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Collaboration, License, and Other Agreements - Amounts Recognized in Statement of Operations with Roche (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Disaggregation of Revenue [Line Items]
Revenues	$ 12,172.9	$ 16,071.7	$ 8,497.1
Roche Collaboration Agreement | Ronapreve | Other collaboration revenue
Disaggregation of Revenue [Line Items]
Revenues	627.3	361.8	0.0
Roche Collaboration Agreement | Ronapreve | Cost of goods sold
Disaggregation of Revenue [Line Items]
Revenues	0.0	259.6	0.0
Roche Collaboration Agreement | Reimbursement of R&D expenses | Reduction of R&D expense
Disaggregation of Revenue [Line Items]
Revenues	$ 6.8	$ 128.1	$ 78.5

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