth_ref": []
    },
    "pfe_DocumentAndEntityInformationTable": {
     "xbrltype": "stringItemType",
     "nsuri": "http://www.pfizer.com/20251118",
     "localname": "DocumentAndEntityInformationTable",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Document And Entity Information [Table]",
        "terseLabel": "Document And Entity Information [Table]"
       }
      }
     },
     "auth_ref": []
    },
    "dei_DocumentPeriodEndDate": {
     "xbrltype": "dateItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "DocumentPeriodEndDate",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Document Period End Date",
        "terseLabel": "Document Period End Date",
        "documentation": "For the EDGAR submission types of Form 8-K: the date of the report, the date of the earliest event reported; for the EDGAR submission types of Form N-1A: the filing date; for all other submission types: the end of the reporting or transition period. The format of the date is YYYY-MM-DD."
       }
      }
     },
     "auth_ref": []
    },
    "dei_DocumentType": {
     "xbrltype": "submissionTypeItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "DocumentType",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Document Type",
        "terseLabel": "Document Type",
        "documentation": "The type of document being provided (such as 10-K, 10-Q, 485BPOS, etc). The document type is limited to the same value as the supporting SEC submission type, or the word 'Other'."
       }
      }
     },
     "auth_ref": []
    },
    "dei_EntityAddressAddressLine1": {
     "xbrltype": "normalizedStringItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "EntityAddressAddressLine1",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Entity Address, Address Line One",
        "terseLabel": "Entity Address, Address Line One",
        "documentation": "Address Line 1 such as Attn, Building Name, Street Name"
       }
      }
     },
     "auth_ref": []
    },
    "dei_EntityAddressCityOrTown": {
     "xbrltype": "normalizedStringItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "EntityAddressCityOrTown",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Entity Address, City or Town",
        "terseLabel": "Entity Address, City or Town",
        "documentation": "Name of the City or Town"
       }
      }
     },
     "auth_ref": []
    },
    "dei_EntityAddressPostalZipCode": {
     "xbrltype": "normalizedStringItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "EntityAddressPostalZipCode",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Entity Address, Postal Zip Code",
        "terseLabel": "Entity Address, Postal Zip Code",
        "documentation": "Code for the postal or zip code"
       }
      }
     },
     "auth_ref": []
    },
    "dei_EntityAddressStateOrProvince": {
     "xbrltype": "stateOrProvinceItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "EntityAddressStateOrProvince",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Entity Address, State or Province",
        "terseLabel": "Entity Address, State or Province",
        "documentation": "Name of the state or province."
       }
      }
     },
     "auth_ref": []
    },
    "dei_EntityCentralIndexKey": {
     "xbrltype": "centralIndexKeyItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "EntityCentralIndexKey",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Entity Central Index Key",
        "terseLabel": "Entity Central Index Key",
        "documentation": "A unique 10-digit SEC-issued value to identify entities that have filed disclosures with the SEC. It is commonly abbreviated as CIK."
       }
      }
     },
     "auth_ref": [
      "r1"
     ]
    },
    "dei_EntityEmergingGrowthCompany": {
     "xbrltype": "booleanItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "EntityEmergingGrowthCompany",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Entity Emerging Growth Company",
        "terseLabel": "Entity Emerging Growth Company",
        "documentation": "Indicate if registrant meets the emerging growth company criteria."
       }
      }
     },
     "auth_ref": [
      "r1"
     ]
    },
    "dei_EntityFileNumber": {
     "xbrltype": "fileNumberItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "EntityFileNumber",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Entity File Number",
        "terseLabel": "Entity File Number",
        "documentation": "Commission file number. The field allows up to 17 characters. The prefix may contain 1-3 digits, the sequence number may contain 1-8 digits, the optional suffix may contain 1-4 characters, and the fields are separated with a hyphen."
       }
      }
     },
     "auth_ref": []
    },
    "dei_EntityIncorporationStateCountryCode": {
     "xbrltype": "edgarStateCountryItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "EntityIncorporationStateCountryCode",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Entity Incorporation State Country Code",
        "terseLabel": "Entity Incorporation State Country Code",
        "documentation": "Two-character EDGAR code representing the state or country of incorporation."
       }
      }
     },
     "auth_ref": []
    },
    "dei_EntityRegistrantName": {
     "xbrltype": "normalizedStringItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "EntityRegistrantName",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Entity Registrant Name",
        "terseLabel": "Entity Registrant Name",
        "documentation": "The exact name of the entity filing the report as specified in its charter, which is required by forms filed with the SEC."
       }
      }
     },
     "auth_ref": [
      "r1"
     ]
    },
    "dei_EntityTaxIdentificationNumber": {
     "xbrltype": "employerIdItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "EntityTaxIdentificationNumber",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Entity Tax Identification Number",
        "terseLabel": "Entity Tax Identification Number",
        "documentation": "The Tax Identification Number (TIN), also known as an Employer Identification Number (EIN), is a unique 9-digit value assigned by the IRS."
       }
      }
     },
     "auth_ref": [
      "r1"
     ]
    },
    "dei_LocalPhoneNumber": {
     "xbrltype": "normalizedStringItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "LocalPhoneNumber",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Local Phone Number",
        "terseLabel": "Local Phone Number",
        "documentation": "Local phone number for entity."
       }
      }
     },
     "auth_ref": []
    },
    "pfe_M1.000NotesDue20275Member": {
     "xbrltype": "domainItemType",
     "nsuri": "http://www.pfizer.com/20251118",
     "localname": "M1.000NotesDue20275Member",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "M 1.000 Notes Due 20275 [Member]",
        "terseLabel": "M 1.000 Notes Due 20275 [Member]"
       }
      }
     },
     "auth_ref": []
    },
    "pfe_M2.875NotesDue20291Member": {
     "xbrltype": "domainItemType",
     "nsuri": "http://www.pfizer.com/20251118",
     "localname": "M2.875NotesDue20291Member",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "M 2.875 Notes Due 20291 [Member]",
        "terseLabel": "M 2.875 Notes Due 20291 [Member]"
       }
      }
     },
     "auth_ref": []
    },
    "pfe_M3.250NotesDue20322Member": {
     "xbrltype": "domainItemType",
     "nsuri": "http://www.pfizer.com/20251118",
     "localname": "M3.250NotesDue20322Member",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "M 3.250 Notes Due 20322 [Member]",
        "terseLabel": "M 3.250 Notes Due 20322 [Member]"
       }
      }
     },
     "auth_ref": []
    },
    "pfe_M3.875NotesDue20373Member": {
     "xbrltype": "domainItemType",
     "nsuri": "http://www.pfizer.com/20251118",
     "localname": "M3.875NotesDue20373Member",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "M 3.875 Notes Due 20373 [Member]",
        "terseLabel": "M 3.875 Notes Due 20373 [Member]"
       }
      }
     },
     "auth_ref": []
    },
    "pfe_M4.250NotesDue20454Member": {
     "xbrltype": "domainItemType",
     "nsuri": "http://www.pfizer.com/20251118",
     "localname": "M4.250NotesDue20454Member",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "M 4.250 Notes Due 20454 [Member]",
        "terseLabel": "M 4.250 Notes Due 20454 [Member]"
       }
      }
     },
     "auth_ref": []
    },
    "dei_PreCommencementIssuerTenderOffer": {
     "xbrltype": "booleanItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "PreCommencementIssuerTenderOffer",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Pre Commencement Issuer Tender Offer",
        "terseLabel": "Pre Commencement Issuer Tender Offer",
        "documentation": "Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act."
       }
      }
     },
     "auth_ref": [
      "r3"
     ]
    },
    "dei_PreCommencementTenderOffer": {
     "xbrltype": "booleanItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "PreCommencementTenderOffer",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Pre Commencement Tender Offer",
        "terseLabel": "Pre Commencement Tender Offer",
        "documentation": "Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act."
       }
      }
     },
     "auth_ref": [
      "r5"
     ]
    },
    "dei_Security12bTitle": {
     "xbrltype": "securityTitleItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "Security12bTitle",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Security 12b Title",
        "terseLabel": "Security 12b Title",
        "documentation": "Title of a 12(b) registered security."
       }
      }
     },
     "auth_ref": [
      "r0"
     ]
    },
    "dei_SecurityExchangeName": {
     "xbrltype": "edgarExchangeCodeItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "SecurityExchangeName",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Security Exchange Name",
        "terseLabel": "Security Exchange Name",
        "documentation": "Name of the Exchange on which a security is registered."
       }
      }
     },
     "auth_ref": [
      "r2"
     ]
    },
    "dei_SolicitingMaterial": {
     "xbrltype": "booleanItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "SolicitingMaterial",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Soliciting Material",
        "terseLabel": "Soliciting Material",
        "documentation": "Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as soliciting material pursuant to Rule 14a-12 under the Exchange Act."
       }
      }
     },
     "auth_ref": [
      "r4"
     ]
    },
    "us-gaap_StatementClassOfStockAxis": {
     "xbrltype": "stringItemType",
     "nsuri": "http://fasb.org/us-gaap/2025",
     "localname": "StatementClassOfStockAxis",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Class of Stock [Axis]",
        "terseLabel": "Class of Stock [Axis]"
       }
      }
     },
     "auth_ref": []
    },
    "dei_TradingSymbol": {
     "xbrltype": "tradingSymbolItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "TradingSymbol",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Trading Symbol",
        "terseLabel": "Trading Symbol",
        "documentation": "Trading symbol of an instrument as listed on an exchange."
       }
      }
     },
     "auth_ref": []
    },
    "dei_WrittenCommunications": {
     "xbrltype": "booleanItemType",
     "nsuri": "http://xbrl.sec.gov/dei/2025",
     "localname": "WrittenCommunications",
     "presentation": [
      "http://www.pfizer.com//20251118/taxonomy/role/DocumentDocumentAndEntityInformation"
     ],
     "lang": {
      "en-us": {
       "role": {
        "label": "Written Communications",
        "terseLabel": "Written Communications",
        "documentation": "Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as written communications pursuant to Rule 425 under the Securities Act."
       }
      }
     },
     "auth_ref": [
      "r6"
     ]
    }
   }
  }
 },
 "std_ref": {
  "r0": {
   "role": "http://www.xbrl.org/2003/role/presentationRef",
   "Publisher": "SEC",
   "Name": "Exchange Act",
   "Number": "240",
   "Section": "12",
   "Subsection": "b"
  },
  "r1": {
   "role": "http://www.xbrl.org/2003/role/presentationRef",
   "Publisher": "SEC",
   "Name": "Exchange Act",
   "Number": "240",
   "Section": "12",
   "Subsection": "b-2"
  },
  "r2": {
   "role": "http://www.xbrl.org/2003/role/presentationRef",
   "Publisher": "SEC",
   "Name": "Exchange Act",
   "Number": "240",
   "Section": "12",
   "Subsection": "d1-1"
  },
  "r3": {
   "role": "http://www.xbrl.org/2003/role/presentationRef",
   "Publisher": "SEC",
   "Name": "Exchange Act",
   "Number": "240",
   "Section": "13e",
   "Subsection": "4c"
  },
  "r4": {
   "role": "http://www.xbrl.org/2003/role/presentationRef",
   "Publisher": "SEC",
   "Name": "Exchange Act",
   "Number": "240",
   "Section": "14a",
   "Subsection": "12"
  },
  "r5": {
   "role": "http://www.xbrl.org/2003/role/presentationRef",
   "Publisher": "SEC",
   "Name": "Exchange Act",
   "Number": "240",
   "Section": "14d",
   "Subsection": "2b"
  },
  "r6": {
   "role": "http://www.xbrl.org/2003/role/presentationRef",
   "Publisher": "SEC",
   "Name": "Securities Act",
   "Number": "230",
   "Section": "425"
  }
 }
}
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>ZIP
<SEQUENCE>21
<FILENAME>0001193125-25-291406-xbrl.zip
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
begin 644 0001193125-25-291406-xbrl.zip
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M%JM>60X5-K>%->;WW^90B*D8H),FOZ@!N#5 QBPY1&")%R\! 0YM=#LQGXN
M@!>+(, /7AM$<0&$%@6AO1#$XMI,,0JBN !B?>87E=/H&(I1 ,4( )C$C>?!
M*$5AG$9AG,[#0!!IF.A[TBT7KH,XY[8H@FE1,).7X#E@[O19BSS[$,5HY*M@
MH+**C]O<T)4E%]QM)Q_SOL_F%!DQD7@^@0\VH :;<X2PV.TS:W;1G7# W"#:
M(_"PWN' =B8_S0)OA?M:V?+&4:05R^,QV%(IK^5/(H%)/? XI^;MD;F>0+"!
MLS>(C0M#O/.80KY[AB*8XM>]$3)@P1L7VD%E6^ %(G8E/$=&OBK_5M+@4II
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M$OLZ?486DZ*K0.?9CF-,X+GO#:S:_P-02P,$%     @ %X)U6QY3C,QI8
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M( -I6Z<#KT8&CD] EK>S<;&YL;NIV6A$B],4"GPZ@K'T=1,NI5=4 "_Q*!8
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MI6:P3?F:5.?P,BZBIK'IR'D@80.5^FP7C8)?1H_4EDKHKPP7T+@*R:H?,PZ
M-GA+A&K@W="+T)H5S5Y=_: &/:LA*ZB!2Y:0)F%GF]4)TFZSZIOK[EW[MML
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MSWG4'U;RY^8RI[WMG:=[VR\W?<6>K*+WFO_4-_J*I7Z!<K9I_N" #7+WYE8
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M0E90/3:KI&O 1IT+CDVGC60>9; ^EV/9Z$$5" ;0ATT31YLW#A#')_H!="G
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MOR1CC8,&C!GZ493U0;IJ<S]TFC@Y0GM8JH!=.CK**9N0[+\!\R#0=0-?F9[
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M#!]?:'_Z]9EP$@^&SV;4LX5)]&!T\@%?4?+;+T?%XO[G1$O]O&GU2^'SQT=
M+YJO5X&./\]]/EAU8!;C@IE="<CX ]A)]-CU*9!P8-,@RS,@B],@BQL'.3/=
MI?(TR/*&0>IGDB= EJ=!EC</\G :Y,$TR(,D2$(=,T<,85G,P+>262,RY/Y
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M>;J)04;F8E$N;GB0<7Z&;F?4)2_(V+QH<I>EI5'YZAK#B?5OHM4X:US2'Q]
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MT_PJE^#GP\!_!%U'L79Z81B.G4';U7?,%F\.CC^$8CP(8;(XO8Y[)P<,*V*
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M\"2-CL5R:<9S,7-_B'FV1Q00M4]7I2)R#E=S<UM$6/2)7"Z]X$C>+$\%.#K
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ML]A"':L"*%DIE*PDLBU^G6Y-OH'X0^0E7)L4:JO:)YT5K;Y\!YY$5H<0Z2&
M_6D_8W\W7S5@ 2'](!*3,LR7N[7=<W#?PE3E(F'?H=VFA#*N]E/BGHQ_5K2\
MX[,8 04K.QDZZ"@GW$0SV\ 2^$Q:"('ZS-P;>W0FRC]-\-UD3::=:CG\0$A[
M2VIPH_C\(*V@X!@$,L'+>U+I#-2:446V0<W$<QOCSV)4EC29V6"['\BU,+63
M'V/0]KRM%K*MJMNSK0[UMII_/UD;IUR:>^?(PW*BC*[^^$RN/W5\@CJ1-R;J
M.LY.KIYTC@H^1K=XOV_B,>H4/;SNZ'C!?[@/3J^KQ77*Z:1/&/3E]1$#A]X
M?**V%%/MT,8'PK !G5X477KR>CWY9Z&SK#+I<$Q<M%:$\K@HUJU]D3SB5.1.
MD;X)_A1M>#](+$+Z.W+RP!IO,"XV_P]Y.FX;(^J'OT1$G97=)AHW+U%V,OB'
M*3^PE9]A:X(N>?1PDYOH=8;JL^-9F1J)3ESX)V8-8>V=&4V9!<_Y.C0VCC.
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M'-34+TA76Q$*EXC,IRN';N" PI/L=7[H&(.*0.C.29JLW'7\U3?#U9D15M:
MG21 "0BC1)K!!V[/_2OVGXWEC>F$/Q^(TO'"=N#:V#8Y:C=JR,G"LTSAV43I
M =<8STV3;0?B 0=O9)ICL#K ^U<E61T?CC9C#<U@R%>,4XRE5'!&:LQ%4YBH
MBA*C)."'J:E.\?M4BM!O0B_CG8YQ!:V4)\R: $LP\$+3*6Z"HT;&A:DJH ))
MC#0XH8)B<X*>IQJH28LSX38F_*:TI3;E_5%.7JQ;F7$=8[YKXMTZ-I*X U^#
MD>KN9O1U<V.1./AH AE0(TY*@+)B@D +\TMP1'NAKXQ45Z5.:!J1'4HW KUG
MDPJ=O,Q?7ZSEA&(M=5,,+\Y<*MJ3;G149"9WH EU48DAU5IZV+O3>@1)_+=J
M91_[O:@LZ'N,-JD,6LF6OQW0#[!,Z&=;UE>I]/\UD^-W(D?4<2VGRD[GAE.V
M"L89QW?_5@Y($'5K4U?2_C#C.%[W2@_V)>-E@J+.8J<K+(OKZOZ+] .R6J?:
MJLS_%M54!MAD%_LNV/=C^GI#T6G0T8GJ(X./XP\(^536:OJP9R7F+Q6&$NY7
M%'K_[ ?^^)[R&BZ= >C7$2K"4W6]K".;Z^W@\;75:&QR#P_91&PS6G<<+JAU
MAZRJ6WCKCL.]D^/:WU??L\/N\Q9OU:'N1.Q.'=AA;L96'5L9[CS@<.<R-^ <
M351L.44Y3);_;D0#E<.%-U#1JX^*,F0#';L!:JIO2O1E=KL4BY2+[I)B#9W7
M'&7"=+):HD3?EDNK:85BK:%P!Q0Q6P,4FT.V8*3[GH"=GSFSV?N=3&9)7IN3
MI(Q8O4ZBH>=M;K*^"]_#&;J;B)SF)AFD*=+3!/,.-JZIB5A.3Y-R:>.:FASN
MUXCSZ9XF:;[.ULI$]R@IEXIU*2&EA; ?6(P':O[)[8$>GB5YQAI(]FK?E<>)
M:2A6/:#SL*;=09VII8Q,TZ6D8BIML=NK;/8::QCR(;.51:SN-E&GK@HD95@B
M5;">/4V95*FC<C8R2G;%-N@\91!GEOG35=B8"K(CE?1!*?V,\8JU*KF$,T'V
M((FL$.K@%FLY(G\E&XV\K%?(R[J#T'MC#5+$0OH^9'-;9ESF3E;V!E!Y@5%+
MY;S2=I/)9VK<U<5NQ^J=@*[1#$7K:)# >6W7N)/=(O.PY?"8L@3#3:YO5W,H
ME_13TPK>G0E2:Z:!%JZ]R,F+6?]I>31?R$[,%[$#=WN30G:'*ELL*V1G'2*H
M+(H'Z5!P.V[8#KP[S+2RO.PFYG5M" %.BD;R1,% GG1S5A_)V\ZX197C%DL*
ML9Y??6^9V&51#;R8$*N8'&$]W$]$6-=W3KQ;8(BU4'-D+%*<'F)]MU?%'GUV
MB/5P?R4A5N31C"'6F9LAKY/-\P7R##6L'LAV'.]P':UH$BM<?B O00P5QTO$
M>_2W>9$S0\K%!_+,T 4">=%BL@)YDT:L8(WNP@-YYHW+"^1%')H<R,N>&!IX
MLP?R)A$P/Y 7EY%7%LA[-U<@+T4:#N1M32#OW81 7I*OKRZ0ITP9#N1Q((\#
M>1S(FUUG<B O1HY)@3QSB"P_D+>50:=##CHM4S07&6*59:N_=K+D^<4_-SQ7
M\K"Z*;F2M<W.E7PGP39B@;SJ:@)YU67D2JZ/S7,&\JHFD)>=D7=87?L*5Y>1
MIZF1F9&GO\R-G%67%\BKOB"05YT8R*NN.B//K&&)@;SJ;(&\9(36[($B@;P)
M+)D0R*N^XD!>;;Y 7I(T',C;FD!>;5(@K_KJ WDU#N1Q((\#>=L8R-O.N,T[
MCMLL\S";/\**5>VOI+JY-CG"6HTBK-AO=*X0J]C(5,G:U#A>N31OKN2O%<>[
MN?C7AH?Q:IL2QCO:]#!>JN3YL+::,%[M-87QCN8-X]6FA?%J:U_A"L-XM4EA
MO-J4,%YM>6&\V@O">+6)8;S:RL-XM>6'\6HO"^/57A+&F\"2"6&\VBL.XQW-
M%\9+DH;#>%L3QCN:%,:KO?HP'A?6<AB/PW@<QEM9&*_&8;QE'F8<QHN18V(8
MK_;JPWA'',9;=!BO\<]&<[,#>;6-">0=;W8@K[9WE,S'JZTFD%=[58&\XSD#
M>;5I@;S:N@-YQRL,Y-4F!?)J4P)YM>4%\FHO".35)@;R:BL/Y-66'\BKO2R0
M5WM)(&\22_(#>;77',@[GBN0ER(-!_(*!_*VTBL]8J]TF7LR/\2:W''30ZP2
MBGJ&N.A&1%B5C;F(""MVB\F*([WV"&NY%(58Q2\38<WA]NN/L,+^5I-8>X1U
MG68,5SS'R#$ID%>S GFOM'7A\2MN7;B6.%[CXLO76[3UUAC(F](A[R@9QUN?
M.CK9[ YYM;WC9"#O:#6!O*/9 WE;T"'O9,Y WE$4R,OLD'=46_\*5]8A[R@>
MQTO$>XZF!/*.EA?(.WI!(.]H8B!OTHC+Z9!WM/Q WM&,@;SLB17KD#>)@/F!
MO*/7',@[F2N0ER(-!_)^C4#>,0?REKDG\P-YR1WW^@)YQQS(XT >!_(XD%=,
M97(@+T:.28&\H]<?R#OA0-YB WG-BV;CQ1&R.>=P=8TAN_HWT6J<-2[ICP^B
M>07V8/,?%\TOXOQ[\VP#HG>_J^C=U5"YCM'N0U]([1XI?"N?Z8ZSFXJ\X"F'
M>]Z55DT,3UP+]LC>^>A)'1Q_"+5>&,+Y$J#FT"&1=2SL;E?4)\U2GMSGWD\X
M$ZR5J8B&7+_;P2@/6%A^CQQ6].*=8%3!]2.U*#R%FSPC6&6(0'%49SCL>6TZ
M4:Y!<9SB,4-GZXY]LCHZ^F.K7!UFM<0&G]3N*\W%?@!>W(9QW9_H<H<R6NO@
MH8];!_RI>/10A53)<_7'.F(R>@A _77<MM>'WPQ[8,:#J2ZCK&VGUQ[WG VM
MO9($39/L&JEB: ;V&JQ+V37WX#"@!:2.LZ[?Z_E/.!5)F_#]%COD)^R0)PFJ
M/L*'W[_[>US-O"NL9KQ=L?-S5T:'QWTM0RK:)1Z=WM@U4>G [3L>^5EA^\$%
M1R_R&&0*JK4ME6U)QK@T'L$0]<(V2J3>HZY(Z 2QXX#=VJ<WH!K)T&X8T-4;
MUPN2-PL5;7FT'>FER7A>!+6L7(@\=9;SO(7P\A!O>DG*,59RGKA35OYGZJY'
M*^A=Z:5A%."M# ,H=:2.J%N0U7 </$LJ#'OC4-34+\@$#/.AE@?1C#)&.=B?
M99CXRF/# +L+C%/-'4=-9Z95Q>G\XF%2["DX$MC(R3B_H"C[SO.NU).I^,O(
MKXB[\0@KG'KC#MV_9&P Z1'G*]FCU>@$4 JHW2)MH+8UV &Q&\S4_KQS<>]J
MV=;GJRG[3*UVR9?GGSY>?$)F?OSMXA-M;2HU5I/'+4ZJ#4PM5(-(>?HG_OO.
M?T1F*.91 <EX0"$NPUFUN,R%9W";%%J" *OW)G?:NSACM+"4O6997CE<+9=,
M6.'>P^MFI2-AP($;1#>%3UY(\0:@FA]T\#XENDFB@&"H Q#QIN][^X?ZU=:=
MW47<.<<XHWS[P$S?MC+#*.:HIF?&DA8NV(:A"2'-LFBP$WOJMLOZ.=VE4L"3
M(ES.H^/U=/ PZT0+W*Y+%X<C7TX,]+I<045?S=G+[,@[1^-!FUA5-SDZ&80R
M_A5)J4@(:46H5 L=(\O0.+'@&RS;Q:,/9FM7+&=L=2 +N/XRIJ2B0R*39/)2
M.$,A9FX)$VZD=6#, 12NU_4D7^D)2;YU^&2=W<S;7*_[K$X1&7;)8Q9(*/R-
MT1/##>V,>)+,,L34=#UY\VZ-.?!51LNI]80,VLC=28(I-W0X1'?DSNMAH 69
M@1_;;\(PO8OW^BHJB*35AV3>Y)6ZB.PH&A06Y ]P$F;R=OS)Z WXA3?J2:YC
MF-M[5$===]SK/;\%PHS@W9+'<%I01&H\1"?7&91+5Q15"HP#?.J"W,%'%.G6
MEQ>:*;3#PA'=+B0%C%:RYA#>[RI+1MN=,G!2U]ZXY X)B(S$Y9NJ]JK1[;=B
M'E-,UI0E99E$2D/&,E#R0@AIM]TXIIGV@Y4 1:S),H@KTJZL3%)K2"5K@&TY
M?!-R('.)FKZX\2@CIUPZAT-*RD.34@RZEH6!06U[&U'@PAVX76]D0B]R'#KK
MUAE4O;5JG%<<4SV_:EUB#N2FI#["-I#1TW/,X0$^I:.1R3N<R"<A)9JI]3#F
M/X8?@3RTU>'A2SW;\0.,F2F7&PSVP%7?A>,[4(L#=1>@[ M,+4KD%C9^/L#9
M,1)UNO(8;74^Q^\</EJJ;%=CLFT"+?:MG(Z]Y,DUIA 5%VSQ<KG^')/KM:J&
MPP3YU*&=C<>V0+4@TRE>1K[3N%I8(_7>):E735.O&J=>N;0H\KU0^,XV1_AJ
M2?+5TN1+Q\G6*WR-C1&^HP3U:FGJ):.,:Q>^\\T1ON,$^8[2Y#O:-.'[,H/P
M+;WPZ%NL@]"J,Q9:%U\N,&/AXN;F>T/4+Z^^-V\WRMP^T,D*.K6;2C14?9%R
MJ%#(X"=9B0%2_K(R!I1X3*SJ*9?^5MO?Q]0I2I_J8WH=1C' $W7;XRC:Z(7@
M\OT$X;H9@W/O8H /9QJ5*J'@TB,RW3R6I 2;H>/VO$<WB/Q '6^A6$]L&U22
MNT?&9-2\*!0SE/ZC><-5T'&#BCV.:[]5A.B)QTB$;7=HH\:#L/3#V*CK5ML'
MRF"=)!V6R2JEP3)ADT(0N_$T@\CLN5<N!N42L=>V[S>?^X>S<%];W)K[Q@*7
MW >7>F)EWZOEOH33C6D!VSV9D?O;&$:H[G,88:G[\MU,^[*:V)?5HONR6OMU
M]F5U>[1R;2;NUQ+<KVFK8Q;+[%5Q'Q@^T3:S_?;-Y_[1+-RO:6YK]EL-[V;A
M_O::Y>52(;O<CCIL/N^/)_)>M[0\2FS]HU?,>RP>?JE/9H=,YN']TJ\'_VQ\
M^^?:JBXN+VY.&]^^U9N-J^\;$;*HJI %>-(RFJ6$T@A?%!2SY)&J<;2H:IF<
M*L4>;1I,(5#I'EBM3N]5%^UM?]#U BH<D%(Z9<@HQ4-=OF-R0"J;*R-C3&T3
M("-FCZ@6 VICQ-H-K#U8655! [U;88>)ELZQZ<D=WG+;'M#%*L$*U">T)DI'
MD6G2:G78/\+Q!DCUP)6I9!E:9>"/RJ6[6')16GM0RK2+Q9U9J3^49.0',)W1
M(%;(9^?I])T?>@"5^>WHK#K%IT=P%CI4MP7*9HSY.)X[:#_/I#PW@(/2\?_B
M@ZZD_/5OSI-FU30!IYY#CLHUB<3]GL:2&T]MG'!$^2KI#$AYD/6<)Y-)3VGK
ML]; K89$T@>[<6$#.U)^)(4N!C(9'F72[GMA<GM,8F<DT[3=L41_(F5E-E&4
MX2)IJ_/5,",;*\RP\K+7T1V2!B2(H,AZ/3CR>X(:G+@#>*CMZGI7G00'"ZSH
MNG(MO^9))<O6PW+/R$E0H72WB_EPM&Y*QXOGL.:(O=5R"L>W4WAD5M)TE:HW
M>**D-Y(P66%MKXQHF4<2,V_QX(!.<=%@H S6B&%**TE]8?6$W\IHS0%':Y:J
M*:2_?DJ5/ &>]^&,NK02*5.Y+\HEN;,Z?GLLCT=C8V<U02.)'<C9Z-3R63=3
MW :WC>?GQ"95%91F)DJC#,;4TP&SG*V5F]6H+A9ZLSH#TUWH VU[W*WE4NQ1
M^6/3$<MJ<84/H*[5DZ>^71YM?UR@/+S=G^T'9R#K(=O^T',GJ26;";**.T%X
MRN('I4(M\I!P*/6AY#D<<6X/R![X Z]--Z3.2.Q\O/CD[;E[LK9"%2P..UU5
MHRBPDEQ]"O:EJ5P<!<X@['LAZ2-) 6OA+NE<X(KEGZ59-0O/LQ=I[!GD@*=Z
M6V&N.SRA^#X.)<][GCO6DF$:1<WTVK14TYD&*XVZ8]UH.AN3(#$C1:>1LNU?
M0G^10?ZDN2Z/U5&\'58832X]\[7;<D>1-6X1O]X>S6K183/%J#M$PHA1W,@8
M7DC@-K373;\42;YLGX?$07KV<6<GRNBN)"U)DMIH-J;+2W2$*]-J\@JI326H
M,DS&1M^.LKK1M8/WZE(V9Y"P:G %2M.:GI?60L$1<75[(6,PD/'[/!O]*KHT
M7/>:,2\V:@ DO+=^2_AX#^0;3&&S"R*O[@G,^E#O*Z.B*GK/J2]P_X 'G?$I
MC9?\0BLW\SFUW: W 35[W@^@>Q]K;80TT0*W)^_>2:RFR8(RI[4RTJE#-,6,
M(Q5]E:(^/Y4VR;Y3EIZ*M$A%ZV\OJB_XX;I#52X?4&\FBDPDU%PE[WA54D;G
MHK1ZY<E1B3FJ"=.>^@@ QV6K+7V^ETL18\3PX3F$K=F+#ASE+^MICV59L -[
M?N@&;^\</"WD O2*PF?PJ?L5W3&3G"=YMJ04P: 3B]1UI4=$WG]4]0%^8T71
M5S>'THT7&Q&YK ,%AE!]^Z@;E:/:=ISZ_3XV49![D:PO[7TJ?S1[.!RDI5A$
MCRJ)DNJ#0AO2MY7$4(;;]X%';2NM,6_Q2'/:LF2,1M+V3>+LT[U1Y3\[X[8L
MA1[9SZ.V</M#V<<!GY.-/^-'9=]U!IMP9,FF/;*,B8H P(D  HMZ&+J@CT^E
MYA,WSD"MKA6+PR@%M..HXN);*TQD(C:AK'P:J-HQ;T0E8P05A+8S?'\SO@MA
M;SBX#6%+>A@3\H-0NJE4826K3(C60!%W)*,]\JC4-29FCFIWF7#XU.6I3?O]
M!MM; L?MPD9=@%W)_@G)9T4+%K*\J=I9J=:4V(=F/&A[/279C7'@#X'[^'-9
M4O45M-JE\V\7_#.306C*OG?:?J\G+4]0#4HO&W9HZ^G#E.KLY76"L3G>!GMA
MX.0P'"^#R4J>E>&R7RA]U2.E^6- S4,H(])\/E8!(-/M@2*68!1BW]313 =1
M1>QX2GZQI>UX0$&+KM-&Y2SO,YZQSY3W*!N-2IUKNNPIF^49&\&$U#70K^@>
M"5@X1U).!@8.32>+-3I=NZ@.?D:@ R/EW6CK4;7;H^?W3!S>4L76K[!,? &K
M(8<P(,*#7QC(EJ^Z75_N1HS-MER:8;KP/,S8,]T)+ VN@O+T4I(&T"?8]AA_
M%*=$I)^TW4>\V.98495C17,U6+AHPG1OFXV;&_'GUT:K<75>R3K1J3BY[8QE
M)O8T^U*:J-1(U$1A'-GP5<:$9,B=.B]UO0"+RK%?@W@*T%].XUE:*ZI&PI@K
MF[8L$HD5#\ ]?A@1"S[>UC]_:PB\1[RYKI]>-+_\\6;_#?U]73\[TW\K1KY#
M/GZ^:ITU6O2QFI7\Y"TP_UO]^J;Q7O]C(L63[$'V2BF];7U2_SC3+S[^^QL0
MY]NSZ(M_JJ7(Q4:BIG\8?_[WJOX<_JMEO4DOP9)V;P!'#4C[H^]U1,$E)"8'
MC %:7B%IF[A-/EV?PX9IB8OFZ5XTF_A,K"&M$;\23@>L[RB^/NOSZ$55>ZVK
M6N>GS\_O[9DE&&0D,?T+>GKFG7V ']WY>/4???13A#Y>'OS7/OVGX-;_+?Q-
M? ZP;?CG9Z?GT&Y9/?WF(%X3O,?W\25LT_1OL13\/1JK![^_^W#C#K!?WS_1
M!+^&$]SK: ]3&;EN\.*]$]N,JR=2[/5+/,L0-^=SO?D/*FAI_"G^NFK]0UR"
M3K]JHC<_P8O,VW#%7B\OXR?M(]9R*]=REBFP5=J!E-MV35DJ--O>@/]!0^N3
MM,Q7B++U/Q\OHOBON,:NHR-_HM&*US#_JR--[$BP(\&.!#L2?,3R$;M14TX>
ML>P(L"/ 6FKF<,<W-^QYKKCT Z?GAENJL5*KV*85Q(,>\6C'UGL.VWF%PC<H
MBZ1GXU]?+SY?W(KZB[(6YGFSW3IQWDONPCW';[]>W(B;QNGWUL7M7P+^72^7
MOGR[^ES_%GT*_N%7<!/Q=+YLU)L(D:/0KB^:9\#=[ZV&0-?QHED_!U:+5N.\
MT6HUSL3M%:%DPZBMQI>+&_@./E0C->N7#1RF+LX:UU<W%[?UUE_BJ@5_-Z\N
M+YJ-!OX*W=$]$9_C9?TO))7XW!"-?YU^K3>_R$'__'H%'MT5>AGBNMZZ%><T
MFGDNFD*%9M6\$K>M>O,&YBJ7<W%3+D64R!@0WPQOM0=*+J;YE[ANM&ZNFN(*
MIP]?UIOBYOOIUVFKK.!B&M>W>L1O%Y<7M["PTXO6Z??+F]MZ\[1Q X/<G+8N
M/D=4- QX6;+-2\16.=&GWV\NKD73WU-(]P?'^R<'XORT.FDBRZIPO.["HP&H
M]O:>F(P-OPS5@>U/OUW5;V%CE$NM.NSB)K5E.OO>D'U:,J8T1T2C</A"JN-E
MQ2^2U)@0SCAY-VL\HYH=SSAXM[9XQB<0]8_?/Y$!5/N@["#J:#75J)IB6OTM
M,>Q,_V/>O&D6Y*(\B>+>8QW3IA^]T&3&+5<+?+I16#P8UI2K!OV#=W[20UGB
MF_U G+GJ5<(;+/EM<2SJYV5[X0A6B)15D>>XLQ<Y&$M&+]& IGB>7-CG2T4X
M0/R>\X09FQJ&$?.T=G2%L<1BP#BWRF>T<.2J!Q\J*J<:80!T^G8H\T4)##4,
M@;W7,ME.YM;&RQOD:R22@05RL5NA-&8"CM*M_CL5^O4=%0KTO5#V?!\B,*V?
M!8DND]P-AKH38H:VZE0?M7A0<%7_\]__=?#N]P__*\[PV&C=B)V_Z8]V*0D[
MOAF%WBZRQ%Y++V9.VK*<0#Y'P,N8.!"PA@;Z57F^$G3X6%8*F%;U@0TY?"&Q
M."V<6HEE:Q+;D4<*QN[FZKPE,4DE4H/,K3YW[X*Q$SSKW&()="PAB_;W:C&0
M:9H)+ EY)*F7GA4Q/#D=C<&1F$TE/9U1'*' #'06@Y<X,ZA*F5-,3,L0 Q.;
M1UC$$L#7F)VJ 'SPWL8 1R?Q>+*:-]J8(EKN)=H)?!B-'Z%O9U :N'OI6'_4
MQ_?C<*3_C@$_FP\UXA!>,%40+ -\_S;.+3TV<7&'?NT,](Z-KR43W%CG)B.:
MS,CK)?:(KIP,#3PW)NZ62Q%L#<J RNJE:J,%K%IEBM.M6C[H] Q(TIIM"2&;
M@2IQ_#E?-0B;)AH&5F+BK'84;,_T7TH4;E7C;OT(5+,[Z#B!A'Q4^!HHDU0K
M\H+5VH2R9U N90.,2W"]N3E=R2+SU UHJ)P]MQA NH&!TDBL!FHT[TU:X,JE
M-,RY!:84;1&_FUI&9>HZ;'3S22(P$>'<G IY@.:)92_?MT:+X](=/?A4"WRM
MU0*:'C$U'=+I+2L8<<+#\: ]DF556L_0I;M=V:2@J)YG%NA*HHL1V24/B9Y,
M]#I55:6,%8E6 QMI@-5A,DE G^([6/I@-;&X1M 89>NH'WF(%$NECY$!(LL,
MVCU?5G^9-'Z#^87547+F7<K4M\ZE2K)VC60KOO?LK9?8>1)[+K'S<K:.W-;3
MR2OAAF*SI$V#;)V!DU*&J3TVU3$8Q##B!XF%9LE7OX>6H][Q-J%TR;4J7\GD
M):&PKY"9CKA!M#'"N(ZS-*$^:#5G$JL-QC14ED3H$E9:LF^/PJU3!87H06QG
MQ+_^]H C_O,HV7+IP7G$'4I-6"2H(0B.W"L:'U%)KVEX$,KJ6=RF"C00S,2#
M?;2%PPBKF^0R0X:I ,B ZEG@W[%*(/ FN^.>+@C"5\$A*9&M4>XUF"/VJ*,:
M;@W\*PL#HSE'G2FT84..5^ZB5.>%'KY'-1ZC'GT6VA^>!0;:7!60ZWIY_;H*
M=2K 'Z(V(&2Y=!>\.;M2%6)T"]UB%[M >:'V@,ER4$JN.PYR&PMI)1<A$1@P
MU4>0$MT419\N&4-9[92L!@XR@XZX2-73KNIR)%L*F9<YJE$10:>_J"2_J-T1
MAV^01L?W"""S'0=[2+1S4> ."!)*FRK9JE$I893<"(XSDZ"">$0XS%A!GE'.
M3K5\$IT-BRQQ)GX Z^RHG_BRW#+!1M-6*H&&B%M'P[AEA5GDOC5-GOP[4%,.
M50GJ1EF*L]M;A5=_6^4#91FYLS9VKITS&W42RLR0E6*(LJWCBN"]NDYO3]DL
M2]0#>%9UWHOH)D)A=<SX%X91XI^DE#RG\+XLA?=@YCNSG &.CS<@![BVJAS@
M=]N77?>R[$K.!\[(!]Z^[,9MI;F5T/PZB+["U,5/MZWO-[>-AFJ'<@-G5NOV
MXOSB%%-',(OH^^U7L'CP[XNKYO+=)>K<YH7"@CY.^HRN=AD[KC2VW:AAM&W:
MJY@[>JPP([1TP$MP)WI_KR<39I(9\*XVYS$^U0S(>NAPWI?6UI=O<Y;I<;Z?
MDBPS6T9.KE9:T"D^J9!AN_3\@@CBA,)45RR]LF)1O_D%F+3%=2';:CFMY]%Z
M%"V[4=&RY\RTJJV,8QUR'&NQ^<S_TU+!V>A2Y/E_%P+:4KA"@9+Q+.OQ0MJK
M)L(;&:Z.C*=9@6&/@(WPWC!ES^H877[:7F0#FUR?<HE&[&@D%>S,*S_ #K'6
ME:BREF5$SQG8E^<=1U;#2](.1];]\C'&T0Y.,D%FG"E-_NQAX[?6U0/*<JJ)
M'1S6CXU<$:GEF^[A9O HU>G.'3VY*H/(QDO!)(7/SN"'C:PA+MU>;V)>I(4K
M/2DO4D1ID2.%FY(1L-^E)J]RB'@O:+P \/0G-F&=GO1AL,=RD'=E1-'^"$A&
MBX_"N<".Z122#"NR^;/JCHG===7'G3&)':6Z]/OC@93"4=0Z-2Z0%?O>Q#1J
MM>XH$^Z9ZA]/+0M=A-"F&[S,VS]'(P$8)/,$I%TG#JFE>WJG=UJV0ZCN=;I.
M.[HE\V3B)6Q+(H]JZY\/' ;3LH'#YN\A^Q)]<S54K7M;;L?M#Z-[,;L=*-Z*
MXKT2)C^X_12M1S933>-3GP:+[HU-GI%FM#6$3)3,N+K"W^FK*WT)[ U^X,TV
M-L2<NY'W2TBF<C)TUV+,DL$T^(M/JI6Z:#RJW:-^*6^UU3:B4DU;1:MNV$K&
MY"6>WX8?T/@2E&7D#<:PYF1Z<DX$(W7KW7';/0?#%IVQW&<ZA2:-F:4OX/6E
MK7VY'5-"ZQ'7.BBF#BJGBKCT.Q&6&4[]3P?WLF3$;>R"<XAYPJB@5"Y1@) T
M>*?O#J4.<T(3XM$+EK1V]/M,DVXEO>52WWZ_5I6D"*6BDK>H=L-Z^QBQ?JV^
MS==[\ DE[2JF2M @<XD6O\NU$R\RT+YLA6M8K7MAIR>"O<S_[4N-.,A&(D=Q
MU1.+6N6*J_$(#A+9)==,>*1.FYU'G]+''*EE03C#<#?)-(4<%-KY!I*1(]VC
MW)II/&DE-N],R$;J)FW-,4[N:%$5U;'>VKWRP*&&]VI_9S%";F3*A*#='*@C
M)[:ALRE!:8QW+@S0S>))KS=E]I2QHJ>/$\:-D2O\"C-AZ(0CLZ#4FJTAY?%.
M-[<@-O\9HR41)IGG]##13VZ[);.*\H+D6J>1;3:2@4)6-,-T^F'/(Y"UQ&:*
M$3.-36&I29,':;99($</])@Z@S&5EV/!<H&-&.*,2(0\N80H@4F-8+*:*"MG
M3)R(J15[=&5-X6+T9\;FIT&D[8=)C4&DY+ _/IB/.I-%H@F89"S:X&A&RL\)
MWR9*(I(81+Y,^X+_-Z/FD,=3/<#5;*S)K^?P:;E "D]:PJ>Z0WK6>=/Q=1H=
M&H*@'L@GP_/7O1LE3P,-=9#NI[Z>59ZY U]7U<">NM4<1WEI*$9'B\ZW/9Q
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M>]5:VIV+4S;<4.)KM?:PR"1OZG%[K'YE=[MRP\ED,;DXZD4E4]3"2"?U'6]
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MVR^$C++^RE'6MU]$&5_]U\%7_S(-7QV6>W7V%WSX]?;RVZ?_#U!+ P04
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M9[U[/-C&7_:$0?H]T/\"4$L#!!0    ( !>"=5OY[_,&/@0  %,3   0
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M9CZ1V_BB17]4^/+IG+KX%U!+ P04    "  7@G5;ZPO$/&<(  !-80  %
M '!F92TR,#(U,3$Q.%]L86(N>&ULS9QK;]LV%(:_#]A_./.^;$!M1W:#-D;3
M(<ME")8T09-=L&(H9)EVB$FB0<F-_>]'4E(BV91$F4=1/C15I,/WG%=Y#D/K
MD@^_K ,?OA$>418>]YS!00](Z+$9#1?'O574=R./TAY$L1O.7)^%Y+BW(5'O
MEX_??_?AAWX?SBXN/T$?'N)X&4V&P\?'Q\%L3L.(^:M82$8#CP5#Z/>S^-/[
M/^#/)-T$/A.?N!&!T:$S@E]7U)]-1@>CPX-WH]' R0_BQ)5J,'-C,@''&8Y&
M0QD)HXDSGHR/X.0:SMTH)CR$>QJ0_%BVW'"Z>(CA)^]G4(/.6!@2WR<;N*"A
M&WK4]>$N*_@-7(;> $Y\'S[+89&H,B+\&YD-4E6?AO]-Y)>IK!V^_PY G,0P
M4ON.>_)4I&=B/>7^@/&%J/5@/,R&])Y'K'>&/([5 .?HZ&BHCN:C(ZJ+%>+.
M\._KJSOO@01N7YQ\\</RTC01G41J_Q7SU#DT*!!*(^1W_2RL+W?UG5%_[ S6
MT:SW429,SXX[)?Z5V +E8<*93RH2R\,J>R^-CS=+$4_6,0EG)%5^TF9>&O7
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MKT=WJ($64B:BY[HO+R_-<$:H8-%2*I>B&;#818V&J3^<?$*_;9KKH4>(  M
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M.#ED97@Q,2YH=&U02P$"% ,4    "  7@G5;P=PT=+,7  "G^@  #P
M        @ &8=0  9#@P,#@Y9&5X,3(N:'1M4$L! A0#%     @ %X)U6WZ&
MKO?69@  H,\%  \              ( !>(T  &0X,# X.61E>#0R+FAT;5!+
M 0(4 Q0    ( !>"=5LXS@Y2FA,  !94   /              "  7OT  !D
M.# P.#ED97@U,2YH=&U02P$"% ,4    "  7@G5;^>_S!CX$  !3$P  $
M            @ %"" $ <&9E+3(P,C4Q,3$X+GAS9%!+ 0(4 Q0    ( !>"
M=5MA,7;)' 8  (0Y   4              "  :X, 0!P9F4M,C R-3$Q,3A?
M9&5F+GAM;%!+ 0(4 Q0    ( !>"=5OK"\0\9P@  $UA   4
M  "  ?P2 0!P9F4M,C R-3$Q,3A?;&%B+GAM;%!+ 0(4 Q0    ( !>"=5NQ
MG<K>U@4  ! ^   4              "  94; 0!P9F4M,C R-3$Q,3A?<')E
:+GAM;%!+!08     "0 ) #,"  "=(0$    !

end
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>22
<FILENAME>d80089d8k_htm.xml
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<XML>
<?xml version="1.0" encoding="utf-8"?>
<xbrl
  xmlns="http://www.xbrl.org/2003/instance"
  xmlns:dei="http://xbrl.sec.gov/dei/2025"
  xmlns:link="http://www.xbrl.org/2003/linkbase"
  xmlns:pfe="http://www.pfizer.com/20251118"
  xmlns:us-gaap="http://fasb.org/us-gaap/2025"
  xmlns:xbrldi="http://xbrl.org/2006/xbrldi"
  xmlns:xlink="http://www.w3.org/1999/xlink">
    <link:schemaRef xlink:href="pfe-20251118.xsd" xlink:type="simple"/>
    <context id="duration_2025-11-18_to_2025-11-18">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000078003</identifier>
        </entity>
        <period>
            <startDate>2025-11-18</startDate>
            <endDate>2025-11-18</endDate>
        </period>
    </context>
    <context id="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_us-gaap-CommonStockMember">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000078003</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementClassOfStockAxis">us-gaap:CommonStockMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2025-11-18</startDate>
            <endDate>2025-11-18</endDate>
        </period>
    </context>
    <context id="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M1.000NotesDue20275Member">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000078003</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementClassOfStockAxis">pfe:M1.000NotesDue20275Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2025-11-18</startDate>
            <endDate>2025-11-18</endDate>
        </period>
    </context>
    <context id="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M2.875NotesDue20291Member">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000078003</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementClassOfStockAxis">pfe:M2.875NotesDue20291Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2025-11-18</startDate>
            <endDate>2025-11-18</endDate>
        </period>
    </context>
    <context id="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M3.250NotesDue20322Member">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000078003</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementClassOfStockAxis">pfe:M3.250NotesDue20322Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2025-11-18</startDate>
            <endDate>2025-11-18</endDate>
        </period>
    </context>
    <context id="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M3.875NotesDue20373Member">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000078003</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementClassOfStockAxis">pfe:M3.875NotesDue20373Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2025-11-18</startDate>
            <endDate>2025-11-18</endDate>
        </period>
    </context>
    <context id="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M4.250NotesDue20454Member">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000078003</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementClassOfStockAxis">pfe:M4.250NotesDue20454Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2025-11-18</startDate>
            <endDate>2025-11-18</endDate>
        </period>
    </context>
    <dei:EntityRegistrantName
      contextRef="duration_2025-11-18_to_2025-11-18"
      id="Hidden_dei_EntityRegistrantName">PFIZER INC</dei:EntityRegistrantName>
    <dei:AmendmentFlag contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-439">false</dei:AmendmentFlag>
    <dei:EntityCentralIndexKey
      contextRef="duration_2025-11-18_to_2025-11-18"
      id="Hidden_dei_EntityCentralIndexKey">0000078003</dei:EntityCentralIndexKey>
    <dei:DocumentType contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-498">8-K</dei:DocumentType>
    <dei:DocumentPeriodEndDate contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-499">2025-11-18</dei:DocumentPeriodEndDate>
    <dei:EntityIncorporationStateCountryCode contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-500">DE</dei:EntityIncorporationStateCountryCode>
    <dei:EntityFileNumber contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-501">1-3619</dei:EntityFileNumber>
    <dei:EntityTaxIdentificationNumber contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-502">13-5315170</dei:EntityTaxIdentificationNumber>
    <dei:EntityAddressAddressLine1 contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-503">66 Hudson Boulevard East</dei:EntityAddressAddressLine1>
    <dei:EntityAddressCityOrTown contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-504">New York</dei:EntityAddressCityOrTown>
    <dei:EntityAddressStateOrProvince contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-505">NY</dei:EntityAddressStateOrProvince>
    <dei:EntityAddressPostalZipCode contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-506">10001-2192</dei:EntityAddressPostalZipCode>
    <dei:CityAreaCode contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-507">(212)</dei:CityAreaCode>
    <dei:LocalPhoneNumber contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-508">733-2323</dei:LocalPhoneNumber>
    <dei:WrittenCommunications contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-509">false</dei:WrittenCommunications>
    <dei:SolicitingMaterial contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-510">false</dei:SolicitingMaterial>
    <dei:PreCommencementTenderOffer contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-511">false</dei:PreCommencementTenderOffer>
    <dei:PreCommencementIssuerTenderOffer contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-512">false</dei:PreCommencementIssuerTenderOffer>
    <dei:Security12bTitle
      contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_us-gaap-CommonStockMember"
      id="ixv-513">Common Stock, $0.05 par value</dei:Security12bTitle>
    <dei:TradingSymbol
      contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_us-gaap-CommonStockMember"
      id="ixv-514">PFE</dei:TradingSymbol>
    <dei:SecurityExchangeName
      contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_us-gaap-CommonStockMember"
      id="ixv-515">NYSE</dei:SecurityExchangeName>
    <dei:Security12bTitle
      contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M1.000NotesDue20275Member"
      id="ixv-516">1.000% Notes due 2027</dei:Security12bTitle>
    <dei:TradingSymbol
      contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M1.000NotesDue20275Member"
      id="ixv-517">PFE/27</dei:TradingSymbol>
    <dei:SecurityExchangeName
      contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M1.000NotesDue20275Member"
      id="ixv-518">NYSE</dei:SecurityExchangeName>
    <dei:Security12bTitle
      contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M2.875NotesDue20291Member"
      id="ixv-519">2.875% Notes due 2029</dei:Security12bTitle>
    <dei:TradingSymbol
      contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M2.875NotesDue20291Member"
      id="ixv-520">PFE/29</dei:TradingSymbol>
    <dei:SecurityExchangeName
      contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M2.875NotesDue20291Member"
      id="ixv-521">NYSE</dei:SecurityExchangeName>
    <dei:Security12bTitle
      contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M3.250NotesDue20322Member"
      id="ixv-522">3.250% Notes due 2032</dei:Security12bTitle>
    <dei:TradingSymbol
      contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M3.250NotesDue20322Member"
      id="ixv-523">PFE/32</dei:TradingSymbol>
    <dei:SecurityExchangeName
      contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M3.250NotesDue20322Member"
      id="ixv-524">NYSE</dei:SecurityExchangeName>
    <dei:Security12bTitle
      contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M3.875NotesDue20373Member"
      id="ixv-525">3.875% Notes due 2037</dei:Security12bTitle>
    <dei:TradingSymbol
      contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M3.875NotesDue20373Member"
      id="ixv-526">PFE/37A</dei:TradingSymbol>
    <dei:SecurityExchangeName
      contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M3.875NotesDue20373Member"
      id="ixv-527">NYSE</dei:SecurityExchangeName>
    <dei:Security12bTitle
      contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M4.250NotesDue20454Member"
      id="ixv-528">4.250% Notes due 2045</dei:Security12bTitle>
    <dei:TradingSymbol
      contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M4.250NotesDue20454Member"
      id="ixv-529">PFE/45</dei:TradingSymbol>
    <dei:SecurityExchangeName
      contextRef="duration_2025-11-18_to_2025-11-18_us-gaap-StatementClassOfStockAxis_pfe-M4.250NotesDue20454Member"
      id="ixv-530">NYSE</dei:SecurityExchangeName>
    <dei:EntityEmergingGrowthCompany contextRef="duration_2025-11-18_to_2025-11-18" id="ixv-531">false</dei:EntityEmergingGrowthCompany>
</xbrl>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
