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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Millions | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Cash flows from operating activities |  |  |
Net income | $ 722.2 | $ 583.6 | $ 569.5
Adjustments to reconcile net income to cash provided by operating activities: |  |  |
Depreciation and amortization | 77.4 | 81.9 | 71.2
Stock-based compensation (Notes 2 and 13) | 71.0 | 61.6 | 56.9
Excess tax benefit from stock plans | 0.0 | 0.0 | (64.3)
Impairment charges (Note 4) | 118.8 | 31.0 | 0.0
Change in fair value of contingent consideration liabilities | (5.7) | (9.9) | 1.1
Deferred income taxes | (27.3) | 17.8 | (37.4)
Purchased in-process research and development | 0.0 | 6.7 | 34.5
Other | 13.0 | (6.2) | 7.9
Changes in operating assets and liabilities: |  |  |
Accounts and other receivables, net | (28.7) | (27.8) | (60.4)
Inventories | (65.7) | (124.0) | (65.6)
Accounts payable and accrued liabilities | 192.5 | 93.8 | 77.7
Income taxes | (157.8) | 293.7 | 105.1
Prepaid expenses and other current assets | 15.7 | (9.9) | (12.6)
Other | 1.4 | 8.4 | 20.8
Net cash provided by operating activities | 926.8 | 1,000.7 | 704.4
Cash flows from investing activities |  |  |
Capital expenditures | (238.7) | (168.1) | (176.1)
Deposit of cash in escrow | 0.0 | (25.0) | 0.0
Purchases of held-to-maturity investments (Note 6) | (210.0) | (804.9) | (594.7)
Proceeds from held-to-maturity investments (Note 6) | 578.1 | 654.7 | 852.5
Purchases of available-for-sale investments (Note 6) | (249.3) | (529.8) | (470.4)
Proceeds from available-for-sale investments (Note 6) | 223.2 | 448.7 | 232.6
Investments in unconsolidated affiliates (Note 6) | (6.6) | 0.0 | (7.6)
Proceeds from unconsolidated affiliates (Note 6) | 0.4 | 8.3 | 1.9
Investments in trading securities, net | (12.6) | (12.7) | (9.8)
Payment of contingent consideration | (10.0) | 0.0 | 0.0
Acquisitions (Notes 7 and 8) | 0.0 | (192.9) | 0.0
Issuances of notes receivable | 0.0 | (18.9) | 0.0
Investments in intangible assets and in-process research and development | (3.0) | (7.4) | (41.3)
Other | 5.2 | 0.8 | 1.2
Net cash provided by (used in) investing activities | 76.7 | (647.2) | (211.7)
Cash flows from financing activities |  |  |
Proceeds from issuance of debt | 688.0 | 994.7 | 253.5
Payments on debt and capital lease obligations | (1,125.3) | (818.4) | (31.4)
Purchases of treasury stock | (795.5) | (763.3) | (662.3)
Proceeds from stock plans | 147.0 | 113.8 | 103.3
Payment of contingent consideration | (15.1) | 0.0 | 0.0
Excess tax benefit from stock plans | 0.0 | 0.0 | 64.3
Other | (0.3) | 0.0 | 4.1
Net cash used in financing activities | (1,101.2) | (473.2) | (268.5)
Effect of currency exchange rate changes on cash and cash equivalents | (6.5) | 7.9 | (12.5)
Net (decrease) increase in cash and cash equivalents | (104.2) | (111.8) | 211.7
Cash and cash equivalents at beginning of year | 818.3 | 930.1 | 718.4
Cash and cash equivalents at end of year | $ 714.1 | $ 818.3 | $ 930.1

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- Definition Amount of cash outflow through purchase of long-term held-to-maturity securities. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3213-108585 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=109979856&loc=d3e26853-111562 + Details
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- Definition The cash outflow to acquire asset without physical form usually arising from contractual or other legal rights, excluding goodwill. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3213-108585 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3213-108585 + Details
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- Definition The cash outflow to acquire securities classified as trading securities and held for investment purposes. Excludes payments for trading securities purchased and held principally for the purpose of selling them in the near term (thus held for only a short period of time). + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3213-108585 + Details
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- Definition The cash inflow associated with the deconsolidation of a previously consolidated subsidiary or sale of an entity that is related to it but not strictly controlled. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3179-108585 + Details
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- Definition The cash inflow from a debt initially having maturity due after one year or beyond the operating cycle, if longer. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585 + Details
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- Definition Amount of cash inflow (outflow) from financing activities classified as other. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 3 -Subparagraph (SX 210.12-04(a)) -URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e24072-122690 Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585 Reference 3: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3291-108585 + Details
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- Definition Amount of cash inflow from sale, maturity, prepayment and call of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale). + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3151-108585 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3179-108585 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=109979856&loc=d3e26853-111562 + Details
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- Definition Amount of cash inflow from the sale or maturity of long-term held-to-maturity securities. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=109979856&loc=d3e26853-111562 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3179-108585 + Details
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- Definition The cash inflow associated with the amount received from the stock plan during the period. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585 + Details
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- Definition The cash outflow associated with security instruments that either represent a creditor or an ownership relationship with the holder of the investment security with a maturity of beyond one year or normal operating cycle, if longer. Includes repayments of (a) debt, (b) capital lease obligations, (c) mandatory redeemable capital securities, and (d) any combination of (a), (b), or (c). + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3291-108585 + Details
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- Definition The amount of the write-off for research and development assets that were acquired in a transaction other than a business combination. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 30 -Section 50 -Paragraph 1 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=66006027&loc=d3e16265-109275 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3602-108585 + Details
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