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Proc-Type: 2001,MIC-CLEAR
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<SEC-DOCUMENT>0000036104-04-000064.txt : 20040130
<SEC-HEADER>0000036104-04-000064.hdr.sgml : 20040130
<ACCEPTANCE-DATETIME>20040130095446
ACCESSION NUMBER:		0000036104-04-000064
CONFORMED SUBMISSION TYPE:	SC 13G
PUBLIC DOCUMENT COUNT:		3
FILED AS OF DATE:		20040130

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			HOLLIS EDEN PHARMACEUTICALS INC /DE/
		CENTRAL INDEX KEY:			0000899394
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				133697002
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-53005
		FILM NUMBER:		04554251

	BUSINESS ADDRESS:	
		STREET 1:		4435 EASTGATE MALL
		STREET 2:		SUITE 400
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121
		BUSINESS PHONE:		858-587-9333

	MAIL ADDRESS:	
		STREET 1:		4435 EASTGATE MALL
		STREET 2:		SUITE 400
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	INITIAL ACQUISITION CORP
		DATE OF NAME CHANGE:	19930329

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			US BANCORP \DE\
		CENTRAL INDEX KEY:			0000036104
		STANDARD INDUSTRIAL CLASSIFICATION:	NATIONAL COMMERCIAL BANKS [6021]
		IRS NUMBER:				410255900
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G

	BUSINESS ADDRESS:	
		STREET 1:		U.S.BANCORP
		STREET 2:		800 NICOLLET MALL
		CITY:			MINNEAPOLIS
		STATE:			MN
		ZIP:			55402
		BUSINESS PHONE:		(612)973-1111

	MAIL ADDRESS:	
		STREET 1:		U.S.BANCORP
		STREET 2:		800 NICOLLET MALL
		CITY:			MINNEAPOLIS
		STATE:			MN
		ZIP:			55402

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	FIRST BANK SYSTEM INC
		DATE OF NAME CHANGE:	19920703

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	FIRST BANK STOCK CORP
		DATE OF NAME CHANGE:	19720317
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G
<SEQUENCE>1
<FILENAME>hollis2003.txt
<DESCRIPTION>HOLLIS 2003 13G
<TEXT>


UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G
Under the Securities Exchange Act of 1934
(Amendment No.      )*


Hollis-Eden Pharmaceuticals, Inc.
(Name of Issuer)

Common
(Title of Class of Securities)

435902101
(CUSIP Number)

December 31, 2003
(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:
[x] Rule 13d-1(b)
[ ] Rule 13d-1(c)
[ ] Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities,
and for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act
(however, see the Notes).


13G
CUSIP No.  435902101


1.
Names of Reporting Persons.
U.S. Bancorp

I.R.S. Identification Nos. of above persons (entities only).
41-0255900

2.
Check the Appropriate Box if a Member of a Group (See Instructions)
(a)
(b)

3.
SEC Use Only

4.
Citizenship or Place of Organization
Delaware, U.S.A.

Number of Shares Beneficially Owned by Each Reporting Person
With:
	5.Sole Voting Power: 942,182
	6.Shared Voting Power: 0
	7.Sole Dispositive Power: 972,552
	8.Shared Dispositive Power: 300

9.
Aggregate Amount Beneficially Owned by Each Reporting Person:
972,852

10.
Check if the Aggregate Amount in Row (9) Excludes Certain Shares
(See Instructions)

11.
Percent of Class Represented by Amount in Row (9):
5.10

12.
Type of Reporting Person (See Instructions)
H.C.


13G
CUSIP No.  435902101


1.
Names of Reporting Persons.
U.S. Bancorp Asset Management, Inc.

I.R.S. Identification Nos. of above persons (entities only).
41-2003732

2.
Check the Appropriate Box if a Member of a Group (See Instructions)
(a)
(b)

3.
SEC Use Only

4.
Citizenship or Place of Organization
Delaware, U.S.A.

Number of Shares Beneficially Owned by Each Reporting Person
With:
	5.Sole Voting Power: 942,182
	6.Shared Voting Power: 0
	7.Sole Dispositive Power: 972,552
	8.Shared Dispositive Power: 300

9.
Aggregate Amount Beneficially Owned by Each Reporting Person:
972,852

10.
Check if the Aggregate Amount in Row (9) Excludes Certain Shares
(See Instructions)

11.
Percent of Class Represented by Amount in Row (9):
5.10

12.
Type of Reporting Person (See Instructions)
IA



Item 1.
(a) Name of Issuer
Hollis-Eden Pharmaceuticals, Inc.

(b) Address of Issuer's Principal Executive Offices
4435 Eastgate Mall
Suite 400
San Diego, CA 92121

Item 2.
(a) Name of Person Filing
U.S. Bancorp

U.S. Bancorp Asset Management, Inc.

(b) Address of Principal Business Office or, if none, Residence
U.S. Bancorp
800 Nicollet Mall
Minneapolis, Minnesota 55402

U.S. Bancorp Asset Management, Inc.
800 Nicollet Mall
Minneapolis, MN  55402

(c) Citizenship
U.S. Bancorp:  Delaware

U.S. Bancorp Asset Management, Inc.,Delaware

(d) Title of Class of Securities
Common

(e) CUSIP Number
435902101

Item 3.
The person filing this statement is a:
U.S. Bancorp:  (g) [x] Parent Holding Company

U.S. Bancorp Asset Management, Inc.:  (e) [x] Investment Advisor


Item 4.
Ownership.

Provide the following information regarding the aggregate number and
percentage of the class of securities of the issuer identified in
Item 1.

(a) Amount beneficially owned:
972,852

(b) Percent of class:
5.10

(c) Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote:
		942,182
	(ii) Shared power to vote or to direct vote:
		0
	(iii) Sole power to dispose or to direct the disposition of:
                972,552
	(iv) Shared power to dispose or to direct the disposition of:
                300
Item 5.
Ownership of Five Percent or Less of a Class

If this statement is being filed to report the fact that as of the date
hereof the reporting person has ceased to be the beneficial owner of more
than five percent of the class of securities, check the following [ ].

Item 6.
Ownership of More than Five Percent on Behalf of Another Person.
Accounts or persons have the right to receive or the power to direct the
receipt of dividends from, or the proceeds from the sale of, shares reported
in this filing.  To our knowledge no such interest of any account or person
relates to more than 5% of the class.


Item 7.
Identification and Classification of the Subsidiary Which Acquired the
Security Being Reported on By the Parent Holding Company:
See Exhibit A

Item 8.
Identification and Classification of Members of the Group:
Not Applicable

Item 9.
Notice of Dissolution of Group:
Not Applicable

Item 10.
Certification

By signing below I certify that, to the best of my knowledge and belief,
the securities referred to above were acquired and are held in the ordinary
course of business and were not acquired and are not held for the purpose
of or with the effect of changing or influencing the control of the issuer
of the securities and were not acquired and are not held in connection
with or as a participant in any transaction having that purpose or effect.



SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete
and correct.

01/31/04
Date

__________________________________
Signature

Beverly Antonich, Vice President
Name/Title











</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99
<SEQUENCE>2
<FILENAME>hollis2003exhb.txt
<DESCRIPTION>HOLLIS 2003 EXHIBIT B
<TEXT>
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

EXHIBIT B DISCLAIMER

Information on the attached Schedule 13G is provided solely for the
purpose of complying with Section 13(g) of the Securities
Exchange Act of 1934 and Regulations promulgated under authority
thereof and is not intended as an admission that U.S. Bancorp or
any of its subsidiaries is a beneficial owner of the securities described
herein for any other purpose (including without limitation for purposes
of the Minnesota Control Share Acquisition Act).


</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99
<SEQUENCE>3
<FILENAME>hollis2003exha.txt
<DESCRIPTION>HOLLIS 2003 EXHIBIT A
<TEXT>
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON D.C.  20549

SCHEDULE 13G
Under the Securities Exchange Act of 1934

Exhibit A

The Schedule 13G to which this attachment is appended is filed by U.S. Bancorp
on behalf of the following subsidiary or subsidiaries listed below:



U.S. Bancorp Asset Management, Inc.				IA
800 Nicollet Mall
Minneapolis, MN  55402


</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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