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Property, Plant, and Equipment | 12 Months Ended
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Dec. 31, 2022
Property, Plant and Equipment [Abstract] |
Property, Plant and Equipment | Property, Plant, and Equipment Property, plant, and equipment consists of the following:
| As of December 31,
(In millions) | 2022 |  | 2021
Land | $ | 264.5 |  |  | $ | 248.0 |
Building and improvements | 2,270.0 |  |  | 2,088.5 |
Leasehold improvements | 114.3 |  |  | 113.9 |
Construction in progress | 980.5 |  |  | 767.7 |
Laboratory equipment | 1,315.3 |  |  | 1,225.5 |
Computer equipment and software | 337.4 |  |  | 291.5 |
Furniture, office equipment, and other | 150.2 |  |  | 145.2 |
| 5,432.2 |  |  | 4,880.3 |
Less, accumulated depreciation and amortization | (1,669.2) |  |  | (1,398.1) |
| $ | 3,763.0 |  |  | $ | 3,482.2 |
Property, plant, and equipment in the table above includes leased property under the Company's finance lease at its Tarrytown, New York facility. See Note 11. Depreciation and amortization expense on property, plant, and equipment was $303.9 million, $281.1 million, and $230.8 million for the years ended December 31, 2022, 2021, and 2020, respectively. As of December 31, 2022 and 2021, $2.960 billion and $2.684 billion, respectively, of the Company's net property, plant, and equipment was located in the United States and $803.0 million and $797.8 million, respectively, was located outside the United States (primarily in Ireland).

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- Definition The entire disclosure for long-lived, physical asset used in normal conduct of business and not intended for resale. Includes, but is not limited to, work of art, historical treasure, and similar asset classified as collections. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 6 -URI https://asc.fasb.org/extlink&oid=126982197&loc=d3e99893-112916 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -URI https://asc.fasb.org/topic&trid=2155823 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 7 -URI https://asc.fasb.org/extlink&oid=126982197&loc=SL120174063-112916 Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 1 -Subparagraph (d) -URI https://asc.fasb.org/extlink&oid=126982197&loc=d3e99779-112916 + Details
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