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Stockholders' Equity - Summary of Anti-Dilutive Options Excluded (Details) - $ / shares
3 Months Ended 6 Months Ended
Jun. 30, 2016
Jun. 30, 2015
Jun. 30, 2016
Jun. 30, 2015
Stockholders' Equity Note [Abstract]        
Options to purchase shares of common stock (in shares) 3,253,343 2,724,639 2,941,864 2,395,247
Weighted average exercise price of options (in dollars per share) $ 49.91 $ 51.56 $ 50.39 $ 52.97