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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Cash flows from operating activities
Net income	$ 722.2	$ 583.6	$ 569.5
Adjustments to reconcile net income to cash provided by operating activities:
Depreciation and amortization	77.4	81.9	71.2
Stock-based compensation (Notes 2 and 13)	71.0	61.6	56.9
Excess tax benefit from stock plans	0.0	0.0	(64.3)
Impairment charges (Note 4)	118.8	31.0	0.0
Change in fair value of contingent consideration liabilities	(5.7)	(9.9)	1.1
Deferred income taxes	(27.3)	17.8	(37.4)
Purchased in-process research and development	0.0	6.7	34.5
Other	13.0	(6.2)	7.9
Changes in operating assets and liabilities:
Accounts and other receivables, net	(28.7)	(27.8)	(60.4)
Inventories	(65.7)	(124.0)	(65.6)
Accounts payable and accrued liabilities	192.5	93.8	77.7
Income taxes	(157.8)	293.7	105.1
Prepaid expenses and other current assets	15.7	(9.9)	(12.6)
Other	1.4	8.4	20.8
Net cash provided by operating activities	926.8	1,000.7	704.4
Cash flows from investing activities
Capital expenditures	(238.7)	(168.1)	(176.1)
Deposit of cash in escrow	0.0	(25.0)	0.0
Purchases of held-to-maturity investments (Note 6)	(210.0)	(804.9)	(594.7)
Proceeds from held-to-maturity investments (Note 6)	578.1	654.7	852.5
Purchases of available-for-sale investments (Note 6)	(249.3)	(529.8)	(470.4)
Proceeds from available-for-sale investments (Note 6)	223.2	448.7	232.6
Investments in unconsolidated affiliates (Note 6)	(6.6)	0.0	(7.6)
Proceeds from unconsolidated affiliates (Note 6)	0.4	8.3	1.9
Investments in trading securities, net	(12.6)	(12.7)	(9.8)
Payment of contingent consideration	(10.0)	0.0	0.0
Acquisitions (Notes 7 and 8)	0.0	(192.9)	0.0
Issuances of notes receivable	0.0	(18.9)	0.0
Investments in intangible assets and in-process research and development	(3.0)	(7.4)	(41.3)
Other	5.2	0.8	1.2
Net cash provided by (used in) investing activities	76.7	(647.2)	(211.7)
Cash flows from financing activities
Proceeds from issuance of debt	688.0	994.7	253.5
Payments on debt and capital lease obligations	(1,125.3)	(818.4)	(31.4)
Purchases of treasury stock	(795.5)	(763.3)	(662.3)
Proceeds from stock plans	147.0	113.8	103.3
Payment of contingent consideration	(15.1)	0.0	0.0
Excess tax benefit from stock plans	0.0	0.0	64.3
Other	(0.3)	0.0	4.1
Net cash used in financing activities	(1,101.2)	(473.2)	(268.5)
Effect of currency exchange rate changes on cash and cash equivalents	(6.5)	7.9	(12.5)
Net (decrease) increase in cash and cash equivalents	(104.2)	(111.8)	211.7
Cash and cash equivalents at beginning of year	818.3	930.1	718.4
Cash and cash equivalents at end of year	$ 714.1	$ 818.3	$ 930.1

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Amount of cash outflow to acquire investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

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The cash outflow associated with the acquisition of a controlling interest in another entity or an entity that is related to it but not strictly controlled (for example, an unconsolidated subsidiary, affiliate, joint venture or equity method investment).

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The cash outflow associated with the acquisition of a business, net of the cash acquired from the purchase.

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Amount of cash outflow through purchase of long-term held-to-maturity securities.

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The cash outflow to acquire asset without physical form usually arising from contractual or other legal rights, excluding goodwill.

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The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets.

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The cash outflow to acquire securities classified as trading securities and held for investment purposes. Excludes payments for trading securities purchased and held principally for the purpose of selling them in the near term (thus held for only a short period of time).

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The cash inflow associated with the deconsolidation of a previously consolidated subsidiary or sale of an entity that is related to it but not strictly controlled.

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The cash inflow from a debt initially having maturity due after one year or beyond the operating cycle, if longer.

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Amount of cash inflow (outflow) from financing activities classified as other.

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Amount of cash inflow from sale, maturity, prepayment and call of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

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Amount of cash inflow from the sale or maturity of long-term held-to-maturity securities.

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The cash inflow associated with the amount received from the stock plan during the period.

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The cash outflow associated with security instruments that either represent a creditor or an ownership relationship with the holder of the investment security with a maturity of beyond one year or normal operating cycle, if longer. Includes repayments of (a) debt, (b) capital lease obligations, (c) mandatory redeemable capital securities, and (d) any combination of (a), (b), or (c).

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The amount of the write-off for research and development assets that were acquired in a transaction other than a business combination.

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The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method.

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