v3.25.4
NET PRODUCT REVENUES - Schedule of Net Product Revenues (Detail) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Dec. 31, 2023
Disaggregation of Revenue [Line Items]      
Total revenues $ 3,713,937 $ 2,248,243 $ 1,828,292
AMVUTTRA      
Disaggregation of Revenue [Line Items]      
Total revenues 2,313,836 970,450 557,838
ONPATTRO      
Disaggregation of Revenue [Line Items]      
Total revenues 172,789 252,857 354,546
TTR      
Disaggregation of Revenue [Line Items]      
Total revenues 2,486,625 1,223,307 912,384
GIVLAARI      
Disaggregation of Revenue [Line Items]      
Total revenues 308,487 255,871 219,251
OXLUMO      
Disaggregation of Revenue [Line Items]      
Total revenues 191,437 167,050 109,839
Rare      
Disaggregation of Revenue [Line Items]      
Total revenues 499,924 422,921 329,090
United States | AMVUTTRA      
Disaggregation of Revenue [Line Items]      
Total revenues 1,731,222 630,613 411,169
United States | ONPATTRO      
Disaggregation of Revenue [Line Items]      
Total revenues 62,126 74,787 97,739
United States | GIVLAARI      
Disaggregation of Revenue [Line Items]      
Total revenues 205,715 165,373 141,954
United States | OXLUMO      
Disaggregation of Revenue [Line Items]      
Total revenues 68,467 62,766 38,159
Europe | AMVUTTRA      
Disaggregation of Revenue [Line Items]      
Total revenues 405,899 235,441 70,898
Europe | ONPATTRO      
Disaggregation of Revenue [Line Items]      
Total revenues 79,429 134,197 210,916
Europe | GIVLAARI      
Disaggregation of Revenue [Line Items]      
Total revenues 77,715 65,906 57,498
Europe | OXLUMO      
Disaggregation of Revenue [Line Items]      
Total revenues 88,049 80,753 60,025
Rest of World | AMVUTTRA      
Disaggregation of Revenue [Line Items]      
Total revenues 176,715 104,396 75,771
Rest of World | ONPATTRO      
Disaggregation of Revenue [Line Items]      
Total revenues 31,234 43,873 45,891
Rest of World | GIVLAARI      
Disaggregation of Revenue [Line Items]      
Total revenues 25,057 24,592 19,799
Rest of World | OXLUMO      
Disaggregation of Revenue [Line Items]      
Total revenues $ 34,921 $ 23,531 $ 11,655