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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (Unaudited) - USD ($)
shares in Millions, $ in Millions
 3 Months Ended
Mar. 31, 2025
Mar. 31, 2024
Revenues:    
Revenues $ 3,028.7 $ 3,145.0
Expenses:    
Research and development 1,327.4 1,248.4
Acquired in-process research and development 12.3 7.1
Selling, general, and administrative 633.0 689.0
Other operating expense (income), net 0.0 15.3
Total Expenses 2,437.0 2,393.6
Income from operations 591.7 751.4
Other income (expense):    
Other income (expense), net 322.0 (34.6)
Interest expense (8.7) (16.1)
Total other income (expense) 313.3 (50.7)
Income before income taxes 905.0 700.7
Income tax expense (benefit) 96.3 (21.3)
Net income $ 808.7 $ 722.0
Net income per share - basic (in dollars per share) $ 7.58 $ 6.70
Net income per share - diluted (in dollars per share) $ 7.27 $ 6.27
Weighted average shares outstanding - basic (in shares) 106.7 107.8
Weighted average shares outstanding - diluted (in shares) 111.2 115.1
Statements of Comprehensive Income    
Net income $ 808.7 $ 722.0
Other comprehensive income (loss), net of tax:    
Unrealized gain on debt securities 38.1 3.5
(Loss) gain on foreign currency translation (1.1) 0.2
Comprehensive income 845.7 725.7
Net product sales    
Revenues:    
Revenues 1,415.6 1,761.3
Expenses:    
Cost of goods sold, collaboration and contract manufacturing 265.5 240.4
Collaboration revenue    
Revenues:    
Revenues 1,531.2 1,266.8
Other revenue    
Revenues:    
Revenues 81.9 116.9
Cost of collaboration and contract manufacturing    
Expenses:    
Cost of goods sold, collaboration and contract manufacturing $ 198.8 $ 193.4