<SEC-DOCUMENT>0001973141-25-000098.txt : 20250218
<SEC-HEADER>0001973141-25-000098.hdr.sgml : 20250218
<ACCEPTANCE-DATETIME>20250218161454
ACCESSION NUMBER:		0001973141-25-000098
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250218
DATE AS OF CHANGE:		20250218

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ALNYLAM PHARMACEUTICALS, INC.
		CENTRAL INDEX KEY:			0001178670
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				770602661
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-36407
		FILM NUMBER:		25635046

	BUSINESS ADDRESS:	
		STREET 1:		675 WEST KENDALL STREET
		STREET 2:		HENRI A. TERMEER SQUARE
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02142
		BUSINESS PHONE:		(617) 551-8200

	MAIL ADDRESS:	
		STREET 1:		675 WEST KENDALL STREET
		STREET 2:		HENRI A. TERMEER SQUARE
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02142

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ALNYLAM PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	20020724

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Garg Pushkal
		CENTRAL INDEX KEY:			0001829252
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		C/O SQZ BIOTECHNOLOGIES COMPANY
		STREET 2:		200 ARSENAL YARDS BOULEVARD, SUITE 210
		CITY:			WATERTOWN
		STATE:			MA
		ZIP:			02472
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001829252</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001178670</issuerCik>
      <issuerName>ALNYLAM PHARMACEUTICALS, INC.</issuerName>
      <secFileNumber>001-36407</secFileNumber>
      <issuerAddress>
        <com:street1>675 WEST KENDALL STREET</com:street1>
        <com:street2>HENRI A. TERMEER SQUARE</com:street2>
        <com:city>CAMBRIDGE</com:city>
        <com:stateOrCountry>MA</com:stateOrCountry>
        <com:zipCode>02142</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>(617) 551-8200</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Garg Pushkal</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>UBS Financial Services, Inc.</name>
        <address>
          <com:street1>1000 Harbor Blvd</com:street1>
          <com:street2>3rd Floor</com:street2>
          <com:city>Weehawken</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07086</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>1548</noOfUnitsSold>
      <aggregateMarketValue>397758.60</aggregateMarketValue>
      <noOfUnitsOutstanding>128980917</noOfUnitsOutstanding>
      <approxSaleDate>02/18/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>02/13/2025</acquiredDate>
      <natureOfAcquisitionTransaction>PSU Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1548</amountOfSecuritiesAcquired>
      <paymentDate>02/13/2025</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Pushkal Garg</name>
        <address>
          <com:street1>c/o 675 WEST KENDALL STREET</com:street1>
          <com:street2>HENRI A. TERMEER SQUARE</com:street2>
          <com:city>CAMBRIDGE</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02142</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>12/12/2024</saleDate>
      <amountOfSecuritiesSold>1752</amountOfSecuritiesSold>
      <grossProceeds>439763.04</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Pushkal Garg</name>
        <address>
          <com:street1>c/o 675 West Kendall Street</com:street1>
          <com:street2>Henri A. Termeer Square</com:street2>
          <com:city>Cambridge</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02142</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>01/27/2025</saleDate>
      <amountOfSecuritiesSold>52592</amountOfSecuritiesSold>
      <grossProceeds>14988720.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>02/18/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>09/11/2024</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ UBS Financial Services Inc, as attorney-in-fact for Pushkal Garg</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
