v3.25.4
NET PRODUCT REVENUES
 12 Months Ended
Dec. 31, 2025
Revenue from Contract with Customer [Abstract]  
NET PRODUCT REVENUES
3. NET PRODUCT REVENUES
Net product revenues, classified based on the geographic region in which the product is sold and by franchise (“TTR,” which includes AMVUTTRA and ONPATTRO, and “Rare,” which includes GIVLAARI and OXLUMO) consisted of the following: 
Years Ended December 31,
(In thousands)202520242023
AMVUTTRA
United States$1,731,222 $630,613 $411,169 
Europe405,899 235,441 70,898 
Rest of World176,715 104,396 75,771 
Total2,313,836 970,450 557,838 
ONPATTRO
United States62,126 74,787 97,739 
Europe79,429 134,197 210,916 
Rest of World31,234 43,873 45,891 
Total172,789 252,857 354,546 
Total TTR
2,486,625 1,223,307 912,384 
GIVLAARI
United States205,715 165,373 141,954 
Europe77,715 65,906 57,498 
Rest of World25,057 24,592 19,799 
Total308,487 255,871 219,251 
OXLUMO
United States68,467 62,766 38,159 
Europe88,049 80,753 60,025 
Rest of World34,921 23,531 11,655 
Total191,437 167,050 109,839 
Total Rare
499,924 422,921 329,090 
Total net product revenues$2,986,549 $1,646,228 $1,241,474 
As of December 31, 2025 and 2024, net product revenue-related receivables of $669.5 million and $269.9 million, respectively, were included in accounts receivable, net on our consolidated balance sheets.
The following table summarizes balances and activity in each product revenue allowance and reserve category:
As of December 31, 2025
(In thousands)
Chargebacks and Rebates
Other Incentives and Allowances
Total
Beginning balance$350,908 $10,908 $361,816 
Provision related to current period sales779,332 90,435 869,767 
Provision related to prior period sales
(48,816)— (48,816)
Credit or payments made during the period for current year sales(474,781)(65,454)(540,235)
Credit or payments made during the period for prior year sales(206,790)(10,092)(216,882)
Total$399,853 $25,797 $425,650 
As of December 31, 2024
(In thousands)Chargebacks and Rebates
Other Incentives and Allowances
Total
Beginning balance$325,672 $20,269 $345,941 
Provision related to current period sales382,892 31,204 414,096 
Credit or payments made during the period for current year sales(194,973)(34,776)(229,749)
Credit or payments made during the period for prior period sales(162,683)(5,789)(168,472)
Total$350,908 $10,908 $361,816