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Pay vs Performance Disclosure - USD ($) | 12 Months Ended
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Dec. 31, 2025 | Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Pay vs Performance Disclosure |  |  |  |  |
Pay vs Performance Disclosure, Table |
|  |  |  |  | VALUE OF INITIAL FIXED $100 INVESTMENT BASED ON: |  | (IN THOUSANDS)
YEAR | SUMMARY COMPENSATION TABLE TOTAL FOR PEO ($)(1) | COMPENSATION ACTUALLY PAID TO PEO ($)(1)(3)(5) | AVERAGE SUMMARY COMPENSATION TABLE TOTAL FOR NON-PEO NEOS ($)(2) | AVERAGE COMPENSATION ACTUALLY PAID TO NON-PEO NEOS ($)(2)(4)(5) | TSR ($)(6) | PEER GROUP TSR ($)(6) |  | NET INCOME (LOSS) ($) | CSM - GLOBAL NET PRODUCT REVENUES ($)
2025 | 14,867,600 |  | 77,428,521 |  | 6,582,418 |  | 19,817,949 |  | 305.96 |  | 124.75 |  |  | 313,747 |  | 2,986,549 |
2024 | 11,492,970 |  | 29,836,503 |  | 3,034,948 |  | 7,842,013 |  | 181.05 |  | 93.49 |  |  | (278,157) |  | 1,646,228 |
2023 | 8,895,670 |  | 11,410,294 |  | 2,922,458 |  | 1,574,481 |  | 147.27 |  | 94.03 |  |  | (440,242) |  | 1,241,474 |
2022 | 4,588,810 |  | 19,043,460 |  | 3,580,510 |  | 12,601,300 |  | 182.85 |  | 89.90 |  |  | (1,131,156) |  | 894,329 |
2021 | 10,176,685 |  | 17,514,345 |  | 5,918,910 |  | 10,714,290 |  | 130.48 |  | 100.02 |  |  | (852,824) |  | 662,138 |
Company Selected Measure Name | global net product revenues |  |  |  |
Named Executive Officers, Footnote | For 2025, 2024, 2023 and 2022, our PEO was Yvonne L. Greenstreet, M.D. For 2021 our PEO was John M. Maraganore, Ph.D. For 2025 our non-PEO NEOs were Jeffrey V. Poulton, Bryan A. Supran, Pushkal Garg, M.D., and Tolga Tanguler. For 2024, our non-PEO NEOs were Mr. Poulton, Dr. Garg, Mr. Tanguler, and Kevin J. Fitzgerald, Ph.D. For 2023, our non-PEO NEOs were Mr. Poulton, Dr. Garg, Mr. Tanguler, Indrani L. Franchini, and Akshay K. Vaishnaw, M.D., Ph.D. For 2022, our non-PEO NEOs were Dr. Vaishnaw, Mr. Poulton, Dr. Garg, and Ms. Franchini. For 2021, our non-PEO NEOs were Dr. Greenstreet, Dr. Vaishnaw, Mr. Poulton, and Mr. Tanguler. |  |  |  |
Peer Group Issuers, Footnote | The company TSR and the company’s Peer Group TSR reflected in these columns for each applicable fiscal year is calculated based on a fixed investment of $100 at the applicable measurement point on the same cumulative basis as is used in Item 201(e) of Regulation S-K. The peer group used to determine the company’s Peer Group TSR for each applicable fiscal year is the following published industry index, as disclosed in our Annual Report on Form 10-K for the year ended December 31, 2025 pursuant to Item 201(e) of Regulation S-K: Nasdaq Biotechnology Index (NBI). |  |  |  |
PEO Total Compensation Amount | $ 14,867,600 | $ 11,492,970 | $ 8,895,670 | $ 4,588,810 | $ 10,176,685
PEO Actually Paid Compensation Amount | $ 77,428,521 | 29,836,503 | 11,410,294 | 19,043,460 | 17,514,345
Adjustment To PEO Compensation, Footnote | The following is a summary of the adjustments made to PEO compensation as reported in the Summary Compensation Table to determine PEO CAP as reported in this table:
| 2025 | 2024 | 2023 | 2022 | 2021
Total Compensation Reported in SCT | 14,867,600 |  | 11,492,970 |  | 8,895,670 |  | 4,588,810 |  | 10,176,685 |
LESS: the grant date fair value of equity awards granted in the year indicated | (9,875,880) |  | (7,239,400) |  | (6,744,150) |  | (2,498,790) |  | (7,861,410) |
ADD: the year-end fair value of outstanding and unvested equity awards granted in the year indicated(a) | 34,291,241 |  | 17,187,024 |  | 8,173,520 |  | 5,823,820 |  | 9,100,080 |
ADD: the change in fair value of equity awards granted in years prior to the year indicated that were outstanding and unvested at the end of the year indicated (as compared to fair value at the end of the immediately prior year)(a) | 21,947,941 |  | 2,538,755 |  | 344,240 |  | 7,353,620 |  | 2,419,780 |
ADD: the change in fair value of equity awards granted in years prior to the year indicated that vested in the year indicated (fair value at vesting date as compared to the end of the immediately prior year)(a) | 16,197,619 |  | 5,857,154 |  | 741,014 |  | 3,776,000 |  | 3,679,210 |
Total (Net) Adjustments | 77,428,521 |  | 29,836,503 |  | 11,410,294 |  | 19,043,460 |  | 17,514,345 |
(a)We determined the year-end fair value of PSUs for the year indicated. If the achievement of the performance condition for the PSU was not probable, as defined under applicable accounting guidance, we assigned a fair value of $0. |  |  |  |
Non-PEO NEO Average Total Compensation Amount | $ 6,582,418 | 3,034,948 | 2,922,458 | 3,580,510 | 5,918,910
Non-PEO NEO Average Compensation Actually Paid Amount | $ 19,817,949 | 7,842,013 | 1,574,481 | 12,601,300 | 10,714,290
Adjustment to Non-PEO NEO Compensation Footnote | The following is a summary of the adjustments made to average non-PEO NEO compensation as reported in the Summary Compensation Table to determine average non-PEO NEO CAP as reported in this table:
| 2025 | 2024 | 2023 | 2022 | 2021
Average Total Compensation Reported in SCT | 6,582,418 |  | 3,034,948 |  | 2,922,458 |  | 3,580,510 |  | 5,918,910 |
LESS: the grant date fair value of equity awards granted in the year indicated | (5,105,633) |  | (1,688,240) |  | (1,888,468) |  | (2,548,800) |  | (4,891,560) |
ADD: the year-end fair value of outstanding and unvested equity awards granted in the year indicated(a) | 10,365,563 |  | 3,978,386 |  | 2,288,708 |  | 5,582,350 |  | 6,583,990 |
ADD: the change in fair value of equity awards granted in years prior to the year indicated that were outstanding and unvested at the end of the year indicated (as compared to fair value at the end of the immediately prior year)(a) | 4,471,311 |  | 1,028,665 |  | (852,294) |  | 3,941,750 |  | 962,260 |
ADD: the change in fair value of equity awards granted in years prior to the year indicated that vested in the year indicated (fair value at vesting date as compared to the end of the immediately prior year)(a) | 3,504,290 |  | 1,488,254 |  | (895,923) |  | 2,045,490 |  | 2,140,690 |
Total (Net) Adjustments | 19,817,949 |  | 7,842,013 |  | 1,574,481 |  | 12,601,300 |  | 10,714,290 |
(a)We determined the year-end fair value of PSUs for the year indicated. If the achievement of the performance condition for the PSU was not probable, as defined under applicable accounting guidance, we assigned a fair value of $0. |  |  |  |
Compensation Actually Paid vs. Total Shareholder Return | The following graphs reflect the relationships between (i) CAP for our PEO, and the average of CAP for our non-PEO NEOs, to our net income (loss), (ii) CAP for our PEO, and the average of CAP for our non-PEO NEOs, to our cumulative total shareholder return and our cumulative total shareholder return to our peer group total shareholder return, and (iii) CAP for our PEO, and the average of CAP for our non-PEO NEOs, to our global net product revenues (the CSM), in each case for the years 2021 through 2025.
| PEO CAP |  | Non-PEO Avg CAP |  | Alnylam TSR |  | Peer Group TSR
Compensation Actually Paid vs. Net Income | The following graphs reflect the relationships between (i) CAP for our PEO, and the average of CAP for our non-PEO NEOs, to our net income (loss), (ii) CAP for our PEO, and the average of CAP for our non-PEO NEOs, to our cumulative total shareholder return and our cumulative total shareholder return to our peer group total shareholder return, and (iii) CAP for our PEO, and the average of CAP for our non-PEO NEOs, to our global net product revenues (the CSM), in each case for the years 2021 through 2025.
| PEO CAP |  | Non-PEO Avg CAP |  | Net Income (Loss)
Compensation Actually Paid vs. Company Selected Measure | The following graphs reflect the relationships between (i) CAP for our PEO, and the average of CAP for our non-PEO NEOs, to our net income (loss), (ii) CAP for our PEO, and the average of CAP for our non-PEO NEOs, to our cumulative total shareholder return and our cumulative total shareholder return to our peer group total shareholder return, and (iii) CAP for our PEO, and the average of CAP for our non-PEO NEOs, to our global net product revenues (the CSM), in each case for the years 2021 through 2025.
| PEO CAP |  | Non-PEO Avg CAP |  | Global Net Product Revenues
Total Shareholder Return Vs Peer Group | The following graphs reflect the relationships between (i) CAP for our PEO, and the average of CAP for our non-PEO NEOs, to our net income (loss), (ii) CAP for our PEO, and the average of CAP for our non-PEO NEOs, to our cumulative total shareholder return and our cumulative total shareholder return to our peer group total shareholder return, and (iii) CAP for our PEO, and the average of CAP for our non-PEO NEOs, to our global net product revenues (the CSM), in each case for the years 2021 through 2025.
| PEO CAP |  | Non-PEO Avg CAP |  | Alnylam TSR |  | Peer Group TSR
Tabular List, Table | Net product revenues ▪Collaboration and royalty revenues ▪Non-GAAP operating expenses* ▪Non-GAAP operating income (loss)* |  |  |  |
Total Shareholder Return Amount | $ 305.96 | 181.05 | 147.27 | 182.85 | 130.48
Peer Group Total Shareholder Return Amount | 124.75 | 93.49 | 94.03 | 89.90 | 100.02
Net Income (Loss) | $ 313,747,000 | $ (278,157,000) | $ (440,242,000) | $ (1,131,156,000) | $ (852,824,000)
Company Selected Measure Amount | 2,986,549,000 | 1,646,228,000 | 1,241,474,000 | 894,329,000 | 662,138,000
PEO Name | Yvonne L. Greenstreet, M.D. | Yvonne L. Greenstreet, M.D. | Yvonne L. Greenstreet, M.D. | Yvonne L. Greenstreet, M.D. | John M. Maraganore, Ph.D.
Additional 402(v) Disclosure | In calculating CAP reflected in these columns, the fair value or change in fair value, as applicable, of the equity award adjustments included in such calculations was determined in accordance with FASB ASC Topic 718. We did not report a change in pension benefit values for any of the years reflected in the table, and therefore adjustments to pension benefit values were not included in calculating CAP reflected in these columns, because we do not sponsor, maintain or contribute to a defined benefit pension plan. |  |  |  |
Measure:: 1 |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Name | Net product revenues |  |  |  |
Measure:: 2 |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Name | Collaboration and royalty revenues |  |  |  |
Measure:: 3 |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Name | Non-GAAP operating expenses |  |  |  |
Measure:: 4 |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Name | Non-GAAP operating income (loss) |  |  |  |
PEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | $ (9,875,880) | $ (7,239,400) | $ (6,744,150) | $ (2,498,790) | $ (7,861,410)
PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 34,291,241 | 17,187,024 | 8,173,520 | 5,823,820 | 9,100,080
PEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 21,947,941 | 2,538,755 | 344,240 | 7,353,620 | 2,419,780
PEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 16,197,619 | 5,857,154 | 741,014 | 3,776,000 | 3,679,210
Non-PEO NEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | (5,105,633) | (1,688,240) | (1,888,468) | (2,548,800) | (4,891,560)
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 10,365,563 | 3,978,386 | 2,288,708 | 5,582,350 | 6,583,990
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 4,471,311 | 1,028,665 | (852,294) | 3,941,750 | 962,260
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | $ 3,504,290 | $ 1,488,254 | $ (895,923) | $ 2,045,490 | $ 2,140,690

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