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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Millions | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Cash flows from operating activities |  |  |
Net income | $ 1,503.1 | $ 823.4 | $ 1,046.9
Adjustments to reconcile net income to cash provided by operating activities: |  |  |
Depreciation and amortization | 134.8 | 107.2 | 89.3
Non-cash operating lease cost | 28.5 | 28.2 | 25.3
Stock-based compensation (Notes 2 and 14) | 109.3 | 92.6 | 81.3
Inventory write off (Note 2) | 0.0 | 0.0 | 73.1
Impairment charges (Note 4) | 0.0 | 0.0 | 40.6
Change in fair value of contingent consideration liabilities, net (Note 11) | (124.1) | 13.6 | (6.1)
Deferred income taxes | (41.4) | (49.4) | 12.1
Purchased in-process research and development (Note 4) | 0.0 | 0.0 | 24.0
Other | (23.4) | (3.5) | (2.8)
Changes in operating assets and liabilities: |  |  |
Accounts and other receivables, net | (91.1) | 41.9 | (88.0)
Inventories | 19.0 | (120.6) | (105.4)
Prepaid expenses and other current assets | 7.9 | (28.5) | (6.8)
Accounts payable and accrued liabilities | 195.2 | (84.5) | 116.5
Litigation settlement accrual | (29.2) | 270.5 | (180.0)
Income taxes | 62.0 | (52.9) | 43.2
Other | (18.5) | 16.3 | 19.7
Net cash provided by operating activities | 1,732.1 | 1,054.3 | 1,182.9
Cash flows from investing activities |  |  |
Capital expenditures | (325.8) | (407.0) | (254.4)
Purchases of held-to-maturity investments (Note 7) | (250.0) | (162.0) | (130.2)
Proceeds from sales and maturities of held-to-maturity investments (Note 7) | 138.0 | 212.2 | 50.0
Purchases of available-for-sale investments (Note 7) | (1,629.3) | (689.7) | (437.9)
Proceeds from sales and maturities of available-for-sale investments (Note 7) | 391.2 | 564.8 | 359.9
Acquisition (Note 8) | 0.0 | 0.0 | (100.2)
Payment for acquisition option | (13.1) | (10.0) | (35.0)
Issuances of notes receivable | (5.1) | (27.0) | (12.9)
Collections of notes receivable | 20.0 | 0.0 | 0.0
Investments in intangible assets and in-process research and development | (4.0) | (0.3) | (24.0)
Other | (44.4) | (12.1) | (11.1)
Net cash used in investing activities | (1,722.5) | (531.1) | (595.8)
Cash flows from financing activities |  |  |
Proceeds from issuance of debt | 5.2 | 16.2 | 18.9
Payments on debt and finance lease obligations | (7.0) | (17.0) | (28.9)
Purchases of treasury stock | (512.8) | (625.4) | (263.3)
Proceeds from stock plans | 158.6 | 140.5 | 160.5
Other | (0.3) | (1.2) | (2.8)
Net cash used in financing activities | (356.3) | (486.9) | (115.6)
Effect of currency exchange rate changes on cash, cash equivalents, and restricted cash | 13.9 | (20.5) | (3.0)
Net (decrease) increase in cash, cash equivalents, and restricted cash | (332.8) | 15.8 | 468.5
Cash, cash equivalents, and restricted cash at beginning of year | 1,200.2 | 1,184.4 | 715.9
Cash, cash equivalents, and restricted cash at end of year | $ 867.4 | $ 1,200.2 | $ 1,184.4

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- Definition Amount of cash outflow to acquire investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale). + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3213-108585 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3151-108585 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=124260329&loc=d3e26853-111562 + Details
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- Definition The cash outflow associated with the acquisition of business during the period. The cash portion only of the acquisition price. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 805 -SubTopic 30 -Section 50 -Paragraph 1 -Subparagraph (b)(1) -URI http://asc.fasb.org/extlink&oid=120321790&loc=d3e6927-128479 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3213-108585 + Details
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- Definition Amount of cash outflow through purchase of long-term held-to-maturity securities. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3213-108585 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=124260329&loc=d3e26853-111562 + Details
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- Definition The cash outflow to acquire asset without physical form usually arising from contractual or other legal rights, excluding goodwill. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3213-108585 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3213-108585 + Details
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- Definition The cash inflow associated with principal collections from a borrowing supported by a written promise to pay an obligation. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3179-108585 + Details
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- Definition The cash inflow from a debt initially having maturity due after one year or beyond the operating cycle, if longer. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3255-108585 + Details
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- Definition Amount of cash inflow (outflow) from financing activities classified as other. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3255-108585 Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3291-108585 + Details
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- Definition Amount of cash inflow from sale, maturity, prepayment and call of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale). + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3151-108585 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3179-108585 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=124260329&loc=d3e26853-111562 + Details
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- Definition Amount of cash inflow from the sale or maturity of long-term held-to-maturity securities. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=124260329&loc=d3e26853-111562 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3179-108585 + Details
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- Definition The cash inflow associated with the amount received from the stock plan during the period. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3255-108585 + Details
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- Definition Amount of cash outflow for debt, mandatory redeemable security, and principal payment for finance lease obligation. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3291-108585 + Details
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- Definition The amount of the write-off for research and development assets that were acquired in a transaction other than a business combination. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 30 -Section 50 -Paragraph 1 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=66006027&loc=d3e16265-109275 + Details
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- Definition Amount of noncash expense for share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3602-108585 + Details
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