<SEC-DOCUMENT>0001844358-25-000009.txt : 20251125
<SEC-HEADER>0001844358-25-000009.hdr.sgml : 20251125
<ACCEPTANCE-DATETIME>20251125182850
ACCESSION NUMBER:		0001844358-25-000009
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20251124
FILED AS OF DATE:		20251125
DATE AS OF CHANGE:		20251125

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			De Boo Alexander A.
		CENTRAL INDEX KEY:			0001844358
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-09328
		FILM NUMBER:		251523053

	MAIL ADDRESS:	
		STREET 1:		1 ECOLAB PLACE
		CITY:			SAINT PAUL
		STATE:			MN
		ZIP:			55102

	FORMER NAME:	
		FORMER CONFORMED NAME:	De Boo Sam
		DATE OF NAME CHANGE:	20210203

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ECOLAB INC.
		CENTRAL INDEX KEY:			0000031462
		STANDARD INDUSTRIAL CLASSIFICATION:	SOAP, DETERGENT, CLEANING PREPARATIONS, PERFUMES, COSMETICS [2840]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		EIN:				410231510
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		1 ECOLAB PLACE
		CITY:			SAINT PAUL
		STATE:			MN
		ZIP:			55102
		BUSINESS PHONE:		18002326522

	MAIL ADDRESS:	
		STREET 1:		1 ECOLAB PLACE
		CITY:			SAINT PAUL
		STATE:			MN
		ZIP:			55102

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ECOLAB INC
		DATE OF NAME CHANGE:	19920703

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ECONOMICS LABORATORY INC
		DATE OF NAME CHANGE:	19861203
</SEC-HEADER>
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    <periodOfReport>2025-11-24</periodOfReport>

    <issuer>
        <issuerCik>0000031462</issuerCik>
        <issuerName>ECOLAB INC.</issuerName>
        <issuerTradingSymbol>ECL</issuerTradingSymbol>
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    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001844358</rptOwnerCik>
            <rptOwnerName>De Boo Alexander A.</rptOwnerName>
        </reportingOwnerId>
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            <rptOwnerStreet1>1 ECOLAB PLACE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SAINT PAUL</rptOwnerCity>
            <rptOwnerState>MN</rptOwnerState>
            <rptOwnerZipCode>55102</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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        <reportingOwnerRelationship>
            <isDirector>false</isDirector>
            <isOfficer>true</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
            <officerTitle>EVP &amp; PRES - GLOBAL MARKETS</officerTitle>
            <otherText></otherText>
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    <aff10b5One>0</aff10b5One>

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            <securityTitle>
                <value>Common Stock</value>
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            <transactionDate>
                <value>2025-11-24</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>M</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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            <transactionAmounts>
                <transactionShares>
                    <value>2153</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>119.120</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
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                <sharesOwnedFollowingTransaction>
                    <value>7147.604</value>
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                <value>2025-11-24</value>
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                <transactionCode>S</transactionCode>
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                <transactionPricePerShare>
                    <value>268.250</value>
                </transactionPricePerShare>
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                    <value>D</value>
                </directOrIndirectOwnership>
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                    <value></value>
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        </nonDerivativeTransaction>
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    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Employee Stock Option (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>119.120</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2025-11-24</value>
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                    <value>2153</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2016-12-02</value>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2025-12-02</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>2153</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
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            <ownershipNature>
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    <footnotes>
        <footnote id="F1">Option granted under the Ecolab Inc. 2010 Stock Incentive Plan. The option became exercisable, on a cumulative basis, as to one-third of the option shares (excluding any fractional portion less than one share), on each of the first and second anniversaries of the date of grant and as to the remaining shares on the third anniversary of the date of grant. The date listed in the &quot;Date Exercisable&quot; column is the first anniversary of the date of grant.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Youhao Dong, as Attorney-in-Fact for Alexander A. De Boo</signatureName>
        <signatureDate>2025-11-25</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</SEC-DOCUMENT>
