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CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Millions, $ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Income Statement [Abstract]      
Net sales $ 5,232.5 $ 4,386.3 $ 4,348.0
Cost of sales 1,248.9 1,080.6 1,114.4
Gross profit 3,983.6 3,305.7 3,233.6
Selling, general, and administrative expenses 1,493.7 1,228.4 1,242.2
Research and development expenses 903.1 760.7 752.7
Intellectual property litigation expenses, net (Note 3) 20.6 405.4 33.4
Change in fair value of contingent consideration liabilities, net (124.1) 13.6 (6.1)
Special charges (Note 4) 0.0 0.0 64.6
Operating income 1,690.3 897.6 1,146.8
Interest expense 18.4 15.8 20.7
Interest income (17.4) (23.4) (32.2)
Other income, net (Note 16) (12.7) (11.5) (8.2)
Income before provision for income taxes 1,702.0 916.7 1,166.5
Provision for income taxes (Note 17) 198.9 93.3 119.6
Net income $ 1,503.1 $ 823.4 $ 1,046.9
Earnings per share:      
Basic (in dollars per share) $ 2.41 $ 1.32 $ 1.68
Diluted (in dollars per share) $ 2.38 $ 1.30 $ 1.64
Weighted-average number of common shares outstanding:      
Basic (in shares) 623.3 622.6 624.8
Diluted (in shares) 631.2 631.9 636.7