<SEC-DOCUMENT>0000875320-26-000219.txt : 20260513
<SEC-HEADER>0000875320-26-000219.hdr.sgml : 20260513
<ACCEPTANCE-DATETIME>20260513161016
ACCESSION NUMBER:		0000875320-26-000219
CONFORMED SUBMISSION TYPE:	S-8 POS
PUBLIC DOCUMENT COUNT:		4
FILED AS OF DATE:		20260513
DATE AS OF CHANGE:		20260513
EFFECTIVENESS DATE:		20260513

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			VERTEX PHARMACEUTICALS INC / MA
		CENTRAL INDEX KEY:			0000875320
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				043039129
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-8 POS
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-232948
		FILM NUMBER:		26973333

	BUSINESS ADDRESS:	
		STREET 1:		50 NORTHERN AVENUE
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210
		BUSINESS PHONE:		6173416393

	MAIL ADDRESS:	
		STREET 1:		50 NORTHERN AVENUE
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02210
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-8 POS
<SEQUENCE>1
<FILENAME>s-8pos2013plan.htm
<DESCRIPTION>S-8 POS
<TEXT>
<html><head><title>S-8 POS 2013 Plan </title></head><body><div style="background-color:#E4E4E4;font-family:Arial, sans-serif;word-wrap:break-word"><div style="--justify:justify;--position:absolute;background-color:#FFFFFF;border:1px solid #CCCC;content-visibility:auto;float:none;font-size:0;height:792pt;margin:10px auto 10px auto;overflow:hidden;padding:0;position:relative;width:612pt"><div style="position:absolute;top:756pt"><div style="width:513pt"></div></div><div style="position:absolute"><div style="width:468pt"></div></div><div><div id="ia79f0db91da5425ea39a51d319962353_1" style="position:absolute;top:63pt"></div><div style="line-height:5.41pt;position:absolute;top:63pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:184.31pt;position:absolute;white-space:pre">As filed with the Securities and Exchange Commission on May 13, 2026</font></div><div style="line-height:5.41pt;position:absolute;top:82.28pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:467.39pt;position:absolute;white-space:pre">Registration No. 333-</font></div><div style="line-height:10.83pt;position:absolute;top:111.16pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:16pt;font-style:normal;font-weight:bold;left:242.22pt;position:absolute;white-space:pre">UNITED STATES</font></div><div style="line-height:10.83pt;position:absolute;top:130.36pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:16pt;font-style:normal;font-weight:bold;left:133.82pt;position:absolute;white-space:pre">SECURITIES AND EXCHANGE COMMISSION</font></div><div style="line-height:5.41pt;position:absolute;top:149.56pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:264.57pt;position:absolute;white-space:pre">Washington, D.C. 20549</font></div><div style="line-height:9.48pt;position:absolute;top:174.84pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:14pt;font-style:normal;font-weight:bold;left:162.75pt;position:absolute;white-space:pre">POST-EFFECTIVE AMENDMENT NO. 1 TO&#58;</font></div><div style="line-height:9.48pt;position:absolute;top:191.64pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:14pt;font-style:normal;font-weight:bold;left:121.72pt;position:absolute;white-space:pre">FORM S-8 REGISTRATION STATEMENT NO. 333-188737</font></div><div style="line-height:9.48pt;position:absolute;top:208.44pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:14pt;font-style:normal;font-weight:bold;left:121.72pt;position:absolute;white-space:pre">FORM S-8 REGISTRATION STATEMENT NO. 333-197466</font></div><div style="line-height:9.48pt;position:absolute;top:225.24pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:14pt;font-style:normal;font-weight:bold;left:121.72pt;position:absolute;white-space:pre">FORM S-8 REGISTRATION STATEMENT NO. 333-206075</font></div><div style="line-height:9.48pt;position:absolute;top:242.04pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:14pt;font-style:normal;font-weight:bold;left:121.72pt;position:absolute;white-space:pre">FORM S-8 REGISTRATION STATEMENT NO. 333-219559</font></div><div style="line-height:9.48pt;position:absolute;top:258.84pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:14pt;font-style:normal;font-weight:bold;left:121.72pt;position:absolute;white-space:pre">FORM S-8 REGISTRATION STATEMENT NO. 333-226363</font></div><div style="line-height:9.48pt;position:absolute;top:275.64pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:14pt;font-style:normal;font-weight:bold;left:121.72pt;position:absolute;white-space:pre">FORM S-8 REGISTRATION STATEMENT NO. 333-232948</font></div><div style="line-height:9.48pt;position:absolute;top:292.44pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:14pt;font-style:normal;font-weight:bold;left:121.72pt;position:absolute;white-space:pre">FORM S-8 REGISTRATION STATEMENT NO. 333-266582</font></div><div style="line-height:6.77pt;position:absolute;top:321.29pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:bold;left:234.51pt;position:absolute;white-space:pre">REGISTRATION STATEMENT</font></div><div style="line-height:6.77pt;position:absolute;top:333.29pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:bold;left:288.23pt;position:absolute;white-space:pre">UNDER</font></div><div style="line-height:6.77pt;position:absolute;top:345.29pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:bold;left:232.7pt;position:absolute;white-space:pre">THE SECURITIES ACT OF 1933</font></div><div style="line-height:10.83pt;position:absolute;top:375.34pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:16pt;font-style:normal;font-weight:bold;left:120.27pt;position:absolute;white-space:pre">VERTEX PHARMACEUTICALS INCORPORATED</font></div><div style="line-height:5.54pt;position:absolute;top:394.54pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:normal;left:223.41pt;position:absolute;white-space:pre">(Exact name of registrant as specified in its charter)</font></div><div style="position:absolute;top:416.14pt;width:612pt"><div style="font-size:0pt;left:72pt;position:absolute;width:468.75pt"><div><table style="border-collapse:collapse;display:inline-table;width:100%"><tr style="height:0"><td style="padding:0;width:229.5pt"></td><td style="padding:0;width:9.75pt"></td><td style="padding:0;width:229.5pt"></td></tr><tr style="height:36pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;width:229.5pt"><div><div style="line-height:6.93pt;position:absolute;top:5.866pt;width:229.5pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:90.1pt;position:absolute;top:-2.101pt;white-space:pre">Massachusetts</font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:139.39pt;position:absolute;top:-2.626pt;white-space:pre"> </font></div><div style="line-height:6.93pt;position:absolute;top:15.24pt;width:229.5pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:normal;left:41.47pt;position:absolute;white-space:pre">(State or other jurisdiction of incorporation or </font></div><div style="line-height:5.54pt;position:absolute;top:27.24pt;width:229.5pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:normal;left:93.43pt;position:absolute;white-space:pre">organization)</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:239.25pt;position:absolute;width:229.5pt"><div><div style="line-height:6.93pt;position:absolute;top:16.046pt;width:229.5pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:95.42pt;position:absolute;top:-2.101pt;white-space:pre">04-3039129</font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:134.07999999999998pt;position:absolute;top:-2.626pt;white-space:pre"> </font></div><div style="line-height:6.93pt;position:absolute;top:25.42pt;width:229.5pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:normal;left:49.47pt;position:absolute;white-space:pre">(I.R.S. Employer Identification Number)</font></div></div></div></td></tr></table></div></div></div><div style="line-height:5.41pt;position:absolute;top:465.49pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:271.14pt;position:absolute;white-space:pre">50 Northern Avenue</font></div><div style="line-height:5.41pt;position:absolute;top:475.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:256.58pt;position:absolute;white-space:pre">Boston, Massachusetts 02210 </font></div><div style="line-height:5.54pt;position:absolute;top:484.69pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:normal;left:240.73pt;position:absolute;white-space:pre">(Address of Principal Executive Offices)</font></div><div style="line-height:5.41pt;position:absolute;top:509.89pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:244.71pt;position:absolute;white-space:pre">2026 STOCK AND OPTION PLAN</font></div><div style="line-height:5.41pt;position:absolute;top:519.49pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:190.88pt;position:absolute;white-space:pre">AMENDED AND RESTATED 2013 STOCK AND OPTION PLAN</font></div><div style="line-height:5.54pt;position:absolute;top:529.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:normal;left:275.92pt;position:absolute;white-space:pre">(Full Title of Plan)</font></div><div style="line-height:5.41pt;position:absolute;top:544.69pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:267.92pt;position:absolute;white-space:pre">Reshma Kewalramani</font></div><div style="line-height:5.41pt;position:absolute;top:554.29pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:265.82pt;position:absolute;white-space:pre">Chief Executive Officer</font></div><div style="line-height:5.41pt;position:absolute;top:563.89pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:241.4pt;position:absolute;white-space:pre">Vertex Pharmaceuticals Incorporated</font></div><div style="line-height:5.41pt;position:absolute;top:573.49pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:271.14pt;position:absolute;white-space:pre">50 Northern Avenue</font></div><div style="line-height:5.41pt;position:absolute;top:583.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:256.58pt;position:absolute;white-space:pre">Boston, Massachusetts 02210</font></div><div style="line-height:5.41pt;position:absolute;top:592.69pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:281.01pt;position:absolute;white-space:pre">(617) 341-6100</font></div><div style="line-height:5.54pt;position:absolute;top:602.29pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:normal;left:175.99pt;position:absolute;white-space:pre">(Name, address, and telephone number, including area code, of agent for service)</font></div><div style="line-height:5.54pt;position:absolute;top:623.94pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:normal;left:108pt;position:absolute;white-space:pre">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller </font></div><div style="line-height:5.54pt;position:absolute;top:633.54pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">reporting company or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting </font></div><div style="line-height:5.54pt;position:absolute;top:643.14pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">company&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</font></div><div style="position:absolute;top:652.74pt;width:612pt"><div style="font-size:0pt;left:75.25pt;position:absolute;width:469.5pt"><div><table style="border-collapse:collapse;display:inline-table;width:100%"><tr style="height:0"><td style="padding:0;width:103.5pt"></td><td style="padding:0;width:103.5pt"></td><td style="padding:0;width:145.5pt"></td><td style="padding:0;width:117pt"></td></tr><tr style="height:3pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td></tr><tr style="height:14.25pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:3pt;width:103.5pt"><div><div style="line-height:6.93pt;position:absolute;top:6.296pt;width:103.5pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:normal;left:10.89pt;position:absolute;top:-2.101pt;white-space:pre">Large accelerated filer </font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:84.79pt;position:absolute;top:-2.626pt;white-space:pre">&#9746;</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:103.5pt;position:absolute;top:3pt;width:103.5pt"><div><div style="line-height:6.93pt;position:absolute;top:6.296pt;width:103.5pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:normal;left:20.1pt;position:absolute;top:-2.101pt;white-space:pre">Accelerated filer </font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:75.58pt;position:absolute;top:-2.626pt;white-space:pre">&#9744;</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:207pt;position:absolute;top:3pt;width:145.5pt"><div><div style="line-height:6.93pt;position:absolute;top:6.296pt;width:145.5pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:normal;left:34pt;position:absolute;top:-2.101pt;white-space:pre">Non-accelerated filer </font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:103.69pt;position:absolute;top:-2.626pt;white-space:pre">&#9744;</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:352.5pt;position:absolute;top:3pt;width:117pt"><div><div style="line-height:6.93pt;position:absolute;top:6.296pt;width:117pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:normal;left:9.85pt;position:absolute;top:-2.101pt;white-space:pre">Smaller reporting company </font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:99.33999999999999pt;position:absolute;top:-2.626pt;white-space:pre">&#9744;</font></div></div></div></td></tr><tr style="height:14.25pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:352.5pt;position:absolute;top:17.25pt;width:117pt"><div><div style="line-height:6.93pt;position:absolute;top:6.296pt;width:117pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:normal;left:9.84pt;position:absolute;top:-2.101pt;white-space:pre">Emerging growth company </font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:99.34pt;position:absolute;top:-2.626pt;white-space:pre">&#9744;</font></div></div></div></td></tr></table></div></div></div><div style="background-color:#808080;border-color:#000000;border-style:solid;border-width:0.75pt;height:1.5pt;left:72pt;opacity:1;position:absolute;top:701.24pt;width:468pt;z-index:1"></div><div style="line-height:5.54pt;position:absolute;top:725.24pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with </font></div><div style="line-height:6.93pt;position:absolute;top:737.466pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;top:-2.101pt;white-space:pre">any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.</font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:430.38pt;position:absolute;top:-2.626pt;white-space:pre"> </font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:normal;left:432.88pt;position:absolute;top:-2.101pt;white-space:pre">&#9744;</font></div></div></div><div style="--justify:justify;--position:absolute;background-color:#FFFFFF;border:1px solid #CCCC;content-visibility:auto;float:none;font-size:0;height:792pt;margin:10px auto 10px auto;overflow:hidden;padding:0;position:relative;width:612pt"><div style="position:absolute;top:720pt"><div style="width:513pt"></div></div><div style="position:absolute"><div style="width:468pt"></div></div><div><div id="ia79f0db91da5425ea39a51d319962353_77" style="position:absolute;top:72pt"></div><div style="line-height:6.77pt;position:absolute;top:72pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:bold;left:252.01pt;position:absolute;white-space:pre">EXPLANATORY NOTE</font></div><div style="line-height:6.93pt;position:absolute;top:90pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:108pt;position:absolute;white-space:pre">Pursuant to Securities Act Forms Compliance and Disclosure Interpretation 126.43 (&#8220;C&#38;DI 126.43&#8221;) </font></div><div style="line-height:6.93pt;position:absolute;top:102pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">published by the Securities and Exchange Commission (the &#8220;Commission&#8221;), Vertex Pharmaceuticals Incorporated </font></div><div style="line-height:6.93pt;position:absolute;top:114pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">(the &#8220;Registrant&#8221;) is filing this Post-Effective Amendment No. 1 to Registration Statements on Form S-8 (this &#8220;Post-</font></div><div style="line-height:6.93pt;position:absolute;top:126pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">Effective Amendment&#8221;) to the following registration statements on Form S-8 (collectively, the &#8220;Prior Registration </font></div><div style="line-height:6.93pt;position:absolute;top:138pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">Statements&#8221;) filed by the Registrant with the Commission&#58;</font></div><div style="line-height:6.93pt;position:absolute;top:156pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:108pt;position:absolute;text-decoration:none;white-space:pre">1)</font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:126pt;position:absolute;text-decoration:none;white-space:pre">Registration Statement on Form S-8 (File No. 333-188737) filed on May 21, 2013 with respect to </font></div><div style="line-height:6.93pt;position:absolute;top:168pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:126pt;position:absolute;text-decoration:none;white-space:pre">3,300,000 shares of Common Stock, $0.01 par value per share (&#8220;Common Stock&#8221;) issued or issuable </font></div><div style="line-height:6.93pt;position:absolute;top:180pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:126pt;position:absolute;text-decoration:none;white-space:pre">under the Vertex Pharmaceuticals Incorporated 2013 Stock and Option Plan (as amended, the &#8220;2013 </font></div><div style="line-height:6.93pt;position:absolute;top:192pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:126pt;position:absolute;text-decoration:none;white-space:pre">Plan&#8221;). </font></div><div style="line-height:6.93pt;position:absolute;top:210pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:108pt;position:absolute;text-decoration:none;white-space:pre">2)</font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:126pt;position:absolute;text-decoration:none;white-space:pre">Registration Statement on Form S-8 (File No. 333-197466) filed on July 16, 2014 with respect to </font></div><div style="line-height:6.93pt;position:absolute;top:222pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:126pt;position:absolute;text-decoration:none;white-space:pre">9,500,000 shares of Common Stock, $0.01 par value per share (&#8220;Common Stock&#8221;) issued or issuable </font></div><div style="line-height:6.93pt;position:absolute;top:234pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:126pt;position:absolute;text-decoration:none;white-space:pre">under the 2013 Plan. </font></div><div style="line-height:6.93pt;position:absolute;top:252pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:108pt;position:absolute;text-decoration:none;white-space:pre">3)</font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:126pt;position:absolute;text-decoration:none;white-space:pre">Registration Statement on Form S-8 (File No. 333-206075) filed on August 4, 2015 with respect to </font></div><div style="line-height:6.93pt;position:absolute;top:264pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:126pt;position:absolute;text-decoration:none;white-space:pre">8,997,196 additional shares of Common Stock issued or issuable under the Amended and Restated </font></div><div style="line-height:6.93pt;position:absolute;top:276pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:126pt;position:absolute;text-decoration:none;white-space:pre">2013 Plan. </font></div><div style="line-height:6.93pt;position:absolute;top:294pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:108pt;position:absolute;text-decoration:none;white-space:pre">4)</font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:126pt;position:absolute;text-decoration:none;white-space:pre">Registration Statement on Form S-8 (File No. 333-219559) filed on July 28, 2017 with respect to </font></div><div style="line-height:6.93pt;position:absolute;top:306pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:126pt;position:absolute;text-decoration:none;white-space:pre">6,750,000 additional shares of Common Stock issued or issuable under the Amended and Restated </font></div><div style="line-height:6.93pt;position:absolute;top:318pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:126pt;position:absolute;text-decoration:none;white-space:pre">2013 Plan.</font></div><div style="line-height:6.93pt;position:absolute;top:336pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:108pt;position:absolute;text-decoration:none;white-space:pre">5)</font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:126pt;position:absolute;text-decoration:none;white-space:pre">Registration Statement on Form S-8 (File No. 333-226363) filed on July 26, 2018 with respect to </font></div><div style="line-height:6.93pt;position:absolute;top:348pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:126pt;position:absolute;text-decoration:none;white-space:pre">8,000,000 additional shares of Common Stock issued or issuable under the Amended and Restated </font></div><div style="line-height:6.93pt;position:absolute;top:360pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:126pt;position:absolute;text-decoration:none;white-space:pre">2013 Plan.&#160; </font></div><div style="line-height:6.93pt;position:absolute;top:378pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:108pt;position:absolute;text-decoration:none;white-space:pre">6)</font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:126pt;position:absolute;text-decoration:none;white-space:pre">Registration Statement on Form S-8 (File No. 333-232948) filed on August 1, 2019, with respect to </font></div><div style="line-height:6.93pt;position:absolute;top:390pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:126pt;position:absolute;text-decoration:none;white-space:pre">5,000,000 shares of Common Stock issued or issuable under the Amended and Restated 2013 Plan. </font></div><div style="line-height:6.93pt;position:absolute;top:408pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:108pt;position:absolute;text-decoration:none;white-space:pre">7)</font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:126pt;position:absolute;text-decoration:none;white-space:pre">Registration Statement on Form S-8 (File No. 333-266582) filed on August 5, 2022, with respect to </font></div><div style="line-height:6.93pt;position:absolute;top:420pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:126pt;position:absolute;text-decoration:none;white-space:pre">13,500,000 shares of Common Stock issued or issuable under the Amended and Restated 2013 Plan. </font></div><div style="line-height:6.93pt;position:absolute;top:438pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">On May 13, 2026, the Registrant&#8217;s stockholders approved the Vertex Pharmaceuticals Incorporated 2026 Stock and </font></div><div style="line-height:6.93pt;position:absolute;top:450pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">Option Plan (the &#8220;2026 Plan&#8221;), which replaces the 2013 Plan. No further awards will be made under the 2013 Plan. </font></div><div style="line-height:6.93pt;position:absolute;top:468pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">The number of shares of Common Stock initially authorized for issuance pursuant to the awards under the 2026 Plan </font></div><div style="line-height:6.93pt;position:absolute;top:480pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">includes (a) 6,400,000 shares of Common Stock, (b) 9,051,356 shares of Common Stock, which equals the number </font></div><div style="line-height:6.93pt;position:absolute;top:492pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">of shares available for future grant under the 2013 Plan as of May 13, 2026 and (c) up to 4,136,226 shares of </font></div><div style="line-height:6.93pt;position:absolute;top:504pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">Common Stock, underlying awards outstanding under the 2013 Plan that, on or after May 13, 2026, terminate, </font></div><div style="line-height:6.93pt;position:absolute;top:516pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">expire or lapse for any reason without the delivery of shares to the holder thereof (such shares under clauses (b) and </font></div><div style="line-height:6.93pt;position:absolute;top:528pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">(c) , the &#8220;Carryover Shares&#8221;).</font></div><div style="line-height:6.93pt;position:absolute;top:546pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">Contemporaneously with the filing of this Post-Effective Amendment, the Registrant is filing a Registration </font></div><div style="line-height:6.93pt;position:absolute;top:558pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">Statement on Form S-8 to register the 6,400,000 newly authorized shares of Common Stock that have become </font></div><div style="line-height:6.93pt;position:absolute;top:570pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">available for offer or sale pursuant to the 2026 Plan, which number does not include the Carryover Shares.</font></div><div style="line-height:6.93pt;position:absolute;top:588pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">In accordance with C&#38;DI 126.43 and pursuant to the undertaking in Item 512(a)(1)(iii) of Regulation S-K that the </font></div><div style="line-height:6.93pt;position:absolute;top:600pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">Registrant disclose a material change in the plan of distribution as it was originally disclosed in the Prior </font></div><div style="line-height:6.93pt;position:absolute;top:612pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">Registration Statements, this Post-Effective Amendment is filed to indicate that the Prior Registration Statements </font></div><div style="line-height:6.93pt;position:absolute;top:624pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">will also cover the issuance of the Carryover Shares under the 2026 Plan (as such shares would no longer be issuable </font></div><div style="line-height:6.93pt;position:absolute;top:636pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">under the 2013 Plan as described above). No additional securities are being registered by this Post-Effective </font></div><div style="line-height:6.93pt;position:absolute;top:648pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">Amendment.</font></div><div id="ia79f0db91da5425ea39a51d319962353_147" style="position:absolute;top:666pt"></div><div style="line-height:6.77pt;position:absolute;top:666pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:bold;left:289.2pt;position:absolute;white-space:pre">PART I</font></div><div style="line-height:6.77pt;position:absolute;top:684pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:bold;left:151.92pt;position:absolute;white-space:pre">INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</font></div><div style="line-height:6.93pt;position:absolute;top:696pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:96.5pt;position:absolute;white-space:pre">The information specified in Item 1 and Item 2 of Part I of Form S-8 is omitted from this Post-Effective </font></div><div style="line-height:6.93pt;position:absolute;top:708pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">Amendment in accordance with the provisions of Rule 428 under the Securities Act of 1933, as amended (the </font></div></div></div><div style="--justify:justify;--position:absolute;background-color:#FFFFFF;border:1px solid #CCCC;content-visibility:auto;float:none;font-size:0;height:792pt;margin:10px auto 10px auto;overflow:hidden;padding:0;position:relative;width:612pt"><div style="position:absolute;top:720pt"><div style="width:513pt"></div></div><div style="position:absolute"><div style="width:468pt"></div></div><div><div style="line-height:6.93pt;position:absolute;top:72pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">&#8220;Securities Act&#8221;), and the introductory note to Part I of Form S-8. The document(s) containing the information </font></div><div style="line-height:6.93pt;position:absolute;top:84pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">specified in Part I will be sent or given to participants in the equity plans covered by this Post-Effective Amendment </font></div><div style="line-height:6.93pt;position:absolute;top:96pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">as specified by Rule 428(b)(1) of the Securities Act.</font></div><div id="ia79f0db91da5425ea39a51d319962353_163" style="position:absolute;top:126pt"></div><div style="line-height:6.77pt;position:absolute;top:126pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:bold;left:287.26pt;position:absolute;white-space:pre">PART II</font></div><div style="line-height:6.77pt;position:absolute;top:144pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:bold;left:149.29pt;position:absolute;white-space:pre">INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</font></div><div style="line-height:6.77pt;position:absolute;top:174pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:bold;left:72pt;position:absolute;white-space:pre">Item 3. Incorporation of Documents by Reference.</font></div><div style="line-height:6.93pt;position:absolute;top:194.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:96.5pt;position:absolute;white-space:pre">The following documents filed by Vertex Pharmaceuticals Incorporated (the &#8220;Registrant&#8221;) with the Securities </font></div><div style="line-height:6.93pt;position:absolute;top:206.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">and Exchange Commission (the &#8220;SEC&#8221;) pursuant to the Securities Exchange Act of 1934, as amended (the </font></div><div style="line-height:6.93pt;position:absolute;top:218.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">&#8220;Exchange Act&#8221;), are incorporated by reference into this Registration Statement&#58;</font></div><div style="line-height:6.93pt;position:absolute;top:242.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:96.5pt;position:absolute;white-space:pre">(a) The Registrant&#8217;s Annual Report on Form 10-K for the fiscal year ended December 31, 2025 (including </font></div><div style="line-height:6.93pt;position:absolute;top:254.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">those portions of the Registrant&#8217;s definitive proxy statement for its 2026 annual meeting of shareholders </font></div><div style="line-height:6.93pt;position:absolute;top:266.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">incorporated by reference therein)&#59;</font></div><div style="line-height:6.93pt;position:absolute;top:290.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:96.5pt;position:absolute;white-space:pre">(b) The Registrant&#8217;s Quarterly Report on Form 10-Q for the quarter ended March 31, 2026&#59;</font></div><div style="line-height:6.93pt;position:absolute;top:314.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:96.5pt;position:absolute;white-space:pre">(c) The Registrant&#8217;s Current Reports on Form 8-K filed on March 31, 2026, April 29, 2026, and May 13, </font></div><div style="line-height:6.93pt;position:absolute;top:326.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">2026&#59;</font></div><div style="line-height:6.93pt;position:absolute;top:350.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:96.5pt;position:absolute;white-space:pre">(d) All other reports filed pursuant to Section 13(a) or 15(d) of the Exchange Act since the end of the fiscal </font></div><div style="line-height:6.93pt;position:absolute;top:362.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">year covered by the document referred to in (a) above&#59; and </font></div><div style="line-height:6.93pt;position:absolute;top:386.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:96.5pt;position:absolute;white-space:pre">(e) The description of the Registrant&#8217;s common stock, filed as Exhibit 4.1 to the Form 10-K for the fiscal year </font></div><div style="line-height:6.93pt;position:absolute;top:398.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">ended December 31, 2025, which updates the description contained in the Registrant&#8217;s Registration Statement on </font></div><div style="line-height:6.93pt;position:absolute;top:410.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">Form 8-A (filing date May 30, 1991), and as amended by any amendments or reports filed for the purpose of </font></div><div style="line-height:6.93pt;position:absolute;top:422.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">updating such description.</font></div><div style="line-height:6.93pt;position:absolute;top:446.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:96.5pt;position:absolute;white-space:pre">All documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the </font></div><div style="line-height:6.93pt;position:absolute;top:458.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">Exchange Act (other than Current Reports on Form 8-K furnished pursuant to Item 2.02 or Item 7.01 of Form 8-K, </font></div><div style="line-height:6.93pt;position:absolute;top:470.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">including any exhibits included with such information, unless otherwise indicated therein), prior to the filing of a </font></div><div style="line-height:6.93pt;position:absolute;top:482.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">post-effective amendment that indicates that all securities offered hereby have been sold or that deregisters all </font></div><div style="line-height:6.93pt;position:absolute;top:494.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">securities then remaining unsold, shall be deemed to be incorporated by reference into this Registration Statement </font></div><div style="line-height:6.93pt;position:absolute;top:506.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">and to be a part hereof from the date of the filing of such documents.</font></div><div style="line-height:6.93pt;position:absolute;top:530.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:96.5pt;position:absolute;white-space:pre">Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall </font></div><div style="line-height:6.93pt;position:absolute;top:542.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement </font></div><div style="line-height:6.93pt;position:absolute;top:554.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">contained herein or in any other subsequently filed document that also is, or is deemed to be, incorporated by </font></div><div style="line-height:6.93pt;position:absolute;top:566.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">reference herein modifies or supersedes such statement. Any such statement so modified or superseded shall not be </font></div><div style="line-height:6.93pt;position:absolute;top:578.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">deemed, except as so modified or superseded, to constitute a part of this Registration Statement.</font></div><div style="line-height:6.77pt;position:absolute;top:610.18pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:bold;left:72pt;position:absolute;white-space:pre">Item 4. Description of Securities.</font></div><div style="line-height:6.93pt;position:absolute;top:630.27pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:96.75pt;position:absolute;white-space:pre">Not applicable.</font></div><div style="line-height:6.77pt;position:absolute;top:650.36pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:bold;left:72pt;position:absolute;white-space:pre">Item 5. Interests of Named Experts and Counsel.</font></div><div style="line-height:6.93pt;position:absolute;top:670.45pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:96.75pt;position:absolute;white-space:pre">Not applicable.</font></div><div style="line-height:6.77pt;position:absolute;top:690.54pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:bold;left:72pt;position:absolute;white-space:pre">Item 6. Indemnification of Directors and Officers.</font></div></div></div><div style="--justify:justify;--position:absolute;background-color:#FFFFFF;border:1px solid #CCCC;content-visibility:auto;float:none;font-size:0;height:792pt;margin:10px auto 10px auto;overflow:hidden;padding:0;position:relative;width:612pt"><div style="position:absolute;top:720pt"><div style="width:513pt"></div></div><div style="position:absolute"><div style="width:468pt"></div></div><div><div style="line-height:6.93pt;position:absolute;top:72pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:96.5pt;position:absolute;white-space:pre">Section 2.02(b)(4) of the Massachusetts Business Corporations Act (the &#8220;MBCA&#8221;) provides that a </font></div><div style="line-height:6.93pt;position:absolute;top:84pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">Massachusetts corporation may, in its articles of organization, eliminate or limit the personal liability of a director </font></div><div style="line-height:6.93pt;position:absolute;top:96pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">for monetary damages for breach of fiduciary duty notwithstanding any law to the contrary, except for liabilities </font></div><div style="line-height:6.93pt;position:absolute;top:108pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">involving (i) any breach of duty of loyalty to the corporation or to the shareholders, (ii) acts or omissions not in good </font></div><div style="line-height:6.93pt;position:absolute;top:120pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">faith, intentional misconduct or knowing violations of law, (iii) certain improper distributions or (iv) any transaction </font></div><div style="line-height:6.93pt;position:absolute;top:132pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">from which the director derived an improper personal benefit.</font></div><div style="line-height:6.93pt;position:absolute;top:156pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:96.5pt;position:absolute;white-space:pre">Section 8.51 of the MBCA authorizes a Massachusetts corporation to indemnify an individual who is a party </font></div><div style="line-height:6.93pt;position:absolute;top:168pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">to a proceeding because he or she is a director against liability incurred in the proceeding if (1) (i) such individual </font></div><div style="line-height:6.93pt;position:absolute;top:180pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">conducted himself&#47;herself in good faith, (ii) such individual reasonably believed that his&#47;her conduct was in the best </font></div><div style="line-height:6.93pt;position:absolute;top:192pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">interests of the corporation or that his&#47;her conduct was at least not opposed to the best interests of the corporation, </font></div><div style="line-height:6.93pt;position:absolute;top:204pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">and (iii) in the case of any criminal proceeding, such individual had no reasonable cause to believe that his&#47;her </font></div><div style="line-height:6.93pt;position:absolute;top:216pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">conduct was unlawful or (2) such individual engaged in conduct for which he or she shall not be liable under a </font></div><div style="line-height:6.93pt;position:absolute;top:228pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">provision of the articles of organization authorized by Section 2.02(b)(4) of the MBCA.</font></div><div style="line-height:6.93pt;position:absolute;top:252pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:96.5pt;position:absolute;white-space:pre">Section 8.52 of the MBCA provides that a corporation must indemnify a director who is wholly successful, on </font></div><div style="line-height:6.93pt;position:absolute;top:264pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">the merits or otherwise, in the defense of any proceeding to which the director was a party because he or she was a </font></div><div style="line-height:6.93pt;position:absolute;top:276pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">director of the corporation against reasonable expenses incurred by him or her in connection with the proceeding.</font></div><div style="line-height:6.93pt;position:absolute;top:300pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:96.5pt;position:absolute;white-space:pre">Section 8.56 of the MBCA authorizes a corporation to indemnify an officer of the corporation who is a party </font></div><div style="line-height:6.93pt;position:absolute;top:312pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">to a proceeding because he or she is an officer of the corporation to the same extent as a director and, if he or she is </font></div><div style="line-height:6.93pt;position:absolute;top:324pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">an officer but not a director, to such further extent as may be provided by the articles of organization, by-laws or a </font></div><div style="line-height:6.93pt;position:absolute;top:336pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">resolution of the board of directors or contract, except for liability arising out of acts or omissions not in good faith </font></div><div style="line-height:6.93pt;position:absolute;top:348pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">or which involve intentional misconduct or a knowing violation of law. Section 8.56 of the MBCA requires that a </font></div><div style="line-height:6.93pt;position:absolute;top:360pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">Massachusetts corporation indemnify an officer of the corporation who was wholly successful, on the merits or </font></div><div style="line-height:6.93pt;position:absolute;top:372pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">otherwise, in the defense of any proceeding to which such officer was a party because he or she was an officer of the </font></div><div style="line-height:6.93pt;position:absolute;top:384pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">corporation.</font></div><div style="line-height:6.93pt;position:absolute;top:408pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:96.5pt;position:absolute;white-space:pre">Part D of Article VI of the Restated Articles of Organization of the Registrant provides that no director of the </font></div><div style="line-height:6.93pt;position:absolute;top:420pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">Registrant shall be personally liable to the Registrant or its shareholders for monetary damages for any breach of </font></div><div style="line-height:6.93pt;position:absolute;top:432pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">fiduciary duty as a director. Such paragraph provides further, however, that to the extent provided by applicable law </font></div><div style="line-height:6.93pt;position:absolute;top:444pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">it will not eliminate or limit the liability of a director (i) for any breach of the director&#8217;s duty of loyalty to the </font></div><div style="line-height:6.93pt;position:absolute;top:456pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">Registrant or its shareholders, (ii) for acts or omissions not in good faith or which involve intentional misconduct or </font></div><div style="line-height:6.93pt;position:absolute;top:468pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">a knowing violation of law, (iii) under Section 61 or 62 of the Massachusetts Business Corporation Law, or (iv) for </font></div><div style="line-height:6.93pt;position:absolute;top:480pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">any transactions from which the director derived an improper personal benefit.</font></div><div style="line-height:6.93pt;position:absolute;top:504pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:96.5pt;position:absolute;white-space:pre">Article V of the Registrant&#8217;s Amended and Restated By-laws provides that the Registrant shall indemnify, and </font></div><div style="line-height:6.93pt;position:absolute;top:516pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">advance funds to pay for or reimburse the reasonable expenses incurred by, its directors and the officers that have </font></div><div style="line-height:6.93pt;position:absolute;top:528pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">been appointed by the Board of Directors (including persons who serve at the Registrant&#8217;s request as a director, </font></div><div style="line-height:6.93pt;position:absolute;top:540pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">officer, or trustee of another organization in which the Registrant has any interest, direct or indirect, as a </font></div><div style="line-height:6.93pt;position:absolute;top:552pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">shareholder, creditor, or otherwise or who serve at the Registrant&#8217;s request in any capacity with respect to any </font></div><div style="line-height:6.93pt;position:absolute;top:564pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">employee benefit plan) to the fullest extent permitted by law, and may indemnify, and advance funds to pay for or </font></div><div style="line-height:6.93pt;position:absolute;top:576pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">reimburse the reasonable expenses incurred by, such other employees and agents as are identified by the Board of </font></div><div style="line-height:6.93pt;position:absolute;top:588pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">Directors.</font></div><div style="line-height:6.93pt;position:absolute;top:612pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:96.5pt;position:absolute;white-space:pre">Article V of the Registrant&#8217;s Amended and Restated By-laws gives the Board of Directors of the Registrant </font></div><div style="line-height:6.93pt;position:absolute;top:624pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">the power to authorize the purchase and maintenance of insurance, in such amounts as the Board of Directors may </font></div><div style="line-height:6.93pt;position:absolute;top:636pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">from time to time deem appropriate, on behalf of any person who is or was a director, officer, or agent of the </font></div><div style="line-height:6.93pt;position:absolute;top:648pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">Registrant, or who is or was serving at the request of the Registrant as a director, officer or agent of another </font></div><div style="line-height:6.93pt;position:absolute;top:660pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">organization in which the Registrant has any interest, direct or indirect, as a shareholder, creditor or otherwise, or </font></div><div style="line-height:6.93pt;position:absolute;top:672pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">with respect to any employee benefit plan, against any liability incurred by such person in any such capacity, or </font></div><div style="line-height:6.93pt;position:absolute;top:684pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">arising out of such person&#8217;s status as such agent, whether or not such person is entitled to indemnification by the </font></div><div style="line-height:6.93pt;position:absolute;top:696pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">Registrant pursuant to Article V or otherwise and whether or not the Registrant would have the power to indemnify </font></div><div style="line-height:6.93pt;position:absolute;top:708pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">the person against such liability.</font></div></div></div><div style="--justify:justify;--position:absolute;background-color:#FFFFFF;border:1px solid #CCCC;content-visibility:auto;float:none;font-size:0;height:792pt;margin:10px auto 10px auto;overflow:hidden;padding:0;position:relative;width:612pt"><div style="position:absolute;top:720pt"><div style="width:513pt"></div></div><div style="-sec-extract:summary;position:absolute"><div style="width:468pt"></div></div><div><div style="line-height:6.77pt;position:absolute;top:72pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:bold;left:72pt;position:absolute;white-space:pre">Item 7. Exemption from Registration Claimed.</font></div><div style="line-height:6.93pt;position:absolute;top:92.09pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:96.75pt;position:absolute;white-space:pre">Not applicable.</font></div><div id="ia79f0db91da5425ea39a51d319962353_180" style="position:absolute;top:112.18pt"></div><div style="line-height:6.77pt;position:absolute;top:112.18pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:bold;left:72pt;position:absolute;white-space:pre">Item 8. Exhibits.</font></div><div style="position:absolute;top:142.78pt;width:612pt"><div style="font-size:0pt;left:75.25pt;position:absolute;width:464.25pt"><div><table style="border-collapse:collapse;display:inline-table;width:100%"><tr style="height:0"><td style="padding:0;width:36.75pt"></td><td style="padding:0;width:5.25pt"></td><td style="padding:0;width:159pt"></td><td style="padding:0;width:5.25pt"></td><td style="padding:0;width:48.75pt"></td><td style="padding:0;width:5.25pt"></td><td style="padding:0;width:60.75pt"></td><td style="padding:0;width:5.25pt"></td><td style="padding:0;width:70.5pt"></td><td style="padding:0;width:5.25pt"></td><td style="padding:0;width:62.25pt"></td></tr><tr style="height:15.75pt"><td style="font-size:0;text-align:left;vertical-align:top" colspan="11"></td></tr><tr style="height:15.75pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td></tr><tr style="height:50.25pt"><td style="border-bottom:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:31.5pt;width:36.75pt"><div><div style="line-height:5.41pt;position:absolute;top:33.62pt;width:36.75pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">Exhibit </font></div><div style="line-height:5.41pt;position:absolute;top:41.62pt;width:36.75pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">Number</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="border-bottom:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:42pt;position:absolute;top:31.5pt;width:159pt"><div><div style="line-height:5.41pt;position:absolute;top:41.62pt;width:159pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:46.09pt;position:absolute;white-space:pre">Exhibit Description</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="border-bottom:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:206.25pt;position:absolute;top:31.5pt;width:48.75pt"><div><div style="line-height:5.41pt;position:absolute;top:12.82pt;width:48.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:15.72pt;position:absolute;white-space:pre">Filed </font></div><div style="line-height:5.41pt;position:absolute;top:22.42pt;width:48.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:9.61pt;position:absolute;white-space:pre">with this </font></div><div style="line-height:5.41pt;position:absolute;top:32.02pt;width:48.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:3.28pt;position:absolute;white-space:pre">Registration </font></div><div style="line-height:5.41pt;position:absolute;top:41.62pt;width:48.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:7.06pt;position:absolute;white-space:pre">Statement</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="border-bottom:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:260.25pt;position:absolute;top:31.5pt;width:60.75pt"><div><div style="line-height:5.41pt;position:absolute;top:3.22pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:7.73pt;position:absolute;white-space:pre">Incorporated </font></div><div style="line-height:5.41pt;position:absolute;top:12.82pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:8.07pt;position:absolute;white-space:pre">by Reference </font></div><div style="line-height:5.41pt;position:absolute;top:22.42pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:8.73pt;position:absolute;white-space:pre">herein from-</font></div><div style="line-height:5.41pt;position:absolute;top:32.02pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:16.05pt;position:absolute;white-space:pre">Form or </font></div><div style="line-height:5.41pt;position:absolute;top:41.62pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:15.06pt;position:absolute;white-space:pre">Schedule</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="border-bottom:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:326.25pt;position:absolute;top:31.5pt;width:70.5pt"><div><div style="line-height:5.41pt;position:absolute;top:41.62pt;width:70.5pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:16.27pt;position:absolute;white-space:pre">Filing Date</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="border-bottom:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:402pt;position:absolute;top:31.5pt;width:62.25pt"><div><div style="line-height:5.41pt;position:absolute;top:32.02pt;width:62.25pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:14.81pt;position:absolute;white-space:pre">SEC File&#47; </font></div><div style="line-height:5.41pt;position:absolute;top:41.62pt;width:62.25pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:8.26pt;position:absolute;white-space:pre">Reg. Number</font></div></div></div></td></tr><tr style="height:38.25pt"><td style="border-top:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:81.75pt;width:36.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:36.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:21.62pt;position:absolute;white-space:pre">4.1</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="border-top:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:42pt;position:absolute;top:81.75pt;width:159pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532026000056/a10k_2025-exhibit31.htm">Restated Articles of Organization of </a></font></div><div style="line-height:6.93pt;position:absolute;top:14.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532026000056/a10k_2025-exhibit31.htm">Vertex Pharmaceuticals Incorporated, </a></font></div><div style="line-height:6.93pt;position:absolute;top:26.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532026000056/a10k_2025-exhibit31.htm">as amended.</a></font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="border-top:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="border-top:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:260.25pt;position:absolute;top:81.75pt;width:60.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:20.1pt;position:absolute;white-space:pre">10-K </font></div><div style="line-height:6.93pt;position:absolute;top:14.63pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:4.84pt;position:absolute;white-space:pre">(Exhibit 3.1)</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="border-top:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:326.25pt;position:absolute;top:81.75pt;width:70.5pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:70.5pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:9.71pt;position:absolute;white-space:pre">February 13, </font></div><div style="line-height:6.93pt;position:absolute;top:14.63pt;width:70.5pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:25.25pt;position:absolute;white-space:pre">2026</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="border-top:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:402pt;position:absolute;top:81.75pt;width:62.25pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:62.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:16.29pt;position:absolute;text-decoration:none;white-space:pre">000-19319</font></div></div></div></td></tr><tr style="height:26.25pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:120pt;width:36.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:36.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:21.62pt;position:absolute;white-space:pre">4.2</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:42pt;position:absolute;top:120pt;width:159pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532025000053/a10k_2024-exhibit32.htm">Amended and Restated By-laws of </a></font></div><div style="line-height:6.93pt;position:absolute;top:14.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532025000053/a10k_2024-exhibit32.htm">Vertex Pharmaceuticals Incorporated.</a></font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:260.25pt;position:absolute;top:120pt;width:60.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:20.1pt;position:absolute;white-space:pre">10-Q </font></div><div style="line-height:6.93pt;position:absolute;top:14.63pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:4.84pt;position:absolute;white-space:pre">(Exhibit 3.2)</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:326.25pt;position:absolute;top:120pt;width:70.5pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:70.5pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:9.71pt;position:absolute;white-space:pre">February 13, </font></div><div style="line-height:6.93pt;position:absolute;top:14.63pt;width:70.5pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:25.25pt;position:absolute;white-space:pre">2025</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:402pt;position:absolute;top:120pt;width:62.25pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:62.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:16.29pt;position:absolute;text-decoration:none;white-space:pre">000-19319</font></div></div></div></td></tr><tr style="height:26.25pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:146.25pt;width:36.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:36.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:21.62pt;position:absolute;white-space:pre">4.3</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:42pt;position:absolute;top:146.25pt;width:159pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532018000009/a10k2017exhibit41.htm">Specimen stock certificate.</a></font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:260.25pt;position:absolute;top:146.25pt;width:60.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:20.1pt;position:absolute;white-space:pre">10-K </font></div><div style="line-height:6.93pt;position:absolute;top:14.63pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:4.84pt;position:absolute;white-space:pre">(Exhibit 4.1)</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:326.25pt;position:absolute;top:146.25pt;width:70.5pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:70.5pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:9.71pt;position:absolute;white-space:pre">February 15, </font></div><div style="line-height:6.93pt;position:absolute;top:14.63pt;width:70.5pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:25.25pt;position:absolute;white-space:pre">2018</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:402pt;position:absolute;top:146.25pt;width:62.25pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:62.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:16.29pt;position:absolute;text-decoration:none;white-space:pre">000-19319</font></div></div></div></td></tr><tr style="height:33.75pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:172.5pt;width:36.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:36.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:21.62pt;position:absolute;white-space:pre">5.1</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:42pt;position:absolute;top:172.5pt;width:159pt"><div><div style="font-size:12pt;line-height:6.93pt;position:absolute;top:2.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="a2026s-8pos_ex51xopinion20.htm">Opinion of Ropes &#38; Gray LLP as to </a></font></div><div style="font-size:12pt;line-height:6.93pt;position:absolute;top:12.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="a2026s-8pos_ex51xopinion20.htm">the legality of the shares being </a></font></div><div style="font-size:12pt;line-height:6.93pt;position:absolute;top:22.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="a2026s-8pos_ex51xopinion20.htm">registered.</a></font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:206.25pt;position:absolute;top:172.5pt;width:48.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:48.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:20.76pt;position:absolute;white-space:pre">X</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td></tr><tr style="height:50.25pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:206.25pt;width:36.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:36.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:21.62pt;position:absolute;white-space:pre">5.2</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:42pt;position:absolute;top:206.25pt;width:159pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532013000033/ex-51.htm">Opinion of Mintz, Levin, Cohn, </a></font></div><div style="line-height:6.93pt;position:absolute;top:14.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532013000033/ex-51.htm">Ferris, Glovsky and Popeo, P.C. as to </a></font></div><div style="line-height:6.93pt;position:absolute;top:26.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532013000033/ex-51.htm">the legality of the shares being </a></font></div><div style="line-height:6.93pt;position:absolute;top:38.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532013000033/ex-51.htm">registered.</a></font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:260.25pt;position:absolute;top:206.25pt;width:60.75pt"><div><div style="line-height:6.93pt;position:absolute;top:27.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:23.43pt;position:absolute;white-space:pre">S-8</font></div><div style="line-height:6.93pt;position:absolute;top:39.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:4.84pt;position:absolute;white-space:pre">(Exhibit 5.1)</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:326.25pt;position:absolute;top:206.25pt;width:70.5pt"><div><div style="line-height:6.93pt;position:absolute;top:39.67pt;width:70.5pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:7.34pt;position:absolute;text-decoration:none;white-space:pre">May 21, 2013</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:402pt;position:absolute;top:206.25pt;width:62.25pt"><div><div style="line-height:6.93pt;position:absolute;top:39.67pt;width:62.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:11.29pt;position:absolute;text-decoration:none;white-space:pre">333-188737</font></div></div></div></td></tr><tr style="height:26.25pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:256.5pt;width:36.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:36.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:21.62pt;position:absolute;white-space:pre">5.3</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:42pt;position:absolute;top:256.5pt;width:159pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532014000050/exhibit51.htm">Opinion of Counsel as to the legality </a></font></div><div style="line-height:6.93pt;position:absolute;top:14.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532014000050/exhibit51.htm">of the shares being registered.</a></font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:260.25pt;position:absolute;top:256.5pt;width:60.75pt"><div><div style="line-height:6.93pt;position:absolute;top:3.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:23.43pt;position:absolute;white-space:pre">S-8</font></div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:4.84pt;position:absolute;white-space:pre">(Exhibit 5.1)</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:326.25pt;position:absolute;top:256.5pt;width:70.5pt"><div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:70.5pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:8.17pt;position:absolute;text-decoration:none;white-space:pre">July 16, 2014</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:402pt;position:absolute;top:256.5pt;width:62.25pt"><div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:62.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:11.29pt;position:absolute;text-decoration:none;white-space:pre">333-197466</font></div></div></div></td></tr><tr style="height:26.25pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:282.75pt;width:36.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:36.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:21.62pt;position:absolute;white-space:pre">5.4</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:42pt;position:absolute;top:282.75pt;width:159pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532015000049/exhibit511.htm">Opinion of Counsel as to the legality </a></font></div><div style="line-height:6.93pt;position:absolute;top:14.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532015000049/exhibit511.htm">of the shares being registered.</a></font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:260.25pt;position:absolute;top:282.75pt;width:60.75pt"><div><div style="line-height:6.93pt;position:absolute;top:3.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:23.43pt;position:absolute;white-space:pre">S-8</font></div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:4.84pt;position:absolute;white-space:pre">(Exhibit 5.1)</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:326.25pt;position:absolute;top:282.75pt;width:70.5pt"><div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:70.5pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:4.56pt;position:absolute;text-decoration:none;white-space:pre">August 4, 2015</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:402pt;position:absolute;top:282.75pt;width:62.25pt"><div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:62.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:11.29pt;position:absolute;text-decoration:none;white-space:pre">333-206075</font></div></div></div></td></tr><tr style="height:26.25pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:309pt;width:36.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:36.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:21.62pt;position:absolute;white-space:pre">5.5</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:42pt;position:absolute;top:309pt;width:159pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:1.75pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532017000048/exhibit512017.htm">Opinion of Counsel as to the legality </a></font></div><div style="line-height:6.93pt;position:absolute;top:14.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:1.75pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532017000048/exhibit512017.htm">of the shares being registered.</a></font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:260.25pt;position:absolute;top:309pt;width:60.75pt"><div><div style="line-height:6.93pt;position:absolute;top:3.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:23.43pt;position:absolute;white-space:pre">S-8</font></div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:4.84pt;position:absolute;white-space:pre">(Exhibit 5.1)</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:326.25pt;position:absolute;top:309pt;width:70.5pt"><div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:70.5pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:8.17pt;position:absolute;text-decoration:none;white-space:pre">July 28, 2017</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:402pt;position:absolute;top:309pt;width:62.25pt"><div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:62.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:11.29pt;position:absolute;text-decoration:none;white-space:pre">333-219559</font></div></div></div></td></tr><tr style="height:26.25pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:335.25pt;width:36.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:36.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:21.62pt;position:absolute;white-space:pre">5.6</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:42pt;position:absolute;top:335.25pt;width:159pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532018000024/a51.htm">Opinion of Counsel as to the legality </a></font></div><div style="line-height:6.93pt;position:absolute;top:14.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532018000024/a51.htm">of the shares being registered.</a></font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:260.25pt;position:absolute;top:335.25pt;width:60.75pt"><div><div style="line-height:6.93pt;position:absolute;top:3.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:23.43pt;position:absolute;white-space:pre">S-8</font></div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:4.84pt;position:absolute;white-space:pre">(Exhibit 5.1)</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:326.25pt;position:absolute;top:335.25pt;width:70.5pt"><div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:70.5pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:8.17pt;position:absolute;text-decoration:none;white-space:pre">July 26, 2018</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:402pt;position:absolute;top:335.25pt;width:62.25pt"><div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:62.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:11.29pt;position:absolute;text-decoration:none;white-space:pre">333-226363</font></div></div></div></td></tr><tr style="height:26.25pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:361.5pt;width:36.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:36.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:21.62pt;position:absolute;white-space:pre">5.7</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:42pt;position:absolute;top:361.5pt;width:159pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532019000040/exhibit51-opinionxsx8x2013.htm">Opinion of Counsel as to the legality </a></font></div><div style="line-height:6.93pt;position:absolute;top:14.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532019000040/exhibit51-opinionxsx8x2013.htm">of the shares being registered.</a></font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:260.25pt;position:absolute;top:361.5pt;width:60.75pt"><div><div style="line-height:6.93pt;position:absolute;top:3.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:23.43pt;position:absolute;white-space:pre">S-8</font></div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:4.84pt;position:absolute;white-space:pre">(Exhibit 5.1)</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:326.25pt;position:absolute;top:361.5pt;width:70.5pt"><div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:70.5pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:4.56pt;position:absolute;text-decoration:none;white-space:pre">August 1, 2019</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:402pt;position:absolute;top:361.5pt;width:62.25pt"><div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:62.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:11.29pt;position:absolute;text-decoration:none;white-space:pre">333-232948</font></div></div></div></td></tr><tr style="height:38.25pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:387.75pt;width:36.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:36.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:21.62pt;position:absolute;white-space:pre">5.8</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:42pt;position:absolute;top:387.75pt;width:159pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532022000032/a2022s-8_exhibit51xopinion.htm">Opinion of Ropes &#38; Gray LLP as to </a></font></div><div style="line-height:6.93pt;position:absolute;top:14.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532022000032/a2022s-8_exhibit51xopinion.htm">the legality of the shares being </a></font></div><div style="line-height:6.93pt;position:absolute;top:26.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532022000032/a2022s-8_exhibit51xopinion.htm">registered.</a></font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:260.25pt;position:absolute;top:387.75pt;width:60.75pt"><div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:23.43pt;position:absolute;white-space:pre">S-8</font></div><div style="line-height:6.93pt;position:absolute;top:27.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:4.84pt;position:absolute;white-space:pre">(Exhibit 5.1)</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:326.25pt;position:absolute;top:387.75pt;width:70.5pt"><div><div style="line-height:6.93pt;position:absolute;top:27.67pt;width:70.5pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:4.56pt;position:absolute;text-decoration:none;white-space:pre">August 5, 2022</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:402pt;position:absolute;top:387.75pt;width:62.25pt"><div><div style="line-height:6.93pt;position:absolute;top:27.67pt;width:62.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:11.29pt;position:absolute;text-decoration:none;white-space:pre">333-266582</font></div></div></div></td></tr><tr style="height:14.25pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:426pt;width:36.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:36.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:16.62pt;position:absolute;white-space:pre">23.1</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:42pt;position:absolute;top:426pt;width:159pt"><div><div style="font-size:12pt;line-height:6.93pt;position:absolute;top:2.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="a2013s-8pos_ex231xeyconsent.htm">Consent of Ernst &#38; Young LLP.</a></font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:206.25pt;position:absolute;top:426pt;width:48.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:48.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:20.76pt;position:absolute;white-space:pre">X</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td></tr><tr style="height:23.25pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:440.25pt;width:36.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:36.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:16.62pt;position:absolute;white-space:pre">23.2</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:42pt;position:absolute;top:440.25pt;width:159pt"><div><div style="font-size:12pt;line-height:6.93pt;position:absolute;top:2.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="a2026s-8pos_ex51xopinion20.htm">Consent of Ropes &#38; Gray LLP </a></font></div><div style="font-size:12pt;line-height:6.93pt;position:absolute;top:12.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="a2026s-8pos_ex51xopinion20.htm">(included as part of Exhibit 5.1).</a></font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:206.25pt;position:absolute;top:440.25pt;width:48.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:48.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:20.76pt;position:absolute;white-space:pre">X</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td></tr><tr style="height:38.25pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:463.5pt;width:36.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:36.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:16.62pt;position:absolute;white-space:pre">23.3</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:42pt;position:absolute;top:463.5pt;width:159pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532013000033/ex-51.htm">Consent of Mintz, Levin, Cohn, </a></font></div><div style="line-height:6.93pt;position:absolute;top:14.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532013000033/ex-51.htm">Ferris, Glovsky and Popeo, P.C </a></font></div><div style="line-height:6.93pt;position:absolute;top:26.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532013000033/ex-51.htm">(included as part of Exhibit 5.2).</a></font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:260.25pt;position:absolute;top:463.5pt;width:60.75pt"><div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:23.43pt;position:absolute;white-space:pre">S-8</font></div><div style="line-height:6.93pt;position:absolute;top:27.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:4.84pt;position:absolute;white-space:pre">(Exhibit 5.1)</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:326.25pt;position:absolute;top:463.5pt;width:70.5pt"><div><div style="line-height:6.93pt;position:absolute;top:27.67pt;width:70.5pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:7.34pt;position:absolute;text-decoration:none;white-space:pre">May 21, 2013</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:402pt;position:absolute;top:463.5pt;width:62.25pt"><div><div style="line-height:6.93pt;position:absolute;top:27.67pt;width:62.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:11.29pt;position:absolute;text-decoration:none;white-space:pre">333-188737</font></div></div></div></td></tr><tr style="height:26.25pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:501.75pt;width:36.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:36.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:16.62pt;position:absolute;white-space:pre">23.4</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:42pt;position:absolute;top:501.75pt;width:159pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:1.75pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532014000050/exhibit51.htm">Consent of Counsel (included as part </a></font></div><div style="line-height:6.93pt;position:absolute;top:14.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:1.75pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532014000050/exhibit51.htm">of Exhibit 5.3).</a></font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:260.25pt;position:absolute;top:501.75pt;width:60.75pt"><div><div style="line-height:6.93pt;position:absolute;top:3.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:23.43pt;position:absolute;white-space:pre">S-8</font></div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:4.84pt;position:absolute;white-space:pre">(Exhibit 5.1)</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:326.25pt;position:absolute;top:501.75pt;width:70.5pt"><div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:70.5pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:8.17pt;position:absolute;text-decoration:none;white-space:pre">July 16, 2014</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:402pt;position:absolute;top:501.75pt;width:62.25pt"><div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:62.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:11.29pt;position:absolute;text-decoration:none;white-space:pre">333-197466</font></div></div></div></td></tr><tr style="height:26.25pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:528pt;width:36.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:36.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:16.62pt;position:absolute;white-space:pre">23.5</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:42pt;position:absolute;top:528pt;width:159pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:1.75pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532015000049/exhibit511.htm">Consent of Counsel (included as part </a></font></div><div style="line-height:6.93pt;position:absolute;top:14.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:1.75pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532015000049/exhibit511.htm">of Exhibit 5.4).</a></font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:260.25pt;position:absolute;top:528pt;width:60.75pt"><div><div style="line-height:6.93pt;position:absolute;top:3.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:23.43pt;position:absolute;white-space:pre">S-8</font></div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:4.84pt;position:absolute;white-space:pre">(Exhibit 5.1)</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:326.25pt;position:absolute;top:528pt;width:70.5pt"><div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:70.5pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:4.56pt;position:absolute;text-decoration:none;white-space:pre">August 4, 2015</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:402pt;position:absolute;top:528pt;width:62.25pt"><div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:62.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:11.29pt;position:absolute;text-decoration:none;white-space:pre">333-206075</font></div></div></div></td></tr></table></div></div></div></div></div><div style="--justify:justify;--position:absolute;background-color:#FFFFFF;border:1px solid #CCCC;content-visibility:auto;float:none;font-size:0;height:792pt;margin:10px auto 10px auto;overflow:hidden;padding:0;position:relative;width:612pt"><div style="-sec-extract:summary;position:absolute;top:720pt"><div style="width:513pt"></div></div><div style="-sec-extract:summary;position:absolute"><div style="width:468pt"></div></div><div><div style="position:absolute;top:72pt;width:612pt"><div style="font-size:0pt;left:75.25pt;position:absolute;width:464.25pt"><div><table style="border-collapse:collapse;display:inline-table;width:100%"><tr style="height:0"><td style="padding:0;width:36.75pt"></td><td style="padding:0;width:5.25pt"></td><td style="padding:0;width:159pt"></td><td style="padding:0;width:5.25pt"></td><td style="padding:0;width:48.75pt"></td><td style="padding:0;width:5.25pt"></td><td style="padding:0;width:60.75pt"></td><td style="padding:0;width:5.25pt"></td><td style="padding:0;width:70.5pt"></td><td style="padding:0;width:5.25pt"></td><td style="padding:0;width:62.25pt"></td></tr><tr style="height:26.25pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;width:36.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:36.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:16.62pt;position:absolute;white-space:pre">23.6</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:42pt;position:absolute;width:159pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:1.75pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532017000048/exhibit512017.htm">Consent of Counsel (included as part </a></font></div><div style="line-height:6.93pt;position:absolute;top:14.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:1.75pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532017000048/exhibit512017.htm">of Exhibit 5.5).</a></font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:260.25pt;position:absolute;width:60.75pt"><div><div style="line-height:6.93pt;position:absolute;top:3.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:23.43pt;position:absolute;white-space:pre">S-8</font></div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:4.84pt;position:absolute;white-space:pre">(Exhibit 5.1)</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:326.25pt;position:absolute;width:70.5pt"><div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:70.5pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:8.17pt;position:absolute;text-decoration:none;white-space:pre">July 28, 2017</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:402pt;position:absolute;width:62.25pt"><div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:62.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:11.29pt;position:absolute;text-decoration:none;white-space:pre">333-219559</font></div></div></div></td></tr><tr style="height:26.25pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:26.25pt;width:36.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:36.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:16.62pt;position:absolute;white-space:pre">23.7</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:42pt;position:absolute;top:26.25pt;width:159pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:1.75pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532018000024/a51.htm">Consent of Counsel (included as part </a></font></div><div style="line-height:6.93pt;position:absolute;top:14.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:1.75pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532018000024/a51.htm">of Exhibit 5.6).</a></font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:260.25pt;position:absolute;top:26.25pt;width:60.75pt"><div><div style="line-height:6.93pt;position:absolute;top:3.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:23.43pt;position:absolute;white-space:pre">S-8</font></div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:4.84pt;position:absolute;white-space:pre">(Exhibit 5.1)</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:326.25pt;position:absolute;top:26.25pt;width:70.5pt"><div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:70.5pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:8.17pt;position:absolute;text-decoration:none;white-space:pre">July 26, 2018</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:402pt;position:absolute;top:26.25pt;width:62.25pt"><div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:62.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:11.29pt;position:absolute;text-decoration:none;white-space:pre">333-226363</font></div></div></div></td></tr><tr style="height:26.25pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:52.5pt;width:36.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:36.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:16.62pt;position:absolute;white-space:pre">23.8</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:42pt;position:absolute;top:52.5pt;width:159pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:1.75pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532019000040/exhibit51-opinionxsx8x2013.htm">Consent of Counsel (included as part </a></font></div><div style="line-height:6.93pt;position:absolute;top:14.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:1.75pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532019000040/exhibit51-opinionxsx8x2013.htm">of Exhibit 5.7).</a></font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:260.25pt;position:absolute;top:52.5pt;width:60.75pt"><div><div style="line-height:6.93pt;position:absolute;top:3.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:23.43pt;position:absolute;white-space:pre">S-8</font></div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:4.84pt;position:absolute;white-space:pre">(Exhibit 5.1)</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:326.25pt;position:absolute;top:52.5pt;width:70.5pt"><div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:70.5pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:4.56pt;position:absolute;text-decoration:none;white-space:pre">August 1, 2019</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:402pt;position:absolute;top:52.5pt;width:62.25pt"><div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:62.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:11.29pt;position:absolute;text-decoration:none;white-space:pre">333-232948</font></div></div></div></td></tr><tr style="height:26.25pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:78.75pt;width:36.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:36.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:16.62pt;position:absolute;white-space:pre">23.9</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:42pt;position:absolute;top:78.75pt;width:159pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:1.75pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532022000032/a2022s-8_exhibit51xopinion.htm">Consent of Counsel (included as part </a></font></div><div style="line-height:6.93pt;position:absolute;top:14.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:1.75pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/875320/000087532022000032/a2022s-8_exhibit51xopinion.htm">of Exhibit 5.8).</a></font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:260.25pt;position:absolute;top:78.75pt;width:60.75pt"><div><div style="line-height:6.93pt;position:absolute;top:3.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:23.43pt;position:absolute;white-space:pre">S-8</font></div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:4.84pt;position:absolute;white-space:pre">(Exhibit 5.1)</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:326.25pt;position:absolute;top:78.75pt;width:70.5pt"><div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:70.5pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:4.56pt;position:absolute;text-decoration:none;white-space:pre">August 5, 2022</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:402pt;position:absolute;top:78.75pt;width:62.25pt"><div><div style="line-height:6.93pt;position:absolute;top:15.67pt;width:62.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:11.29pt;position:absolute;text-decoration:none;white-space:pre">333-266582</font></div></div></div></td></tr><tr style="height:33.75pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:105pt;width:36.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:36.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:16.62pt;position:absolute;white-space:pre">24.1</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:42pt;position:absolute;top:105pt;width:159pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="#ia79f0db91da5425ea39a51d319962353_209">Power of Attorney to file future </a></font></div><div style="line-height:6.93pt;position:absolute;top:12.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="#ia79f0db91da5425ea39a51d319962353_209">amendments (set forth on signature </a></font></div><div style="line-height:6.93pt;position:absolute;top:22.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="#ia79f0db91da5425ea39a51d319962353_209">page of this Registration Statement).</a></font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:206.25pt;position:absolute;top:105pt;width:48.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:48.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:20.76pt;position:absolute;white-space:pre">X</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td></tr><tr style="height:38.25pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:138.75pt;width:36.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:36.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:16.62pt;position:absolute;white-space:pre">99.1</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:42pt;position:absolute;top:138.75pt;width:159pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/0000875320/000130817922000210/lvrtx2022_def14a.htm">Vertex Pharmaceuticals Incorporated </a></font></div><div style="line-height:6.93pt;position:absolute;top:14.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/0000875320/000130817922000210/lvrtx2022_def14a.htm">Amended and Restated 2013 Stock </a></font></div><div style="line-height:6.93pt;position:absolute;top:26.63pt;width:159pt"><font style="color:#0000ff;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:2.4pt;position:absolute;text-decoration:underline;white-space:pre"><a style="-sec-extract:exhibit;color:inherit;text-decoration:inherit;z-index:1" href="https://www.sec.gov/Archives/edgar/data/0000875320/000130817922000210/lvrtx2022_def14a.htm">and Option Plan.</a></font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:260.25pt;position:absolute;top:138.75pt;width:60.75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:10.66pt;position:absolute;white-space:pre">DEF-14A </font></div><div style="line-height:6.93pt;position:absolute;top:14.63pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:9pt;position:absolute;white-space:pre">(Appendix </font></div><div style="line-height:6.93pt;position:absolute;top:26.63pt;width:60.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:25.1pt;position:absolute;white-space:pre">A)</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:326.25pt;position:absolute;top:138.75pt;width:70.5pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:70.5pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:8.45pt;position:absolute;white-space:pre">April 7, 2022</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:402pt;position:absolute;top:138.75pt;width:62.25pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:62.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:16.29pt;position:absolute;text-decoration:none;white-space:pre">000-19319</font></div></div></div></td></tr></table></div></div></div><div style="-sec-extract:summary;background-color:#808080;border-color:#000000;border-style:solid;border-width:0.75pt;height:1.5pt;left:72pt;opacity:1;position:absolute;top:266pt;width:468pt;z-index:1"></div><div id="ia79f0db91da5425ea39a51d319962353_195" style="position:absolute;top:302.1pt"></div><div style="line-height:6.77pt;position:absolute;top:302.1pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:bold;left:72pt;position:absolute;white-space:pre">Item 9. Undertakings.</font></div><div style="line-height:6.93pt;position:absolute;top:326.2pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;text-decoration:none;white-space:pre">(a)</font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:90pt;position:absolute;text-decoration:none;white-space:pre">The undersigned Registrant hereby undertakes&#58;</font></div><div style="line-height:6.93pt;position:absolute;top:350.3pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:90pt;position:absolute;text-decoration:none;white-space:pre">(1)</font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:108pt;position:absolute;text-decoration:none;white-space:pre">To file, during any period in which offers or sales are being made, a post-effective amendment to this </font></div><div style="line-height:6.93pt;position:absolute;top:362.3pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:108pt;position:absolute;text-decoration:none;white-space:pre">Registration Statement&#58;</font></div><div style="line-height:6.93pt;position:absolute;top:386.3pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:108pt;position:absolute;text-decoration:none;white-space:pre">(i)</font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:144pt;position:absolute;text-decoration:none;white-space:pre">To include any prospectus required by Section 10(a)(3) of the Securities Act&#59;</font></div><div style="line-height:6.93pt;position:absolute;top:410.3pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:108pt;position:absolute;text-decoration:none;white-space:pre">(ii)</font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:144pt;position:absolute;text-decoration:none;white-space:pre">To reflect in the prospectus any facts or events arising after the effective date of the Registration </font></div><div style="line-height:6.93pt;position:absolute;top:422.3pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:144pt;position:absolute;text-decoration:none;white-space:pre">Statement (or the most recent post-effective amendment thereof) which, individually or in the </font></div><div style="line-height:6.93pt;position:absolute;top:434.3pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:144pt;position:absolute;text-decoration:none;white-space:pre">aggregate, represent a fundamental change in the information set forth in the Registration </font></div><div style="line-height:6.93pt;position:absolute;top:446.3pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:144pt;position:absolute;text-decoration:none;white-space:pre">Statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered </font></div><div style="line-height:6.93pt;position:absolute;top:458.3pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:144pt;position:absolute;text-decoration:none;white-space:pre">(if the total dollar value of securities offered would not exceed that which was registered) and any </font></div><div style="line-height:6.93pt;position:absolute;top:470.3pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:144pt;position:absolute;text-decoration:none;white-space:pre">deviation from the low or high end of the estimated maximum offering range may be reflected in </font></div><div style="line-height:6.93pt;position:absolute;top:482.3pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:144pt;position:absolute;text-decoration:none;white-space:pre">the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the </font></div><div style="line-height:6.93pt;position:absolute;top:494.3pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:144pt;position:absolute;text-decoration:none;white-space:pre">changes in volume and price represent no more than a 20% change in the maximum aggregate </font></div><div style="line-height:6.93pt;position:absolute;top:506.3pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:144pt;position:absolute;text-decoration:none;white-space:pre">offering price set forth in the &#8220;Calculation of Registration Fee&#8221; table in the effective Registration </font></div><div style="line-height:6.93pt;position:absolute;top:518.3pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:144pt;position:absolute;text-decoration:none;white-space:pre">Statement.</font></div><div style="line-height:6.93pt;position:absolute;top:542.3pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:108pt;position:absolute;text-decoration:none;white-space:pre">(iii)</font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:144pt;position:absolute;text-decoration:none;white-space:pre">To include any material information with respect to the plan of distribution not previously </font></div><div style="line-height:6.93pt;position:absolute;top:554.3pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:144pt;position:absolute;text-decoration:none;white-space:pre">disclosed in the Registration Statement or any material change to such information in the </font></div><div style="line-height:6.93pt;position:absolute;top:566.3pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:144pt;position:absolute;text-decoration:none;white-space:pre">Registration Statement&#59;</font></div><div style="line-height:6.94pt;position:absolute;top:590.3pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:italic;font-weight:normal;left:144pt;position:absolute;text-decoration:none;white-space:pre">provided, however</font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:218.36pt;position:absolute;text-decoration:none;white-space:pre">, that paragraphs (a)(1)(i) and (a)(1)(ii) of this section do not apply if the </font></div><div style="line-height:6.93pt;position:absolute;top:602.3pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:144pt;position:absolute;text-decoration:none;white-space:pre">registration statement is on Form S-8, and the information required to be included in a post-</font></div><div style="line-height:6.93pt;position:absolute;top:614.3pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:144pt;position:absolute;text-decoration:none;white-space:pre">effective amendment by those paragraphs is contained in reports filed with or furnished to the </font></div><div style="line-height:6.93pt;position:absolute;top:626.3pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:144pt;position:absolute;text-decoration:none;white-space:pre">Commission by the Registrant pursuant to Section 13 or Section 15(d) of the Exchange Act that </font></div><div style="line-height:6.93pt;position:absolute;top:638.3pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:144pt;position:absolute;text-decoration:none;white-space:pre">are incorporated by reference in this Registration Statement.</font></div><div style="line-height:6.93pt;position:absolute;top:662.3pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:90pt;position:absolute;text-decoration:none;white-space:pre">(2)</font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:108pt;position:absolute;text-decoration:none;white-space:pre">That, for the purpose of determining any liability under the Securities Act, each such post-effective </font></div><div style="line-height:6.93pt;position:absolute;top:674.3pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:108pt;position:absolute;text-decoration:none;white-space:pre">amendment shall be deemed to be a new registration statement relating to the securities offered therein, and </font></div><div style="line-height:6.93pt;position:absolute;top:686.3pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:108pt;position:absolute;text-decoration:none;white-space:pre">the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.</font></div></div></div><div style="--justify:justify;--position:absolute;background-color:#FFFFFF;border:1px solid #CCCC;content-visibility:auto;float:none;font-size:0;height:792pt;margin:10px auto 10px auto;overflow:hidden;padding:0;position:relative;width:612pt"><div style="position:absolute;top:720pt"><div style="width:513pt"></div></div><div style="position:absolute"><div style="width:468pt"></div></div><div><div style="line-height:6.93pt;position:absolute;top:72pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:90pt;position:absolute;text-decoration:none;white-space:pre">(3)</font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:108pt;position:absolute;text-decoration:none;white-space:pre">To remove from registration by means of a post-effective amendment any of the securities being registered </font></div><div style="line-height:6.93pt;position:absolute;top:84pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:108pt;position:absolute;text-decoration:none;white-space:pre">which remain unsold at the termination of the offering.</font></div><div style="line-height:6.93pt;position:absolute;top:108pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;text-decoration:none;white-space:pre">(b)</font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:90pt;position:absolute;text-decoration:none;white-space:pre">The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the </font></div><div style="line-height:6.93pt;position:absolute;top:120pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:90pt;position:absolute;text-decoration:none;white-space:pre">Securities Act, each filing of the Registrant&#8217;s annual report pursuant to Section 13(a) or Section 15(d) of the </font></div><div style="line-height:6.93pt;position:absolute;top:132pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:90pt;position:absolute;text-decoration:none;white-space:pre">Exchange Act (and, where applicable, each filing of an employee benefit plan&#8217;s annual report pursuant to </font></div><div style="line-height:6.93pt;position:absolute;top:144pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:90pt;position:absolute;text-decoration:none;white-space:pre">Section 15(d) of the Exchange Act) that is incorporated by reference in this registration statement shall be </font></div><div style="line-height:6.93pt;position:absolute;top:156pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:90pt;position:absolute;text-decoration:none;white-space:pre">deemed to be a new registration statement relating to the securities offered therein, and the offering of such </font></div><div style="line-height:6.93pt;position:absolute;top:168pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:90pt;position:absolute;text-decoration:none;white-space:pre">securities at that time shall be deemed to be the initial bona fide offering thereof.</font></div><div style="line-height:6.93pt;position:absolute;top:192pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;text-decoration:none;white-space:pre">(c)</font><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:90pt;position:absolute;text-decoration:none;white-space:pre">Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers </font></div><div style="line-height:6.93pt;position:absolute;top:204pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:90pt;position:absolute;text-decoration:none;white-space:pre">and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has </font></div><div style="line-height:6.93pt;position:absolute;top:216pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:90pt;position:absolute;text-decoration:none;white-space:pre">been advised that in the opinion of the Securities and Exchange Commission such indemnification is against </font></div><div style="line-height:6.93pt;position:absolute;top:228pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:90pt;position:absolute;text-decoration:none;white-space:pre">public policy as expressed in the Act and is, therefore, unenforceable. In the event that a claim for </font></div><div style="line-height:6.93pt;position:absolute;top:240pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:90pt;position:absolute;text-decoration:none;white-space:pre">indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid </font></div><div style="line-height:6.93pt;position:absolute;top:252pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:90pt;position:absolute;text-decoration:none;white-space:pre">by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or </font></div><div style="line-height:6.93pt;position:absolute;top:264pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:90pt;position:absolute;text-decoration:none;white-space:pre">proceeding) is asserted by such director, officer or controlling person in connection with the securities being </font></div><div style="line-height:6.93pt;position:absolute;top:276pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:90pt;position:absolute;text-decoration:none;white-space:pre">registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling </font></div><div style="line-height:6.93pt;position:absolute;top:288pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:90pt;position:absolute;text-decoration:none;white-space:pre">precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is </font></div><div style="line-height:6.93pt;position:absolute;top:300pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:90pt;position:absolute;text-decoration:none;white-space:pre">against public policy as expressed in the Act and will be governed by the final adjudication of such issue.</font></div></div></div><div style="--justify:justify;--position:absolute;background-color:#FFFFFF;border:1px solid #CCCC;content-visibility:auto;float:none;font-size:0;height:792pt;margin:10px auto 10px auto;overflow:hidden;padding:0;position:relative;width:612pt"><div style="position:absolute;top:720pt"><div style="width:513pt"></div></div><div style="position:absolute"><div style="width:468pt"></div></div><div><div style="line-height:6.77pt;position:absolute;top:72pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:bold;left:273.51pt;position:absolute;white-space:pre">SIGNATURES</font></div><div style="line-height:6.93pt;position:absolute;top:96.1pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:108pt;position:absolute;white-space:pre">Pursuant to the requirements of the Securities Act, the Registrant certifies that it has reasonable grounds to </font></div><div style="line-height:6.93pt;position:absolute;top:108.1pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to </font></div><div style="line-height:6.93pt;position:absolute;top:120.1pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">be signed on its behalf by the undersigned, thereunto duly authorized, in Boston, Massachusetts on May 13, 2026.</font></div><div style="position:absolute;top:132.1pt;width:612pt"><div style="font-size:0pt;left:75.25pt;position:absolute;width:468.75pt"><div><table style="border-collapse:collapse;display:inline-table;width:100%"><tr style="height:0"><td style="padding:0;width:226.5pt"></td><td style="padding:0;width:36pt"></td><td style="padding:0;width:206.25pt"></td></tr><tr style="height:15.75pt"><td style="font-size:0;text-align:left;vertical-align:top" colspan="3"></td></tr><tr style="height:15.75pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td></tr><tr style="height:14.25pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top" colspan="2"><div style="left:226.5pt;position:absolute;top:31.5pt;width:242.25pt"><div><div style="line-height:6.77pt;position:absolute;top:2.63pt;width:242.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:bold;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">VERTEX PHARMACEUTICALS INCORPORATED</font></div></div></div></td></tr><tr style="height:15.75pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top" colspan="2"></td></tr><tr style="height:14.25pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:226.5pt;position:absolute;top:61.5pt;width:36pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:36pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">By&#58;</font></div></div></div></td><td style="border-bottom:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:262.5pt;position:absolute;top:61.5pt;width:206.25pt"><div><div style="line-height:6.93pt;position:absolute;top:3.67pt;width:206.25pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:52.92pt;position:absolute;white-space:pre">&#47;s&#47; Reshma Kewalramani</font></div></div></div></td></tr><tr style="height:14.25pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="border-top:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:262.5pt;position:absolute;top:75.75pt;width:206.25pt"><div><div style="line-height:6.93pt;position:absolute;top:3.67pt;width:206.25pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:58.88pt;position:absolute;white-space:pre">Reshma Kewalramani</font></div></div></div></td></tr><tr style="height:14.25pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:262.5pt;position:absolute;top:90pt;width:206.25pt"><div><div style="line-height:6.94pt;position:absolute;top:3.66pt;width:206.25pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:italic;font-weight:normal;left:27.13pt;position:absolute;white-space:pre">Chief Executive Officer and President</font></div></div></div></td></tr></table></div></div></div></div></div><div style="--justify:justify;--position:absolute;background-color:#FFFFFF;border:1px solid #CCCC;content-visibility:auto;float:none;font-size:0;height:792pt;margin:10px auto 10px auto;overflow:hidden;padding:0;position:relative;width:612pt"><div style="position:absolute;top:720pt"><div style="width:513pt"></div></div><div style="position:absolute"><div style="width:468pt"></div></div><div><div id="ia79f0db91da5425ea39a51d319962353_209" style="position:absolute;top:72pt"></div><div style="line-height:6.77pt;position:absolute;top:72pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:bold;left:249.37pt;position:absolute;white-space:pre">POWER OF ATTORNEY</font></div><div style="line-height:6.93pt;position:absolute;top:96.1pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:108pt;position:absolute;white-space:pre">Each person whose signature appears below constitutes and appoints Reshma Kewalramani, Joy Liu, and </font></div><div style="line-height:6.93pt;position:absolute;top:108.1pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">Omar White, and each of them singly, his&#47;her true and lawful attorneys-in-fact and agents, with full power of </font></div><div style="line-height:6.93pt;position:absolute;top:120.1pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">substitution and resubstitution in each of them singly, for him&#47;her and in his&#47;her name, place and stead, and in any </font></div><div style="line-height:6.93pt;position:absolute;top:132.1pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration </font></div><div style="line-height:6.93pt;position:absolute;top:144.1pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">Statement on Form S-8 of Vertex Pharmaceuticals Incorporated, and to file the same, with all exhibits thereto and </font></div><div style="line-height:6.93pt;position:absolute;top:156.1pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">other documents in connection therewith, with the Securities and Exchange Commission, granting to the attorneys-</font></div><div style="line-height:6.93pt;position:absolute;top:168.1pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing </font></div><div style="line-height:6.93pt;position:absolute;top:180.1pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">requisite or necessary to be done in or about the premises, as full to all intents and purposes as he might or could do </font></div><div style="line-height:6.93pt;position:absolute;top:192.1pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">in person, hereby ratifying and confirming all that the attorneys-in-fact and agents or any of each of them or their </font></div><div style="line-height:6.93pt;position:absolute;top:204.1pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">substitute may lawfully do or cause to be done by virtue hereof.</font></div><div style="line-height:6.93pt;position:absolute;top:228.1pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:108pt;position:absolute;white-space:pre">Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the </font></div><div style="line-height:6.93pt;position:absolute;top:240.1pt;width:612pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:72pt;position:absolute;white-space:pre">following persons in the capacities and on the date indicated.</font></div><div style="position:absolute;top:252.1pt;width:612pt"><div style="font-size:0pt;left:75.25pt;position:absolute;width:468pt"><div><table style="border-collapse:collapse;display:inline-table;width:100%"><tr style="height:0"><td style="padding:0;width:33pt"></td><td style="padding:0;width:144.75pt"></td><td style="padding:0;width:14.25pt"></td><td style="padding:0;width:191.25pt"></td><td style="padding:0;width:9.75pt"></td><td style="padding:0;width:75pt"></td></tr><tr style="height:15.75pt"><td style="font-size:0;text-align:left;vertical-align:top" colspan="6"></td></tr><tr style="height:15.75pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td></tr><tr style="height:12pt"><td style="font-size:0;text-align:left;vertical-align:top" colspan="2"><div style="position:absolute;top:31.5pt;width:177.75pt"><div><div style="line-height:5.41pt;position:absolute;top:3.37pt;width:177.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:72.22pt;position:absolute;white-space:pre">Signature</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:192pt;position:absolute;top:31.5pt;width:191.25pt"><div><div style="line-height:5.41pt;position:absolute;top:3.37pt;width:191.25pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:87.63pt;position:absolute;white-space:pre">Title</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:393pt;position:absolute;top:31.5pt;width:75pt"><div><div style="line-height:5.41pt;position:absolute;top:3.37pt;width:75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:8pt;font-style:normal;font-weight:bold;left:29.51pt;position:absolute;white-space:pre">Date</font></div></div></div></td></tr><tr style="height:15.75pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td></tr><tr style="height:14.25pt"><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="position:absolute;top:59.25pt;width:33pt"><div><div style="line-height:6.58pt;position:absolute;top:2.63pt;width:33pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">By&#58;</font></div></div></div></td><td style="border-bottom:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:33pt;position:absolute;top:59.25pt;width:144.75pt"><div><div style="line-height:6.93pt;position:absolute;top:3.67pt;width:144.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:22.17pt;position:absolute;white-space:pre">&#47;s&#47; Reshma Kewalramani</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="left:192pt;position:absolute;top:59.25pt;width:191.25pt"><div><div style="line-height:6.58pt;position:absolute;top:2.63pt;width:191.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">Chief Executive Officer, President and Director </font></div><div style="line-height:6.58pt;position:absolute;top:12.13pt;width:191.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">(Principal Executive Officer)</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="left:393pt;position:absolute;top:59.25pt;width:75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:9.59pt;position:absolute;white-space:pre">May 13, 2026</font></div></div></div></td></tr><tr style="height:14.25pt"><td style="border-top:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:33pt;position:absolute;top:73.5pt;width:144.75pt"><div><div style="line-height:6.93pt;position:absolute;top:3.67pt;width:144.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:28.13pt;position:absolute;white-space:pre">Reshma Kewalramani</font></div></div></div></td></tr><tr style="height:15.75pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td></tr><tr style="height:18pt"><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="position:absolute;top:103.5pt;width:33pt"><div><div style="line-height:6.58pt;position:absolute;top:2.63pt;width:33pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">By&#58;</font></div></div></div></td><td style="border-bottom:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:33pt;position:absolute;top:103.5pt;width:144.75pt"><div><div style="line-height:6.93pt;position:absolute;top:7.42pt;width:144.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:21.45pt;position:absolute;white-space:pre">&#47;s&#47; Charles F. Wagner, Jr.</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="left:192pt;position:absolute;top:103.5pt;width:191.25pt"><div><div style="line-height:6.58pt;position:absolute;top:2.63pt;width:191.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">Executive Vice President and Chief Operating </font></div><div style="line-height:6.58pt;position:absolute;top:12.13pt;width:191.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">&#38; Financial Officer (Principal Financial </font></div><div style="line-height:6.58pt;position:absolute;top:21.63pt;width:191.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">Officer)</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="left:393pt;position:absolute;top:103.5pt;width:75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:9.59pt;position:absolute;white-space:pre">May 13, 2026</font></div></div></div></td></tr><tr style="height:14.25pt"><td style="border-top:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:33pt;position:absolute;top:121.5pt;width:144.75pt"><div><div style="line-height:6.58pt;position:absolute;top:4.12pt;width:144.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:29.69pt;position:absolute;white-space:pre">Charles F. Wagner, Jr.</font></div></div></div></td></tr><tr style="height:15.75pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td></tr><tr style="height:14.25pt"><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="position:absolute;top:151.5pt;width:33pt"><div><div style="line-height:6.58pt;position:absolute;top:2.63pt;width:33pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">By&#58;</font></div></div></div></td><td style="border-bottom:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:33pt;position:absolute;top:151.5pt;width:144.75pt"><div><div style="line-height:6.93pt;position:absolute;top:3.67pt;width:144.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:26.3pt;position:absolute;white-space:pre">&#47;s&#47; Kristen C. Ambrose</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="left:192pt;position:absolute;top:151.5pt;width:191.25pt"><div><div style="line-height:6.58pt;position:absolute;top:2.63pt;width:191.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">Senior Vice President and Chief Accounting </font></div><div style="line-height:6.58pt;position:absolute;top:12.13pt;width:191.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">Officer (Principal Accounting Officer)</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="left:393pt;position:absolute;top:151.5pt;width:75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:9.59pt;position:absolute;white-space:pre">May 13, 2026</font></div></div></div></td></tr><tr style="height:14.25pt"><td style="border-top:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:33pt;position:absolute;top:165.75pt;width:144.75pt"><div><div style="line-height:6.58pt;position:absolute;top:4.12pt;width:144.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:34.29pt;position:absolute;white-space:pre">Kristen C. Ambrose</font></div></div></div></td></tr><tr style="height:15.75pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td></tr><tr style="height:14.25pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:195.75pt;width:33pt"><div><div style="line-height:6.58pt;position:absolute;top:2.63pt;width:33pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">By&#58;</font></div></div></div></td><td style="border-bottom:0.5pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:33pt;position:absolute;top:195.75pt;width:144.75pt"><div><div style="line-height:6.93pt;position:absolute;top:3.67pt;width:144.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:30.48pt;position:absolute;white-space:pre">&#47;s&#47; Jeffrey M. Leiden</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:192pt;position:absolute;top:195.75pt;width:191.25pt"><div><div style="line-height:6.58pt;position:absolute;top:2.63pt;width:191.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">Executive Chairman</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"><div style="left:393pt;position:absolute;top:195.75pt;width:75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:9.59pt;position:absolute;white-space:pre">May 13, 2026</font></div></div></div></td></tr><tr style="height:14.25pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="border-top:0.5pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:33pt;position:absolute;top:210pt;width:144.75pt"><div><div style="line-height:6.58pt;position:absolute;top:4.12pt;width:144.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:38.25pt;position:absolute;white-space:pre">Jeffrey M. Leiden</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td></tr><tr style="height:15.75pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td></tr><tr style="height:14.25pt"><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="position:absolute;top:240pt;width:33pt"><div><div style="line-height:6.58pt;position:absolute;top:2.63pt;width:33pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">By&#58;</font></div></div></div></td><td style="border-bottom:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:33pt;position:absolute;top:240pt;width:144.75pt"><div><div style="line-height:6.93pt;position:absolute;top:3.67pt;width:144.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:27.99pt;position:absolute;white-space:pre">&#47;s&#47; Sangeeta N. Bhatia</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="left:192pt;position:absolute;top:240pt;width:191.25pt"><div><div style="line-height:6.58pt;position:absolute;top:2.63pt;width:191.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">Director</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="left:393pt;position:absolute;top:240pt;width:75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:9.59pt;position:absolute;white-space:pre">May 13, 2026</font></div></div></div></td></tr><tr style="height:14.25pt"><td style="border-top:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:33pt;position:absolute;top:254.25pt;width:144.75pt"><div><div style="line-height:6.58pt;position:absolute;top:4.12pt;width:144.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:35.88pt;position:absolute;white-space:pre">Sangeeta N. Bhatia</font></div></div></div></td></tr><tr style="height:15.75pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td></tr><tr style="height:14.25pt"><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="position:absolute;top:284.25pt;width:33pt"><div><div style="line-height:6.58pt;position:absolute;top:2.63pt;width:33pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">By&#58;</font></div></div></div></td><td style="border-bottom:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:33pt;position:absolute;top:284.25pt;width:144.75pt"><div><div style="line-height:6.93pt;position:absolute;top:3.67pt;width:144.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:38.8pt;position:absolute;white-space:pre">&#47;s&#47; Lloyd Carney</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="left:192pt;position:absolute;top:284.25pt;width:191.25pt"><div><div style="line-height:6.58pt;position:absolute;top:2.63pt;width:191.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">Director</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="left:393pt;position:absolute;top:284.25pt;width:75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:9.59pt;position:absolute;white-space:pre">May 13, 2026</font></div></div></div></td></tr><tr style="height:14.25pt"><td style="border-top:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:33pt;position:absolute;top:298.5pt;width:144.75pt"><div><div style="line-height:6.58pt;position:absolute;top:4.12pt;width:144.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:46.14pt;position:absolute;white-space:pre">Lloyd Carney</font></div></div></div></td></tr><tr style="height:15.75pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td></tr><tr style="height:14.25pt"><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="position:absolute;top:328.5pt;width:33pt"><div><div style="line-height:6.58pt;position:absolute;top:2.63pt;width:33pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">By&#58;</font></div></div></div></td><td style="border-bottom:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:33pt;position:absolute;top:328.5pt;width:144.75pt"><div><div style="line-height:6.93pt;position:absolute;top:3.67pt;width:144.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:41.58pt;position:absolute;white-space:pre">&#47;s&#47; Alan Garber</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="left:192pt;position:absolute;top:328.5pt;width:191.25pt"><div><div style="line-height:6.58pt;position:absolute;top:2.63pt;width:191.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">Director</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="left:393pt;position:absolute;top:328.5pt;width:75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:9.59pt;position:absolute;white-space:pre">May 13, 2026</font></div></div></div></td></tr><tr style="height:14.25pt"><td style="border-top:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:33pt;position:absolute;top:342.75pt;width:144.75pt"><div><div style="line-height:6.58pt;position:absolute;top:4.12pt;width:144.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:48.79pt;position:absolute;white-space:pre">Alan Garber</font></div></div></div></td></tr><tr style="height:15.75pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td></tr><tr style="height:14.25pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:372.75pt;width:33pt"><div><div style="line-height:6.58pt;position:absolute;top:2.63pt;width:33pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:6.25pt;position:absolute;white-space:pre">By&#58;</font></div></div></div></td><td style="border-bottom:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:33pt;position:absolute;top:372.75pt;width:144.75pt"><div><div style="line-height:6.93pt;position:absolute;top:3.67pt;width:144.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:34.65pt;position:absolute;white-space:pre">&#47;s&#47; Michel Lagarde</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="left:192pt;position:absolute;top:372.75pt;width:191.25pt"><div><div style="line-height:6.58pt;position:absolute;top:2.63pt;width:191.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">Director</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="left:393pt;position:absolute;top:372.75pt;width:75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:9.59pt;position:absolute;white-space:pre">May 13, 2026</font></div></div></div></td></tr><tr style="height:14.25pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="border-top:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:33pt;position:absolute;top:387pt;width:144.75pt"><div><div style="line-height:6.58pt;position:absolute;top:4.12pt;width:144.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:42.21pt;position:absolute;white-space:pre">Michel Lagarde</font></div></div></div></td></tr><tr style="height:15.75pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td></tr><tr style="height:14.25pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:417pt;width:33pt"><div><div style="line-height:6.58pt;position:absolute;top:2.63pt;width:33pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">By&#58;</font></div></div></div></td><td style="border-bottom:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:33pt;position:absolute;top:417pt;width:144.75pt"><div><div style="line-height:6.93pt;position:absolute;top:3.67pt;width:144.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:32.43pt;position:absolute;white-space:pre">&#47;s&#47; Diana McKenzie</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="left:192pt;position:absolute;top:417pt;width:191.25pt"><div><div style="line-height:6.58pt;position:absolute;top:2.63pt;width:191.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">Director</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="left:393pt;position:absolute;top:417pt;width:75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:9.59pt;position:absolute;white-space:pre">May 13, 2026</font></div></div></div></td></tr><tr style="height:14.25pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="border-top:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:33pt;position:absolute;top:431.25pt;width:144.75pt"><div><div style="line-height:6.58pt;position:absolute;top:4.12pt;width:144.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:40.1pt;position:absolute;white-space:pre">Diana McKenzie</font></div></div></div></td></tr><tr style="height:15.75pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td></tr></table></div></div></div></div></div><div style="--justify:justify;--position:absolute;background-color:#FFFFFF;border:1px solid #CCCC;content-visibility:auto;float:none;font-size:0;height:792pt;margin:10px auto 10px auto;overflow:hidden;padding:0;position:relative;width:612pt"><div style="position:absolute;top:720pt"><div style="width:513pt"></div></div><div style="position:absolute"><div style="width:468pt"></div></div><div><div style="position:absolute;top:72pt;width:612pt"><div style="font-size:0pt;left:75.25pt;position:absolute;width:468pt"><div><table style="border-collapse:collapse;display:inline-table;width:100%"><tr style="height:0"><td style="padding:0;width:33pt"></td><td style="padding:0;width:144.75pt"></td><td style="padding:0;width:14.25pt"></td><td style="padding:0;width:191.25pt"></td><td style="padding:0;width:9.75pt"></td><td style="padding:0;width:75pt"></td></tr><tr style="height:14.25pt"><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="position:absolute;width:33pt"><div><div style="line-height:6.58pt;position:absolute;top:2.63pt;width:33pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">By&#58;</font></div></div></div></td><td style="border-bottom:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:33pt;position:absolute;width:144.75pt"><div><div style="line-height:6.93pt;position:absolute;top:3.67pt;width:144.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:23.25pt;position:absolute;white-space:pre">&#47;s&#47; Nancy A. Thornberry</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="left:192pt;position:absolute;width:191.25pt"><div><div style="line-height:6.58pt;position:absolute;top:2.63pt;width:191.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">Director</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="left:393pt;position:absolute;width:75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:9.59pt;position:absolute;white-space:pre">May 13, 2026</font></div></div></div></td></tr><tr style="height:14.25pt"><td style="border-top:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:33pt;position:absolute;top:14.25pt;width:144.75pt"><div><div style="line-height:6.58pt;position:absolute;top:4.12pt;width:144.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:31.38pt;position:absolute;white-space:pre">Nancy A. Thornberry</font></div></div></div></td></tr><tr style="height:15.75pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td></tr><tr style="height:14.25pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:44.25pt;width:33pt"><div><div style="line-height:6.58pt;position:absolute;top:2.63pt;width:33pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">By&#58;</font></div></div></div></td><td style="border-bottom:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:33pt;position:absolute;top:44.25pt;width:144.75pt"><div><div style="line-height:6.93pt;position:absolute;top:3.67pt;width:144.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:37.41pt;position:absolute;white-space:pre">&#47;s&#47; Bruce I. Sachs</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="left:192pt;position:absolute;top:44.25pt;width:191.25pt"><div><div style="line-height:6.58pt;position:absolute;top:2.63pt;width:191.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">Director</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="left:393pt;position:absolute;top:44.25pt;width:75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:9.59pt;position:absolute;white-space:pre">May 13, 2026</font></div></div></div></td></tr><tr style="height:14.25pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="border-top:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:33pt;position:absolute;top:58.5pt;width:144.75pt"><div><div style="line-height:6.58pt;position:absolute;top:4.12pt;width:144.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:44.84pt;position:absolute;white-space:pre">Bruce I. Sachs</font></div></div></div></td></tr><tr style="height:15.75pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td></tr><tr style="height:14.25pt"><td style="font-size:0;text-align:left;vertical-align:top"><div style="position:absolute;top:88.5pt;width:33pt"><div><div style="line-height:6.58pt;position:absolute;top:2.63pt;width:33pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">By&#58;</font></div></div></div></td><td style="border-bottom:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:33pt;position:absolute;top:88.5pt;width:144.75pt"><div><div style="line-height:6.93pt;position:absolute;top:3.67pt;width:144.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:29.09pt;position:absolute;white-space:pre">&#47;s&#47; Jennifer Schneider</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="left:192pt;position:absolute;top:88.5pt;width:191.25pt"><div><div style="line-height:6.58pt;position:absolute;top:2.63pt;width:191.25pt"><font style="color:#000000;font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:4.75pt;position:absolute;text-decoration:none;white-space:pre">Director</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"></td><td style="font-size:0;text-align:left;vertical-align:top" rowspan="2"><div style="left:393pt;position:absolute;top:88.5pt;width:75pt"><div><div style="line-height:6.93pt;position:absolute;top:2.63pt;width:75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:10pt;font-style:normal;font-weight:normal;left:9.59pt;position:absolute;white-space:pre">May 13, 2026</font></div></div></div></td></tr><tr style="height:14.25pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="border-top:0.75pt solid #000000;font-size:0;text-align:left;vertical-align:top"><div style="left:33pt;position:absolute;top:102.75pt;width:144.75pt"><div><div style="line-height:6.58pt;position:absolute;top:4.12pt;width:144.75pt"><font style="font-family:&#39;Times New Roman&#39;, serif;font-size:9.5pt;font-style:normal;font-weight:normal;left:36.93pt;position:absolute;white-space:pre">Jennifer Schneider</font></div></div></div></td><td style="font-size:0;text-align:left;vertical-align:top"></td></tr><tr style="height:15.75pt"><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td><td style="font-size:0;text-align:left;vertical-align:top"></td></tr></table></div></div></div></div></div></div></body></html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>a2026s-8pos_ex51xopinion20.htm
<DESCRIPTION>EX-5.1
<TEXT>
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<title>Document</title></head><body><div id="ic47e440afd9c45d780bb60bd2cef5c03_1"></div><div style="min-height:90pt;width:100%"><div style="text-align:right"><font style="color:#000000;font-family:'Times New Roman',serif;font-size:10pt;font-weight:700;line-height:120%">Exhibit 5.1</font></div><div><img alt="image_0.jpg" src="image_0.jpg" style="height:79px;margin-bottom:5pt;vertical-align:text-bottom;width:62px"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:21.610%"><tr><td style="width:1.0%"></td><td style="width:98.900%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><font style="color:#000000;font-family:'Times New Roman',serif;font-size:7pt;font-weight:400;letter-spacing:0.007em;line-height:11.00pt">ROPES &#38; GRAY LLP</font></div><div><font style="color:#000000;font-family:'Times New Roman',serif;font-size:7pt;font-weight:400;letter-spacing:0.007em;line-height:11.00pt">PRUDENTIAL TOWER</font></div><div><font style="color:#000000;font-family:'Times New Roman',serif;font-size:7pt;font-weight:400;letter-spacing:0.007em;line-height:11.00pt">800 BOYLSTON STREET</font></div><div><font style="color:#000000;font-family:'Times New Roman',serif;font-size:7pt;font-weight:400;letter-spacing:0.007em;line-height:11.00pt">BOSTON, MA 02199-3600</font></div><div><font style="color:#000000;font-family:'Times New Roman',serif;font-size:7pt;font-weight:400;letter-spacing:0.007em;line-height:11.00pt">WWW.ROPESGRAY.COM</font></div></td></tr></table></div></div><div style="margin-bottom:60pt;margin-top:54pt;padding-left:216pt"><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%">May 13, 2026</font></div><div><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%">Vertex Pharmaceuticals Incorporated</font></div><div><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%">50 Northern Avenue</font></div><div><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%">Boston, MA 02210</font></div><div><font><br></font></div><div style="margin-bottom:12pt;text-align:justify"><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%">Ladies and Gentlemen&#58; </font></div><div style="margin-bottom:12pt;text-indent:36pt"><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%">This opinion letter is furnished to you in connection with the Post-Effective Amendment No. 1 to Registration Statements on Form S-8, Reg. Nos. 333-188737, 333-197466, 333-206075, 333-219559, 333-226363, 333-232948 and 333-266582 (the &#8220;</font><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%;text-decoration:underline">Post-Effective Amendment</font><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%">&#8221;), filed by Vertex Pharmaceuticals Incorporated, a Massachusetts corporation (the &#8220;</font><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%;text-decoration:underline">Company</font><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%">&#8221;), on the date hereof, with the Securities and Exchange Commission under the Securities Act of 1933, as amended (the &#8220;</font><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%;text-decoration:underline">Securities Act</font><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%">&#8221;). On May 13, 2026, the stockholders of the Company approved the Vertex Pharmaceuticals, Inc. 2026 Stock and Option Plan (the &#8220;</font><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%;text-decoration:underline">2026 Plan</font><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%">&#8221;). The total number of shares of the Company&#8217;s common stock, $0.01 par value per share (the &#8220;</font><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%;text-decoration:underline">Common Stock</font><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%">&#8221;), that may be issued under the 2026 Plan is 19,587,582, which is equal to the sum of (i) 6,400,000 shares of Common Stock, (ii) 9,051,356 shares of Common Stock which had been available for issuance and were not issued or subject to outstanding awards under the Company&#8217;s 2013 Stock and Option Plan (the &#8220;</font><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%;text-decoration:underline">2013 Plan</font><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%">&#8221;) and (iii) 4,136,226 shares of Common Stock subject to outstanding awards under the 2013 Plan that may expire or otherwise terminate without having been exercised in full, or are forfeited to the Company and would have become available again for issuance under the terms of the 2013 Plan (the shares described in clause (ii) and clause (iii), the &#8220;</font><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%;text-decoration:underline">Carryover Shares</font><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%">&#8221;).</font></div><div style="margin-bottom:12pt;text-indent:36pt"><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%">We are familiar with the actions taken by the Company in connection with the adoption of the 2026 Plan.  We have examined such certificates, documents and records and have made such investigation of fact and such examination of law as we have deemed appropriate in order to enable us to render the opinions set forth herein.  In conducting such investigation, we have relied, without independent verification, upon certificates of officers of the Company, public officials and other appropriate persons.</font></div><div style="margin-bottom:12pt;text-indent:36pt"><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%">The opinions expressed below are limited to the Massachusetts Business Corporation Act. </font></div><div style="margin-bottom:12pt;text-indent:36pt"><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%">Based upon and subject to the foregoing, we are of the opinion that the Carryover Shares have been duly authorized and, when the Carryover Shares have been issued and sold in accordance with the terms of the 2026 Plan, the Carryover Shares will be validly issued, fully paid and nonassessable.</font></div><div style="margin-bottom:12pt;text-indent:36pt"><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%">We hereby consent to the filing of this opinion letter as an exhibit to the Post-Effective Amendment.  In giving such consent, we do not thereby admit that we are in the category of persons </font></div><div style="height:72pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div><font><br></font></div></div></div><hr style="page-break-after:always"><div style="min-height:90pt;width:100%"><div><font><br></font></div></div><div style="margin-bottom:12pt"><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%">whose consent is required under Section 7 of the Securities Act or the rules and regulations thereunder.</font></div><div style="padding-left:216pt"><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%">Very truly yours,</font></div><div style="padding-left:216pt"><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%"><br>&#47;s&#47; Ropes &#38; Gray LLP</font></div><div style="margin-bottom:12pt;padding-left:216pt"><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%"><br>Ropes &#38; Gray LLP</font></div><div style="height:72pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div style="text-align:center"><font style="color:#000000;font-family:'Times New Roman',serif;font-size:12pt;font-weight:400;line-height:120%">-2-</font></div><div><font><br></font></div></div></div></body></html>
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<title>Document</title></head><body><div id="i45e4aa90d05f4271a3f43d3d8bceeb6c_1"></div><div style="min-height:72pt;width:100%"><div><font><br></font></div></div><div style="text-align:right"><font style="color:#000000;font-family:'Times New Roman',serif;font-size:11pt;font-weight:700;line-height:173%">Exhibit 23.1</font></div><div><font><br></font></div><div style="text-align:center"><font><br></font></div><div style="text-align:center"><font style="color:#000000;font-family:'Times New Roman',serif;font-size:11pt;font-weight:700;line-height:173%">Consent of Independent Registered Public Accounting Firm</font></div><div><font><br></font></div><div style="text-align:justify"><font style="color:#000000;font-family:'Times New Roman',serif;font-size:11pt;font-weight:400;line-height:173%">We consent to the incorporation by reference in the Registration Statement (Form S-8) pertaining to the Amended and Restated 2013 Stock and Option Plan of Vertex Pharmaceuticals Incorporated of our reports dated February 13, 2026, with respect to the consolidated financial statements of Vertex Pharmaceuticals Incorporated and the effectiveness of internal control over financial reporting of Vertex Pharmaceuticals Incorporated included in its Annual Report (Form 10-K) for the year ended December 31, 2025, filed with the Securities and Exchange Commission.</font></div><div style="text-align:justify"><font><br></font></div><div style="margin-bottom:14pt;text-align:justify"><font style="color:#000000;font-family:'Times New Roman',serif;font-size:11pt;font-weight:400;line-height:120%">&#47;s&#47; Ernst &#38; Young LLP</font></div><div style="margin-top:5pt;text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:100.000%"><tr><td style="width:1.0%"></td><td style="width:39.284%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.919%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:46.497%"></td><td style="width:0.1%"></td></tr><tr style="height:15pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr></table></div><div style="text-align:justify"><font style="color:#000000;font-family:'Times New Roman',serif;font-size:11pt;font-weight:400;line-height:173%">Boston, Massachusetts</font></div><div style="text-align:justify"><font style="color:#000000;font-family:'Times New Roman',serif;font-size:11pt;font-weight:400;line-height:173%">May 13, 2026</font></div><div style="height:72pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div style="margin-bottom:8pt;text-align:right"><font><br></font></div></div></div></body></html>
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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
