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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($) $ in Millions | 9 Months Ended
--- | ---
Sep. 30, 2022 | Sep. 30, 2021
Cash flows from operating activities: |  |
Net income | $ 3,141.3 | $ 5,846.3
Adjustments to reconcile net income to net cash provided by operating activities: |  |
Depreciation and amortization | 241.3 | 211.7
Stock-based compensation expense | 493.0 | 413.3
Losses (gains) on marketable and other securities, net | 117.4 | (524.6)
Other non-cash items, net | 199.0 | 264.4
Deferred taxes | (466.7) | 58.8
Acquired in-process research and development in connection with asset acquisition | 195.0 | 0.0
Changes in assets and liabilities: |  |
Decrease (increase) in accounts receivable | 488.2 | (1,342.9)
Increase in inventories | (552.2) | (330.6)
Increase in prepaid expenses and other assets | (167.3) | (316.8)
Increase (decrease) in deferred revenue | 92.0 | (71.2)
(Decrease) increase in accounts payable, accrued expenses, and other liabilities | (486.0) | 500.4
Total adjustments | 153.7 | (1,137.5)
Net cash provided by operating activities | 3,295.0 | 4,708.8
Cash flows from investing activities: |  |
Purchases of marketable and other securities | (4,345.0) | (4,872.3)
Sales or maturities of marketable and other securities | 4,013.1 | 1,897.3
Capital expenditures | (437.9) | (397.0)
Payments for Libtayo intangible asset | (926.8) | 0.0
Asset acquisition, net of cash acquired | (230.3) | 0.0
Net cash used in investing activities | (1,926.9) | (3,372.0)
Cash flows from financing activities: |  |
Proceeds from issuance of Common Stock | 1,146.9 | 1,129.6
Payments in connection with Common Stock tendered for employee tax obligations | (256.6) | (450.3)
Repurchases of Common Stock | (1,651.7) | (778.5)
Net cash used in financing activities | (761.4) | (99.2)
Net increase in cash, cash equivalents, and restricted cash | 606.7 | 1,237.6
Cash, cash equivalents, and restricted cash at beginning of period | 2,898.1 | 2,207.3
Cash, cash equivalents, and restricted cash at end of period | $ 3,504.8 | $ 3,444.9

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