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    <link:label id="lab_csx_IntermodalMember_B56875CD16F2A6DC91AD07BF41E75A73_documentation_en-US" xlink:label="lab_csx_IntermodalMember_B56875CD16F2A6DC91AD07BF41E75A73" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Intermodal [Member]</link:label>
    <link:loc xlink:href="csx-20190331.xsd#csx_IntermodalMember" xlink:label="loc_csx_IntermodalMember_B56875CD16F2A6DC91AD07BF41E75A73" xlink:type="locator" />
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    <link:label id="lab_csx_OtherServicesMember_64A41A8B50D12E454F8407BF41E72289_terseLabel_en-US" xlink:label="lab_csx_OtherServicesMember_64A41A8B50D12E454F8407BF41E72289" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Other</link:label>
    <link:label id="lab_csx_OtherServicesMember_64A41A8B50D12E454F8407BF41E72289_label_en-US" xlink:label="lab_csx_OtherServicesMember_64A41A8B50D12E454F8407BF41E72289" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Other Services [Member]</link:label>
    <link:label id="lab_csx_OtherServicesMember_64A41A8B50D12E454F8407BF41E72289_documentation_en-US" xlink:label="lab_csx_OtherServicesMember_64A41A8B50D12E454F8407BF41E72289" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Other Services [Member]</link:label>
    <link:loc xlink:href="csx-20190331.xsd#csx_OtherServicesMember" xlink:label="loc_csx_OtherServicesMember_64A41A8B50D12E454F8407BF41E72289" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_csx_OtherServicesMember_64A41A8B50D12E454F8407BF41E72289" xlink:to="lab_csx_OtherServicesMember_64A41A8B50D12E454F8407BF41E72289" xlink:type="arc" />
    <link:label id="lab_us-gaap_DisaggregationOfRevenueLineItems_B102FDD75489A39C419707BF41E71F51_terseLabel_en-US" xlink:label="lab_us-gaap_DisaggregationOfRevenueLineItems_B102FDD75489A39C419707BF41E71F51" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Disaggregation of Revenue [Line Items]</link:label>
    <link:label id="lab_us-gaap_DisaggregationOfRevenueLineItems_B102FDD75489A39C419707BF41E71F51_label_en-US" xlink:label="lab_us-gaap_DisaggregationOfRevenueLineItems_B102FDD75489A39C419707BF41E71F51" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Disaggregation of Revenue [Line Items]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_B102FDD75489A39C419707BF41E71F51" xlink:type="locator" />
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    <link:label id="lab_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_55B379162EF1A27A768907BF41E7B27E_verboseLabel_en-US" xlink:label="lab_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_55B379162EF1A27A768907BF41E7B27E" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Revenue</link:label>
    <link:label id="lab_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_55B379162EF1A27A768907BF41E7B27E_label_en-US" xlink:label="lab_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_55B379162EF1A27A768907BF41E7B27E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Revenue from Contract with Customer, Excluding Assessed Tax</link:label>
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    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsFairValue_70DC37776F598E20E1D2DF422FA9036B_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsFairValue_70DC37776F598E20E1D2DF422FA9036B" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Less than 1 year</link:label>
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsFairValue_70DC37776F598E20E1D2DF422FA9036B_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsFairValue_70DC37776F598E20E1D2DF422FA9036B" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Securities, Available-for-sale, Maturity, Allocated and Single Maturity Date, Rolling within One Year, Fair Value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsFairValue_70DC37776F598E20E1D2DF422FA9036B" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsFairValue_70DC37776F598E20E1D2DF422FA9036B" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesNextRollingTwelveMonthsFairValue_70DC37776F598E20E1D2DF422FA9036B" xlink:type="arc" />
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveFairValue_A4DCE593188919F7A74ADF422FA9E1F4_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveFairValue_A4DCE593188919F7A74ADF422FA9E1F4" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">1 - 5 years</link:label>
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveFairValue_A4DCE593188919F7A74ADF422FA9E1F4_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveFairValue_A4DCE593188919F7A74ADF422FA9E1F4" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Securities, Available-for-sale, Maturity, Allocated and Single Maturity Date, Rolling after One Through Five Years, Fair Value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveFairValue_A4DCE593188919F7A74ADF422FA9E1F4" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveFairValue_A4DCE593188919F7A74ADF422FA9E1F4" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearTwoThroughFiveFairValue_A4DCE593188919F7A74ADF422FA9E1F4" xlink:type="arc" />
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenFairValue_DE993D46C5CA27E5ECB0DF422FA9E63C_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenFairValue_DE993D46C5CA27E5ECB0DF422FA9E63C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">5 - 10 years</link:label>
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenFairValue_DE993D46C5CA27E5ECB0DF422FA9E63C_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenFairValue_DE993D46C5CA27E5ECB0DF422FA9E63C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Securities, Available-for-sale, Maturity, Allocated and Single Maturity Date, Rolling after Five Through Ten Years, Fair Value</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenFairValue_DE993D46C5CA27E5ECB0DF422FA9E63C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenFairValue_DE993D46C5CA27E5ECB0DF422FA9E63C" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingYearSixThroughTenFairValue_DE993D46C5CA27E5ECB0DF422FA9E63C" xlink:type="arc" />
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenFairValue_54CCD2EA603889C33D72DF422FA91ABC_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenFairValue_54CCD2EA603889C33D72DF422FA91ABC" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Greater than 10 years</link:label>
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    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenFairValue_54CCD2EA603889C33D72DF422FA91ABC" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenFairValue_54CCD2EA603889C33D72DF422FA91ABC" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesRollingAfterYearTenFairValue_54CCD2EA603889C33D72DF422FA91ABC" xlink:type="arc" />
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesDebtSecurities_AC2E84E8544B39BBE5F4DF422FA9337A_totalLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesDebtSecurities_AC2E84E8544B39BBE5F4DF422FA9337A" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total investments at fair value</link:label>
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    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_AC2E84E8544B39BBE5F4DF422FA9337A" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_AC2E84E8544B39BBE5F4DF422FA9337A" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesDebtSecurities_AC2E84E8544B39BBE5F4DF422FA9337A" xlink:type="arc" />
    <link:label id="lab_us-gaap_LesseeLeaseDescriptionTable_9F6B1A915D136D12D4D113BBF92C217E_terseLabel_en-US" xlink:label="lab_us-gaap_LesseeLeaseDescriptionTable_9F6B1A915D136D12D4D113BBF92C217E" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Lessee, Lease, Description [Table]</link:label>
    <link:label id="lab_us-gaap_LesseeLeaseDescriptionTable_9F6B1A915D136D12D4D113BBF92C217E_label_en-US" xlink:label="lab_us-gaap_LesseeLeaseDescriptionTable_9F6B1A915D136D12D4D113BBF92C217E" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Lessee, Lease, Description [Table]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LesseeLeaseDescriptionTable" xlink:label="loc_us-gaap_LesseeLeaseDescriptionTable_9F6B1A915D136D12D4D113BBF92C217E" xlink:type="locator" />
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    <link:label id="lab_us-gaap_LesseeLeaseDescriptionLineItems_32C5415E5FA5B494A61613BBF92C050C_terseLabel_en-US" xlink:label="lab_us-gaap_LesseeLeaseDescriptionLineItems_32C5415E5FA5B494A61613BBF92C050C" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Lessee, Lease, Description [Line Items]</link:label>
    <link:label id="lab_us-gaap_LesseeLeaseDescriptionLineItems_32C5415E5FA5B494A61613BBF92C050C_label_en-US" xlink:label="lab_us-gaap_LesseeLeaseDescriptionLineItems_32C5415E5FA5B494A61613BBF92C050C" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Lessee, Lease, Description [Line Items]</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LesseeLeaseDescriptionLineItems" xlink:label="loc_us-gaap_LesseeLeaseDescriptionLineItems_32C5415E5FA5B494A61613BBF92C050C" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_32C5415E5FA5B494A61613BBF92C050C" xlink:to="lab_us-gaap_LesseeLeaseDescriptionLineItems_32C5415E5FA5B494A61613BBF92C050C" xlink:type="arc" />
    <link:label id="lab_us-gaap_LesseeOperatingLeaseTermOfContract_52713B8DE4B8A5045E4213BBCEDD0961_terseLabel_en-US" xlink:label="lab_us-gaap_LesseeOperatingLeaseTermOfContract_52713B8DE4B8A5045E4213BBCEDD0961" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Term of lease agreements (up to)</link:label>
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    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LesseeOperatingLeaseTermOfContract" xlink:label="loc_us-gaap_LesseeOperatingLeaseTermOfContract_52713B8DE4B8A5045E4213BBCEDD0961" xlink:type="locator" />
    <link:labelArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LesseeOperatingLeaseTermOfContract_52713B8DE4B8A5045E4213BBCEDD0961" xlink:to="lab_us-gaap_LesseeOperatingLeaseTermOfContract_52713B8DE4B8A5045E4213BBCEDD0961" xlink:type="arc" />
    <link:label id="lab_us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability_9FEE940881346CCA4C3913BBCEEC760D_terseLabel_en-US" xlink:label="lab_us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability_9FEE940881346CCA4C3913BBCEEC760D" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Right-of-use asset recognized as non-cash asset addition</link:label>
    <link:label id="lab_us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability_9FEE940881346CCA4C3913BBCEEC760D_label_en-US" xlink:label="lab_us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability_9FEE940881346CCA4C3913BBCEEC760D" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Right-of-Use Asset Obtained in Exchange for Operating Lease Liability</link:label>
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability" xlink:label="loc_us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability_9FEE940881346CCA4C3913BBCEEC760D" xlink:type="locator" />
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    <link:label id="lab_us-gaap_OperatingLeasePayments_710A9F2635B8D8612B8A13BBCEEC2CA3_terseLabel_en-US" xlink:label="lab_us-gaap_OperatingLeasePayments_710A9F2635B8D8612B8A13BBCEEC2CA3" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Cash paid for amounts included in measurement of operating lease liabilities</link:label>
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