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Insider Trading Arrangements
 3 Months Ended
Mar. 31, 2025
shares
Trading Arrangements, by Individual  
Material Terms of Trading Arrangement
As disclosed in the table below, during the three months ended March 31, 2025, certain of our directors and/or executive officers adopted plans for trading arrangements intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) of the Exchange Act.
NamePositionDate of Plan Adoption
Scheduled End Date of Trading Arrangement(a)
Total Number of Securities to Be Sold Under the Plan
Joseph L. Goldstein, M.D.
Director
2/13/202511/30/20251,929 
(a) The trading arrangement may expire on an earlier date if and when all transactions under the arrangement are completed
Non-Rule 10b5-1 Arrangement Adopted false
Rule 10b5-1 Arrangement Terminated false
Non-Rule 10b5-1 Arrangement Terminated false
Joseph L. Goldstein, M.D. [Member]  
Trading Arrangements, by Individual  
Name Joseph L. Goldstein, M.D.
Title Director
Rule 10b5-1 Arrangement Adopted true
Adoption Date 2/13/2025
Expiration Date 11/30/2025
Arrangement Duration 290 days
Aggregate Available 1,929