<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2021 Workiva-->
<!--r:3683eefc-d4f7-49d3-bac4-a47a56d4b266,g:f1a89c1d-9ea3-4933-8a2b-3b308fbb1cee-->
<xs:schema xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:csx="http://www.csx.com/20210331" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" attributeFormDefault="unqualified" elementFormDefault="qualified" targetNamespace="http://www.csx.com/20210331">
  <xs:import namespace="http://fasb.org/srt/2020-01-31" schemaLocation="http://xbrl.fasb.org/srt/2020/elts/srt-2020-01-31.xsd"/>
  <xs:import namespace="http://fasb.org/us-gaap/2020-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2020/elts/us-gaap-2020-01-31.xsd"/>
  <xs:import namespace="http://www.w3.org/1999/xlink" schemaLocation="http://www.xbrl.org/2003/xlink-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/non-numeric" schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/numeric" schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei/2020-01-31" schemaLocation="https://xbrl.sec.gov/dei/2020/dei-2020-01-31.xsd"/>
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="csx-20210331_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="csx-20210331_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="csx-20210331_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="csx-20210331_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:type="simple"/>
      <link:roleType id="Cover" roleURI="http://www.csx.com/role/Cover">
        <link:definition>0001001 - Document - Cover</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDINCOMESTATEMENTSUnaudited" roleURI="http://www.csx.com/role/CONSOLIDATEDINCOMESTATEMENTSUnaudited">
        <link:definition>1001002 - Statement - CONSOLIDATED INCOME STATEMENTS (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONDENSEDCONSOLIDATEDCOMPREHENSIVEINCOMESTATEMENTSUnaudited" roleURI="http://www.csx.com/role/CONDENSEDCONSOLIDATEDCOMPREHENSIVEINCOMESTATEMENTSUnaudited">
        <link:definition>1002003 - Statement - CONDENSED CONSOLIDATED COMPREHENSIVE INCOME STATEMENTS (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDBALANCESHEETS" roleURI="http://www.csx.com/role/CONSOLIDATEDBALANCESHEETS">
        <link:definition>1003004 - Statement - CONSOLIDATED BALANCE SHEETS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDBALANCESHEETSParenthetical" roleURI="http://www.csx.com/role/CONSOLIDATEDBALANCESHEETSParenthetical">
        <link:definition>1004005 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDCASHFLOWSTATEMENTSUnaudited" roleURI="http://www.csx.com/role/CONSOLIDATEDCASHFLOWSTATEMENTSUnaudited">
        <link:definition>1005006 - Statement - CONSOLIDATED CASH FLOW STATEMENTS (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDSTATEMENTSOFCHANGESINSHAREHOLDERSEQUITYUnaudited" roleURI="http://www.csx.com/role/CONSOLIDATEDSTATEMENTSOFCHANGESINSHAREHOLDERSEQUITYUnaudited">
        <link:definition>1006007 - Statement - CONSOLIDATED STATEMENTS OF CHANGES IN SHAREHOLDERS' EQUITY (Unaudited)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDSTATEMENTSOFCHANGESINSHAREHOLDERSEQUITYUnauditedParenthetical" roleURI="http://www.csx.com/role/CONSOLIDATEDSTATEMENTSOFCHANGESINSHAREHOLDERSEQUITYUnauditedParenthetical">
        <link:definition>1007008 - Statement - CONSOLIDATED STATEMENTS OF CHANGES IN SHAREHOLDERS' EQUITY (Unaudited) (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NatureofOperationsandSignificantAccountingPolicies" roleURI="http://www.csx.com/role/NatureofOperationsandSignificantAccountingPolicies">
        <link:definition>2101101 - Disclosure - Nature of Operations and Significant Accounting Policies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NatureofOperationsandSignificantAccountingPoliciesPolicies" roleURI="http://www.csx.com/role/NatureofOperationsandSignificantAccountingPoliciesPolicies">
        <link:definition>2202201 - Disclosure - Nature of Operations and Significant Accounting Policies (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NatureofOperationsandSignificantAccountingPoliciesDetails" roleURI="http://www.csx.com/role/NatureofOperationsandSignificantAccountingPoliciesDetails">
        <link:definition>2403401 - Disclosure - Nature of Operations and Significant Accounting Policies (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EarningsPerShare" roleURI="http://www.csx.com/role/EarningsPerShare">
        <link:definition>2104102 - Disclosure - Earnings Per Share</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EarningsPerShareTables" roleURI="http://www.csx.com/role/EarningsPerShareTables">
        <link:definition>2305301 - Disclosure - Earnings Per Share (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EarningsPerShareComputationofBasicEarningsPerShareAssumingDilutionDetails" roleURI="http://www.csx.com/role/EarningsPerShareComputationofBasicEarningsPerShareAssumingDilutionDetails">
        <link:definition>2406402 - Disclosure - Earnings Per Share - Computation of Basic Earnings Per Share, Assuming Dilution (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EarningsPerShareAntidilutiveStockOptionsExcludedfromDilutedEarningsPerShareCalculationDetails" roleURI="http://www.csx.com/role/EarningsPerShareAntidilutiveStockOptionsExcludedfromDilutedEarningsPerShareCalculationDetails">
        <link:definition>2407403 - Disclosure - Earnings Per Share - Antidilutive Stock Options Excluded from Diluted Earnings Per Share Calculation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EarningsPerShareNarrativeDetails" roleURI="http://www.csx.com/role/EarningsPerShareNarrativeDetails">
        <link:definition>2408404 - Disclosure - Earnings Per Share - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EarningsPerShareShareRepurchasesDetails" roleURI="http://www.csx.com/role/EarningsPerShareShareRepurchasesDetails">
        <link:definition>2409405 - Disclosure - Earnings Per Share - Share Repurchases (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockPlansandShareBasedCompensation" roleURI="http://www.csx.com/role/StockPlansandShareBasedCompensation">
        <link:definition>2110103 - Disclosure - Stock Plans and Share-Based Compensation</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockPlansandShareBasedCompensationTables" roleURI="http://www.csx.com/role/StockPlansandShareBasedCompensationTables">
        <link:definition>2311302 - Disclosure - Stock Plans and Share-Based Compensation (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockPlansandShareBasedCompensationPretaxExpenseandIncomeTaxBenefitsDetails" roleURI="http://www.csx.com/role/StockPlansandShareBasedCompensationPretaxExpenseandIncomeTaxBenefitsDetails">
        <link:definition>2412406 - Disclosure - Stock Plans and Share-Based Compensation - Pre-tax Expense and Income Tax Benefits (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockPlansandShareBasedCompensationNarrativeDetails" roleURI="http://www.csx.com/role/StockPlansandShareBasedCompensationNarrativeDetails">
        <link:definition>2413407 - Disclosure - Stock Plans and Share-Based Compensation - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockPlansandShareBasedCompensationWeightedAverageAssumptionsUsedforPerformanceUnitsDetails" roleURI="http://www.csx.com/role/StockPlansandShareBasedCompensationWeightedAverageAssumptionsUsedforPerformanceUnitsDetails">
        <link:definition>2414408 - Disclosure - Stock Plans and Share-Based Compensation - Weighted Average Assumptions Used for Performance Units (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockPlansandShareBasedCompensationFairValueAssumptionsUsedforStockOptionsDetails" roleURI="http://www.csx.com/role/StockPlansandShareBasedCompensationFairValueAssumptionsUsedforStockOptionsDetails">
        <link:definition>2415409 - Disclosure - Stock Plans and Share-Based Compensation - Fair Value Assumptions Used for Stock Options (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockPlansandShareBasedCompensationSharesIssuedUnderEmployeeStockPurchasePlanDetails" roleURI="http://www.csx.com/role/StockPlansandShareBasedCompensationSharesIssuedUnderEmployeeStockPurchasePlanDetails">
        <link:definition>2416410 - Disclosure - Stock Plans and Share-Based Compensation - Shares Issued Under Employee Stock Purchase Plan (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CasualtyEnvironmentalandOtherReserves" roleURI="http://www.csx.com/role/CasualtyEnvironmentalandOtherReserves">
        <link:definition>2117104 - Disclosure - Casualty, Environmental and Other Reserves</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CasualtyEnvironmentalandOtherReservesTables" roleURI="http://www.csx.com/role/CasualtyEnvironmentalandOtherReservesTables">
        <link:definition>2318303 - Disclosure - Casualty, Environmental and Other Reserves (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CasualtyEnvironmentalandOtherReservesScheduleofCasualtyEnvironmentalandOtherReservesDetails" roleURI="http://www.csx.com/role/CasualtyEnvironmentalandOtherReservesScheduleofCasualtyEnvironmentalandOtherReservesDetails">
        <link:definition>2419411 - Disclosure - Casualty, Environmental and Other Reserves - Schedule of Casualty, Environmental and Other Reserves (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CasualtyEnvironmentalandOtherReservesNarrativeDetails" roleURI="http://www.csx.com/role/CasualtyEnvironmentalandOtherReservesNarrativeDetails">
        <link:definition>2420412 - Disclosure - Casualty, Environmental and Other Reserves - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CommitmentsandContingencies" roleURI="http://www.csx.com/role/CommitmentsandContingencies">
        <link:definition>2121105 - Disclosure - Commitments and Contingencies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CommitmentsandContingenciesDetails" roleURI="http://www.csx.com/role/CommitmentsandContingenciesDetails">
        <link:definition>2422413 - Disclosure - Commitments and Contingencies (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EmployeeBenefitPlans" roleURI="http://www.csx.com/role/EmployeeBenefitPlans">
        <link:definition>2123106 - Disclosure - Employee Benefit Plans</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EmployeeBenefitPlansTables" roleURI="http://www.csx.com/role/EmployeeBenefitPlansTables">
        <link:definition>2324304 - Disclosure - Employee Benefit Plans (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EmployeeBenefitPlansNarrativeDetails" roleURI="http://www.csx.com/role/EmployeeBenefitPlansNarrativeDetails">
        <link:definition>2425414 - Disclosure - Employee Benefit Plans - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="EmployeeBenefitPlansComponentsofNetPeriodicBenefitCostsDetails" roleURI="http://www.csx.com/role/EmployeeBenefitPlansComponentsofNetPeriodicBenefitCostsDetails">
        <link:definition>2426415 - Disclosure - Employee Benefit Plans - Components of Net Periodic Benefit Costs (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DebtandCreditAgreements" roleURI="http://www.csx.com/role/DebtandCreditAgreements">
        <link:definition>2127107 - Disclosure - Debt and Credit Agreements</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DebtandCreditAgreementsTables" roleURI="http://www.csx.com/role/DebtandCreditAgreementsTables">
        <link:definition>2328305 - Disclosure - Debt and Credit Agreements (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DebtandCreditAgreementsActivityRelatedtoLongTermDebtDetails" roleURI="http://www.csx.com/role/DebtandCreditAgreementsActivityRelatedtoLongTermDebtDetails">
        <link:definition>2429416 - Disclosure - Debt and Credit Agreements - Activity Related to Long-Term Debt (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="DebtandCreditAgreementsNarrativeDetails" roleURI="http://www.csx.com/role/DebtandCreditAgreementsNarrativeDetails">
        <link:definition>2430417 - Disclosure - Debt and Credit Agreements - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="Revenues" roleURI="http://www.csx.com/role/Revenues">
        <link:definition>2131108 - Disclosure - Revenues</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RevenuesTables" roleURI="http://www.csx.com/role/RevenuesTables">
        <link:definition>2332306 - Disclosure - Revenues (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RevenuesRevenuesDisaggregatedbyLinesofBusinessDetails" roleURI="http://www.csx.com/role/RevenuesRevenuesDisaggregatedbyLinesofBusinessDetails">
        <link:definition>2433418 - Disclosure - Revenues - Revenues Disaggregated by Lines of Business (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RevenuesNarrativeDetails" roleURI="http://www.csx.com/role/RevenuesNarrativeDetails">
        <link:definition>2434419 - Disclosure - Revenues - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="RevenuesAccountsReceivableDetails" roleURI="http://www.csx.com/role/RevenuesAccountsReceivableDetails">
        <link:definition>2435420 - Disclosure - Revenues - Accounts Receivable (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncomeTaxes" roleURI="http://www.csx.com/role/IncomeTaxes">
        <link:definition>2136109 - Disclosure - Income Taxes</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurements" roleURI="http://www.csx.com/role/FairValueMeasurements">
        <link:definition>2137110 - Disclosure - Fair Value Measurements</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsTables" roleURI="http://www.csx.com/role/FairValueMeasurementsTables">
        <link:definition>2338307 - Disclosure - Fair Value Measurements (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsFairValueofInvestmentAssetsDetails" roleURI="http://www.csx.com/role/FairValueMeasurementsFairValueofInvestmentAssetsDetails">
        <link:definition>2439421 - Disclosure - Fair Value Measurements - Fair Value of Investment Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsInvestmentMaturitiesDetails" roleURI="http://www.csx.com/role/FairValueMeasurementsInvestmentMaturitiesDetails">
        <link:definition>2440422 - Disclosure - Fair Value Measurements - Investment Maturities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsFairValueandCarryingValueofLongTermDebtDetails" roleURI="http://www.csx.com/role/FairValueMeasurementsFairValueandCarryingValueofLongTermDebtDetails">
        <link:definition>2441423 - Disclosure - Fair Value Measurements - Fair Value and Carrying Value of Long-Term Debt (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementsInterestRateDerivativesDetails" roleURI="http://www.csx.com/role/FairValueMeasurementsInterestRateDerivativesDetails">
        <link:definition>2442424 - Disclosure - Fair Value Measurements - Interest Rate Derivatives (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OtherComprehensiveIncomeLoss" roleURI="http://www.csx.com/role/OtherComprehensiveIncomeLoss">
        <link:definition>2143111 - Disclosure - Other Comprehensive Income (Loss)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OtherComprehensiveIncomeLossTables" roleURI="http://www.csx.com/role/OtherComprehensiveIncomeLossTables">
        <link:definition>2344308 - Disclosure - Other Comprehensive Income (Loss) (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OtherComprehensiveIncomeLossNarrativeDetails" roleURI="http://www.csx.com/role/OtherComprehensiveIncomeLossNarrativeDetails">
        <link:definition>2445425 - Disclosure - Other Comprehensive Income (Loss) - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="OtherComprehensiveIncomeLossChangesinAOCIBalancebyComponentDetails" roleURI="http://www.csx.com/role/OtherComprehensiveIncomeLossChangesinAOCIBalancebyComponentDetails">
        <link:definition>2446426 - Disclosure - Other Comprehensive Income (Loss) - Changes in AOCI Balance by Component (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SubsequentEvent" roleURI="http://www.csx.com/role/SubsequentEvent">
        <link:definition>2147112 - Disclosure - Subsequent Event</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SubsequentEventDetails" roleURI="http://www.csx.com/role/SubsequentEventDetails">
        <link:definition>2448427 - Disclosure - Subsequent Event (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:element id="csx_ShareBasedCompensationArrangementByShareBasedPaymentAwardPerShareWeightedAveragePriceOfSharesIssued" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPerShareWeightedAveragePriceOfSharesIssued" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:perShareItemType"/>
  <xs:element id="csx_TotalMerchandiseMember" abstract="true" name="TotalMerchandiseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_LossContingencyNumberOfConsolidatedClassActionLawsuits" abstract="false" name="LossContingencyNumberOfConsolidatedClassActionLawsuits" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="csx_LineSegmentsMember" abstract="true" name="LineSegmentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_NumberofmilespertainingtoPassaicRivertidalreachrequiredtobestudiedbyEPA" abstract="false" name="NumberofmilespertainingtoPassaicRivertidalreachrequiredtobestudiedbyEPA" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:lengthItemType"/>
  <xs:element id="csx_LongtermIncentivePlanMember" abstract="true" name="LongtermIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_AccumulatedOtherAdjustmentstoParentMember" abstract="true" name="AccumulatedOtherAdjustmentstoParentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_CurrentLiabilitiesMember" abstract="true" name="CurrentLiabilitiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_AgriculturalandFoodProductsMember" abstract="true" name="AgriculturalandFoodProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_CasualtyEnvironmentalAndOtherReservesAbstract" abstract="true" name="CasualtyEnvironmentalAndOtherReservesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="csx_MetalsandEquipmentMember" abstract="true" name="MetalsandEquipmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_UnsecuredRevolvingCreditFacilityDue2024Member" abstract="true" name="UnsecuredRevolvingCreditFacilityDue2024Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_OtherServicesMember" abstract="true" name="OtherServicesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_ScheduleofSharebasedPaymentAwardAwardsOtherthanOptionsValuationAssumptionsTableTextBlock" abstract="false" name="ScheduleofSharebasedPaymentAwardAwardsOtherthanOptionsValuationAssumptionsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="csx_AutomotiveMember" abstract="true" name="AutomotiveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsPayoutPercentageAdjustment" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsPayoutPercentageAdjustment" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="csx_StockAwardsDirectorsMember" abstract="true" name="StockAwardsDirectorsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_ForestProductsMember" abstract="true" name="ForestProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_SharebasedCompensationArrangementbySharebasedPaymentAwardMinimumEmployeeSubscriptionRate" abstract="false" name="SharebasedCompensationArrangementbySharebasedPaymentAwardMinimumEmployeeSubscriptionRate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="csx_EmployeeStockPurchasePlanMember" abstract="true" name="EmployeeStockPurchasePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_A325NotesDue2027Member" abstract="true" name="A325NotesDue2027Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_ChemicalsMember" abstract="true" name="ChemicalsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_LossContingencyNumberOfClaimsExpectedToExceedSelfInsuredRetentionAmount" abstract="false" name="LossContingencyNumberOfClaimsExpectedToExceedSelfInsuredRetentionAmount" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="csx_EnvironmentalLitigationMember" abstract="true" name="EnvironmentalLitigationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_StockIssuedDuringPeriodValueStockOptionsExercisedandOther" abstract="false" name="StockIssuedDuringPeriodValueStockOptionsExercisedandOther" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="csx_SiteContingencyNumberofMilesUnderStudy" abstract="false" name="SiteContingencyNumberofMilesUnderStudy" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:lengthItemType"/>
  <xs:element id="csx_RevenuePerformanceObligationAverageTransitTime" abstract="false" name="RevenuePerformanceObligationAverageTransitTime" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="csx_MineralsMember" abstract="true" name="MineralsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_OccupationalCasualtyMember" abstract="true" name="OccupationalCasualtyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_SharebasedCompensationArrangementbySharebasedPaymentAwardShareOfferingPeriod" abstract="false" name="SharebasedCompensationArrangementbySharebasedPaymentAwardShareOfferingPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="csx_CasualtyEnvironmentalAndOtherLossReservesDisclosureTextBlock" abstract="false" name="CasualtyEnvironmentalAndOtherLossReservesDisclosureTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="csx_DefinedBenefitPlanPlanAmendmentEliminationofBenefitsMinimumAge" abstract="false" name="DefinedBenefitPlanPlanAmendmentEliminationofBenefitsMinimumAge" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="csx_FreightReceivablesMember" abstract="true" name="FreightReceivablesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_ShareRepurchaseProgramOctober2020Member" abstract="true" name="ShareRepurchaseProgramOctober2020Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_ContractwithCustomerTimingofSatisfactionofPerformanceObligationPaymentPeriod" abstract="false" name="ContractwithCustomerTimingofSatisfactionofPerformanceObligationPaymentPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="csx_RailRouteNetworkDistance" abstract="false" name="RailRouteNetworkDistance" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="num:lengthItemType"/>
  <xs:element id="csx_NumberOfImpairedSites" abstract="false" name="NumberOfImpairedSites" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="csx_ShareBasedCompensationArrangementbyShareBasedPaymentAwardMaximumStockValuePurchasedperEmployee" abstract="false" name="ShareBasedCompensationArrangementbyShareBasedPaymentAwardMaximumStockValuePurchasedperEmployee" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="csx_CommonStockDividendRateIncreasePercentage" abstract="false" name="CommonStockDividendRateIncreasePercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="csx_SelfInsuredRetention" abstract="false" name="SelfInsuredRetention" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="csx_DisposalGroupIncludingDiscontinuedOperationsNumberOfPhasesToCompleteSaleTransaction" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationsNumberOfPhasesToCompleteSaleTransaction" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="csx_SharebasedCompensationArrangementbySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsPayoutPercentageofTarget" abstract="false" name="SharebasedCompensationArrangementbySharebasedPaymentAwardEquityInstrumentsOtherThanOptionsPayoutPercentageofTarget" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="csx_CoalServicesMember" abstract="true" name="CoalServicesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_PersonalInjuryCasualtyMember" abstract="true" name="PersonalInjuryCasualtyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_FuelSurchargeAntitrustLitigationMember" abstract="true" name="FuelSurchargeAntitrustLitigationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_CasualtyAndNonCatastrophicPropertyDeductible" abstract="false" name="CasualtyAndNonCatastrophicPropertyDeductible" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="csx_SiteContingencyNumberofPartiesParticipatinginAllocationProcessUnderStudy" abstract="false" name="SiteContingencyNumberofPartiesParticipatinginAllocationProcessUnderStudy" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="csx_NonFreightReceivablesMember" abstract="true" name="NonFreightReceivablesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_LossContingencyClaimsFiledNumberOfEntities" abstract="false" name="LossContingencyClaimsFiledNumberOfEntities" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="csx_TotalCasualtyMember" abstract="true" name="TotalCasualtyMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_PanAmSystemsIncMember" abstract="true" name="PanAmSystemsIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_RailRouteNetworkDistancePartialInterest" abstract="false" name="RailRouteNetworkDistancePartialInterest" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="num:lengthItemType"/>
  <xs:element id="csx_DisposalGroupIncludingDiscontinuedOperationsPeriodToCompleteSaleTransaction" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationsPeriodToCompleteSaleTransaction" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="csx_DefinedBenefitPlanPlanAmendmentEliminationofBenefitsMaximumAge" abstract="false" name="DefinedBenefitPlanPlanAmendmentEliminationofBenefitsMaximumAge" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="csx_LongTermLiabilitiesMember" abstract="true" name="LongTermLiabilitiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_SharebasedCompensationArrangementbySharebasedPaymentAwardOptionsExercisesinPeriodandOther" abstract="false" name="SharebasedCompensationArrangementbySharebasedPaymentAwardOptionsExercisesinPeriodandOther" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="csx_PercentageOfGrantsWithPerformanceVestingAverageAnnualOperatingIncomeGrowth" abstract="false" name="PercentageOfGrantsWithPerformanceVestingAverageAnnualOperatingIncomeGrowth" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="csx_CertainEmployeesMember" abstract="true" name="CertainEmployeesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_PercentageOfGrantsWithPerformanceVestingCumulativeFreeCashFlow" abstract="false" name="PercentageOfGrantsWithPerformanceVestingCumulativeFreeCashFlow" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="csx_IntermodalMember" abstract="true" name="IntermodalMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_MovementDebtInstrumentsRollForward" abstract="true" name="MovementDebtInstrumentsRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="csx_CasualtyAndCatastrophicPropertyDeductible" abstract="false" name="CasualtyAndCatastrophicPropertyDeductible" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="csx_OtherReservesMember" abstract="true" name="OtherReservesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_ShareRepurchaseProgramJanuary2019Member" abstract="true" name="ShareRepurchaseProgramJanuary2019Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfEquivalentSharesOfCommonStockPerUnit" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfEquivalentSharesOfCommonStockPerUnit" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="csx_FertilizersMember" abstract="true" name="FertilizersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="csx_EquipmentandOtherRents" abstract="false" name="EquipmentandOtherRents" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="csx_DisposalGroupIncludingDiscontinuedOperationNumberOfDisposalGroups" abstract="false" name="DisposalGroupIncludingDiscontinuedOperationNumberOfDisposalGroups" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
</xs:schema>
