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Income Taxes - Narrative (Details) - USD ($)
12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Income Tax Contingency [Line Items]      
Valuation allowance $ 630,590,000 $ 552,165,000  
Increase in valuation allowance 78,400,000 74,600,000 $ 208,100,000
Amount of unrecognized tax benefits that would impact the effective income tax rate 600,000    
Amount of unrecognized tax benefits that would impact deferred tax assets 32,400,000    
Income tax expense related to interest and penalties 0 $ 0 $ 0
His Majesty's Revenue and Customs (HMRC)      
Income Tax Contingency [Line Items]      
Net operating loss carryforwards 209,500,000    
Federal      
Income Tax Contingency [Line Items]      
Net operating loss carryforwards 1,604,000,000    
Federal | Research and development tax credit carryforward      
Income Tax Contingency [Line Items]      
Tax credit carryforwards 73,400,000    
State      
Income Tax Contingency [Line Items]      
Net operating loss carryforwards 860,200,000    
State | Research and development tax credit carryforward      
Income Tax Contingency [Line Items]      
Tax credit carryforwards 34,600,000    
Foreign      
Income Tax Contingency [Line Items]      
Tax credit carryforwards $ 600,000