<SEC-DOCUMENT>0001341004-23-000015.txt : 20230127
<SEC-HEADER>0001341004-23-000015.hdr.sgml : 20230127
<ACCEPTANCE-DATETIME>20230127161610
ACCESSION NUMBER:		0001341004-23-000015
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20230127
DATE AS OF CHANGE:		20230127

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			IsoPlexis Corp
		CENTRAL INDEX KEY:			0001615055
		STANDARD INDUSTRIAL CLASSIFICATION:	LABORATORY ANALYTICAL INSTRUMENTS [3826]
		IRS NUMBER:				462179799
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-92954
		FILM NUMBER:		23563074

	BUSINESS ADDRESS:	
		STREET 1:		35 NE INDUSTRIAL ROAD
		CITY:			BRANFORD
		STATE:			CT
		ZIP:			06405
		BUSINESS PHONE:		203-208-4111

	MAIL ADDRESS:	
		STREET 1:		35 NE INDUSTRIAL ROAD
		CITY:			BRANFORD
		STATE:			CT
		ZIP:			06405

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			DANAHER CORP /DE/
		CENTRAL INDEX KEY:			0000313616
		STANDARD INDUSTRIAL CLASSIFICATION:	INDUSTRIAL INSTRUMENTS FOR MEASUREMENT, DISPLAY, AND CONTROL [3823]
		IRS NUMBER:				591995548
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		2200 PENNSYLVANIA AVE. N.W.
		STREET 2:		SUITE 800W
		CITY:			WASHINGTON
		STATE:			DC
		ZIP:			20037-1701
		BUSINESS PHONE:		2028280850

	MAIL ADDRESS:	
		STREET 1:		2200 PENNSYLVANIA AVE. N.W.
		STREET 2:		SUITE 800W
		CITY:			WASHINGTON
		STATE:			DC
		ZIP:			20037-1701

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	DMG INC
		DATE OF NAME CHANGE:	19850221
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>sc13g-a1.htm
<DESCRIPTION>SCHEDULE 13G - AMENDMENT 1
<TEXT>
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    <div style="text-align: center; font-family: 'Times New Roman', serif; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; font-family: 'Times New Roman', serif; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; font-family: 'Times New Roman', serif; font-weight: bold;">Washington, D.C.&#160;&#160;20549</div>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="text-align: center; font-family: 'Times New Roman', serif; font-weight: bold;">SCHEDULE 13G</div>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="text-align: center; font-family: 'Times New Roman', serif; font-weight: bold;">Under the Securities Exchange Act of 1934</div>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="text-align: center; font-family: 'Times New Roman', serif;">(Amendment No. 1)*</div>
    <div style="text-align: center; font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
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            <div style="text-align: center; font-family: 'Times New Roman', serif;">IsoPlexis Corporation</div>
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            <div style="text-align: center; font-family: 'Times New Roman', serif;">(Name of Issuer)</div>
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            <div style="font-family: 'Times New Roman', serif;">&#160;</div>
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            <div style="text-align: center; font-family: 'Times New Roman', serif;">Common Stock, par value $0.001 per share</div>
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            <div style="text-align: center; font-family: 'Times New Roman', serif;">(Title of Class of Securities)</div>
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            <div style="font-family: 'Times New Roman', serif;">&#160;</div>
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            <div style="text-align: center; font-family: 'Times New Roman', serif;">465005106</div>
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            <div style="text-align: center; font-family: 'Times New Roman', serif;">(CUSIP Number)</div>
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            <div style="font-family: 'Times New Roman', serif;">&#160;</div>
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            <div style="text-align: center; font-family: 'Times New Roman', serif;">December 31, 2022</div>
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          <td style="width: 100%; vertical-align: top;">
            <div style="text-align: center; font-family: 'Times New Roman', serif;">(Date of Event Which Requires Filing of this Statement)</div>
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    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="font-family: 'Times New Roman', serif;">Check the appropriate box to designate the rule pursuant to which this Schedule is filed:</div>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
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            <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
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            <div style="font-family: 'MS Gothic', '&#8218;l&#8218;r &#402;S&#402;V&#402;b&#402;N', monospace; font-size: 12pt;">&#9744;</div>
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            <div style="font-family: 'Times New Roman', serif;">Rule 13d-1(b)</div>
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            <div style="font-family: 'Times New Roman', serif;">&#160;</div>
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            <div style="font-family: 'MS Gothic', '&#8218;l&#8218;r &#402;S&#402;V&#402;b&#402;N', monospace; font-size: 12pt;">&#9744;</div>
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            <div style="font-family: 'Times New Roman', serif;">Rule 13d-1(c)</div>
          </td>
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    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
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            <div style="font-family: 'Times New Roman', serif;">&#160;</div>
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            <div style="font-family: 'MS Mincho', 'Yu Gothic', monospace; font-size: 12pt;">&#9746;</div>
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          <td style="width: 84.44%; vertical-align: top;">
            <div style="font-family: 'Times New Roman', serif;">Rule 13d-1(d)</div>
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    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="font-family: 'Times New Roman', serif;">&#160;*The remainder of this cover page shall be filled out for a reporting person&#8217;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing
      information which would alter disclosures provided in a prior cover page.</div>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="font-family: 'Times New Roman', serif;">The information required in the remainder of this cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange Act of 1934 (&#8220;Act&#8221;) or otherwise subject to the
      liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).</div>
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            <div style="font-family: 'Times New Roman',serif; font-weight: normal;">CUSIP No.:&#160; 465005106</div>
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              <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">1.</div>
            </td>
            <td colspan="3" style="width: 93.65%; vertical-align: top; border-left: #000000 0.50pt solid; border-right: #000000 0.50pt solid; border-top: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">NAME OF REPORTING PERSON</div>
              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">&#160;</div>
              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">Danaher Corporation</div>
            </td>
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              <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">2.</div>
            </td>
            <td colspan="3" style="width: 93.65%; vertical-align: top; border-left: #000000 0.50pt solid; border-right: #000000 0.50pt solid;">
              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
            </td>
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              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">&#160;</div>
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            <td rowspan="1" style="width: 2.24%; vertical-align: top; border-left: #000000 0.50pt solid;">
              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">&#160;(a)&#160;</div>
            </td>
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              <div style="font-family: 'MS Gothic','&#8218;l&#8218;r &#402;S&#402;V&#402;b&#402;N',monospace;">&#9744;</div>
            </td>
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              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">&#160;</div>
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              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">&#160;(b)&#160;</div>
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              <div style="font-family: 'MS Gothic','&#8218;l&#8218;r &#402;S&#402;V&#402;b&#402;N',monospace;">&#9744;</div>
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              <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">3.</div>
            </td>
            <td colspan="3" style="width: 93.65%; vertical-align: top; border-left: #000000 0.50pt solid; border-right: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">SEC USE ONLY</div>
              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">&#160;</div>
            </td>
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              <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">4.</div>
            </td>
            <td colspan="3" style="width: 93.65%; vertical-align: top; border-left: #000000 0.50pt solid; border-right: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">Delaware</div>
            </td>
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            <td colspan="2" rowspan="4" style="width: 27.79%; vertical-align: middle; border-left: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
              <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">Number of</div>
              <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">Shares</div>
              <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">Beneficially&#160;</div>
              <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">Owned by</div>
              <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">Each</div>
              <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">Reporting</div>
              <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">Person With:&#160;</div>
              <div style="font-family: 'Times New Roman', serif;">&#160;</div>
            </td>
            <td style="width: 7.78%; vertical-align: top; border-left: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
              <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">5.</div>
            </td>
            <td style="width: 64.44%; vertical-align: top; border-left: #000000 0.50pt solid; border-right: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">SOLE VOTING POWER</div>
              <div style="margin-left: 3pt;">&#160;</div>
              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">1,976,791&#160; <br>
              </div>
            </td>
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              <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">6.</div>
            </td>
            <td style="width: 5.78%; vertical-align: top; border-left: #000000 0.50pt solid; border-right: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">SHARED VOTING POWER</div>
              <div style="margin-left: 3pt;">&#160;</div>
              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">0</div>
            </td>
          </tr>
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            <td style="width: 2.24%; vertical-align: top; border-left: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
              <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">7.&#160;</div>
            </td>
            <td style="width: 5.78%; vertical-align: top; border-left: #000000 0.50pt solid; border-right: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">SOLE DISPOSITIVE POWER</div>
              <div style="margin-left: 3pt;">&#160;</div>
              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">1,976,791 <br>
              </div>
            </td>
          </tr>
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            <td style="width: 2.24%; vertical-align: top; border-left: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;" nowrap="nowrap">
              <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">8.&#160;&#160;</div>
            </td>
            <td style="width: 5.78%; vertical-align: top; border-left: #000000 0.50pt solid; border-right: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">SHARED DISPOSITIVE POWER</div>
              <div style="margin-left: 3pt;">&#160;</div>
              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">0</div>
            </td>
          </tr>
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            <td style="width: 6.35%; vertical-align: top; border-left: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
              <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">9.</div>
            </td>
            <td colspan="3" style="width: 93.65%; vertical-align: top; border-left: #000000 0.50pt solid; border-right: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
              <div style="margin-left: 3pt;">&#160;</div>
              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">1,976,791</div>
            </td>
          </tr>
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            <td style="width: 6.35%; vertical-align: top; border-left: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;" nowrap="nowrap">
              <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">10.&#160;</div>
            </td>
            <td colspan="3" style="width: 93.65%; vertical-align: top; border-left: #000000 0.50pt solid; border-right: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES</div>
              <div style="text-align: right; font-family: 'MS Mincho','Yu Gothic',monospace; font-size: 12pt; font-weight: bold; margin-left: 3pt;"><font style="font-weight: normal;">&#9744;</font>&#160; <br>
              </div>
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            <td style="width: 6.35%; vertical-align: top; border-left: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
              <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">11.</div>
            </td>
            <td colspan="3" style="width: 93.65%; vertical-align: top; border-left: #000000 0.50pt solid; border-right: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</div>
              <div style="margin-left: 3pt;">&#160;</div>
              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">4.99%&#160;</div>
            </td>
          </tr>
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            <td style="width: 6.35%; vertical-align: top; border-left: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;" nowrap="nowrap">
              <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">12.&#160;</div>
            </td>
            <td colspan="3" style="width: 93.65%; vertical-align: top; border-left: #000000 0.50pt solid; border-right: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">TYPE OF REPORTING PERSON</div>
              <div style="margin-left: 3pt;">&#160;</div>
              <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">CO <br>
              </div>
            </td>
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            <div style="font-family: 'Times New Roman',serif; font-weight: normal;">CUSIP No.:&#160; 465005106</div>
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          <td style="width: 38.56%; vertical-align: top; border-bottom: #000000 0.50pt solid;">&#160;</td>
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    <div><br>
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    <div><br>
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            <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">1.</div>
          </td>
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            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">NAME OF REPORTING PERSON</div>
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            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">Danaher Ventures LLC</div>
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        <tr>
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            <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">2.</div>
          </td>
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            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</div>
          </td>
        </tr>
        <tr>
          <td style="width: 6.35%; vertical-align: top; border-left: #000000 0.50pt solid;">
            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">&#160;</div>
          </td>
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            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">&#160;(a)&#160;</div>
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          <td colspan="2" style="width: 85.64%; vertical-align: top; border-right: 0.5pt solid rgb(0, 0, 0); font-size: 12pt; font-weight: normal;">
            <div style="font-family: 'MS Gothic','&#8218;l&#8218;r &#402;S&#402;V&#402;b&#402;N',monospace;">&#9744;</div>
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        </tr>
        <tr>
          <td style="width: 6.35%; vertical-align: top; border-left: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">&#160;</div>
          </td>
          <td rowspan="1" style="width: 2.24%; vertical-align: top; border-left: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">&#160;(b)&#160;</div>
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            <div style="font-family: 'MS Gothic','&#8218;l&#8218;r &#402;S&#402;V&#402;b&#402;N',monospace;">&#9744;</div>
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        <tr>
          <td style="width: 6.35%; vertical-align: top; border-left: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
            <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">3.</div>
          </td>
          <td colspan="3" style="width: 93.65%; vertical-align: top; border-left: #000000 0.50pt solid; border-right: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">SEC USE ONLY</div>
            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 6.35%; vertical-align: top; border-left: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
            <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">4.</div>
          </td>
          <td colspan="3" style="width: 93.65%; vertical-align: top; border-left: #000000 0.50pt solid; border-right: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">Delaware</div>
          </td>
        </tr>
        <tr>
          <td colspan="2" rowspan="4" style="width: 27.79%; vertical-align: middle; border-left: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
            <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">Number of</div>
            <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">Shares</div>
            <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">Beneficially&#160;</div>
            <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">Owned by</div>
            <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">Each</div>
            <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">Reporting</div>
            <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">Person With:&#160;</div>
            <div style="font-family: 'Times New Roman', serif;">&#160;</div>
          </td>
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            <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">5.</div>
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          <td style="width: 64.44%; vertical-align: top; border-left: #000000 0.50pt solid; border-right: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">SOLE VOTING POWER</div>
            <div style="margin-left: 3pt;">&#160;</div>
            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">1,976,791&#160; <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 2.24%; vertical-align: top; border-left: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
            <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">6.</div>
          </td>
          <td style="width: 5.78%; vertical-align: top; border-left: #000000 0.50pt solid; border-right: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">SHARED VOTING POWER</div>
            <div style="margin-left: 3pt;">&#160;</div>
            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 2.24%; vertical-align: top; border-left: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
            <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">7.&#160;</div>
          </td>
          <td style="width: 5.78%; vertical-align: top; border-left: #000000 0.50pt solid; border-right: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">SOLE DISPOSITIVE POWER</div>
            <div style="margin-left: 3pt;">&#160;</div>
            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">1,976,791</div>
          </td>
        </tr>
        <tr>
          <td style="width: 2.24%; vertical-align: top; border-left: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;" nowrap="nowrap">
            <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">8.&#160;&#160;</div>
          </td>
          <td style="width: 5.78%; vertical-align: top; border-left: #000000 0.50pt solid; border-right: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">SHARED DISPOSITIVE POWER</div>
            <div style="margin-left: 3pt;">&#160;</div>
            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 6.35%; vertical-align: top; border-left: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
            <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">9.</div>
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            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
            <div style="margin-left: 3pt;">&#160;</div>
            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">1,976,791</div>
          </td>
        </tr>
        <tr>
          <td style="width: 6.35%; vertical-align: top; border-left: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;" nowrap="nowrap">
            <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">10.&#160;</div>
          </td>
          <td colspan="3" style="width: 93.65%; vertical-align: top; border-left: #000000 0.50pt solid; border-right: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES</div>
            <div style="text-align: right; font-family: 'MS Mincho','Yu Gothic',monospace; font-size: 12pt; font-weight: bold; margin-left: 3pt;"><font style="font-weight: normal;">&#9744;</font>&#160; <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 6.35%; vertical-align: top; border-left: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
            <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">11.</div>
          </td>
          <td colspan="3" style="width: 93.65%; vertical-align: top; border-left: #000000 0.50pt solid; border-right: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</div>
            <div style="margin-left: 3pt;">&#160;</div>
            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">4.99%&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 6.35%; vertical-align: top; border-left: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;" nowrap="nowrap">
            <div style="font-family: 'Times New Roman',serif; font-weight: bold; margin-left: 3pt;">12.&#160;</div>
          </td>
          <td colspan="3" style="width: 93.65%; vertical-align: top; border-left: #000000 0.50pt solid; border-right: #000000 0.50pt solid; border-bottom: #000000 0.50pt solid;">
            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">TYPE OF REPORTING PERSON</div>
            <div style="margin-left: 3pt;">&#160;</div>
            <div style="font-family: 'Times New Roman',serif; margin-left: 3pt;">OO&#160;</div>
          </td>
        </tr>

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    <div><br>
    </div>
    <div><br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
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      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">3</font></div>
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        </div>
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    <div style="text-indent: -72pt; margin-left: 72pt; font-family: 'Times New Roman', serif; font-weight: bold;">Item 1.</div>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
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          <td style="width: auto; vertical-align: top;">
            <div style="font-family: 'Times New Roman', serif; font-weight: bold;">Name of Issuer:</div>
          </td>
        </tr>

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    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="margin-left: 108pt; font-family: 'Times New Roman', serif;">The name of the issuer is IsoPlexis Corporation (the &#8220;Issuer&#8221;).</div>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z2a38451b186744d1801db77b580065ec" cellpadding="0" cellspacing="0">

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          <td style="width: 36pt; vertical-align: top; align: right; font-family: 'Times New Roman', serif; font-weight: bold;">(b)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-family: 'Times New Roman', serif; font-weight: bold;">Address of Issuer&#8217;s Principal Executive Offices:</div>
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    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="margin-left: 108pt; font-family: 'Times New Roman', serif;">The address of the Issuer&#8217;s principal executive offices is:</div>
    <div><br>
    </div>
    <div style="margin-left: 108pt; font-family: 'Times New Roman', serif;">IsoPlexis Corporation</div>
    <div style="margin-left: 108pt; font-family: 'Times New Roman', serif;">35 NE Industrial Road</div>
    <div style="margin-left: 108pt; font-family: 'Times New Roman', serif;">Branford, CT 06405</div>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="text-indent: -72pt; margin-left: 72pt; font-family: 'Times New Roman', serif; font-weight: bold;">Item 2.</div>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z2ab7f30076ca4e77a3027dcf85b05245" cellpadding="0" cellspacing="0">

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          <td style="width: 72pt;"><br>
          </td>
          <td style="width: 36pt; vertical-align: top; align: right; font-family: 'Times New Roman', serif; font-weight: bold;">(a)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-family: 'Times New Roman', serif; font-weight: bold;">Name of Person Filing:</div>
          </td>
        </tr>

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    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="margin-left: 108pt; font-family: 'Times New Roman', serif;">This schedule is filed by Danaher Corporation, a Delaware corporation (&#8220;Danaher&#8221;), and its subsidiary, Danaher Ventures LLC, a Delaware limited liability company (&#8220;DV&#8221;).&#160; DV was
      formerly known as Danaher Innovation Center LLC prior to an internal restructuring that resulted in a change of its name. Danaher and DV are collectively referred to herein as the &#8220;Reporting Persons.&#8221;</div>
    <div><br>
    </div>
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          <td style="width: 72pt;"><br>
          </td>
          <td style="width: 36pt; vertical-align: top; align: right; font-family: 'Times New Roman', serif; font-weight: bold;">(b)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-family: 'Times New Roman', serif; font-weight: bold;">Address of Principal Business Office:</div>
          </td>
        </tr>

    </table>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="margin-left: 108pt; font-family: 'Times New Roman', serif;">The address of the principal office of each of the Reporting Persons is:</div>
    <div><br>
    </div>
    <div style="margin-left: 108pt; font-family: 'Times New Roman', serif;">2200 Pennsylvania Avenue, NW</div>
    <div style="margin-left: 108pt; font-family: 'Times New Roman', serif;">Suite 800W</div>
    <div style="margin-left: 108pt; font-family: 'Times New Roman', serif;">Washington, DC 20037-1701</div>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z3bab3180bfdd4ccfa866fc33695afaaa" cellpadding="0" cellspacing="0">

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          <td style="width: 72pt;"><br>
          </td>
          <td style="width: 36pt; vertical-align: top; align: right; font-family: 'Times New Roman', serif; font-weight: bold;">(c)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-family: 'Times New Roman', serif; font-weight: bold;">Citizenship:</div>
          </td>
        </tr>

    </table>
    <div style="text-indent: -36pt; margin-left: 108pt; font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="margin-left: 108pt; font-family: 'Times New Roman', serif;">Danaher is a Delaware corporation.&#160; DV is a Delaware limited liability company.</div>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z35dff371368544ba8ef825addb7fc12d" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 72pt;"><br>
          </td>
          <td style="width: 36pt; vertical-align: top; align: right; font-family: 'Times New Roman', serif; font-weight: bold;">(d)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-family: 'Times New Roman', serif; font-weight: bold;">Title of Class of Securities:</div>
          </td>
        </tr>

    </table>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="margin-left: 108pt; font-family: 'Times New Roman', serif;">Common Stock, par value $0.001 per share (the &#8220;Common Stock&#8221;)</div>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zf1c9ef1876114c9cb503ded9ac56a68f" cellpadding="0" cellspacing="0">

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          <td style="width: 72pt;"><br>
          </td>
          <td style="width: 36pt; vertical-align: top; align: right; font-family: 'Times New Roman', serif; font-weight: bold;">(e)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-family: 'Times New Roman', serif; font-weight: bold;">CUSIP Number:</div>
          </td>
        </tr>

    </table>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="margin-left: 108pt; font-family: 'Times New Roman', serif;">465005106</div>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
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        <tr>
          <td style="width: 72pt; vertical-align: top; align: right; font-family: 'Times New Roman', serif; font-weight: bold;">Item 3.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-family: 'Times New Roman', serif; font-weight: bold;">Statement filed pursuant to &#167;&#167;240.13d-1(b) or 240.13d-2(b) or (c).</div>
          </td>
        </tr>

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    <div><br>
    </div>
    <div style="margin-left: 72pt; font-family: 'Times New Roman', serif;">Not applicable.<font style="font-size: 12pt;">&#160;</font></div>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z30c27f4dfe404e5290a904cfc472e511" cellpadding="0" cellspacing="0">

        <tr>
          <td style="width: 72pt; vertical-align: top; align: right; font-family: 'Times New Roman', serif; font-weight: bold;">Item 4.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-family: 'Times New Roman', serif; font-weight: bold;">Ownership.</div>
          </td>
        </tr>

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    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <table style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z14abbd7086554e7c8c99ce3891b8f2c2" cellpadding="0" cellspacing="0">

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          <td style="width: 36pt; vertical-align: top; align: right; font-family: 'Times New Roman', serif; font-weight: bold;">(a)</td>
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            <div style="font-family: 'Times New Roman', serif;">Amount beneficially owned: See Item 9 of the cover page for each Reporting Person.</div>
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      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">4</font></div>
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            <div style="font-family: 'Times New Roman', serif;">The Reporting Persons may each be deemed the beneficial owner of 4.99% of the Common Stock outstanding, based on 39,575,989 shares of Common Stock outstanding, as reported in the Issuer&#8217;s
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    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
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              <td style="width: 36pt; vertical-align: top; align: right; font-family: 'Times New Roman', serif; font-weight: bold;">(c)</td>
              <td style="width: 36pt; vertical-align: top; align: right;"><font style="font-family: 'Times New Roman', serif;">(i)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</td>
              <td style="width: auto; vertical-align: top; font-family: 'Times New Roman', serif;">Sole power to vote or direct the vote:</td>
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    <div style="margin-left: 144pt; font-family: 'Times New Roman', serif;">See Item 5 of the cover page for each Reporting Person.</div>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
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          <td style="width: 36pt; vertical-align: top; align: right; font-family: 'Times New Roman', serif;">(ii)</td>
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            <div style="font-family: 'Times New Roman', serif;">Shared power to vote or direct the vote:</div>
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    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="margin-left: 144pt; font-family: 'Times New Roman', serif;">See Item 6 of the cover page for each Reporting Person.</div>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
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          <td style="width: 36pt; vertical-align: top; align: right; font-family: 'Times New Roman', serif;">(iii)</td>
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            <div style="font-family: 'Times New Roman', serif;">Sole power to dispose or direct the disposition:&#160;&#160;</div>
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    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="margin-left: 144pt; font-family: 'Times New Roman', serif;">See Item 7 of the cover page for each Reporting Person.</div>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
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          <td style="width: 108pt;"><br>
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          <td style="width: 36pt; vertical-align: top; align: right; font-family: 'Times New Roman', serif;">(iv)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-family: 'Times New Roman', serif;">Shared power to dispose or direct the disposition:&#160;&#160;</div>
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    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="margin-left: 144pt; font-family: 'Times New Roman', serif;">See Item 8 of the cover page for each Reporting Person.</div>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
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          <td style="width: 72pt; vertical-align: top; align: right; font-family: 'Times New Roman', serif; font-weight: bold;">Item 5.</td>
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            <div style="font-family: 'Times New Roman', serif; font-weight: bold;">Ownership of Five Percent or Less of a Class.</div>
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        </tr>

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    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="margin-left: 72pt; font-family: 'Times New Roman', serif;">If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than 5 percent of the class of
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        <tr>
          <td style="width: 72pt; vertical-align: top; align: right; font-family: 'Times New Roman', serif; font-weight: bold;">Item 6.</td>
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            <div style="font-family: 'Times New Roman', serif; font-weight: bold;">Ownership of More than Five Percent on Behalf of Another Person.</div>
          </td>
        </tr>

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    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="text-indent: 36pt; margin-left: 36pt; font-family: 'Times New Roman', serif;">Not applicable.</div>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
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        <tr>
          <td style="width: 72pt; vertical-align: top; align: right; font-family: 'Times New Roman', serif; font-weight: bold;">Item 7.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-family: 'Times New Roman', serif; font-weight: bold;">Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.</div>
          </td>
        </tr>

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    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="text-indent: 36pt; margin-left: 36pt; font-family: 'Times New Roman', serif;">Not applicable.</div>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
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          <td style="width: 72pt; vertical-align: top; align: right; font-family: 'Times New Roman', serif; font-weight: bold;">Item 8.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-family: 'Times New Roman', serif; font-weight: bold;">Identification and Classification of Members of the Group.</div>
          </td>
        </tr>

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    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="text-indent: 36pt; margin-left: 36pt; font-family: 'Times New Roman', serif;">Not applicable.</div>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
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        <tr>
          <td style="width: 72pt; vertical-align: top; align: right; font-family: 'Times New Roman', serif; font-weight: bold;">Item 9.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-family: 'Times New Roman', serif; font-weight: bold;">Notice of Dissolution of Group.</div>
          </td>
        </tr>

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    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="text-indent: 36pt; margin-left: 36pt; font-family: 'Times New Roman', serif;">Not applicable.</div>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
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          <td style="width: 72pt; vertical-align: top; align: right; font-family: 'Times New Roman', serif; font-weight: bold;">Item 10.</td>
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            <div style="font-family: 'Times New Roman', serif; font-weight: bold;">Certifications.</div>
          </td>
        </tr>

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    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="text-indent: 36pt; margin-left: 36pt; font-family: 'Times New Roman', serif;">Not applicable.</div>
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      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-weight: normal; font-style: normal;">5</font></div>
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    <div style="text-align: center; font-family: 'Times New Roman', serif; font-weight: bold;">SIGNATURE</div>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="font-family: 'Times New Roman', serif;">After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</div>
    <div style="font-family: 'Times New Roman', serif; font-size: 12pt;">&#160;</div>
    <div style="font-family: 'Times New Roman', serif;">Dated: January 27, 2023</div>
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              <div style="font-family: 'Times New Roman', serif;">&#160;</div>
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              <div style="font-family: 'Times New Roman', serif;">DANAHER CORPORATION</div>
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            <td style="width: 46.15%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', serif;">&#160;</div>
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              <div style="font-family: 'Times New Roman', serif;">&#160;</div>
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              <div style="font-family: 'Times New Roman', serif;">&#160;</div>
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              <div style="font-family: 'Times New Roman', serif;">&#160;</div>
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              <div style="font-family: 'Times New Roman', serif;">By:&#160;&#160;</div>
            </td>
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              <div style="font-family: 'Times New Roman', serif;">/s/ Jose-Carlos Gutierrez-Ramos</div>
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              <div style="font-family: 'Times New Roman', serif;">&#160;</div>
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              <div style="font-family: 'Times New Roman', serif;">Name:&#160;&#160;</div>
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            <td style="width: 46.15%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', serif;">&#160;</div>
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              <div style="font-family: 'Times New Roman', serif;">Title:&#160;&#160;</div>
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          <tr>
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            <td colspan="3" style="width: 53.85%; vertical-align: top;">&#160;</td>
          </tr>
          <tr>
            <td style="width: 46.15%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', serif;">&#160;</div>
            </td>
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              <div style="font-family: 'Times New Roman', serif;">DANAHER VENTURES LLC</div>
            </td>
          </tr>
          <tr>
            <td style="width: 46.15%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', serif;">&#160;</div>
            </td>
            <td colspan="3" style="width: 53.85%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', serif;">&#160;</div>
            </td>
          </tr>
          <tr>
            <td style="width: 46.15%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', serif;">&#160;</div>
            </td>
            <td colspan="3" style="width: 53.85%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', serif;">&#160;</div>
            </td>
          </tr>
          <tr>
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              <div style="font-family: 'Times New Roman', serif;">&#160;</div>
            </td>
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              <div style="font-family: 'Times New Roman', serif;">By:&#160;&#160;</div>
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            <td style="width: 46%; vertical-align: top; border-bottom: #000000 0.50pt solid;">
              <div style="font-family: 'Times New Roman', serif;">/s/ Jose-Carlos Gutierrez-Ramos</div>
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          </tr>
          <tr>
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              <div style="font-family: 'Times New Roman', serif;">&#160;</div>
            </td>
            <td style="width: 7.7%; vertical-align: top;">
              <div style="font-family: 'Times New Roman', serif;">Name:&#160;&#160;</div>
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              <div style="font-family: 'Times New Roman', serif;">Title:&#160;&#160;</div>
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              <div style="font-family: 'Times New Roman', serif;">President</div>
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