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Stockholders' Equity - Stock-Based Compensation Expense (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |  |
Stock-based compensation expense | $ 106,176 | $ 303,331 | $ 133,572
Income tax benefit | 25,154 | 30,586 | 29,329
Cost of product sales and service sales |  |  |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |  |
Stock-based compensation expense | 4,607 | 5,844 | 3,464
Sales, general and administrative expenses |  |  |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |  |
Stock-based compensation expense | 51,301 | 238,813 | 103,860
Research and development expenses |  |  |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] |  |  |
Stock-based compensation expense | $ 50,268 | $ 58,674 | $ 26,248

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