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Supplemental Income Statement Information (Details) - USD ($) $ in Millions | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Other (income) expense, net |  |  |
Global Growth and Efficiency Program | $ 0 | $ (13) | $ 57
Amortization of intangible assets | 89 | 88 | 62
Equity income | (12) | (12) | (9)
Value-added tax matter in Brazil | (26) | 0 | (30)
Write-off of certain investments and fixed assets | 10 | 0 | 51
Acquisition-related costs | 0 | 2 | 21
Charges for a change in go-to-market strategy in certain countries | 0 | 0 | 15
Other, net | 4 | 48 | 29
Total Other (income) expense, net | 65 | 113 | 196
Interest (income) expense, net |  |  |
Interest incurred | 195 | 184 | 193
Interest capitalized | (3) | (1) | (1)
Interest income | (17) | (19) | (47)
Total Interest (income) expense, net | 175 | 164 | 145
Research and development | 307 | 290 | 281
Advertising | $ 2,021 | $ 1,948 | $ 1,694

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