<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2023 Workiva-->
<!--r:09c298d5-11ee-4936-ade7-8535768ed861,g:f497b53e-3b07-4b48-bf94-a9933b101e5d-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://xbrl.sec.gov/ecd/role/PvpAdjustmentsOnly" xlink:type="simple" xlink:href="https://xbrl.sec.gov/ecd/2022q4/ecd-2022q4.xsd#PvpAdjustmentsOnly"/>
  <link:definitionLink xlink:role="http://xbrl.sec.gov/ecd/role/PvpAdjustmentsOnly" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AllAdjToCompMember" xlink:href="https://xbrl.sec.gov/ecd/2022q4/ecd-2022q4.xsd#ecd_AllAdjToCompMember"/>
    <link:loc xlink:type="locator" xlink:label="loc_coin_EquityAwardsGrantedInPriorYearsUnvestedMember_97e1837d-9bc2-4f56-a9c9-20250f43a761" xlink:href="coin-20230428.xsd#coin_EquityAwardsGrantedInPriorYearsUnvestedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ecd_AllAdjToCompMember" xlink:to="loc_coin_EquityAwardsGrantedInPriorYearsUnvestedMember_97e1837d-9bc2-4f56-a9c9-20250f43a761" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_coin_EquityAwardsGrantedInPriorYearsVestedMember_45f84908-3233-4a92-9e9f-13d68eabb8fb" xlink:href="coin-20230428.xsd#coin_EquityAwardsGrantedInPriorYearsVestedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ecd_AllAdjToCompMember" xlink:to="loc_coin_EquityAwardsGrantedInPriorYearsVestedMember_45f84908-3233-4a92-9e9f-13d68eabb8fb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_coin_EquityAwardsReportedValueMember_99d4b031-eeec-4c56-858b-5b93431ff877" xlink:href="coin-20230428.xsd#coin_EquityAwardsReportedValueMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ecd_AllAdjToCompMember" xlink:to="loc_coin_EquityAwardsReportedValueMember_99d4b031-eeec-4c56-858b-5b93431ff877" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_coin_EquityAwardsGrantedDuringTheYearUnvestedMember_3e0c3e56-5fc8-4d40-bf63-93de3517f894" xlink:href="coin-20230428.xsd#coin_EquityAwardsGrantedDuringTheYearUnvestedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ecd_AllAdjToCompMember" xlink:to="loc_coin_EquityAwardsGrantedDuringTheYearUnvestedMember_3e0c3e56-5fc8-4d40-bf63-93de3517f894" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_coin_EquityAwardsGrantedDuringTheYearVestedMember_c6795c7b-20fc-4816-a9fb-df1a09e39de5" xlink:href="coin-20230428.xsd#coin_EquityAwardsGrantedDuringTheYearVestedMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ecd_AllAdjToCompMember" xlink:to="loc_coin_EquityAwardsGrantedDuringTheYearVestedMember_c6795c7b-20fc-4816-a9fb-df1a09e39de5" xlink:type="arc" order="5"/>
  </link:definitionLink>
</link:linkbase>
