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Collaboration, License, and Other Agreements - Sanofi, Antibody Narrative (Details) - USD ($) $ in Millions |  |  |  | 12 Months Ended
--- | --- | --- | --- | ---
Jul. 01, 2022 | Jun. 30, 2022 | Apr. 01, 2020 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Disaggregation of Revenue [Line Items] |  |  |  |  |  |
One-time payment |  |  |  | $ (56.9) |  |
Revenues |  |  |  | $ 12,172.9 | $ 16,071.7 | $ 8,497.1
Sanofi Collaboration Agreement, Antibody |  |  |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |  |  |
Percentage of quarterly profits require to be paid for reimbursement of development costs |  |  |  | 10.00% |  |
Percentage of share of profits used to reimburse collaborating party for trial costs | 20.00% | 10.00% |  |  |  |
Contingent reimbursement obligation |  |  |  | $ 2,864.0 |  |
Starting share of profits outside the United States, based on sales, for collaborating party |  |  |  | 65.00% |  |
Starting share of profits outside the United States, based on sales, for company |  |  |  | 35.00% |  |
Ending share of profits outside the United States, based on sales, for collaborating party |  |  |  | 55.00% |  |
Ending share of profits outside the United States, based on sales, for company |  |  |  | 45.00% |  |
Share of losses outside the United States, for collaborating party |  |  |  | 55.00% |  |
Share of losses outside the United States, for company |  |  |  | 45.00% |  |
Sanofi Collaboration Agreement, Antibody | First Milestone |  |  |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |  |  |
Levels of twelve month sales at which sales milestone payments would be received |  |  |  |  |  | $ 1,000.0
Sanofi Collaboration Agreement, Antibody | Second Milestone |  |  |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |  |  |
Levels of twelve month sales at which sales milestone payments would be received |  |  |  |  | $ 1,500.0 |
Period for achieving sales target for milestone payment, rolling basis |  |  |  |  | 12 months |
Sanofi Collaboration Agreement, Antibody | Third Milestone |  |  |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |  |  |
Revenues |  |  |  | $ 50.0 |  |
Levels of twelve month sales at which sales milestone payments would be received |  |  |  | 2,000.0 |  |
Sanofi Collaboration Agreement, Antibody | Sales Milestone Four |  |  |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |  |  |
Levels of twelve month sales at which sales milestone payments would be received |  |  |  | $ 2,500.0 |  |
Period for achieving sales target for milestone payment, rolling basis |  |  |  | 12 months |  |
Sanofi Collaboration Agreement, Antibody | Sales Milestone Five |  |  |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |  |  |
Levels of twelve month sales at which sales milestone payments would be received |  |  |  | $ 3,000.0 |  |
Period for achieving sales target for milestone payment, rolling basis |  |  |  | 12 months |  |
Revenue, remaining performance obligation, variable consideration amount |  |  |  | $ 50.0 |  |
Sanofi Collaboration Agreement, Antibody | Minimum |  |  |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |  |  |
Percentage of trial costs required to be funded by collaborating party |  |  |  | 80.00% |  |
Percentage of quarterly profits require to be paid for reimbursement of development costs |  |  |  | 30.00% |  |
Sanofi Collaboration Agreement, Antibody | Maximum |  |  |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |  |  |
Percentage of trial costs required to be funded by collaborating party |  |  |  | 100.00% |  |
Percentage of quarterly profits require to be paid for reimbursement of development costs |  |  |  | 50.00% |  |
Praluent Agreement |  |  |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |  |  |
Royalty percentage to be received on net product sales outside of the United States |  |  | 5.00% |  |  |
Percentage of damages company is responsible for |  |  | 50.00% |  |  |
Praluent Agreement | Sanofi |  |  |  |  |  |
Disaggregation of Revenue [Line Items] |  |  |  |  |  |
Percentage of royalty payment that can be used to offset litigation proceedings |  |  | 50.00% |  |  |

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